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Carotenoids and Alzheimer's disease: an insight into therapeutic role of retinoids in animal models.

Abstract：

:Carotenoids play a pivotal role in prevention of many degenerative diseases mediated by oxidative stress including neurodegenerative diseases like Alzheimer's Disease (AD). The involvement of retinoids in physiology, AD pathology and their therapeutic role in vitro and in vivo has been extensively studied. This review focuses on the role of carotenoids like retinoic acid (RA), all trans retinoic acid (ATRA), lycopene and β-carotene in prevention of AD symptoms primarily through inhibition of amyloid beta (Aβ) formation, deposition and fibril formation either by reducing the levels of p35 or inhibiting corresponding enzymes. The role of antioxidant micronutrients in prevention or delaying of AD symptoms has been included. This study emphasizes the dietary supplementation of carotenoids to combat AD and warrants further studies on animal models to unravel their mechanism of neuroprotection.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Obulesu M,Dowlathabad MR,Bramhachari PV

doi

10.1016/j.neuint.2011.04.004

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

535-41

issue

5

eissn

0197-0186

issn

1872-9754

pii

S0197-0186(11)00158-6

journal_volume

59

pub_type

杂志文章,评审

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