Abstract:
:Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis associated with neuronal activity in the central nervous system, but the roles of AQP4 in adult neurogenesis remain largely unexplored. Based on preliminary evidences over the past years, AQP4 appears to emerge as an important player regulating the multiple steps of adult neurogenesis. In this mini-review, we discuss the recent findings that reveal a specific functional role of AQP4 in regulating the adult neurogenesis, including proliferation of neural progenitors/neural stem cells, fate specification and differentiation, neuronal migration, and the potential mechanisms. Further studies on the regulation of AQP4 in promoting neurogenesis will lead to better understanding of the signaling mechanisms of adult neurogenesis and potentially provide an opportunity to develop AQP4 as new drug target for neurogenesis.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Zheng GQ,Li Y,Gu Y,Chen XM,Zhou Y,Zhao SZ,Shen Jdoi
10.1016/j.neuint.2010.01.014subject
Has Abstractpub_date
2010-04-01 00:00:00pages
651-4issue
5eissn
0197-0186issn
1872-9754pii
S0197-0186(10)00049-5journal_volume
56pub_type
杂志文章,评审abstract::Allosteric modulation of [3H]strychnine binding to glycine receptors (GlyRs) was examined in synaptosomal membranes of rat spinal cord. An allosteric model enabled us to determine the cooperativity factors of the allosteric agents with [3H]strychnine and glycine bindings (alpha and beta, respectively). We modified the...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2003.08.010
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abstract::Cerebral edema is a potentially life-threatening complication shared by diseases of different etiology, such as diabetic ketoacidosis, acute liver failure, high altitude exposure, dialysis disequilibrium syndrome, and salicylate intoxication. Pulmonary edema is also habitually present in these disorders, indicating th...
journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2012.05.007
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abstract::Oxidative stress-induced neuronal death plays a pivotal role in pathogenesis of neurodegenerative disorders. Recently, 7,8-dihydroxyflavone (7,8-DHF) has been shown to exert neuroprotective effects by acting as a selective tyrosine kinase receptor B (TrkB) agonist. In addition, the antioxidant action of 7,8-DHF may pr...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2013.10.018
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journal_title:Neurochemistry international
pub_type: 杂志文章
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journal_title:Neurochemistry international
pub_type: 评论,信件
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更新日期:2010-01-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/s0197-0186(96)00049-6
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journal_title:Neurochemistry international
pub_type: 杂志文章
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abstract::Intracellular Ca2+ signals produced by the glutamate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA; 5 microM) were measured in the somatic and dendritic regions of cerebellar Purkinje neurons in mature cerebellar control cultures (> or = 20 days in vitro) and cultures chronically treated...
journal_title:Neurochemistry international
pub_type: 杂志文章
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2005.12.006
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2017.05.014
更新日期:2017-09-01 00:00:00
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2016.10.007
更新日期:2017-07-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2004.08.008
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2008.01.013
更新日期:2008-05-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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doi:10.1016/j.neuint.2014.06.012
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2006.09.012
更新日期:2007-01-01 00:00:00
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
pub_type: 杂志文章
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journal_title:Neurochemistry international
pub_type: 杂志文章
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journal_title:Neurochemistry international
pub_type: 杂志文章
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journal_title:Neurochemistry international
pub_type: 杂志文章
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