Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products.

abstract：:To investigate the contribution of the dopamine (DA) synthesis to both the calcium-dependent and the carrier-mediated, mechanisms of DA release in the striatum, anaesthetized rats were locally superfused in the striatum with a push pull cannula supplied with an artificial CSF containing tritiated tyrosine. DA, dihydro...

journal_title：Neurochemistry international

authors： Olivier V,Gobert A,Guibert B,Leviel V

更新日期：1999-12-01 00:00:00

abstract：:Astroglial cells have a variety of roles in the central nervous system (CNS), providing a homeostasis for the proper functioning of neuronal cells. The classical view concerning the supportive role of astroglia towards associated neurons has to be extended. A great number of new evidences suggest that astrocytes inter...

journal_title：Neurochemistry international

authors： Struzyńska L

更新日期：2009-07-01 00:00:00

abstract：:Posttranslational processing of peptide-precursors is nowadays believed to play an important role in the functioning of neurons and endocrine cells. Both proenkephalins and chromogranins/secretogranins are considered as precursor molecules in these tissues, resulting in posttranslationally formed degradation products ...

journal_title：Neurochemistry international

authors： Dillen L,Miserez B,Claeys M,Aunis D,De Potter W

更新日期：1993-04-01 00:00:00

abstract：:The synthesis of neurotransmitter glutamate in brain is mainly carried out by glutaminase enzymes. This synthesis must be exquisitely regulated because of its harmful potential giving rise to excitotoxic damage. It is noteworthy that two glutaminase isozymes coded by different genes are expressed in the brain of mamma...

journal_title：Neurochemistry international

authors： de la Rosa V,Campos-Sandoval JA,Martín-Rufián M,Cardona C,Matés JM,Segura JA,Alonso FJ,Márquez J

更新日期：2009-07-01 00:00:00

abstract：:The neuromodulator adenosine, has been shown to have the highest density of central uptake sites in the nucleus tractus solitarius in the dorsal brain stem. The nucleus tractus solitarius is involved in the central regulation of reflex cardiovascular activity suggesting that adenosine may also be involved in central c...

journal_title：Neurochemistry international

authors： Lawrence AJ,Castillo-Meléndez M,Jarrott B

更新日期：1994-09-01 00:00:00

abstract：:Variants in the gene encoding the enzyme glutamic acid decarboxylase like 1 (GADL1) have been associated with response to lithium therapy. Both GADL1 and the related enzyme cysteine sulfinic acid decarboxylase (CSAD) have been proposed to be involved in the pyridoxal-5'-phosphate (PLP)-dependent biosynthesis of taurin...

journal_title：Neurochemistry international

authors： Winge I,Teigen K,Fossbakk A,Mahootchi E,Kleppe R,Sköldberg F,Kämpe O,Haavik J

更新日期：2015-11-01 00:00:00

abstract：:Minocycline is neuroprotective in animal models of a number of acute CNS injuries, neurodegenerative diseases and CNS infection. While anti-inflammatory and anti-apoptotic effects of Minocycline have been characterized, the molecular basis for the neuroprotective effects of Minocycline remains unclear. We report here ...

journal_title：Neurochemistry international

authors： Mishra MK,Ghosh D,Duseja R,Basu A

更新日期：2009-06-01 00:00:00

abstract：:SN1, a system N amino acid transporter specific for astrocytes, is mainly responsible for export of newly synthesized L-glutamine from the cells. Astrocytic retention of L-glutamine which plays a critical role in ammonia-induced astrocytic swelling resulting in brain edema, could be tentatively attributed to the impai...

journal_title：Neurochemistry international

authors： Dąbrowska K,Albrecht J,Zielińska M

更新日期：2018-09-01 00:00:00

abstract：:The present experiments investigated the effect of a neurotoxin purified from the venom of the spider Phoneutria nigriventer. This toxic component, P. nigriventer toxin 3-6 (PnTx3-6), abolished Ca(2+)-dependent glutamate release with an IC(50) of 74.4nM but did not alter Ca(2+)-independent secretion of glutamate when ...

journal_title：Neurochemistry international

authors： Vieira LB,Kushmerick C,Reis HJ,Diniz CR,Cordeiro MN,Prado MA,Kalapothakis E,Romano-Silva MA,Gomez MV

更新日期：2003-03-01 00:00:00

abstract：:The GLS1 gene encodes a mitochondrial glutaminase that is highly expressed in brain, kidney, small intestine and many transformed cells. Recent studies have identified multiple lysine residues in glutaminase that are sites of N-acetylation. Interestingly, these sites are located within either a loop segment that regul...

