Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain.

abstract：:There has been limited success with blood-based biomarkers of neurodegeneration. One perceived reason is that blood has no direct contact to the brain. Recently developed blood-based biomarkers of tau-degradation have shown promise as potential tools for peripheral assessment of neurodegeneration; however, factors con...

journal_title：Neurochemistry international

authors： Neergaard JS,Dragsbæk K,Christiansen C,Nielsen HB,Workman CT,Brix S,Henriksen K,Karsdal MA

更新日期：2017-09-01 00:00:00

abstract：:Protein kinase C (PKC) is involved in several cell events including proliferation, survival and differentiation. The aim of this work was to investigate the role of PKC activation on retinal cells proliferation. We demonstrated that PKC activation by phorbol 12-myristate 13-acetate (PMA), a tumor promoter phorbol este...

journal_title：Neurochemistry international

authors： dos Santos AA,Medina SV,Sholl-Franco A,de Araujo EG

更新日期：2003-01-01 00:00:00

abstract：:The phosphorylation of proteins on tyrosine residues, initially believed to be primarily involved in cell growth and differentiation, is now recognized as having a critical role in regulating the function of mature cells. The brain exhibits one of the highest levels of tyrosine kinase activity in the adult animal and ...

journal_title：Neurochemistry international

authors： Gurd JW

更新日期：1997-11-01 00:00:00

abstract：:Acetylcholinesterase (AChE) hydrolyses acetylcholine to choline and acetate, playing an important role in terminating the neurotransmission in brain and muscle. Recently, the non-neuronal functions of AChE have been proposed in different tissues, in which there are various factors to regulate the expression of AChE. I...

journal_title：Neurochemistry international

authors： Wu Q,Bai P,Xia Y,Lai QWS,Guo MSS,Dai K,Zheng Z,Ling CSJ,Dong TTX,Pi R,Tsim KWK

更新日期：2020-12-01 00:00:00

abstract：:Air pollution is an important contributor to the global burden of disease, particularly to respiratory and cardiovascular diseases. In recent years, evidence is accumulating that air pollution may adversely affect the nervous system as shown by human epidemiological studies and by animal models. Age appears to play a ...

journal_title：Neurochemistry international

authors： Costa LG,Cole TB,Dao K,Chang YC,Garrick JM

更新日期：2019-12-01 00:00:00

abstract：:Cerebral edema is a potentially life-threatening complication shared by diseases of different etiology, such as diabetic ketoacidosis, acute liver failure, high altitude exposure, dialysis disequilibrium syndrome, and salicylate intoxication. Pulmonary edema is also habitually present in these disorders, indicating th...

journal_title：Neurochemistry international

authors： Adeva MM,Souto G,Donapetry C,Portals M,Rodriguez A,Lamas D

更新日期：2012-07-01 00:00:00

abstract：:The saturable and specific high-affinity uptake of [(3)H]serotonin ([(3)H]5HT) (5 x 10(?8) M) was studied in slices from the hippocampus, parietal cortex, septum-preoptic area, and hypothalamus of male 2, 6, 12 and 24-32 month old C57BL/6N mice. Hippocampal [(3)H]5-HT uptake showed a significant biphasic relationship ...

journal_title：Neurochemistry international

authors： Azmitia E,Brennan MJ,Quartermain D

更新日期：1983-01-01 00:00:00

abstract：:The relationship between acidosis and the metabolism of glutamine and glutamate was studied in cultured astrocytes. Acidification of the incubation medium was associated with an increased formation of aspartate from glutamate and glutamine. The rise of the intracellular content of aspartate was accompanied by a signif...

journal_title：Neurochemistry international

authors： Yudkoff M,Daikhin Y,Nissim I,Nissim I

更新日期：2000-04-01 00:00:00

abstract：:To characterise ketamine-induced sympathomimetic action, we examined the effects of ketamine on in vivo cardiac sympathetic nerve endings function. Using adult cats given anaesthesia with pentobarbital, dialysis probes were implanted in the left ventricular myocardium and dialysate noradrenaline (NA) concentrations we...

journal_title：Neurochemistry international

authors： Kitagawa H,Yamazaki T,Akiyama T,Mori H,Sunagawa K

更新日期：2003-02-01 00:00:00

abstract：:Chronic variate stress was seen to decrease the ingestion of sweet food when compared to control rats. Brain monoamines are known to be involved in the control of food intake, serotonin appears to be involved in the mechanisms of satiety, and dopamine in mediating appetite or approach behaviors triggered by incentive ...

