Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder.

abstract：:Concanavalin A-binding glycoprotein with 250 K M(r) found in the postsynaptic density (PSD)-enriched preparation (or synaptic cytoskeleton) from rat cerebellum was identified with P400 protein from the physicochemical properties and enrichment in the cerebellum. Proteins homologous to the cerebellar 250 K M(r) protein...

journal_title：Neurochemistry international

authors： Suzuki T,Abe-Dohmae S,Tanaka R

更新日期：1992-01-01 00:00:00

abstract：:Activation of astrocytes occurs during many forms of CNS injury, but its importance for neuronal survival is poorly understood. When hippocampal cultures of neurons and astrocytes were treated from day 2-4 in vitro (DIV 2-4) with 1 microM cytosine arabinofuranoside (AraC), we observed a stellation of astrocytes, an in...

journal_title：Neurochemistry international

authors： Ahlemeyer B,Kölker S,Zhu Y,Hoffmann GF,Krieglstein J

更新日期：2003-06-01 00:00:00

abstract：:A low density of brain IR2-imidazoline receptive sites has previously been linked to depression. In this study we evaluated brain IR2-binding sites in a rat model of depression, olfactory bulbectomy, and determined the effects of chronic imipramine treatment in vivo on these sites. Compared with sham-operated controls...

journal_title：Neurochemistry international

authors： Zhu H,Paul IA,McNamara M,Redmond A,Nowak G,Piletz JE

更新日期：1997-01-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Rupture of lysosome is a major cellular stress condition leading to cell death in PD. We have previously shown that environmenta...

journal_title：Neurochemistry international

authors： Dong H,Qin Y,Huang Y,Ji D,Wu F

更新日期：2019-06-01 00:00:00

abstract：:Several endogenous brain substances which inhibit [3H]muscimol binding were isolated, and one of them has been purified to apparent homogeneity. The purification involved the extraction of brain tissue with water, followed by several steps of gel filtration column chromatography and high performance liquid chromatogra...

journal_title：Neurochemistry international

authors： Tang XW,Yarom M,Carlson RG,Vander Velde D,Huang PY,Lee YH,Seah EC,Deupree D,Wu JY

更新日期：1993-11-01 00:00:00

abstract：:Insulin receptors from rat brain regions were studied for insulin binding and receptor associated kinase activity, in alloxan induced short-term and long-term diabetes, and insulin induced hypoglycemia. Insulin receptor activity was assessed by [125I]insulin binding, and basal as well as insulin stimulated kinase acti...

journal_title：Neurochemistry international

authors： Gupta G,Azam M,Baquer NZ

更新日期：1992-06-01 00:00:00

abstract：:Acetylcholine enhanced in a concentration-dependent way the K(+) (15 mM)-evoked release of [(3)H]dopamine from synaptosomes isolated from rat corpus striatum and prelabeled with the radioactive catecholamine. The concentration-effect curve of ACh obtained in presence of 1.2 mM Ca(2+) was progressively shifted to the l...

journal_title：Neurochemistry international

authors： Versace P,Bocchieri P,Marchi M,Raiteri M

更新日期：1987-01-01 00:00:00

abstract：:The excitatory action of glutamate and aspartate upon direct application to the motor cortex of dogs was first reported in 1952 by Takashi Hayashi, Keio University School of Medicine, Tokyo. Although this investigation had been performed in the early 1940s during the Second World War, the publication in English was de...

journal_title：Neurochemistry international

authors： Takagaki G

更新日期：1996-09-01 00:00:00

abstract：:Synaptic degeneration is one of the earliest hallmarks of Alzheimer disease (AD) and results in loss of cognitive function. One of the causative agents for the synaptic degeneration is the amyloid β-peptide (Aβ), which is formed from its precursor protein by two sequential cleavages mediated by β- and γ-secretase. We ...

journal_title：Neurochemistry international

authors： Frykman S,Teranishi Y,Hur JY,Sandebring A,Yamamoto NG,Ancarcrona M,Nishimura T,Winblad B,Bogdanovic N,Schedin-Weiss S,Kihara T,Tjernberg LO

更新日期：2012-07-01 00:00:00

abstract：:The phenylglycines 3-hydroxyphenylglycine, 4-carboxy-3-hydroxy-phenylglycine (4C3HPG), 4-carboxyphenylglycine (4CPG) and alpha-methyl-4-carboxyphenylglycine (MCPG) were evaluated as putative selective antagonists of metabotropic glutamate receptors on single neurones of the ventrobasal thalamus of rats, with a view to...

