当前位置： SCI文献检索 > NEUROCHEMISTRY INTERNATIONAL期刊下所有文献 > Norepinephrine acts as D1-dopaminergic agonist in the embryonic avian retina: late expression of beta1-adrenergic receptor shifts norepinephrine specificity in the adult tissue.

Norepinephrine acts as D1-dopaminergic agonist in the embryonic avian retina: late expression of beta1-adrenergic receptor shifts norepinephrine specificity in the adult tissue.

Abstract：

:Dopamine is the main catecholamine found in the chick retina whereas norepinephrine is only found in trace amounts. We compared the effectiveness of dopamine and norepinephrine in promoting cyclic AMP accumulation in retinas at embryonic day 13 (E13) and from post-hatched chicken (P15). Dopamine (EC(50)=10microM) and norepinephrine (EC(50)=30microM), but not the beta(1)-adrenergic agonist isoproterenol, stimulated over seven-fold the production of cyclic AMP in E13 retina. The cyclic AMP accumulation induced by both catecholamines in embryonic tissue was entirely blocked by 2microM SCH23390, a D(1) receptor antagonist, but not by alprenolol (beta-adrenoceptor antagonist). In P15 retinas, 100microM isoproterenol stimulated five-fold the accumulation of cAMP. This effect was blocked by propanolol (10microM), but not by 2microM SCH23390. Embryonic and adult retina display beta(1) adrenergic receptor mRNA as detected by RT-PCR, but the beta(1) adrenergic receptor protein was detected only in post-hatched tissue. We conclude that norepinephrine cross-reacts with D(1) dopaminergic receptor with affinity similar to that of dopamine in the embryonic retina. In the mature retina, however, D(1) receptors become restricted to activation by dopamine. Moreover, as opposed to the embryonic tissue, norepinephrine seems to stimulate cAMP accumulation via beta(1)-like adrenergic receptors in the mature tissue.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Kubrusly RC,Ventura AL,de Melo Reis RA,Serra GC,Yamasaki EN,Gardino PF,de Mello MC,de Mello FG

doi

10.1016/j.neuint.2006.08.004

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

211-8

issue

1

eissn

0197-0186

issn

1872-9754

pii

S0197-0186(06)00266-X

journal_volume

50

pub_type

杂志文章

相关文献

NEUROCHEMISTRY INTERNATIONAL文献大全
  • Potentiation by Ca2+ ionophores and inhibition by extracellular KCl of endothelin-induced phosphoinositide turnover in C6 glioma cells.

    abstract：:Interactions between endothelin-1 (ET)-induced phosphoinositide (PI) hydrolysis and agents that increase Ca2+ influx (i.e. A23187 and ionomycin) or induce depolarization (i.e. KCl) were investigated using C6 glioma. A23187 dose-dependently potentiated ET (30 nM)- and ATP (100 microM)-induced [3H]inositol phosphate (IP...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(92)90161-j

    authors： Lin WW,Chuang DM

    更新日期：1992-09-01 00:00:00

  • Microencapsulation of genetically engineered fibroblasts secreting nerve growth factor.

    abstract：:We demonstrated that genetically modified fibroblasts can be encapsulated into biocompatible, biodegradable spheres retaining their viability and capacity to continuously secrete nerve growth factor (NGF) for at least two months. Genetically engineered rat fibroblasts producing NGF were encapsulated in an alginate-pol...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(93)90089-n

    authors： Maysinger D,Piccardo P,Filipovic-Grcic J,Cuello AC

    更新日期：1993-08-01 00:00:00

  • Structural and dynamic perspectives on the promiscuous transport activity of P-glycoprotein.

    abstract：:The multidrug transporter P-glycoprotein (P-gp) is expressed in the blood-brain barrier endothelium where it effluxes a range of drug substrates, preventing their accumulation within the brain. P-gp has been studied extensively for 40 years because of its crucial role in the absorption, distribution, metabolism and el...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuint.2016.05.005

    authors： Subramanian N,Condic-Jurkic K,O'Mara ML

    更新日期：2016-09-01 00:00:00

  • Ketogenic diet is antiepileptogenic in pentylenetetrazole kindled mice and decrease levels of N-acylethanolamines in hippocampus.

    abstract：:The ketogenic diet (KD) is used for the treatment of refractory epilepsy in children, however, the mechanism(s) remains largely unknown. Also, the antiepileptogenic potential in animal models of epilepsy has been poorly addressed. Activation of cannabinoid type-1 receptor (CB(1)-R) upon seizure activity may mediate ne...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2008.10.012

    authors： Hansen SL,Nielsen AH,Knudsen KE,Artmann A,Petersen G,Kristiansen U,Hansen SH,Hansen HS

