Endogenous modulator of dopamine receptor(s).

Abstract:

:An endogenous modulator(s) of the dopamine receptor(s) in bovine and rat brain striatum was detected by demonstrating that water extracts of the striatum inhibited [(3)H]apomorphine binding. This modulator(s) was partially purified by methanol extraction and then successive ion exchange chromatographies on SP-Sephadex C-25 and QAE-Sephadex A-25, and gel chromatography on Sephadex G-25. The partially purified (about 1,500-fold) modulator was a fluorescamine-positive substance, Mr = 500 1000, which was heat-stable (95 degrees C, 10 min), and was destroyed by acid- and alkali-treatment, but not by treatments with various peptidases. The modulator inhibited binding of the dopamine agonist, [(3)H]apomorphine non-competitively, but did not inhibit binding of the dopamine antagonist, [(3)H]spiroperidol. Direct injection of the modulator into rat brain striatum depressed apomorphine-induced locomotor activity. Moreover the modulator inhibited dopamine-sensitive adenylate cyclase activity. These findings indicate that the modulator acts at a site(s) other than the ligand binding site of the dopamine receptor(s) and modulates the activities of dopamine agonists.

journal_name

Neurochem Int

authors

Hirata A,Yamada I,Fujita N,Saito K,Nakahiro M,Yoshida H

doi

10.1016/0197-0186(86)90082-3

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

401-7

issue

3

eissn

0197-0186

issn

1872-9754

pii

0197-0186(86)90082-3

journal_volume

9

pub_type

杂志文章
  • The dawn of excitatory amino acid research in Japan. The pioneering work by Professor Takashi Hayashi.

    abstract::The excitatory action of glutamate and aspartate upon direct application to the motor cortex of dogs was first reported in 1952 by Takashi Hayashi, Keio University School of Medicine, Tokyo. Although this investigation had been performed in the early 1940s during the Second World War, the publication in English was de...

    journal_title:Neurochemistry international

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/0197-0186(95)00112-3

    authors: Takagaki G

    更新日期:1996-09-01 00:00:00

  • Neurotrophins and their receptors in nerve injury and repair.

    abstract::Cytokines are a heterogenous group of polypeptide mediators that have been associated with activation of numerous functions, including the immune system and inflammatory responses. The cytokine families include, but are not limited to, interleukins (IL-I alpha, IL-I beta, ILIra and IL-2-IL-15), chemokines (IL-8/ NAP-I...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/s0197-0186(96)00071-x

    authors: Ebadi M,Bashir RM,Heidrick ML,Hamada FM,Refaey HE,Hamed A,Helal G,Baxi MD,Cerutis DR,Lassi NK

    更新日期:1997-04-01 00:00:00

  • Electromagnetic fields induce neural differentiation of human bone marrow derived mesenchymal stem cells via ROS mediated EGFR activation.

    abstract::Even though the inducing effect of electromagnetic fields (EMF) on the neural differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) is a distinctive, the underlying mechanism of differentiation remains unclear. To find out the signaling pathways involved in the neural differentiation of BM-MSCs by EMF...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2013.02.002

    authors: Park JE,Seo YK,Yoon HH,Kim CW,Park JK,Jeon S

    更新日期:2013-03-01 00:00:00

  • Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice.

    abstract::Alzheimer's disease has long been associated with increased inflammation in the brain. Activated microglia and increased production of the inflammatory cytokines such as TNF-α, have been proposed to contribute to the onset and progression of the disease. We investigated if systemic administration of an anti-tumor necr...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2014.04.001

    authors: Detrait ER,Danis B,Lamberty Y,Foerch P

    更新日期:2014-06-01 00:00:00

  • Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha.

    abstract::Amyloid deposition within the brains of Alzheimer's Disease patients results in the activation of microglial cells and the induction of a local inflammatory response. The interaction of microglia or monocytes with beta-amyloid (A beta) fibrils elicits the activation a complex tyrosine kinase-based signal transduction ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(01)00052-3

    authors: Combs CK,Bates P,Karlo JC,Landreth GE

    更新日期:2001-11-01 00:00:00

  • Cytoskeletal regulation of normal rat glioblasts differentiated by glia maturation factor.

    abstract::The morphological differentiation of normal rat glioblasts induced by glia maturation factor (GMF) was investigated with regard to the reorganization of the cytoskeletal structures by the use of indirect immunofluorescence staining methods. The microfilaments were reorganized from a stress fiber form to a plasmalemmal...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(90)90080-d

    authors: Ito J,Kato T,Tanaka R

    更新日期:1990-01-01 00:00:00

  • α-Lipoic acid (LA) enantiomers protect SH-SY5Y cells against glutathione depletion.