journal_title：Neurochemistry international

authors： Salt TE,Eaton SA

更新日期：1994-05-01 00:00:00

abstract：:The immunostains of GD3, c-pathway polysialogangliosides and gangliotetraosylgangliosides belonging to the a- and b-pathways were analyzed in embryo optic lobe cells. Cells were cultured in serum free media with, and without, bovine brain ganglioside mixture (largely gangliotetraosylgangliosides). Control cells differ...

journal_title：Neurochemistry international

authors： Cossy-Isasi S,Panzetta P

更新日期：1994-04-01 00:00:00

abstract：:To elucidate the role of Ca(2+)-activated K(+) (K(Ca)) channels in the presynaptic acetylcholine (ACh) release from splanchnic nerve endings and the postsynaptic catecholamine release from chromaffin cells, we applied microdialysis technique to the left adrenal medulla of anesthetized rats and investigated the effects...

journal_title：Neurochemistry international

authors： Akiyama T,Yamazaki T,Kawada T,Shimizu S,Sugimachi M,Shirai M

更新日期：2010-01-01 00:00:00

abstract：:Mitochondria play a pivotal role in the regulation of energy metabolism and apoptotic pathways. Properties and functions of mitochondria might render subsets of selectively vulnerable neurons intrinsically susceptible to a different extent to cellular stress and degeneration. We have investigated the effect of 3-nitro...

journal_title：Neurochemistry international

authors： Singh S,Misiak M,Beyer C,Arnold S

更新日期：2010-10-01 00:00:00

abstract：:Specific binding of [(3)H]d- fenfluramine , an anorectic agent acting on serotonergic system, was characterized in rat total brain minus cerebellum. The binding was reversible, stereospecific and with high affinity (K(d) about 80 nM). The receptor density in total brain was about 32 pmol/g tissue. Subcellular distribu...

journal_title：Neurochemistry international

authors： Mennini T,Gobbi M,Taddei C,Garattini S

更新日期：1988-01-01 00:00:00

abstract：:Preventing or reducing tau hyperphosphorylation is considered to be a therapeutic strategy in the treatment of Alzheimer's disease (AD). Rapamycin may be a potential therapeutic agent for AD, because the rapamycin-induced autophagy may enhance the clearance of the hyperphosphorylated tau. However, recent rodent studie...

journal_title：Neurochemistry international

authors： Liu Y,Su Y,Wang J,Sun S,Wang T,Qiao X,Run X,Li H,Liang Z

更新日期：2013-03-01 00:00:00

abstract：:Radial glial cells play a significant role in the repair of spinal cord injuries as they exert critical role in the neurogenesis and act as a scaffold for neuronal migration. Our previous study showed that mature astrocytes of spinal cord can undergo a de-differentiation process and further transform into pluripotenti...

journal_title：Neurochemistry international

authors： Yang H,Ling W,Vitale A,Olivera C,Min Y,You S

更新日期：2011-12-01 00:00:00

abstract：:The function of PMP70, one of the four ABC half-transporters of mammalian peroxisomes, encoded by ABCD3 gene, is still unclear. The finding that PMP70 over-expression partially corrected very long-chain fatty acid oxidation defects in fibroblasts of X-linked adrenoleukodystrophy patients, has unveiled its potential cl...

journal_title：Neurochemistry international

authors： Di Benedetto R,Denti MA,Salvati S,Sanchez M,Attorri L,David G,Di Biase A

更新日期：2008-05-01 00:00:00

abstract：:In the present study, we investigated the neuroprotective role of p38 inhibition on experimental stroke in rats. p38 inhibition treatment alleviated the brain infarction volume and neurological deficits following ischemia, promoted the activation of Extracellular signal-regulated kinases (ERK1/2), suppressed the activ...

journal_title：Neurochemistry international

authors： Zhang XM,Zhang L,Wang G,Niu W,He Z,Ding L,Jia J

更新日期：2015-11-01 00:00:00

abstract：:Neuroinflammation is an important factor contributing to cognitive impairment and neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), ischemic injury, and multiple sclerosis (MS). These diseases are characterized by inexorable progressive injur...

journal_title：Neurochemistry international

authors： de Araújo Boleti AP,de Oliveira Flores TM,Moreno SE,Anjos LD,Mortari MR,Migliolo L

更新日期：2020-06-01 00:00:00

abstract：:Gastrointestinal peptides and hormones are known to penetrate through the utero-placental barrier and regulate fetal development. In the present study, we tested permeation of maternal brain-derived neurotrophic factor (BDNF) to fetuses, using BDNF-gene deficient mice and exogenous BDNF administration. At embryonic da...

