Abstract:
:Neosurugatoxin, a neurotoxin isolated from the Japanese ivory mollusc (Babylonia japonica ) is a nicotinic antagonist with a specificity towards ganglionic nicotinic receptors. At low concentration (5 x 10(?8) M) neosurugatoxin inhibited the release of [(3)H]dopamine evoked by 1,1-dimethyl-4-phenylpiperazinium (DMPP) from rat striatal nerve terminals, without affecting the response to K(+)-depolarisation. In contrast, ?bungarotoxin did not antagonise the action of DMPP. Neosurugatoxin also inhibited [(3)H] nicotine binding to rat brain membranes but had no effect on [(125)I]?bungarotoxin binding to the same tissue preparation. These results support the view that functional nicotinic receptors in the CNS resemble ganglionic nicotinic receptors. Neosurugatoxin has considerable potential as a useful probe for such receptors in the brain.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Rapier C,Harrison R,Lunt GG,Wonnacott Sdoi
10.1016/0197-0186(85)90131-7subject
Has Abstractpub_date
1985-01-01 00:00:00pages
389-96issue
2eissn
0197-0186issn
1872-9754pii
0197-0186(85)90131-7journal_volume
7pub_type
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