Hypothalamic GABA-ergic activity and T-cell proliferation in aged mammal: effect of dietary protein.

abstract：:Neuroinflammation is believed to play an important role in neurological diseases such as Alzheimer's disease (AD). Growing evidence suggests that n-3 PUFA have protective effects by inhibiting inflammatory processes including synthesis of eicosanoids from arachidonic acid. There is also some evidence suggesting that i...

journal_title：Neurochemistry international

authors： Boudrault C,Bazinet RP,Kang JX,Ma DW

更新日期：2010-03-01 00:00:00

abstract：:The morphological differentiation of normal rat glioblasts induced by glia maturation factor (GMF) was investigated with regard to the reorganization of the cytoskeletal structures by the use of indirect immunofluorescence staining methods. The microfilaments were reorganized from a stress fiber form to a plasmalemmal...

journal_title：Neurochemistry international

authors： Ito J,Kato T,Tanaka R

更新日期：1990-01-01 00:00:00

abstract：:Increasing evidences support that glial connexins are involved in the demyelination pathology of multiple sclerosis (MS), a chronic inflammatory demyelinating disorder. Here, we review the data from patients with MS and animal models of MS that implicate connexins in demyelination. Connexins expressed in oligodendrocy...

journal_title：Neurochemistry international

authors： Xia CY,Xu JK,Pan CH,Lian WW,Yan Y,Ma BZ,He J,Zhang WK

更新日期：2020-06-01 00:00:00

abstract：:While studies with [(3)H]D-aspartate ([(3)H]d-Asp) illustrate specific interactions with excitatory amino acid transporters (EAATs), new insights into the pharmacological characteristics and localization of specific EAAT subtypes depend upon the availability of novel ligands. One such ligand is [(3)H]-(2S,4R)-4-methyl...

journal_title：Neurochemistry international

authors： Apricò K,Beart PM,Crawford D,O'shea RD

更新日期：2007-12-01 00:00:00

abstract：:The ventral pallidum (VP) is a critical component of the basal ganglia neurocircuitry regulating learning and decision making; however, its precise role in controlling associative learning of environmental stimuli conditioned to appetitive or aversive outcomes is still unclear. Here, we investigated the expression of ...

journal_title：Neurochemistry international

authors： Macpherson T,Mizoguchi H,Yamanaka A,Hikida T

更新日期：2019-06-01 00:00:00

abstract：:The effect of aging and CDP-choline treatment (20 mg kg⁻¹ body weight i.p. for 28 days) on the maximal rates (V(max)) of representative mitochondrial enzyme activities related to Krebs' cycle (citrate synthase, α-ketoglutarate dehydrogenase, malate dehydrogenase), glutamate and related amino acid metabolism (glutamate...

journal_title：Neurochemistry international

authors： Villa RF,Ferrari F,Gorini A

更新日期：2012-12-01 00:00:00

abstract：:Previously we demonstrated that p53 mediates dopaminergic neurotoxicity via inducing mitochondrial burdens and proapoptotsis. However, little is known about the role of p53 in the excitotoxicity induced by psychostimulant, such as cocaine. Cocaine-induced kindling (convulsive) behaviors significantly increased p53 exp...

journal_title：Neurochemistry international

authors： Mai HN,Sharma N,Jeong JH,Shin EJ,Pham DT,Trinh QD,Lee YJ,Jang CG,Nah SY,Bing G,Kim HC

更新日期：2019-03-01 00:00:00

abstract：:Alteration in the lysosomal system (LS) may represent a central mechanism in neurodegeneration. 6-Hydroxydopamine (6-OHDA) induces oxidative stress and cell death in catecholaminergic cells. The LS and caspases participate in apoptosis, although the mechanism(s) that is involved is not completely understood. Here, we ...

journal_title：Neurochemistry international

authors： Lee DC,Womble TA,Mason CW,Jackson IM,Lamango NS,Severs WB,Palm DE

更新日期：2007-03-01 00:00:00

abstract：:A procedure for studying 5-hydroxytryptamine synthesis by determining the rate of accumulation of 5-hydroxytryptophan after administering m-hydroxybenzylhydrazine, an inhibitor of aromatic-l-amino acid decarboxylase, and large doses of l-tryptophan was characterized. The utility of this method as an index of 5-hydroxy...

journal_title：Neurochemistry international

authors： Nielsen JA

更新日期：1986-01-01 00:00:00

abstract：:Amiloride, a potassium sparing diuretic, inhibits adenosine A1 receptor-radioligand binding in calf and rat brain membranes in the low micromolar range. The drug interacted with the A1 receptor in a manner different from classical A1 ligands, but structure-activity relationship studies indicated that this inhibitory e...

