Abstract：
:Iron accumulation is considered to be involved in the pathogenesis of Parkinson's disease. To demonstrate the relationship between peripheral iron overload and dopaminergic neuron loss in rat substantia nigra (SN), in the present study we used fast cyclic voltammetry, tyrosine hydroxylase (TH) immunohistochemistry, Perls' iron staining, and high performance liquid chromatography-electrochemical detection to study the degeneration of dopaminergic neurons and increased iron content in the SN of iron dextran overloaded animals. The findings showed that peripheral iron dextran overload increased the iron staining positive cells and reduced the number of TH-immunoreactive neurons in the SN. As a result, dopamine release and content, as well as its metabolites contents were decreased in caudate putamen. Even more dramatic changes were found in chronic overload group. These results suggest that peripheral iron dextran can increase the iron level in the SN, where excessive iron causes the degeneration of dopaminergic neurons. The chronic iron overload may be more destructive to dopaminergic neurons than the acute iron overload.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Jiang H,Song N,Wang J,Ren LY,Xie JXdoi
10.1016/j.neuint.2007.03.006subject
Has Abstractpub_date
2007-07-01 00:00:00pages
32-6issue
1eissn
0197-0186issn
1872-9754pii
S0197-0186(07)00073-3journal_volume
51pub_type
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