Lipoprotein-associated lysolipids are differentially involved in high-density lipoprotein- and its oxidized form-induced neurite remodeling in PC12 cells.


:Oxidatively damaged proteins and lipid peroxidation products have been shown to accumulate in the brain of neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis, and oxidized lipoprotein is considered to be toxic and neurodegenerative. However, the role of lipoprotein and its oxidized form in neurite remodeling has not been well understood. In the present study, we have aimed to clarify whether and, if so, how high-density lipoprotein (HDL) and oxidized HDL (oxHDL) affect neuritogenesis. In the presence of nerve growth factor, exposure of PC12 cells to either HDL or oxHDL induces a rapid neurite retraction, which is followed by re-outgrowth of neurites in either case; however, oxHDL-treated cells exhibit much longer outgrowths than do basal and HDL-treated cells. Thus, processes in the morphological changes of neuronal cells after lipoprotein treatment are composed of two phases: the reversible retraction phase and the extension phase. Characterization of the active fractions of lipids and experiments with desensitization and knockdown of receptors have indicated that the reversible retraction phase involves mainly sphingosine 1-phosphate for HDL and lysophosphatidic acid for oxHDL. The change in the components responsible for the retraction response is comparable with the change in sphingosine 1-phosphate and lysophosphatidic acid contents by the oxidation of HDL. In the extension phase, lysophosphatidylcholine, which is increased by the oxidation of HDL, may play a stimulatory role in neurite outgrowth. We conclude that lipoprotein and its oxidized form differentially regulate neuritogenesis through lipoprotein-associated lysolipid molecules.


Neurochem Int


Sato K,Tobo M,Mogi C,Murata N,Kotake M,Kuwabara A,Im DS,Okajima F




Has Abstract


2014-03-01 00:00:00












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    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Marazziti D,Giannaccini G,Giromella A,Betti L,Pesce D,Nardi I,Rossi A,Lucacchini A,Cassano GB

    更新日期:2003-05-01 00:00:00

  • Effects of nigral dopaminergic lesions and striatal excitotoxin lesions on brain converting enzyme.

    abstract::High levels of angiotensin converting enzyme (ACE) are found in the caudate-putamen (CPu), globus pallidus, entopeduncular nucleus and substantia nigra pars reticulata; these structures were connected by a continuous band of ACE. In order to investigate whether ACE was associated with dopaminergic projections from the...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Chai SY,Christie MJ,Beart PM,Mendelsohn FA

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    authors: Yawalkar R,Changotra H,Gupta GL

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    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Condorelli DF,Belluardo N,Mudò G,Dell'Albani P,Jiang X,Giuffrida-Stella AM

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    authors: Huether G,Thoemke F,Sprotte U,Steinhaus U,Neuhoff V

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    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Büyükuysal RL

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    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Brzin M,Sketelj J,Grubi Z,Kiauta T

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    pub_type: 杂志文章,评审


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    journal_title:Neurochemistry international

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    authors: Souza-Monteiro JR,Hamoy M,Santana-Coelho D,Arrifano GP,Paraense RS,Costa-Malaquias A,Mendonça JR,da Silva RF,Monteiro WS,Rogez H,de Oliveira DL,do Nascimento JL,Crespo-López ME

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    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审


    authors: Reyes RC,Parpura V

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    journal_title:Neurochemistry international

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    authors: Tárnok K,Kiss E,Luiten PG,Nyakas C,Tihanyi K,Schlett K,Eisel UL

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    authors: Gulya K,Kása P

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    authors: Kitano T,Matsumura S,Seki T,Hikida T,Sakimura K,Nagano T,Mishina M,Nakanishi S,Ito S

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    authors: Corbalán R,Hernández-Viadel M,Llansola M,Montoliu C,Felipo V

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    authors: Hamon M,Nelson DL,Mallat M,Bourgoin S

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    authors: Imaizumi S,Kondo T,Deli MA,Gobbel G,Joó F,Epstein CJ,Yoshimoto T,Chan PH

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    authors: Sitges M,Peña F,Chiu LM,Guarneros A

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    abstract::Fatty acids play a critical role in brain function but their specific role in the pathophysiology of Parkinson disease (PD) and levodopa-induced motor complications is still unknown. From a therapeutic standpoint, it is important to determine the relation between brain fatty acids and PD because the brain fatty acid c...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Julien C,Berthiaume L,Hadj-Tahar A,Rajput AH,Bédard PJ,Di Paolo T,Julien P,Calon F

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    pub_type: 杂志文章


    authors: Stutz B,Yamasaki EN,de Mello MC,de Mello FG

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    pub_type: 杂志文章


    authors: Ghidoni R,Fiorilli A,Trinchera M,Venerando B,Chigorno V,Tettamanti G

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    pub_type: 杂志文章


    authors: Sarup A,Larsson OM,Bolvig T,Frølund B,Krogsgaard-Larsen P,Schousboe A

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