journal_title：Neurochemistry international

authors： Garritsen A,Beukers MW,IJzerman AP,Cragoe EJ Jr,Soudijn W

更新日期：1992-02-01 00:00:00

abstract：:NaIO(4) oxidation, exo- and endo-glycosidase treatments and combinations thereof have been applied to acetylcholine receptor from Torpedo marmorata in its membrane-bound and detergent-solubilised forms. The effects of these chemical and enzymatic treatments are made apparent in the electrophoretic properties of the fo...

journal_title：Neurochemistry international

authors： Criado M,Barrantes FJ

更新日期：1982-01-01 00:00:00

abstract：:The effects of a cerebral anti-ischemic drug ifenprodil on the receptor ionophore complex of an N-methyl-D-aspartate (NMDA)-sensitive subclass of central excitatory amino acid receptors were examined using [3H](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10- imine (MK-801) binding in rat brain synaptic memb...

journal_title：Neurochemistry international

authors： Ogita K,Ohkawara A,Suzuki T,Ohgaki T,Uchida S,Meguri H,Yoneda Y

更新日期：1992-07-01 00:00:00

abstract：:Microglia, the primary resident immune cells of the central nervous system (CNS), responds rapidly to pathogens and injury by secreting immune mediators including nitric oxide (NO). The reaction of NO with the anti-oxidant glutathione forms S-nitrosoglutathione (GSNO), the major pool of biologic NO in the body. GSNO i...

journal_title：Neurochemistry international

authors： Rossi-George A,Guo CJ

更新日期：2016-10-01 00:00:00

abstract：:The objectives of this study are to identify the mechanism of mitochondrial dysfunction during cerebral ischemic/reperfusion (I/R) injury and the therapeutic potential of tetrahydrocurcumin (THC) to mitigate mitochondrial dysfunction in experimental stroke model. In our study, 8-10 weeks old male C57BL/6 wild-type mic...

journal_title：Neurochemistry international

authors： Mondal NK,Behera J,Kelly KE,George AK,Tyagi PK,Tyagi N

更新日期：2019-01-01 00:00:00

abstract：:Glutamate is an excitotoxin responsible for causing neuronal damage associated with mitochondria dysfunction. We have analyzed the relationship between the mitochondrial respiratory rate, the membrane potential (delta psi) and the activity of mitochondrial complexes in retinal cells in culture, used as neuronal models...

journal_title：Neurochemistry international

authors： Rego AC,Santos MS,Oliveira CR

更新日期：2000-02-01 00:00:00

abstract：:The release of [(3)H]GABA which is newly synthesized from [(3)H]l-glutamic acid (GLU) has been examined using striatal slices obtained from the rat brain. It was found that 8-10% of [(3)H]GLU transported was converted to [(3)H]GABA during the incubation of striatal slices in the presence of nipecotic acid (5 x 10(?5) ...

journal_title：Neurochemistry international

authors： Yoneda Y,Kanmori K,Takahashi M,Zuo PP,Paik IH,Kuriyama K

更新日期：1984-01-01 00:00:00

abstract：:Electroacupuncture has been shown to induce a preconditioning effect in the brain. The mechanisms for this protection are not fully elucidated. We hypothesize that this protection is mediated by excitatory amino acid transporters (EAATs) that have been shown to be neuroprotective. To test this hypothesis, two-month ol...

journal_title：Neurochemistry international

authors： Zhu X,Yin J,Li L,Ma L,Tan H,Deng J,Chen S,Zuo Z

更新日期：2013-10-01 00:00:00

abstract：:Astrocytes can exocytotically release the transmitter glutamate. Increased cytosolic Ca(2+) concentration is necessary and sufficient in this process. The source of Ca(2+) for the Ca(2+)-dependent exocytotic release of glutamate from astrocytes predominately comes from endoplasmic reticulum (ER) stores with contributi...

journal_title：Neurochemistry international

authors： Reyes RC,Parpura V

更新日期：2009-07-01 00:00:00

abstract：:Diisopropyl phosphorofluoridate (DFP) produces Type I organophosphorus compound-induced delayed neurotoxicity (OPIDN) in adult female chickens. We have proposed that calcium/calmodulin protein kinase II (CaM kinase II) plays a role in the development of OPIDN by increasing the phosphorylation of cytoskeletal proteins....

journal_title：Neurochemistry international

authors： Abou-Donia MB,Viana ME,Gupta RP,Anderson JK

更新日期：1993-02-01 00:00:00

abstract：:The oligosaccharides of rod and cone membranes were investigated with the aid of fluorescence and (125)I-labeled lectins. Additionally, the ability of lectins to cause agglutination in ROS suspensions was used as an index for the presence of the corresponding lectin receptors. The specificities of lectin-ligand intera...

