Does a hypoxic injury from a non-fatal overdose lead to an Alzheimer Disease?

Abstract:

:Long term consequence of non-fatal overdose in people who use opioids are not well understood. The intermittent exposure to non-fatal overdose leads to a tauopathy that is often accompanied by abrogated neuroprotective response, abnormal amyloid processing and other pathologies. The scope and limitations of available literature are discussed including neuropathologies associated with opioid and overdose exposures, contributing comorbidities and proteinopathies. Contrasting postmortem data of overdose victims with animal models of opioid neuropathologies and hypoxic injury paints a picture distinct from other proteinopathies as well as effects of moderate opioid exposure. Furthermore the reported biochemical changes and potential targets for therapeutic intervention were mapped pointing to underlying imbalance between tau kinases and phosphatases that is characteristic of Alzheimer Disease.

journal_name

Neurochem Int

authors

Voronkov M,Cocchiaro B,Stock JB

doi

10.1016/j.neuint.2020.104936

subject

Has Abstract

pub_date

2020-12-10 00:00:00

pages

104936

eissn

0197-0186

issn

1872-9754

pii

S0197-0186(20)30327-2

journal_volume

143

pub_type

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