    abstract::Growing evidence suggests that α-lipoic acid (LA) has neuroprotective effects in various pathological conditions including brain ischemia and neurodegeneration. While anti-oxidative activity has been thought to play a central role in LA-mediated neuroprotection, the precise mechanism and the effect of LA enantiomers (...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2011.09.005

    authors: Yamada T,Hashida K,Takarada-Iemata M,Matsugo S,Hori O

    更新日期:2011-12-01 00:00:00

  • Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus.

    abstract::To identify whether the process of apoptosis bears a topographic relationship to selected aspects of Alzheimer's disease (AD) pathology, we used an in situ nick translation method (TUNEL) to map DNA fragmentation in hippocampal sections immunostained for abnormally phosphorylated tau, which exists in the neurofibrilla...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(96)00158-1

    authors: Sugaya K,Reeves M,McKinney M

    更新日期:1997-08-01 00:00:00

  • Purification of peroxisomal fraction from rat brain.

    abstract::A purification procedure to obtain peroxisomes (microperoxisomes) from the brain of suckling rats is reported. A P2 fraction, (crude light mitochondria) frozen and thawed seven times, was subfractionated yielding a P4 fraction, 4-fold enriched in catalase activity with respect to the cytoplasmic extract S1. The P4 fra...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(93)90116-m

    authors: Cimini AM,Moreno S,Giorgi M,Serafini B,Cerú MP

    更新日期:1993-09-01 00:00:00

  • Interactions between lectins and acetylcholinesterase from the sarcotubular system of skeletal muscle.

    abstract::The oligosaccharide chains attached to the multiple forms of acetylcholinesterase (AChE) in a fraction enriched in membranes of the sarcoplasmic reticulum and T-tubules of rabbit skeletal muscle were studied using lectins. By sequential extraction of the membranes with Triton X-100, two preparations of soluble enzyme ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(90)90065-2

    authors: Cánovas-Muñoz MD,Vidal CJ

    更新日期:1990-01-01 00:00:00

  • Contribution of astrocytes to synaptic transmission in the rat supraoptic nucleus.

    abstract::Astrocytes, besides supporting metabolic and scaffolding functions, play a prominent role in the modulation of neuronal communication. In particular, they are responsible for clearing synaptically-released glutamate via highly specific transporters located on their plasma membrane. Since glutamate is the main excitato...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2003.07.005

    authors: Piet R,Poulain DA,Oliet SH

    更新日期:2004-07-01 00:00:00

  • Acute ethanol administration induces changes in TRH and proenkephalin expression in hypothalamic and limbic regions of rat brain.

    abstract::Thyrotropin releasing hormone (TRH) present in several brain areas has been proposed as a neuromodulator. Its administration produces opposite effects to those observed with acute ethanol consumption. Opioid peptides, in contrast, have been proposed to mediate some of the effects of alcohol intoxication. We measured T...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(00)00059-0

    authors: de Gortari P,Méndez M,Rodríguez-Keller I,Pérez-Martínez L,Joseph-Bravob P

    更新日期:2000-11-01 00:00:00

  • Ageing and monoamine turnover in the lateral geniculate nucleus and visual cortex of the rat.

    abstract::The effects of ageing on the turnover of dopamine, noradrenaline and serotonin in the lateral geniculate nucleus and the visual cortex were evaluated, using high performance liquid chromatography (HPLC) with electrochemical detection. Compared to adult animals, aged rats showed more changes in the visual cortex than i...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(93)90027-3

    authors: Herrera AJ,Machado A,Cano J

    更新日期:1993-06-01 00:00:00

  • Effects of chemical ischemia in cerebral cortex slices. Focus on nitric oxide.

    abstract::Superfused rat cerebral cortex slices were submitted to a continuous electrical (5 Hz) stimulation and treated with sodium azide (1-10 mM) in the presence of 2 mM 2-deoxyglucose ("chemical ischemia"). Presynaptic cholinergic activity, evaluated as acetylcholine release, was inhibited depending on the sodium azide conc...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2005.06.003

    authors: Cavallini S,Marti M,Marino S,Selvatici R,Beani L,Bianchi C,Siniscalchi A

    更新日期:2005-12-01 00:00:00

  • Insulin-stimulated taurine uptake in rat retina and retinal pigment epithelium.

