Glial cells as sources and targets of natriuretic peptides.

abstract：:TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of ubiquitinated inclusions in motor neurons of sporadic amyotrophic lateral sclerosis (ALS). TDP-43 is ubiquitously expressed and the majority of TDP-43 is normally localized to the nucleus. In motor neurons of patients with ALS, TDP-43 is not locali...

journal_title：Neurochemistry international

authors： Hishizawa M,Yamashita H,Akizuki M,Urushitani M,Takahashi R

更新日期：2019-03-01 00:00:00

abstract：:It has been reported that mutations of gammaPKC cause hereditary spinocerebellar atrophy type 14 (SCA14). Our recent study has revealed that the SCA14 mutant gammaPKC is susceptible to aggregation and causes cell death. Among mutations/polymorphisms of gammaPKC, the R659S mutation was firstly segregated from families ...

journal_title：Neurochemistry international

authors： Mochizuki H,Seki T,Adachi N,Saito N,Mishima HK,Sakai N

更新日期：2006-12-01 00:00:00

abstract：:Cholesterol, a molecule critical for cellular function, is found in particular high concentration in the brain and has been implicated to synaptic plasticity and neuronal regeneration. This study was undertaken to investigate the mechanism by which cholesterol shortage modulates glutamate (Glu)-induced excitotoxicity ...

journal_title：Neurochemistry international

authors： Chou YC,Lin SB,Tsai LH,Tsai HI,Lin CM

更新日期：2003-08-01 00:00:00

abstract：:Patients with Parkinson's disease (PD) show a common progressive neurodegenerative movement disorder characterized by rigidity, tremors, postural instability, and bradykinesia due to the loss of dopaminergic neurons in the substantia nigra, and is often accompanied by several non-motor symptoms, called parkinsonism. S...

journal_title：Neurochemistry international

authors： Shimizu J,Kasai T,Yoshida H,Huynh AM,Nakao-Azuma Y,Shinomoto M,Tokuda T,Mizuno T,Yamaguchi M

更新日期：2020-10-01 00:00:00

abstract：:Essential omega-3 polyunsaturated fatty acids (omega3) are crucial to brain development and function, being relevant for behavioral performance. In the present study we examined the influence of dietary omega3 in the development of the glutamatergic system and on behavior parameters in rats. Female rats received isoca...

journal_title：Neurochemistry international

authors： Moreira JD,Knorr L,Ganzella M,Thomazi AP,de Souza CG,de Souza DG,Pitta CF,Mello e Souza T,Wofchuk S,Elisabetsky E,Vinadé L,Perry ML,Souza DO

更新日期：2010-05-01 00:00:00

abstract：:The concentrations of gamma-glutamylglutamate, gamma-glutamylglutamine, gamma-glutamylcysteine, glutamate, aspartate, glutamine, cyst(e)ine and glutathione (including disulfides) were determined by HPLC analysis of both the tissue and the surrounding medium of incubated rat hippocampal slices. High potassium concentra...

journal_title：Neurochemistry international

authors： Li X,Orwar O,Revesjö C,Sandberg M

更新日期：1996-08-01 00:00:00

abstract：:Esters of dimethylcarbamic acid are known to be poor substrates of acetylcholinesterase. They carbamylate the active catalytic site of the enzyme and the subsequent decarbamylation is a slow but measurable process. Similarly, acetylcholinesterase can be phosphonylated, and the dephosphonylation is extremely slow. Rapi...

journal_title：Neurochemistry international

authors： Dawson RM,Poretski M,Upsher CM

更新日期：1981-01-01 00:00:00

abstract：:Concanavalin A-binding glycoprotein with 250 K M(r) found in the postsynaptic density (PSD)-enriched preparation (or synaptic cytoskeleton) from rat cerebellum was identified with P400 protein from the physicochemical properties and enrichment in the cerebellum. Proteins homologous to the cerebellar 250 K M(r) protein...

journal_title：Neurochemistry international

authors： Suzuki T,Abe-Dohmae S,Tanaka R

更新日期：1992-01-01 00:00:00

abstract：:We showed that dextromethorphan (DM) provides neuroprotective/anticonvulsant effects and that DM and its major metabolite, dextrorphan, have a high-affinity for sigma(1) receptors, but a low affinity for sigma(2) receptors. In addition, we found that DM has a higher affinity than DX for sigma(1) sites, whereas DX has ...

journal_title：Neurochemistry international

authors： Shin EJ,Nah SY,Chae JS,Bing G,Shin SW,Yen TP,Baek IH,Kim WK,Maurice T,Nabeshima T,Kim HC

更新日期：2007-05-01 00:00:00

abstract：:Choline acetyltransferase (ChAT), the synthesizing enzyme for acetylcholine, has been implicated to involve multiple isoforms of ChAT mRNA in several animals. Since these isoforms are mostly non-coding splice variants, only a homologous ChAT protein of about 68 kDa has been shown to be produced in vivo. Recent evidenc...