    更新日期：2009-03-01 00:00:00

  • Arsenate accumulation and arsenate-induced glutathione export in astrocyte-rich primary cultures.

    abstract：:Arsenate is a toxic compound that has been connected with neuropathies and impaired cognitive functions. To test whether arsenate affects the viability and the GSH metabolism of brain astrocytes, we have used primary astrocyte cultures as model system. Incubation of astrocytes for 2h with arsenate in concentrations of...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2013.03.014

    authors： Meyer N,Koehler Y,Tulpule K,Dringen R

    更新日期：2013-06-01 00:00:00

  • A personal view from a long-lasting collaborator on the research strategies of Marshall Nirenberg.

    abstract：:In this review, I summarized transition in Dr. Marshall Nirenberg's research interests during 1970s, from a view of a long-lasting collaborator. Nirenberg switched his research filed to neurobiology after his success in deciphering genetic code and being honored with the Nobel Prize in Physiology or Medicine in 1968. ...

    journal_title：Neurochemistry international

    pub_type： 传,历史文章,杂志文章

    doi：10.1016/j.neuint.2012.02.030

    authors： Higashida H

    更新日期：2012-11-01 00:00:00

  • Reduced ability of calcitriol to promote augmented dopamine release in the lesioned striatum of aged rats.

    abstract：:Parkinson's disease (PD) is a progressive and debilitating neurodegenerative disorder that affects over one million people in the United States. Previous studies, carried out in young adult rats, have shown that calcitriol, the active metabolite of vitamin D, can be neuroprotective in 6-hydroxydopamine (6-OHDA) models...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2017.04.001

    authors： Cass WA,Peters LE

    更新日期：2017-09-01 00:00:00

  • Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution 1H NMR spectroscopy.

    abstract：:Ex vivo(1)H NMR spectroscopy was used to measure changes in the concentrations of cerebral metabolites in the prefrontal cortex (PFC) and hippocampus of rats subjected to repeated morphine treatment known to cause tolerance/dependence. The results show that repeated morphine exposure induces significant changes in the...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2006.09.012

    authors： Gao H,Xiang Y,Sun N,Zhu H,Wang Y,Liu M,Ma Y,Lei H

    更新日期：2007-01-01 00:00:00

  • Study on the possible involvement of protein kinases in the modulation of brain presynaptic sodium channels; comparison with calcium channels.

    abstract：:A possible modulatory role of kinases on voltage sensitive Na+ channels of presynaptic brain nerve endings was investigated by testing the effect of several kinase activators and inhibitors on the elevation of [Nai] induced by veratridine in mouse brain synaptosomes loaded with a selective Na+ indicator dye. Veratridi...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(97)00065-x

    authors： Sitges M,Peña F,Chiu LM,Guarneros A

    更新日期：1998-02-01 00:00:00

  • Allosteric modulation of glycine receptors is more efficacious for partial rather than full agonists.

    abstract：:Allosteric modulation of [3H]strychnine binding to glycine receptors (GlyRs) was examined in synaptosomal membranes of rat spinal cord. An allosteric model enabled us to determine the cooperativity factors of the allosteric agents with [3H]strychnine and glycine bindings (alpha and beta, respectively). We modified the...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2003.08.010

    authors： Bíró T,Maksay G

    更新日期：2004-06-01 00:00:00

  • Beyond water channel: aquaporin-4 in adult neurogenesis.

    abstract：:Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis associated with neuronal activity in the central nervous system, but the roles of AQP4 in adult neurogenesis remain largely unexplored. Based on preliminary evidences over the past years, AQP4 appears to emerge as an important player regula...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuint.2010.01.014

    authors： Zheng GQ,Li Y,Gu Y,Chen XM,Zhou Y,Zhao SZ,Shen J

    更新日期：2010-04-01 00:00:00

  • Ontogenetic differences in convulsive action and cerebral uptake of uremic guanidino compounds in juvenile mice.

    abstract：:Guanidinosuccinate (GSA) and methylguanidine (MG) are endogenous, convulsant guanidino compounds which have been shown to be greatly increased in uremic patients. In the present study, we have investigated the age-related differences in convulsive action and cerebral uptake of these compounds in juvenile mice of 7, 14...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(94)90078-7

    authors： D'Hooge R,Pei YQ,Marescau B,De Deyn PP

    更新日期：1994-03-01 00:00:00

  • Matching kinetics of synaptic vesicle recycling and enhanced neurotransmitter influx by Ca2+ in brain plasma membrane vesicles.

