B vitamins in the nervous system.

Abstract:

:The coenzyme functions of the B vitamins in intermediatry metabolism are well established; nevertheless, for none of them is it possible to determine precisely the connection between the biochemical lesions associated with deficiency and the neurological consequences. Although there is convincing evidence of a neurospecific role for thiamin and other B vitamins, in no case has this role been adequately described. Similarly, the neurochemical sequelae of intoxication by massive amounts of vitamins (so-called mega-vitamin therapy or orthomolecular medicine) remain largely unexplained.

journal_name

Neurochem Int

authors

Bender DA

doi

10.1016/0197-0186(84)90072-x

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

297-321

issue

3

eissn

0197-0186

issn

1872-9754

pii

0197-0186(84)90072-X

journal_volume

6

pub_type

杂志文章
  • RNAi-mediated silencing of ABCD3 gene expression in rat C6 glial cells: a model system to study PMP70 function.

    abstract::The function of PMP70, one of the four ABC half-transporters of mammalian peroxisomes, encoded by ABCD3 gene, is still unclear. The finding that PMP70 over-expression partially corrected very long-chain fatty acid oxidation defects in fibroblasts of X-linked adrenoleukodystrophy patients, has unveiled its potential cl...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2007.11.007

    authors: Di Benedetto R,Denti MA,Salvati S,Sanchez M,Attorri L,David G,Di Biase A

    更新日期:2008-05-01 00:00:00

  • Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus.

    abstract::To identify whether the process of apoptosis bears a topographic relationship to selected aspects of Alzheimer's disease (AD) pathology, we used an in situ nick translation method (TUNEL) to map DNA fragmentation in hippocampal sections immunostained for abnormally phosphorylated tau, which exists in the neurofibrilla...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(96)00158-1

    authors: Sugaya K,Reeves M,McKinney M

    更新日期:1997-08-01 00:00:00

  • Distribution of an endogenous lectin during myogenesis as measured by antilectin antibodies.

    abstract::Antibodies to electrolectin, a lectin endogenous to embryonic skeletal muscle, have been used to study the distribution of lectin during myogenesis in L(6) cells by using immunohistofluorescence microscopy. Evidence for both surface and cytoplasmic forms of lectin is presented. Cytoplasmic lectin does not appear to be...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(80)90041-8

    authors: Podleski TR

    更新日期:1980-01-01 00:00:00

  • The role of TNF-alpha/NF-kappa B pathway on the up-regulation of voltage-gated sodium channel Nav1.7 in DRG neurons of rats with diabetic neuropathy.

    abstract::Diabetic neuropathy (DN) is a common form of peripheral neuropathy, yet the mechanisms responsible for chronic pain in this disease are poorly understood. The up-regulation of the expression and function of voltage-gated sodium channel Nav1.7 has been implicated in DN, however, the exact mechanism is unclear. In the p...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2014.05.012

    authors: Huang Y,Zang Y,Zhou L,Gui W,Liu X,Zhong Y

    更新日期:2014-09-01 00:00:00

  • L-NAME prevents GM1 ganglioside-induced vasodilation in the rat brain.

    abstract::Monosialoganglioside (GM1) is a glycosphingolipid present in most cell membranes that displays antioxidant and neuroprotective properties. It has been recently described that GM1 induces vasodilation. However, the mechanisms underlying GM1-induced vasodilation were not evaluated to date. Therefore, in this study we in...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2008.07.011

    authors: Furian AF,Oliveira MS,Magni DV,Souza MA,Bortoluzzi VT,Bueno LM,Royes LF,Mello CF

    更新日期:2008-12-01 00:00:00

  • Effects of exogenous phospholipases on brain membrane phospholipid perturbation, (Na(+) + K(+))-ATPase activity and cellular swelling of brain slices.

    abstract::Rat brain membranes were incubated with bee venom phospholipase A(2) (PLA(2)) or phospholipase C (PLC) from Clostridium perfringens. PLA(2) caused a significant increase in free polyunsaturated fatty acids concomitant with membrane phospholipid degradation as monitored by HPLC and by gas chromatography. Equal concentr...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(87)90104-5

    authors: Chan PH,Chen S,Fishman RA

    更新日期:1987-01-01 00:00:00

  • Unchanged glutamine synthetase activity and increased NMDA receptor density in epileptic human neocortex: implications for the pathophysiology of epilepsy.