journal_title：Neurochemistry international

authors： Gamaro GD,Manoli LP,Torres IL,Silveira R,Dalmaz C

更新日期：2003-01-01 00:00:00

abstract：:Development of tissue structure and three-dimensional microenvironment is crucial for regeneration of axons in the peripheral nerve repair. In this study we aimed to evaluate the efficacy of nerve regeneration by using an acellular nerve allograft (ANA) injected with allogenic skin-derived precursor differentiated Sch...

journal_title：Neurochemistry international

authors： Wang H,Wu J,Zhang X,Ding L,Zeng Q

更新日期：2016-07-01 00:00:00

abstract：:Arsenate is a toxic compound that has been connected with neuropathies and impaired cognitive functions. To test whether arsenate affects the viability and the GSH metabolism of brain astrocytes, we have used primary astrocyte cultures as model system. Incubation of astrocytes for 2h with arsenate in concentrations of...

journal_title：Neurochemistry international

authors： Meyer N,Koehler Y,Tulpule K,Dringen R

更新日期：2013-06-01 00:00:00

abstract：:The amyloid precursor protein (APP) and presenilin-1 (PS-1) are not only of importance for the normal functioning of the various neurons, but also play central roles in the pathogenesis of Alzheimer's disease (AD). Through the use of immunohistochemical and Western blot techniques, the bidirectional axonal transport o...

journal_title：Neurochemistry international

authors： Papp H,Pakaski M,Kasa P

更新日期：2002-12-01 00:00:00

abstract：:The Xenopus oocyte expression and recording system has allowed a detailed analysis of the physiology and pharmacology of neuronal ion channels including their sensitivity to ethanol. It is important however, to ascertain the effects of a particular drug on the channels inherently expressed by oocytes to ensure that dr...

journal_title：Neurochemistry international

authors： Clayton R,Woodward JJ

更新日期：2000-01-01 00:00:00

abstract：:Oxidative stress (OS) has been related to cocaine's actions and also to numerous nervous system pathologies, including seizures. The purpose of this work was to determine the alterations in glutathione (GSH) content, nitrite/nitrate and MDA levels after cocaine-induced toxicity. Male Swiss mice were injected (i.p.) wi...

journal_title：Neurochemistry international

authors： Macêdo DS,Vasconcelos SM,Andrade-Neto M,Belchior LD,Honório Júnior JE,Gonçalves DO,Fonteles MM,Silva MI,Aguiar LM,Viana GS,de Sousa FC

更新日期：2010-01-01 00:00:00

abstract：:Ethanol (15% v/v) was administered in the drinking water to male Wistar rats over period of 3 months. Binding properties of muscarinic receptors were studied in synaptosomes from selected brain areas using [(3)H]quinuclidinyl benzilate and its displacement by the selective antagonist, pirenzepine and the agonist, carb...

journal_title：Neurochemistry international

authors： Pietzak ER,Wilce PA,Shanley BC

更新日期：1988-01-01 00:00:00

abstract：:Retinal melatonin biosynthesis is regulated in part by changes in the activity of serotonin N-acetyltransferase (NAT), which increases at night in dark-adapted retinas, but not in light-exposed retinas. Using an in vitro preparation of Xenopus laevis (African clawed frog) eye cups, we have obtained evidence supporting...

journal_title：Neurochemistry international

authors： Boatright JH,Iuvone PM

更新日期：1989-01-01 00:00:00

abstract：:Rapid administration of large doses of ammonia leads to death of animals, which is largely prevented by pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists. The present study focuses on a subunit(s) of NMDA receptor involved in ammonia-induced death by use of NMDA receptor GluRepsilon subunit-deficient ...

journal_title：Neurochemistry international

authors： Kitano T,Matsumura S,Seki T,Hikida T,Sakimura K,Nagano T,Mishina M,Nakanishi S,Ito S

更新日期：2004-01-01 00:00:00

abstract：:Short-term supplementation of low protein diet (LPD) or high protein diet (HPD) to the aged (18 months old) rats did not change the hypothalamic GABAergic activity and immune response. Long-term supplementation of LPD on the other hand, enhanced hypothalamic GABAergic activity with an immunopotentiation by increasing ...

journal_title：Neurochemistry international

authors： Bandyopadhyay BC,Poddar MK

更新日期：1998-02-01 00:00:00

abstract：:Using a consistent, reproducible and reliable cortical focal ischemia in rat (permanent unilateral occlusion of the left middle cerebral artery & the ipsilateral common carotid artery [MCAo + CCAo] with a 1 h temporary occlusion of the contralateral CCA), the levels of four major membrane fatty acids (palmitic, C16:0;...