    abstract：:Using native plasma membrane vesicle suspensions from the rat cerebral cortex under conditions designed to alter intravesicular [Ca2+], we found that Ca2+ induced 47 +/- 5% more influx of [3H]GABA, [3H]D-aspartate and [3H]glycine at 37 degrees C with half-times 1.7 +/- 0.5, 1.3 +/- 0.4 and 1.3 +/- 0.4 min, respectivel...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(98)00039-4

    authors： Kovács I,Szárics E,Nyitrai G,Blandl T,Kardos J

    更新日期：1998-11-01 00:00:00

  • Are interspecies comparisons in the toxicity of centrally acting drugs valid without brain concentrations? A commentary.

    abstract：:Many pharmacological and toxicological studies of centrally acting drugs are undertaken in animals at doses expressed in mg.kg-1, and the results extrapolated to the clinical dose in man. Safety margins based on such no or lowest effect levels may have little relevance since they do not take into account differences i...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/0197-0186(94)00104-3

    authors： Campbell DB

    更新日期：1995-02-01 00:00:00

  • Omega-3 fatty acids deprivation affects ontogeny of glutamatergic synapses in rats: relevance for behavior alterations.

    abstract：:Essential omega-3 polyunsaturated fatty acids (omega3) are crucial to brain development and function, being relevant for behavioral performance. In the present study we examined the influence of dietary omega3 in the development of the glutamatergic system and on behavior parameters in rats. Female rats received isoca...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2010.02.010

    authors： Moreira JD,Knorr L,Ganzella M,Thomazi AP,de Souza CG,de Souza DG,Pitta CF,Mello e Souza T,Wofchuk S,Elisabetsky E,Vinadé L,Perry ML,Souza DO

    更新日期：2010-05-01 00:00:00

  • N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes.

    abstract：:Depression is highly comorbid with anxiety disorders and associated with profound cognitive impairment. Moreover, cognitive deficits associated with hippocampal dysfunction are central in depression and anxiety disorders. Furthermore, depression is accompanied by glutamatergic dysfunction which can further impair the ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2019.104605

    authors： Chakraborty S,Tripathi SJ,Srikumar BN,Raju TR,Shankaranarayana Rao BS

    更新日期：2020-01-01 00:00:00

  • Profile of prostaglandins induced by endothelin-1 in human brain capillary endothelium.

    abstract：:The vasoactive peptide, endothelin-1 (ET-1) has been implicated in the pathophysiology of various diseases. Recently, we have shown that human brain endothelial cells both secrete and express immunoreactive ET-1 high-affinity ETA receptors coupled to activation of phospholipase C (PLC). The present study demonstrates ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(93)90082-g

    authors： Stanimirovic DB,Bacic F,Uematsu S,Spatz M

    更新日期：1993-10-01 00:00:00

  • Inhibition of chemokine-like factor 1 protects against focal cerebral ischemia through the promotion of energy metabolism and anti-apoptotic effect.

    abstract：:Chemokine-like factor 1 (CKLF1) is a novel C-C chemokine, and plays important roles in immune response and brain development. In previous study, we have found that the expression of CKLF1 increased after focal cerebral ischemia and inhibition of CKLF1 using antagonist C19 peptide protected against cerebral ischemia. H...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2014.07.004

    authors： Kong LL,Wang ZY,Hu JF,Yuan YH,Han N,Li H,Chen NH

    更新日期：2014-10-01 00:00:00

  • Chronic treatment with a dopamine uptake blocker changes dopamine and acetylcholine but not glutamate and GABA concentrations in prefrontal cortex, striatum and nucleus accumbens of the awake rat.

    abstract：:The present study was aimed to investigate the effects of a chronic treatment with the dopamine uptake blocker nomifensine on the in vivo extracellular concentrations of dopamine, acetylcholine, glutamate and GABA in the prefrontal cortex, striatum and nucleus accumbens. Male Wistar rats received intraperitoneal (i.p....

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2007.08.005

    authors： Hernández LF,Segovia G,Mora F

    更新日期：2008-02-01 00:00:00

  • Vesicular release mechanisms in astrocytic signalling.

    abstract：:Astrocytes play an important role in chemical signalling, acting as receptive as well as secretory elements. They can express receptors for essentially all classical neurotransmitter substances and for a large variety of peptides. Recent evidence indicates that astrocytes are involved in the information processing wit...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/s0197-0186(02)00045-1

    authors： Volknandt W

    更新日期：2002-11-01 00:00:00

  • Melatonin protects the brain from apoptosis by enhancement of autophagy after traumatic brain injury in mice.

    abstract：:Melatonin has been proven to possess neuroprotection property against various neurological diseases by decreasing cerebral oxidative stress and inhibiting inflammatory process. However, whether administration of melatonin influences the autophagy pathway, which has recently been reported playing a pivotal role in trau...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2015.10.008

    authors： Ding K,Xu J,Wang H,Zhang L,Wu Y,Li T

    更新日期：2015-12-01 00:00:00

  • Monocyte-mediated regulation of genes by the amyloid and prion peptides in SH-SY5Y neuroblastoma cells.

