Abstract:
:Acetylcholine enhanced in a concentration-dependent way the K(+) (15 mM)-evoked release of [(3)H]dopamine from synaptosomes isolated from rat corpus striatum and prelabeled with the radioactive catecholamine. The concentration-effect curve of ACh obtained in presence of 1.2 mM Ca(2+) was progressively shifted to the left when [Ca(2+)] was lowered to 0.4 and to 0.2 mM. Intrastriatal injections of kainic acid reduced (70%) the uptake of [(3)H]choline in synaptosomes prepared 8 days after the lesion but did not affect significantly the uptake of [(3)H]dopamine. Also the release of [(3)H]dopamine evoked by K(+) was minimally affected by kainic acid treatment. In contrast, acetylcholine (tested in presence of 1.2 or 0.2 mM Ca(2+)) was much more effective in enhancing [(3)H]dopamine release in synaptosomes from kainic acid-lesioned than from unlesioned striata. The results suggest that muscarinic receptors located on dopamine nerve terminals undergo supersensitivity following intrastriatal kainic acid injection.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Versace P,Bocchieri P,Marchi M,Raiteri Mdoi
10.1016/0197-0186(87)90008-8subject
Has Abstractpub_date
1987-01-01 00:00:00pages
183-8issue
2eissn
0197-0186issn
1872-9754pii
0197-0186(87)90008-8journal_volume
11pub_type
杂志文章abstract::Structural analogues of ZAPA, Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid, an isothiouronium analogue of GABA, are potent GABAA agonists as seen in the isolated guinea-pig ileum and in the facilitation of [3H]diazepam binding to rat brain membranes. Compounds with guanidino or amidine groups replacing the amino func...
journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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pub_type: 杂志文章,评审
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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