    abstract::We investigated whether alterations in glutamate metabolising glutamine synthetase activity occur in human epileptic neocortex, as shown previously for human epileptic hippocampus [Eid, T., Thomas, M.J., Spencer, D.D., Rundén-Pran, E., Lai, J.C.K., Malthankar, G.V., Kim, J.H., Danbolt, N.C., Ottersen, O.P., de Lanerol...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2005.06.001

    authors: Steffens M,Huppertz HJ,Zentner J,Chauzit E,Feuerstein TJ

    更新日期:2005-11-01 00:00:00

  • Ubiquitin dimers control the hydrolase activity of UCH-L3.

    abstract::Ubiquitin (Ub) carboxy terminal hydrolase (UCH)-L1 and UCH-L3 are two of the deubiquitinating enzymes expressed in the brain. Both gad mice, which lack UCH-L1 expression and Uchl3 knockout mice exhibit neurodegeneration, although at distinct areas. These phenotypes indicate the importance of UCH-L1 and UCH-L3 in the r...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2008.12.013

    authors: Setsuie R,Sakurai M,Sakaguchi Y,Wada K

    更新日期:2009-05-01 00:00:00

  • Astrocytes and the delivery of glucose from plasma to neurons.

    abstract::Conventional kinetic models of brain glucose uptake and metabolism that visualize brain glucose as being in a single pool in equilibrium with plasma, are unable to account for some recently described experimental findings. These include microdialysis demonstrations of a brain extracellular fluid glucose concentration ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/0197-0186(95)00094-1

    authors: Forsyth RJ

    更新日期:1996-03-01 00:00:00

  • Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons.

    abstract::Catalpol has been shown to rescue neurons from kinds of damage in vitro and in vivo in previous reports. However, the effect of catalpol on the nitric oxide (NO) system via MAPKs signaling pathway of mesencephalic neurons largely remains to be verified. The current study examined that whether catalpol modulated NO and...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2008.12.003

    authors: Bi J,Jiang B,Hao S,Zhang A,Dong Y,Jiang T,An L

    更新日期:2009-03-01 00:00:00

  • In vitro oxidation of vitamin E, vitamin C, thiols and cholesterol in rat brain mitochondria incubated with free radicals.

    abstract::The kinetics of oxidation of endogenous antioxidants such as vitamins C and E and thiols as well as membrane cholesterol in isolated rat brain mitochondria were studied. Oxidation was induced by incubating the mitochondria at 37 degrees C with the free radical generators 2,2' azobis (2'-amidinopropane) dihydrochloride...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(94)00147-m

    authors: Vatassery GT,Smith WE,Quach HT,Lai JC

    更新日期:1995-05-01 00:00:00

  • Quantitative autoradiographic study of somatostatin and neurotensin binding sites in medulla oblongata of SIDS.

    abstract::Quantitative autoradiography analysis of neurotensin (NT) and somatostatin (SS) binding sites was performed on coronal sections of the medulla oblongata from 2 fetuses, 6 controls and 7 victims of Sudden Infant Death Syndrome (SIDS). Throughout the first postnatal year, mean SS binding site density was similar in cont...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(92)90134-d

    authors: Chigr F,Jordan D,Najimi M,Denoroy L,Sarrieau A,de Broca A,Rostene W,Epelbaum J,Kopp N

    更新日期:1992-01-01 00:00:00

  • Cell-selective effects of ammonia on glutamate transporter and receptor function in the mammalian brain.

    abstract::Increased brain ammonia concentrations are a hallmark feature of several neurological disorders including congenital urea cycle disorders, Reye's syndrome and hepatic encephalopathy (HE) associated with liver failure. Over the last decade, increasing evidence suggests that hyperammonemia leads to alterations in the gl...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/s0197-0186(03)00043-3

    authors: Chan H,Butterworth RF

    更新日期:2003-09-01 00:00:00

  • Cyclothiazide binding to functionally active AMPA receptor reveals genuine allosteric interaction with agonist binding sites.

    abstract::The agonist, [3H](-)[S]-1-(2-amino-2-carboxyethyl)-5-fluoro-pyrimidine-2,4-dione ([3H](S)F-Willardiine) binding to functional alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors of resealed plasma membrane vesicles and nerve endings freshly isolated from the rat cerebral cortex displayed two bind...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(03)00137-2

    authors: Kovács I,Simon A,Szárics E,Barabás P,Héja L,Nyikos L,Kardos J

    更新日期:2004-03-01 00:00:00

  • Identification of a calcium binding protein highly localized to the cochlear nucleus.

