Abstract：
:Rapid eye movement sleep deprivation is associated with an increase in Na-K ATPase activity. In order to understand the possible biochemical mechanism of this increase, the kinetics of Na-K ATPase was studied. Although the enzyme activity increased after the deprivation, the catalytic efficiency of the enzyme remained unaltered. The rapid eye movement sleep deprivation increased both the Vmax and the Km suggesting an uncompetitive stimulation of the enzyme. While increase in norepinephrine resulted in an increased Vmax, that of calcium increased the Km. Since an increase in norepinephrine has been suggested after deprivation, the increased Vmax is attributed to increased norepinephrine level following deprivation. However, since rapid eye movement sleep deprivation is reported to be associated with a decrease in calcium levels, the increase in Km following deprivation may be attributed to changes in factor(s) other than calcium.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Adya HV,Mallick BNdoi
10.1016/s0197-0186(99)00121-7subject
Has Abstractpub_date
2000-03-01 00:00:00pages
249-53issue
3eissn
0197-0186issn
1872-9754pii
S0197-0186(99)00121-7journal_volume
36pub_type
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