journal_title：Neurochemistry international

authors： McDonald CJ,Acheff E,Kennedy R,Taylor L,Curthoys NP

更新日期：2015-09-01 00:00:00

abstract：:The phenylglycines 3-hydroxyphenylglycine, 4-carboxy-3-hydroxy-phenylglycine (4C3HPG), 4-carboxyphenylglycine (4CPG) and alpha-methyl-4-carboxyphenylglycine (MCPG) were evaluated as putative selective antagonists of metabotropic glutamate receptors on single neurones of the ventrobasal thalamus of rats, with a view to...

journal_title：Neurochemistry international

authors： Salt TE,Eaton SA

更新日期：1994-05-01 00:00:00

abstract：:Cerebellar granule neurons produce homogenous cultures that provide a unique opportunity for quantifying the apoptosis by propidium iodide- and deoxynucleotidyl transferase-flow cytometry combined analysis and for studying its regulation by neurotrophins. Nerve growth factor (NGF) was found to promote postmitotic surv...

journal_title：Neurochemistry international

authors： Muller Y,Tangre K,Clos J

更新日期：1997-08-01 00:00:00

abstract：:To characterise ketamine-induced sympathomimetic action, we examined the effects of ketamine on in vivo cardiac sympathetic nerve endings function. Using adult cats given anaesthesia with pentobarbital, dialysis probes were implanted in the left ventricular myocardium and dialysate noradrenaline (NA) concentrations we...

journal_title：Neurochemistry international

authors： Kitagawa H,Yamazaki T,Akiyama T,Mori H,Sunagawa K

更新日期：2003-02-01 00:00:00

abstract：:Much attention has been paid to the connection between periodontitis and Alzheimer's disease (AD). We previously showed that infection of P. gingivalis, one of major periodontal pathogen causing periodontitis, induced migration and inflammatory responses in murine microglia through gingipain-induced activation of prot...

journal_title：Neurochemistry international

authors： Nonaka S,Nakanishi H

更新日期：2020-11-01 00:00:00

abstract：:Malfunctioning of high-affinity glutamate transporters is believed to contribute to the accumulation of toxic concentrations of glutamate and, thus, trigger the cellular mechanisms of neurodegeneration. Emerging data point to the presence of excitotoxic component in Alzheimer's disease (AD) and aberrant expression of ...

journal_title：Neurochemistry international

authors： Rodriguez-Kern A,Gegelashvili M,Schousboe A,Zhang J,Sung L,Gegelashvili G

更新日期：2003-09-01 00:00:00

abstract：:Repeated exposure to classical psychomotor stimulants, like amphetamine (AMPH), produces locomotor sensitization and accompanied structural plasticity of dendritic spines in the nucleus accumbens (NAcc). Following our previous report that repeated administration of methiopropamine (MPA), a structural analog to meth-AM...

journal_title：Neurochemistry international

authors： Cai WT,Yoon HS,Lee S,Kim JH

更新日期：2019-10-01 00:00:00

abstract：:Tyrosine hydroxylase (TH) was purified from bovine brain and enzymatically phosphorylated in vitro. Radioactively phosphorylated TH was dephosphorylated by rat tissue extracts. Of tissues examined, rat corpus striatal extracts were highest in specific activity in the TH dephosphorylating assay. Phosphorylated histone ...

journal_title：Neurochemistry international

authors： Lazar MA,Raese JD,Barchas JD

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:and purpose: In this study, we employed a multiple microinfarction (MMI) based vascular dementia (VaD) model in aged rats and tested the therapeutic effects of Sildenafil, a phosphodiesterase type 5 inhibitor, on cognitive decline, white matter damage, autophagy and inflammatory response associated with VaD....

journal_title：Neurochemistry international

authors： Venkat P,Chopp M,Zacharek A,Cui C,Landschoot-Ward J,Qian Y,Chen Z,Chen J

更新日期：2019-07-01 00:00:00

abstract：:The cardiovascular and pulmonary responses to vasoactive intestinal contractor (VIC) were compared with those of endothelin (ET)-1, ET-2, ET-3 and sarafotoxin 6b (S6b) and the mechanism by which ET-1 alters vascular resistance was investigated in the hindquarters vascular bed of the cat. In a manner similar to ET-1 an...

journal_title：Neurochemistry international

authors： Minkes RK,Kadowitz PJ

更新日期：1991-01-01 00:00:00

abstract：:It has been shown recently that the N-terminal domain of the dopamine transporter (DAT) plays a role in several transporter functions. Here we provide evidence for a possible cellular mechanism of how the N-terminus of dopamine transporter might be removed in vivo. We isolated a recombinant N-terminal protein region o...