    abstract::A protein, designated as protein 10 (MW = 29 kDa, pI = 5.3), was shown to be highly localized to the cochlear nuclei of guinea-pigs and rats by the use of two-dimensional gel electrophoresis. In gels from guinea-pig brain, this protein appeared greatest in amounts in the ventral cochlear nucleus and within the deep re...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(89)90154-x

    authors: Winsky L,Nakata H,Jacobowitz DM

    更新日期:1989-01-01 00:00:00

  • Metabolomic analyses of vigabatrin (VGB)-treated mice: GABA-transaminase inhibition significantly alters amino acid profiles in murine neural and non-neural tissues.

    abstract::The anticonvulsant vigabatrin (VGB; SabrilR) irreversibly inhibits GABA transaminase to increase neural GABA, yet its mechanism of retinal toxicity remains unclear. VGB is suggested to alter several amino acids, including homocarnosine, β-alanine, ornithine, glycine, taurine, and 2-aminoadipic acid (AADA), the latter ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.02.015

    authors: Walters DC,Arning E,Bottiglieri T,Jansen EEW,Salomons GS,Brown MN,Schmidt MA,Ainslie GR,Roullet JB,Gibson KM

    更新日期:2019-05-01 00:00:00

  • Disposition of exogenous tritium-labelled GM1lactone in the rat.

    abstract::The disposition of labelled [3H]GM1lactone, the inner ester of ganglioside GM1, was studied in the rat. After i.v. administration [3H]GM1lactone was quickly converted to its corresponding open form most likely by plasma esterases, and then displayed a pharmacokinetic profile identical to [3H]GM1. Following intramuscul...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(92)90050-2

    authors: Bellato P,Milan F,Facchinetti E,Toffano G

    更新日期:1992-04-01 00:00:00

  • Immunocytochemical demonstration of taurine in the retina and pineal organ of the pigeon.

    abstract::Taurine-like immunoreactivity (TLI) is found in the pigeon retina at high levels within cones, in select cells of the inner nuclear layer and in sublaminae of the inner plexiform layer. At the ultrastructural level a high density of immuno-gold particles in visualized in the ellipsoid, but not in the paraboloid area o...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(95)00043-8

    authors: Ueck M,Hach A,Verdone-Smith C,Lake N

    更新日期:1995-12-01 00:00:00

  • Regulation of gene expression by natural antisense RNA transcripts.

    abstract::The use of synthetic antisense oligonucleotides as specific inhibitors of gene expression exploits the susceptibility of mRNA to functional blockade at several levels, including mRNA processing, transport, translation and degradation. It is becoming increasingly apparent that the actions of these synthetic oligomers a...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/s0197-0186(96)00108-8

    authors: Knee R,Murphy PR

    更新日期:1997-09-01 00:00:00

  • Nicotinic acetylcholine receptor (nAChR) mediated dopamine release in larval Drosophila melanogaster.

    abstract::Acetylcholine is an excitatory neurotransmitter in the central nervous system of insects and the nicotinic acetylcholine receptor (nAChR) is a target for neonicotinoid insecticides. Functional insect nAChRs are difficult to express in host cells, and hence difficult to study. In mammals, acetylcholine and nicotine evo...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2017.12.012

    authors: Pyakurel P,Shin M,Venton BJ

    更新日期:2018-03-01 00:00:00

  • Effective delivery of Pep-1-cargo protein into ischemic neurons and long-term neuroprotection of Pep-1-SOD1 against ischemic injury in the gerbil hippocampus.

    abstract::We examined the intracellular delivery of Pep-1-cargo protein against transient ischemic damage in the hippocampal CA1 region in gerbils. For this study, we introduced green fluorescent protein (GFP) and constructed Pep-1-GFP protein. At 12h after Pep-1-GFP treatment, GFP fluorescence was shown in almost CA1 pyramidal...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2007.08.013

    authors: Cho JH,Hwang IK,Yoo KY,Kim SY,Kim DW,Kwon YG,Choi SY,Won MH

    更新日期:2008-03-01 00:00:00

  • Control of mitochondrial physiology and cell death by the Bcl-2 family proteins Bax and Bok.

    abstract::Neuronal cell death is often triggered by events that involve intracellular increases in Ca2+. Under resting conditions, the intracellular Ca2+ concentration is tightly controlled by a number of extrusion and sequestering mechanisms involving the plasma membrane, mitochondria, and ER. These mechanisms act to prevent a...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2017.03.010

    authors: D'Orsi B,Mateyka J,Prehn JHM

    更新日期:2017-10-01 00:00:00

  • Neurotrophins and their receptors in nerve injury and repair.

