Abstract:
BACKGROUND:Axonal injury is the correlate of disease progression in NMO and MS. Neurofilament (Nf) belongs to neuron specific intermediate filaments located in axons. Nf protein subunits are potential biomarkers in cerebrospinal fluid (CSF) for acute axonal injury. However, whether CSF NfH and NfL levels are elevated in NMO patients has remained unclear. METHODS:Nf light subunit (NfL) and Nf heavy subunit NfH in cerebrospinal fluid were measured by enzyme-linked immunosorbent assay (ELISA) in NMO (n=32), MS (n=25), and other non-inflammatory neurological disease patients (OND, n=18). RESULTS:CSF pNf-H levels were increased in the NMO patients compared with OND patients (p=0.001). CSF NfL levels in the NMO patients were also higher compared with MS patients (p=0.001), and OND patients (p=0.000001). When comparing NfL levels between MS and OND patients, there also significant differences (p=0.0003). NMO and MS patients revealed a trend to an increased disability with increased CSF NfL during relapse (NMO: p=0.006; MS: p=0.017). There is positive relationship between CSF pNf-H and disability of MS patients (p=0.041). CONCLUSIONS:CSF levels of NfL are increased in NMO patients and reflect the disease severity in NMO.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Wang H,Wang C,Qiu W,Lu Z,Hu X,Wang Kdoi
10.1016/j.neuint.2013.10.008subject
Has Abstractpub_date
2013-12-01 00:00:00pages
805-8issue
8eissn
0197-0186issn
1872-9754pii
S0197-0186(13)00264-7journal_volume
63pub_type
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