journal_title：Neurochemistry international

authors： Franekova V,Baliova M,Jursky F

更新日期：2008-06-01 00:00:00

abstract：:Rapid eye movement sleep deprivation is associated with an increase in Na-K ATPase activity. In order to understand the possible biochemical mechanism of this increase, the kinetics of Na-K ATPase was studied. Although the enzyme activity increased after the deprivation, the catalytic efficiency of the enzyme remained...

journal_title：Neurochemistry international

authors： Adya HV,Mallick BN

更新日期：2000-03-01 00:00:00

abstract：:The possible influence of cholinergic and dopaminergic mechanisms on neurotensin-containing neurones was examined at two different levels; nucleus accumbens and striatum in the rat brain. The acute treatment with the anticholinergic drugs atropine and scopolamine increased neurotensin concentrations in the striatum an...

journal_title：Neurochemistry international

authors： Frey P,Lis M,Coward DM

更新日期：1988-01-01 00:00:00

abstract：:The presence of nicotinic and muscarinic receptors suggests the occurrence of cholinergic neurotransmission in white matter; however no quantitative information exists on acetylcholine formation and breakdown in white matter. We compared white structures of pig brain (fimbria, corpus callosum, pyramidal tracts, and oc...

journal_title：Neurochemistry international

authors： Hassel B,Solyga V,Lossius A

更新日期：2008-12-01 00:00:00

abstract：:An investigation was made into the effects of hyperammonemia on the metabolism of brain serotonin (5-HT). The animal model used was the sparse fur (spf) mouse, which possesses an inborn error of the urea cycle, i.e. an abnormal form of ornithine transcarbamylase. Several indoles were measured in brain and plasma using...

journal_title：Neurochemistry international

authors： Chaouloff F,Laude D,Mignot E,Kamoun P,Elghozi JL

更新日期：1985-01-01 00:00:00

abstract：:Manganese (Mn) is a widely distributed trace element that is essential for normal brain function and development. However, chronic exposure to excessive Mn has been known to lead to neuronal loss and manganism, a disease with debilitating motor and cognitive deficits, whose clinical syndrome resembling idiopathic Park...

journal_title：Neurochemistry international

authors： Liu X,Yang J,Lu C,Jiang S,Nie X,Han J,Yin L,Jiang J

更新日期：2017-09-01 00:00:00

abstract：:Glial scar is a major impediment to axonal regeneration in central nervous system (CNS) disorders. Overcoming this physical and biochemical barrier might be crucial for axonal regeneration and functional compensation during the progression of CNS disorders. The mammalian target of rapamycin (mTOR) is an evolutionarily...

journal_title：Neurochemistry international

authors： Li CY,Li X,Liu SF,Qu WS,Wang W,Tian DS

更新日期：2015-04-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), an inducer of parkinsonism, causes degeneration of nigro-striatal dopaminergic neurons by producing its neurotoxic metabolite, 1-methyl-4-phenylpiridium ion (MPP+), by monoamine oxidase B in glial cells. We used PC12 (rat pheochromocytoma cell line) as a model cell ...

journal_title：Neurochemistry international

authors： Itano Y,Kitamura Y,Nomura Y

更新日期：1994-11-01 00:00:00

abstract：:The immunostains of GD3, c-pathway polysialogangliosides and gangliotetraosylgangliosides belonging to the a- and b-pathways were analyzed in embryo optic lobe cells. Cells were cultured in serum free media with, and without, bovine brain ganglioside mixture (largely gangliotetraosylgangliosides). Control cells differ...

journal_title：Neurochemistry international

authors： Cossy-Isasi S,Panzetta P

更新日期：1994-04-01 00:00:00

abstract：:Specific binding of [(3)H]d- fenfluramine , an anorectic agent acting on serotonergic system, was characterized in rat total brain minus cerebellum. The binding was reversible, stereospecific and with high affinity (K(d) about 80 nM). The receptor density in total brain was about 32 pmol/g tissue. Subcellular distribu...

journal_title：Neurochemistry international

authors： Mennini T,Gobbi M,Taddei C,Garattini S

更新日期：1988-01-01 00:00:00

abstract：:Sprague-Dawley rats exposed to uncontrollable shock can be separated by a subsequent shock escape test into two groups: a "helpless" (LH) group which demonstrates a deficit in escape behavior, and a "nonlearned helpless" (NLH) group which shows no escape deficit and acquires the escape response as readily as naive con...

journal_title：Neurochemistry international

authors： Edwards E,Kornrich W,van Houtten P,Henn FA

更新日期：1992-07-01 00:00:00