    abstract::Taurine is found at millimolar concentration in the retina and retinal pigment epithelium. High concentrations of taurine are essential for maintenance of retinal function. Taurine uptake by retina and retinal pigment epithelium was significantly enhanced by physiological concentrations of insulin as well as by high g...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(99)00072-8

    authors: Salceda R

    更新日期:1999-10-01 00:00:00

  • Slow anterograde axonal transport of calpain I and II.

    abstract::Following intravitreal injections of (35)S-amino acids to label axonally transported proteins, calpain I and II from the superior colliculi and the lateral geniculate bodies were isolated via hydrophobic interaction chromatography, anion exchange HPLC and sodium-dodecyl sulphate electrophoresis. Among the slowly trans...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(90)90032-o

    authors: Nilsson E,Karlsson JO

    更新日期:1990-01-01 00:00:00

  • Oxidized low density lipoprotein increases acetylcholinesterase activity correlating with reactive oxygen species production.

    abstract::Hyperlipidemia, low density lipoproteins (LDL) and their oxidized forms, and oxidative stress are suspected to be a key combination in the onset of AD and acetylcholinesterase (AChE) plays a part in this pathology. The present study aimed to link these parameters using differentiated SH-SY5Y human neuroblastoma cells ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2014.07.007

    authors: Yamchuen P,Aimjongjun S,Limpeanchob N

    更新日期:2014-12-01 00:00:00

  • Matching kinetics of synaptic vesicle recycling and enhanced neurotransmitter influx by Ca2+ in brain plasma membrane vesicles.

    abstract::Using native plasma membrane vesicle suspensions from the rat cerebral cortex under conditions designed to alter intravesicular [Ca2+], we found that Ca2+ induced 47 +/- 5% more influx of [3H]GABA, [3H]D-aspartate and [3H]glycine at 37 degrees C with half-times 1.7 +/- 0.5, 1.3 +/- 0.4 and 1.3 +/- 0.4 min, respectivel...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(98)00039-4

    authors: Kovács I,Szárics E,Nyitrai G,Blandl T,Kardos J

    更新日期:1998-11-01 00:00:00

  • Developmental impact of air pollution on brain function.

    abstract::Air pollution is an important contributor to the global burden of disease, particularly to respiratory and cardiovascular diseases. In recent years, evidence is accumulating that air pollution may adversely affect the nervous system as shown by human epidemiological studies and by animal models. Age appears to play a ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2019.104580

    authors: Costa LG,Cole TB,Dao K,Chang YC,Garrick JM

    更新日期:2019-12-01 00:00:00

  • Modifiable risk factors promoting neurodegeneration is associated with two novel brain degradation markers measured in serum.

    abstract::There has been limited success with blood-based biomarkers of neurodegeneration. One perceived reason is that blood has no direct contact to the brain. Recently developed blood-based biomarkers of tau-degradation have shown promise as potential tools for peripheral assessment of neurodegeneration; however, factors con...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2017.05.002

    authors: Neergaard JS,Dragsbæk K,Christiansen C,Nielsen HB,Workman CT,Brix S,Henriksen K,Karsdal MA

    更新日期:2017-09-01 00:00:00

  • Exchange of extracellular L-glutamate by intracellular D-aspartate: the main mechanism of D-aspartate release in the avian retina.

    abstract::D-aspartate is present in significant concentrations throughout the nervous tissue but its physiological role is still under discussion. Here, we report the process of d-aspartate release in retinal cells. [(3)H]-d-aspartate release occurs through a glutamate/aspartate exchange mechanism using excitatory amino acid tr...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2011.03.001

    authors: Stutz B,Yamasaki EN,de Mello MC,de Mello FG

    更新日期:2011-06-01 00:00:00

  • TNFalpha induced oxidative stress dependent Akt signaling affects actin cytoskeletal organization in glioma cells.

    abstract::Inflammation which is an indispensable participant in tumor progression is intricately linked with redox modulation. The pro-inflammatory cytokine Tumor Necrosis Factor (TNFalpha) elevates reactive oxygen species (ROS) in glioblastoma multiforme (GBM). As both TNFalpha and oxidative stress independently play role in r...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2009.10.003

    authors: Ghosh S,Tewari R,Dixit D,Sen E

    更新日期:2010-01-01 00:00:00

  • Guanylate cyclase in synaptosomal soluble fraction from rat brain: possible involvement of free radical acceptor in endogenous activation mechanisms.