journal_title：Neurochemistry international

authors： Matsuo A,Bellier JP,Hisano T,Aimi Y,Yasuhara O,Tooyama I,Saito N,Kimura H

更新日期：2005-04-01 00:00:00

abstract：:Streptozotocin (STZ) is a glucosamine-nitrosourea commonly used to induce long-lasting models of diabetes mellitus and Alzheimer's disease. Direct toxicity of STZ on the pancreas and kidneys has been well characterized, but the acute effect of this compound on brain tissue has received less attention. Herein, we inves...

journal_title：Neurochemistry international

authors： Rodrigues L,Wartchow KM,Suardi LZ,Federhen BC,Selistre NG,Gonçalves CA

更新日期：2019-09-01 00:00:00

abstract：:Succinyl-Leu-Leu-Val-Tyr-4-methylcoumaryl-7-amide (Suc-LLVY-MCA) hydrolyzing activities of the 20S and 26S proteasomes in the gerbil cortex following transient forebrain ischemia were examined. Using extraction solutions without ATP, only 20S proteasome activity was noted after separation with glycerol gradient centri...

journal_title：Neurochemistry international

authors： Kamikubo T,Hayashi T

更新日期：1996-02-01 00:00:00

abstract：:Selective dopaminergic neurotoxicity induced by 1-methyl-4-phenylpyridine (MPP+) is believed to be due to the transmembrane uptake by the dopamine transporter and subsequent inhibition of mitochondrial complex I and/or production of free radicals. However, little is known about the molecular sequence of intracellular ...

journal_title：Neurochemistry international

authors： Storch A,Ludolph AC,Schwarz J

更新日期：1999-11-01 00:00:00

abstract：:Phenylalanine and its phenyl metabolites produced a clear inhibition of chick brain mevalonate 5-pyrophosphate decarboxylase, while mevalonate kinase and mevalonate 5-phosphate kinase were not significantly affected. Phenolic derivatives produced a similar or higher inhibition than that found in the presence of phenyl...

journal_title：Neurochemistry international

authors： Castillo M,Iglesias J,Zafra MF,Garcia-Peregrin E

更新日期：1991-01-01 00:00:00

abstract：:The influx of extracellular Zn(2+) into dentate granule cells is nonessential for dentate gyrus long-term potentiation (LTP) and the physiological significance of extracellular Zn(2+) dynamics is unknown in the dentate gyrus. Excess increase in extracellular Zn(2+) in the hippocampal CA1, which is induced with excitat...

journal_title：Neurochemistry international

authors： Suzuki M,Fujise Y,Tsuchiya Y,Tamano H,Takeda A

更新日期：2015-08-01 00:00:00

abstract：:Diabetic mice exhibit increased mortality and morbidity following stroke. Recent studies from our laboratory have indicated that increased morbidity in diabetic db/db mice relative to their non-diabetic db/+ littermates is associated with increased levels of MMP-9 protease activity, increased blood-brain barrier (BBB)...

journal_title：Neurochemistry international

authors： Kumari R,Bettermann K,Willing L,Sinha K,Simpson IA

更新日期：2020-10-01 00:00:00

abstract：:Oxidative stress-induced neuronal death due to hydrogen peroxide overload plays a critical role in the pathogenesis of numerous neurological diseases. Insulin-like growth factor-1 (IGF-1) is important in maintaining neuronal survival, proliferation, and differentiation in the central nervous system. We now report that...

journal_title：Neurochemistry international

authors： Zhong J,Lee WH

更新日期：2007-11-01 00:00:00

abstract：:The presence of corticotropin-releasing hormone (CRH) receptors has been previously demonstrated in corticotrophs from normal pituitaries using a method combining immunocytochemistry and liquid emulsion autoradiography. The aim of this study was to compare the characteristics of the 125I-Tyr0-hCRH binding in corticotr...

journal_title：Neurochemistry international

authors： Abs R,Smets G,Vauquelin G,Verhelst J,Mahler C,Verlooy J,Stevenaert A,Wouters L,Borgers M,Beckers A

更新日期：1997-03-01 00:00:00

abstract：:The possible influence of cholinergic and dopaminergic mechanisms on neurotensin-containing neurones was examined at two different levels; nucleus accumbens and striatum in the rat brain. The acute treatment with the anticholinergic drugs atropine and scopolamine increased neurotensin concentrations in the striatum an...

journal_title：Neurochemistry international

authors： Frey P,Lis M,Coward DM

更新日期：1988-01-01 00:00:00

abstract：:The effects of ?-amino-n-butyric acid (GABA), (+)bicuculline, isoguvacine and 3-(4-chlorophenyl)-4-aminobutyrate [(+/-)baclofen] on the K-induced release of [(3)H]acetylcholine (ACh) were studied in the superior cervical ganglia of the rat in vitro. GABA and isoguvacine inhibited [(3)H]ACh release and these inhibition...