journal_title：Neurochemistry international

authors： Bridges CD,Fong SL

更新日期：1980-01-01 00:00:00

abstract：:Vascular bed calcification is a common feature of ends stage renal disease that may lead to a complication in cardiovascular and cerebrovascular beds, which is a promoting cause of myocardial infarction, stroke, dementia and aneurysms. Sodium thiosulfate (STS) due to its multiple properties such as antioxidant and cal...

journal_title：Neurochemistry international

authors： Subhash N,Sriram R,Kurian GA

更新日期：2015-11-01 00:00:00

abstract：:The effects of ?-amino-n-butyric acid (GABA), (+)bicuculline, isoguvacine and 3-(4-chlorophenyl)-4-aminobutyrate [(+/-)baclofen] on the K-induced release of [(3)H]acetylcholine (ACh) were studied in the superior cervical ganglia of the rat in vitro. GABA and isoguvacine inhibited [(3)H]ACh release and these inhibition...

journal_title：Neurochemistry international

authors： Farkas Z,Kása P,Balcar VJ,Joó F,Wolff JR

更新日期：1986-01-01 00:00:00

abstract：:Natriuretic peptides and their receptors are widely expressed in mammalian CNS and increasing evidence implicates them in the regulation of neural development, synaptic transmission and processing of information, and neuroprotection. Although the peptides have been mainly localized in neuronal populations they are als...

journal_title：Neurochemistry international

authors： Prado J,Baltrons MA,Pifarré P,García A

更新日期：2010-11-01 00:00:00

abstract：:Stroke causes neuronal cell death and destruction of neuronal circuits in the brain and spinal cord. Injury to the brain tissue induces sterile inflammation triggered by the extracellular release of endogenous molecules, but cerebral inflammation after stroke is gradually resolved within several days. In this pro-reso...

journal_title：Neurochemistry international

authors： Sakai S,Shichita T

更新日期：2019-11-01 00:00:00

abstract：:Chronic ingestion of caffeine causes dependence and sleep disturbance in children and adolescents. In rodents, the administration of caffeine may produce behavioral cross-sensitization to some psychostimulants, such as dopaminergic psychoactive drugs. Methylphenidate (MPH; Ritalin) is a psychostimulant used in pediatr...

journal_title：Neurochemistry international

authors： Boeck CR,Marques VB,Valvassori SS,Constantino LC,Rosa DV,Lima FF,Romano-Silva MA,Quevedo J

更新日期：2009-09-01 00:00:00

abstract：:The changes in intracellar Ca(2+)-concentration, which occur during stimulation of vascular smooth muscle cells with excitatory agonists, are discussed. The effects of these agonists on the membrane potential of these cells are indirect, and mainly due to an activation of K(+)- and Cl(?)-channels by the release of cal...

journal_title：Neurochemistry international

authors： Casteels R,Droogmans G,Missiaen L

更新日期：1990-01-01 00:00:00

abstract：:Cortical cells from embryonic mice (E17) showed a rapid cell-death under the serum-free condition. The addition of nefiracetam at 0.1-10 microM increased the survival activity, while aniracetam at the same concentrations did not. The cell death was characterized to be apoptotic, since dead cells showed nuclear condens...

journal_title：Neurochemistry international

authors： Fujita R,Takayama N,Ueda H

更新日期：2002-02-01 00:00:00

abstract：:The venom from the marine snail Conus pennaceus inhibits the binding of [3H]neuropeptide Y to calf brain membranes (Czerwiec et al., 1996a) and, in the present study, also to rat forebrain membranes. These membranes contain about 80% Y1- and 20% Y2-receptors. The inhibition by the venom was concentration-dependent wit...

journal_title：Neurochemistry international

authors： Diallo B,Vanderheyden PM,De Backer JP,Vauquelin G

更新日期：1998-01-01 00:00:00

abstract：:The developmental profile of cytosolic sialidase from the nerve ending and the nerve ending-free compartments of rat forebrain was studied from birth to 150 days. Soluble extracts containing the cytosol from nerve endings and nerve ending-free tissue were separately prepared; the recovery of cytosol in the two extract...

journal_title：Neurochemistry international

authors： Venerando B,Fiorilli A,Malesci A,Goi GC,Lombardo A,Preti A,Tettamanti G

更新日期：1983-01-01 00:00:00

abstract：:The parenchyma of the anterior pituitary gland is constituted of distinct specialized glandular cell types, some of them being able to secrete two, or more, genetically related hormones. The synthesis and the release of each hormone is a discontinuous process controlled by a variety of chemical signals of hypothalamic...

journal_title：Neurochemistry international

authors： Gourdji D

更新日期：1985-01-01 00:00:00