An hypothesis for a vitamin A cycle in the pigment epithelium of bovine retina.

Abstract:

:Several metabolic transformations of vitamin A have now been found in the pigment epithelium of cattle retina, leading to the hypothesis that there may be a vitamin A cycle in these cells. A retinol binding protein of MW ? 17,000 in pigment epithelial cytosol has been identified independently in several laboratories. In addition, a very active esterifying system, capable of utilizing either (3)H-retinol or (3)H-retinol bound to cellular retinol binding protein as substrates, has been demonstrated in the microsomal fraction of the cell. Finally, a retinyl ester hydrolase, with optimum activity between pH 4.0-4.5, utilizing physiological substrate prepared from pigment epithelial microsomes, has been localized in the lysosomal fraction of pigment epithelial cells. When considered together, these transformations could provide a unique cyclic mechanism for storage and mobilization of vitamin A in the pigment epithelium.

journal_name

Neurochem Int

authors

Berman ER,Segal N,Schneider A,Feeney L

doi

10.1016/0197-0186(80)90055-8

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

113-22

eissn

0197-0186

issn

1872-9754

pii

0197-0186(80)90055-8

journal_volume

1C

pub_type

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