    abstract::Guanylate cyclase (GTP pyrophosphate-lyase (cyclizing); EC 4.6.1.2), in the crude synaptosomal soluble (P(2)-soluble) fraction obtained by hypo-osmotic treatment and subsequent centrifugation of crude synaptosomal (P(2)) fraction from the rat brain, showed a significantly high activity when assayed in the presence of ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(81)90008-5

    authors: Yoshikawa K,Kuriyama K

    更新日期:1981-01-01 00:00:00

  • Inhibition of Alzheimer's amyloid-beta aggregation in-vitro by carbenoxolone: Insight into mechanism of action.

    abstract:BACKGROUND:The major hallmark of Alzheimer's disease (AD) is the formation of amyloid aggregates, which are formed due to improper folding of proteins leading to the aggregation of amyloid beta (Aβ) 42 peptide. Inhibition of Aβ 42 aggregation using a drug such as carbenoxolone (Cbx), which has already been stated as ne...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2017.06.011

    authors: Sharma S,Nehru B,Saini A

    更新日期:2017-09-01 00:00:00

  • Differential pharmacological properties of GABAA/benzodiazepine receptor complex in dorsal compared to ventral rat hippocampus.

    abstract::Several studies have indicated a functional differentiation across the septotemporal axis of rat hippocampus. Our previous results have shown that the alpha 1 beta 2 gamma 2-GABAA receptor subtype dominates in dorsal hippocampus (DH), while the alpha 2 beta 1 gamma 2-subtype prevails in ventral hippocampus (VH). We th...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2007.10.016

    authors: Sarantis K,Sotiriou E,Papatheodoropoulos C,Matsokis N,Angelatou F

    更新日期:2008-05-01 00:00:00

  • Impact of the gliotoxin L-serine-O-sulphate on cellular metabolism in cultured rat astrocytes.

    abstract::L-serine-O-sulphate is a member of a group of amino acids collectively called gliotoxins and is a substrate for the high affinity sodium-dependent glutamate transporters. Previous studies have shown that it is toxic to primary cultures of astrocytes but the mode of toxicity is unknown. The current study demonstrates t...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2005.12.004

    authors: Brennan L,Alves PM,Hewage C,Malthouse JP,McBean GJ

    更新日期:2006-06-01 00:00:00

  • Evidence for the localization of 5HT1A binding sites on serotonin containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain.

    abstract::Precise anatomical distribution of 5HT1 binding sites has been investigated in the nuclei raphe dorsalis, raphe centralis and locus caeruleus of the rat brain. An original pattern of distribution was observed in the raphe nuclei, closely correlated to the already known distribution of 5HT containing elements. This pat...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(85)90156-1

    authors: Weissmann-Nanopoulos D,Mach E,Magre J,Demassey Y,Pujol JF

    更新日期:1985-01-01 00:00:00

  • Sandwich enzyme immunoassay of dopamine-?-hydroxylase in cerebrospinal fluid from control and parkinsonian patients.

    abstract::A sandwich enzyme immunoassay (EIA) was established by using purified human serum dopamine-?-hydroxylase (DBH) as a standard protein and a monospecific polyclonal antibody raised against human DBH purified from human pheochromocytoma. The EIA was applied to measuring DBH levels in human CSF from Parkinsonian patients ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(88)90126-x

    authors: Mogi M,Harada M,Kojima K,Inagaki H,Kondo T,Narabayashi H,Arai T,Teradaira R,Fujita K,Kiuchi K,Nagatsu T

    更新日期:1988-01-01 00:00:00

  • Ginkgolide B preconditioning on astrocytes promotes neuronal survival in ischemic injury via up-regulating erythropoietin secretion.

    abstract::Although ischemic preconditioning (IP) can provide powerful protection on brain against ischemic insult, it is rarely used in clinic to prevent the occurrence of ischemic stroke because of safety concerns. It is therefore necessary to seek the safer stimuli to initiate pharmacological preconditioning. Our previous wor...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2012.11.007

    authors: Wu X,Zhou C,Du F,Lu Y,Peng B,Chen L,Zhu L

    更新日期:2013-01-01 00:00:00

  • Glutamate and tumor-associated epilepsy: glial cell dysfunction in the peritumoral environment.

    abstract::Seizures are a serious and debilitating co-morbidity of primary brain tumors that affect most patients, yet their etiology is poorly understood. In many CNS pathologies, including epilepsy and brain injury, high levels of extracellular glutamate have been implicated in seizure generation. It has been shown that glioma...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2013.01.027

    authors: Buckingham SC,Robel S

    更新日期:2013-12-01 00:00:00