    abstract：:Alzheimer's disease as well as prion-related encephalopathies are neurodegenerative disorders of the central nervous system, which cause mental deterioration and progressive dementia. Both pathologies appear to be primarily associated with the pathological accumulation and deposit of β-amyloid or prion peptides in the...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2011.01.019

    authors： Morte B,Martínez T,Zambrano A,Pascual A

    更新日期：2011-05-01 00:00:00

  • Effect of immobilization stress on pipecolic acid transport in mouse brain areas and peripheral tissues.

    abstract：:Transport activity of d-pipecolic acid and of l-pipecolic acid in mouse brain and peripheral tissues were tested, and the effect of immobilization stress was described, along with the method for preparative, enantiomeric resolution and purification of d,l-pipecolic acid using high performance liquid chromatography equ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(88)90057-5

    authors： Nishio H,Sogabe H,Segawa T

    更新日期：1988-01-01 00:00:00

  • Modulation of rat brain insulin receptor kinase activity in diabetes.

    abstract：:Insulin receptors from rat brain regions were studied for insulin binding and receptor associated kinase activity, in alloxan induced short-term and long-term diabetes, and insulin induced hypoglycemia. Insulin receptor activity was assessed by [125I]insulin binding, and basal as well as insulin stimulated kinase acti...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(92)90027-o

    authors： Gupta G,Azam M,Baquer NZ

    更新日期：1992-06-01 00:00:00

  • Light exposure stimulates the activity of ganglioside glycosyltransferases of retina ganglion cells.

    abstract：:In chicks submitted to light stimulation, the synthesis of gangliosides of the retina ganglion cell increases with respect to chicks maintained in the dark. In an attempt to elucidate if the activation of glycosyltransferases participates in the establishment of these light-dark differences detected in vivo, we examin...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(96)00128-3

    authors： Bussolino DF,Guido ME,Caputto BL

    更新日期：1997-07-01 00:00:00

  • Colchicine-binding measurements of tubulin in variously sampled and incubated tissues from the mammalian brain.

    abstract：:Tissue preparations from the brain of rats and guinea-pigs were examined for their activity in binding isotopically labelled colchicine, as a measure of their content of tubulin. The amount of binding material extracted into a cold buffered solution was unaffected by keeping tissues at 0 degrees C. It diminished by on...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(83)90072-4

    authors： McIlwain H,Poll JD

    更新日期：1983-01-01 00:00:00

  • Differentiation of neuroblastoma cells by chick gizzard extract.

    abstract：:Cholinergic neuroblastoma NS20Y cells were differentiated by the chicken gizzard extract. They were first inoculated into a glass culture bottle and the aggregated cells which grew in the suspension culture were collected. The aggregated cells (round and immature neuroblastoma cells) were seeded on a polyornithinecoat...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(82)90026-2

    authors： Miki N,Higashida H,Hayashi Y,Akiyama M,Kuo CH

    更新日期：1982-01-01 00:00:00

  • SM-31900, a novel NMDA receptor glycine-binding site antagonist, reduces infarct volume induced by permanent middle cerebral artery occlusion in spontaneously hypertensive rats.

    abstract：:The purpose of this study was to investigate the effect of (3S)-7-chloro-3-[2-((1R)-1-carboxyethoxy)-4-aminomethylphenyl]aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[c,d]indole-2-carboxylic acid hydrochloride (SM-31900), an antagonist with high selectivity and affinity for the NMDA receptor glycine-binding site, on the ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(02)00137-7

    authors： Ohtani K,Tanaka H,Ohno Y

    更新日期：2003-04-01 00:00:00

  • Brain region specificity of 3-nitropropionic acid-induced vulnerability of neurons involves cytochrome c oxidase.

    abstract：:Mitochondria play a pivotal role in the regulation of energy metabolism and apoptotic pathways. Properties and functions of mitochondria might render subsets of selectively vulnerable neurons intrinsically susceptible to a different extent to cellular stress and degeneration. We have investigated the effect of 3-nitro...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2010.06.008

    authors： Singh S,Misiak M,Beyer C,Arnold S

    更新日期：2010-10-01 00:00:00

  • Maximal GABA and muscimol binding to high-affinity sites differ in physiological and in non-physiological buffers.

    abstract：:The sensitivity of [(3)H]GABA and [(3)H]muscimol high-affinity binding sites to physiological (Krebs-Ringer's bicarbonate) and non-physiological (Tris-citrate) buffers was examined using synaptosomal membranes from bovine retinas. The maximum number of sites (B(max)) for [(3)H]GABA was present when the tissue was assa...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(86)90167-1

    authors： Madtes P Jr,Bashir-Elahi R,Chader GJ

    更新日期：1986-01-01 00:00:00