journal_title：Neurochemistry international

authors： Farkas Z,Kása P,Balcar VJ,Joó F,Wolff JR

更新日期：1986-01-01 00:00:00

abstract：:Mitochondria play a pivotal role in the regulation of energy metabolism and apoptotic pathways. Properties and functions of mitochondria might render subsets of selectively vulnerable neurons intrinsically susceptible to a different extent to cellular stress and degeneration. We have investigated the effect of 3-nitro...

journal_title：Neurochemistry international

authors： Singh S,Misiak M,Beyer C,Arnold S

更新日期：2010-10-01 00:00:00

abstract：:Norepinephrine (NE) metabolism in brain regions was studied in the Purkinje cell degeneration (pcd) mutant mouse. The Purkinje cells, which are target cells for noradrenergic (NA) neurons, degenerate completely in the pcd mutant mouse between 17 and 45 days of age, but the NA terminals remain intact. The purpose of th...

journal_title：Neurochemistry international

authors： Ghetti B,Perry KW,Fuller RW

更新日期：1987-01-01 00:00:00

abstract：:Although many studies have revealed alterations in neurotransmission during ischaemia, few works have been devoted to the neurochemical effects of mild hypoxia, a situation encountered during life in altitude or in several pathologies. In that context, the present work was undertaken to determine the in vivo mechanism...

journal_title：Neurochemistry international

authors： Orset C,Parrot S,Sauvinet V,Cottet-Emard JM,Bérod A,Pequignot JM,Denoroy L

更新日期：2005-06-01 00:00:00

abstract：:Diabetic neuropathy (DN) is a common form of peripheral neuropathy, yet the mechanisms responsible for chronic pain in this disease are poorly understood. The up-regulation of the expression and function of voltage-gated sodium channel Nav1.7 has been implicated in DN, however, the exact mechanism is unclear. In the p...

journal_title：Neurochemistry international

authors： Huang Y,Zang Y,Zhou L,Gui W,Liu X,Zhong Y

更新日期：2014-09-01 00:00:00

abstract：:Whereas carbachol, noradrenaline, serotonin and memantine stimulated inositol phosphates production and calcium mobilization in 3-5 day old rabbit retinal cultures, only carbachol and noradrenaline were effective when 25-30 day old cultures were used. The older retinal cultures contain only Müller cells which shows th...

journal_title：Neurochemistry international

authors： Osborne NN,Quack G

更新日期：1992-10-01 00:00:00

abstract：:Carotenoids play a pivotal role in prevention of many degenerative diseases mediated by oxidative stress including neurodegenerative diseases like Alzheimer's Disease (AD). The involvement of retinoids in physiology, AD pathology and their therapeutic role in vitro and in vivo has been extensively studied. This review...

journal_title：Neurochemistry international

authors： Obulesu M,Dowlathabad MR,Bramhachari PV

更新日期：2011-10-01 00:00:00

abstract：:Potassium bisperoxo(1,10-phenantroline)oxovanadate (V) [bpV(phen)] is a potent protein tyrocine phosphatase inhibitor which mediates a variety of biological effects. The aim of these studies was to examine the role(s) of mitogen activated protein kinase (MAPK) pathways in PC12 cell proliferation and toxicity by bpV(ph...

journal_title：Neurochemistry international

authors： Cerovac Z,Ban J,Morinville A,Yaccato K,Shaver A,Maysinger D

更新日期：1999-04-01 00:00:00

abstract：:Long-term potentiation (LTP) is a well-established experimental model used to investigate the synaptic basis of learning and memory. LTP at mossy fibre - CA3 synapses in the hippocampus is unusual because it is normally N-methyl-d-aspartate (NMDA) receptor-independent. Instead it seems that the trigger for mossy fibre...

journal_title：Neurochemistry international

authors： Sherwood JL,Amici M,Dargan SL,Culley GR,Fitzjohn SM,Jane DE,Collingridge GL,Lodge D,Bortolotto ZA

更新日期：2012-09-01 00:00:00

abstract：:Many peripheral substances, including ghrelin, induce neuronal activation in the brain. In the present study, we compared the effect of subcutaneously administered ghrelin and its three stable agonists: Dpr(3)ghr ([Dpr(N-octanoyl)(3)] ghrelin) (Dpr - diaminopropionic acid), YA GHRP-6 (H-Tyr-Ala-His-DTrp-Ala-Trp-DPhe-L...

journal_title：Neurochemistry international

authors： Pirnik Z,Bundziková J,Holubová M,Pýchová M,Fehrentz JA,Martinez J,Zelezná B,Maletínská L,Kiss A

更新日期：2011-11-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), an inducer of parkinsonism, causes degeneration of nigro-striatal dopaminergic neurons by producing its neurotoxic metabolite, 1-methyl-4-phenylpiridium ion (MPP+), by monoamine oxidase B in glial cells. We used PC12 (rat pheochromocytoma cell line) as a model cell ...

journal_title：Neurochemistry international

authors： Itano Y,Kitamura Y,Nomura Y

更新日期：1994-11-01 00:00:00