    abstract::Cytokines are a heterogenous group of polypeptide mediators that have been associated with activation of numerous functions, including the immune system and inflammatory responses. The cytokine families include, but are not limited to, interleukins (IL-I alpha, IL-I beta, ILIra and IL-2-IL-15), chemokines (IL-8/ NAP-I...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/s0197-0186(96)00071-x

    authors: Ebadi M,Bashir RM,Heidrick ML,Hamada FM,Refaey HE,Hamed A,Helal G,Baxi MD,Cerutis DR,Lassi NK

    更新日期:1997-04-01 00:00:00

  • Agonist binding fraction of dopamine D2/3 receptors in rat brain: a quantitative autoradiographic study.

    abstract::There has arisen considerable interest in the study of dopamine D(2/3) agonist binding sites by positron emission tomography (PET), based on the claim that agonist sites represent a functional subset of the total number of sites labeled by more conventional antagonist ligands. To test the basis of this claim, we used ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2010.01.010

    authors: Minuzzi L,Cumming P

    更新日期:2010-05-01 00:00:00

  • Electron microscopic evidence for neurotoxicity in the basal ganglia.

    abstract::The dopaminergic projection from the substantia nigra to the neostriatum is vulnerable to several neurotoxins including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), amphetamine, and 5-hydroxydopamine. We have treated rats or mice with these agents and examined various regions of their brains with a combination...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/0197-0186(94)00110-g

    authors: Linder JC,Young SJ,Groves PM

    更新日期:1995-02-01 00:00:00

  • Cytoskeletal regulation of normal rat glioblasts differentiated by glia maturation factor.

    abstract::The morphological differentiation of normal rat glioblasts induced by glia maturation factor (GMF) was investigated with regard to the reorganization of the cytoskeletal structures by the use of indirect immunofluorescence staining methods. The microfilaments were reorganized from a stress fiber form to a plasmalemmal...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(90)90080-d

    authors: Ito J,Kato T,Tanaka R

    更新日期:1990-01-01 00:00:00

  • Effect of bimoclomol (N-[2-hydroxy-3-(1-piperidinyl) propoxy]-3 pyridine-carboximidoyl-chloride) on iminodipropionitrile-induced central effects.

    abstract::Dyskinesia is frequently seen in neurological disorders affecting the basal ganglia. Iminodipropionitrile (IDPN) produces a somewhat similar motor syndrome in rodents, one that is a possible model for dyskinesia. Because in previous studies the compound (N-[2-hydroxy-3-(1-piperidinyl) propoxy]-3 pyridine-carboximidoyl...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(98)00058-8

    authors: Tóth E,Gerevich Z,Dóda M,Lajtha A

    更新日期:1998-12-01 00:00:00

  • BMY 7378: Partial agonist at spinal cord 5-HT(1A) receptors.

    abstract::Recent data indicate that BMY 7378 demonstrates high affinity, selectivity and low intrinsic activity at hippocampal 5-HT(1A) receptors, suggesting that BMY 7378 may represent the first selective 5-HT(1A) functional antagonist. The present study examined the agonist and antagonist properties of BMY 7378 at spinal cord...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(90)90011-h

    authors: Zemlan FP,Zieleniewski-Murphy A,Maureen Murphy R,Behbehani MM

    更新日期:1990-01-01 00:00:00

  • Pyrrolidinedithiocarbamate induces apoptosis in cerebellar granule cells: involvement of AP-1 and MAP kinases.

    abstract::Pyrrolidinedithiocarbamate (PDTC) is a compound displaying antioxidant, pro-oxidant and metal chelator properties in different cell types. It has been described that PDTC may exert either anti-apoptotic or apoptotic activity. Moreover it is known that this agent regulates the activity of redox-sensitive transcription ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(02)00197-3

    authors: Porcile C,Stanzione S,Piccioli P,Bajetto A,Barbero S,Bisaglia M,Bonavia R,Florio T,Schettini G

    更新日期:2003-07-01 00:00:00

  • Downregulation of Mfn2 participates in manganese-induced neuronal apoptosis in rat striatum and PC12 cells.

    abstract::Manganese (Mn) is a widely distributed trace element that is essential for normal brain function and development. However, chronic exposure to excessive Mn has been known to lead to neuronal loss and manganism, a disease with debilitating motor and cognitive deficits, whose clinical syndrome resembling idiopathic Park...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2017.02.008

    authors: Liu X,Yang J,Lu C,Jiang S,Nie X,Han J,Yin L,Jiang J

    更新日期:2017-09-01 00:00:00