journal_title：Neurochemistry international

authors： Mahadik SP,Hungund BL,Gokhale VS,Ortiz A,Makar TK,Karpiak SE

更新日期：1993-08-01 00:00:00

abstract：:Long term consequence of non-fatal overdose in people who use opioids are not well understood. The intermittent exposure to non-fatal overdose leads to a tauopathy that is often accompanied by abrogated neuroprotective response, abnormal amyloid processing and other pathologies. The scope and limitations of available ...

journal_title：Neurochemistry international

authors： Voronkov M,Cocchiaro B,Stock JB

更新日期：2020-12-10 00:00:00

abstract：:Increasing evidences support that glial connexins are involved in the demyelination pathology of multiple sclerosis (MS), a chronic inflammatory demyelinating disorder. Here, we review the data from patients with MS and animal models of MS that implicate connexins in demyelination. Connexins expressed in oligodendrocy...

journal_title：Neurochemistry international

authors： Xia CY,Xu JK,Pan CH,Lian WW,Yan Y,Ma BZ,He J,Zhang WK

更新日期：2020-06-01 00:00:00

abstract：:Aminoethylcysteine ketimine is a sulfur-containing cyclic compound produced by the enzymatic alpha-deamination of the parent aminoethylcysteine that has been detected in bovine brain and cerebellum. Aminoethylcysteine ketimine is known to dimerize spontaneously and easily lose one carboxyl group. This decarboxylated c...

journal_title：Neurochemistry international

authors： Matarese RM,Macone A,Crescentini G,Duprè S,Cavallini D

更新日期：1998-04-01 00:00:00

abstract：:Interleukin-1 beta (IL-1 beta) is a pro-inflammatory cytokine produced in the brain by endogenous microglial cells responding to injury. Levels of IL-1 beta are elevated in several neurodegenerative disorders, including Alzheimer's disease. IL-1 beta, which can act as a mitogen for astrocytes, also elicits the express...

journal_title：Neurochemistry international

authors： Chang JW,Young DA,Coleman PD,O'Banion MK

更新日期：2001-11-01 00:00:00

abstract：:Ligand-induced changes in the conformation of extracellular loop (EL) 2 in the rat (r) dopamine transporter (DAT) were examined using limited proteolysis with endoproteinase Asp-N and detection of cleavage products by epitope-specific immunoblotting. The principle N-terminal fragment produced by Asp-N was a 19kDa pept...

journal_title：Neurochemistry international

authors： Gaffaney JD,Shetty M,Felts B,Pramod AB,Foster JD,Henry LK,Vaughan RA

更新日期：2014-07-01 00:00:00

abstract：:Brain edema and the subsequent increase in intracranial pressure are the major neurological complications in fulminant hepatic failure (FHF). Brain edema in FHF is predominantly "cytotoxic" due principally to astrocyte swelling. It is generally believed that ammonia plays a key role in this process, although the mecha...

journal_title：Neurochemistry international

authors： Jayakumar AR,Rao KV,Murthy ChR,Norenberg MD

更新日期：2006-05-01 00:00:00

abstract：:Cholesterol, a molecule critical for cellular function, is found in particular high concentration in the brain and has been implicated to synaptic plasticity and neuronal regeneration. This study was undertaken to investigate the mechanism by which cholesterol shortage modulates glutamate (Glu)-induced excitotoxicity ...

journal_title：Neurochemistry international

authors： Chou YC,Lin SB,Tsai LH,Tsai HI,Lin CM

更新日期：2003-08-01 00:00:00

abstract：:Recent data indicate that BMY 7378 demonstrates high affinity, selectivity and low intrinsic activity at hippocampal 5-HT(1A) receptors, suggesting that BMY 7378 may represent the first selective 5-HT(1A) functional antagonist. The present study examined the agonist and antagonist properties of BMY 7378 at spinal cord...

journal_title：Neurochemistry international

authors： Zemlan FP,Zieleniewski-Murphy A,Maureen Murphy R,Behbehani MM

更新日期：1990-01-01 00:00:00

abstract：:Therapeutic hypothermia as a physical method to lower the brain temperature of patients has been widely used in clinics as an effective and necessary step during the treatment of acute brain injury or edema. However, due to limitations of the ocular structure, the application of hypothermia in retinal neuroprotection ...

journal_title：Neurochemistry international

authors： Sun YJ,Ma S,Fan B,Wang Y,Wang SR,Li GY

更新日期：2019-06-01 00:00:00

abstract：:The system of GABA transporters in neural cells constitutes an efficient mechanism for terminating inhibitory GABAergic neurotransmission. As such these transporter are important therapeutical targets in epilepsy and potentially other neurological diseases related to the GABA system. In this study a number of analogs ...

journal_title：Neurochemistry international

authors： Sarup A,Larsson OM,Bolvig T,Frølund B,Krogsgaard-Larsen P,Schousboe A

更新日期：2003-09-01 00:00:00