journal_title：Neurochemistry international

authors： Kodomari I,Wada E,Nakamura S,Wada K

更新日期：2009-02-01 00:00:00

abstract：:5,7-Dihydroxytryptamine (5,7-DHT) is a selective serotonergic neurotoxin by virtue of its selective uptake into 5-hydroxytryptamine neurons and its ability to undergo autoxidation. The mechanism by which 5,7-DHT induces neurodegenerative effects remains enigmatic. The mechanism of autoxidation of 5,7-DHT, which has be...

journal_title：Neurochemistry international

authors： Sinhababu AK,Borchardt RT

更新日期：1988-01-01 00:00:00

abstract：:L-serine-O-sulphate is a member of a group of amino acids collectively called gliotoxins and is a substrate for the high affinity sodium-dependent glutamate transporters. Previous studies have shown that it is toxic to primary cultures of astrocytes but the mode of toxicity is unknown. The current study demonstrates t...

journal_title：Neurochemistry international

authors： Brennan L,Alves PM,Hewage C,Malthouse JP,McBean GJ

更新日期：2006-06-01 00:00:00

abstract：:Precise anatomical distribution of 5HT1 binding sites has been investigated in the nuclei raphe dorsalis, raphe centralis and locus caeruleus of the rat brain. An original pattern of distribution was observed in the raphe nuclei, closely correlated to the already known distribution of 5HT containing elements. This pat...

journal_title：Neurochemistry international

authors： Weissmann-Nanopoulos D,Mach E,Magre J,Demassey Y,Pujol JF

更新日期：1985-01-01 00:00:00

abstract：:Oxidatively damaged proteins and lipid peroxidation products have been shown to accumulate in the brain of neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis, and oxidized lipoprotein is considered to be toxic and neurodegenerative. However, the role of lipoprotein and its oxidized form in ...

journal_title：Neurochemistry international

authors： Sato K,Tobo M,Mogi C,Murata N,Kotake M,Kuwabara A,Im DS,Okajima F

更新日期：2014-03-01 00:00:00

abstract：:MicroRNAs represent an abundant class of endogenously expressed 18-25 nucleotide non-coding RNA molecules that function to silence gene expression through a process of post-transcriptional modification. They exhibit varied and widespread functions during normal development and tissue homeostasis, and accordingly their...

journal_title：Neurochemistry international

authors： Brower JV,Clark PA,Lyon W,Kuo JS

更新日期：2014-11-01 00:00:00

abstract：:The effects of a cerebral anti-ischemic drug ifenprodil on the receptor ionophore complex of an N-methyl-D-aspartate (NMDA)-sensitive subclass of central excitatory amino acid receptors were examined using [3H](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10- imine (MK-801) binding in rat brain synaptic memb...

journal_title：Neurochemistry international

authors： Ogita K,Ohkawara A,Suzuki T,Ohgaki T,Uchida S,Meguri H,Yoneda Y

更新日期：1992-07-01 00:00:00

abstract：:The consequences of irreversibly-inhibiting D2 dopaminergic receptors on the expression of D1 and D2 dopamine receptor mRNAs and proenkephalin mRNA and on the levels of mu- and delta-opioid receptors in rat striatum were studied following single or repeated administration of the irreversibly-acting D2 dopamine recepto...

journal_title：Neurochemistry international

authors： Chen JF,Aloyo VJ,Qin ZH,Weiss B

更新日期：1994-10-01 00:00:00

abstract：:Multiple signaling pathways via insulin receptor substrate-1 and -2 play crucial roles in health, diseases, and therapeutics (i.e., longevity, tumorigenesis, and neuroprotection). The 90-kDa heat-shock protein (Hsp90) is an emerging target molecule of therapeutics, Hsp90 inhibitors being promising against various dise...

journal_title：Neurochemistry international

authors： Yoshikawa N,Nemoto T,Satoh S,Maruta T,Yanagita T,Chosa E,Wada A

更新日期：2010-01-01 00:00:00

abstract：:The use of synthetic antisense oligonucleotides as specific inhibitors of gene expression exploits the susceptibility of mRNA to functional blockade at several levels, including mRNA processing, transport, translation and degradation. It is becoming increasingly apparent that the actions of these synthetic oligomers a...

journal_title：Neurochemistry international

authors： Knee R,Murphy PR

更新日期：1997-09-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is a novel neurotransmitter. We studied here the effect of ACS 84, a new H(2)S releasing compound, on the cytotoxicity induced by amyloid beta (Aβ) in microglia. Treatment with Aβ(1-40) (25μmol/L) for 24h significantly inhibited MTT reduction and increased lactate dehydrogenase release in BV-2...

journal_title：Neurochemistry international

authors： Liu YY,Sparatore A,Del Soldato P,Bian JS

更新日期：2011-04-01 00:00:00