Biomarkers in Parkinson's disease (recent update).

abstract：:It is well established that histaminergic neurons in the posterior hypothalamus make connections with whole brain areas and regulate several functions. Recent evidence indicates that histaminergic neurons are heterogeneous cell group and organized into distinct circuits. However, functional circuits of histaminergic n...

journal_title：Neurochemistry international

authors： Umehara H,Mizuguchi H,Fukui H

更新日期：2012-11-01 00:00:00

abstract：:Sodium- and energy-dependent accumulation of [(3)H]l-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 ?M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, in concentration-de...

journal_title：Neurochemistry international

authors： Yoneda Y,Ogita K,Yamada K,Kouda T,Ohgaki T,Uchida S,Meguri H

更新日期：1989-01-01 00:00:00

abstract：:Astrocytes, the most versatile cells of the central nervous system, play an important role in the regulation of neurotransmitter homeostasis, energy metabolism, antioxidant defenses and the anti-inflammatory response. Recently, our group characterized cortical astrocyte cultures from adult Wistar rats. In line with th...

journal_title：Neurochemistry international

authors： Souza DG,Bellaver B,Raupp GS,Souza DO,Quincozes-Santos A

更新日期：2015-11-01 00:00:00

abstract：:Choline-O-acetyltransferase (ChAT) is the enzyme which catalyses the biosynthesis of the neurotransmitter acetylcholine in cholinergic neurons. Here we show that in mouse cholinergic NS-20Y neuroblastoma cells cultured in the presence of either okadaic acid (serine/threonine phosphatases 1 and 2A inhibitor) or KN-62 (...

journal_title：Neurochemistry international

authors： Pahud G,Bontron S,Eder-Colli L

更新日期：2001-01-01 00:00:00

abstract：:TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of ubiquitinated inclusions in motor neurons of sporadic amyotrophic lateral sclerosis (ALS). TDP-43 is ubiquitously expressed and the majority of TDP-43 is normally localized to the nucleus. In motor neurons of patients with ALS, TDP-43 is not locali...

journal_title：Neurochemistry international

authors： Hishizawa M,Yamashita H,Akizuki M,Urushitani M,Takahashi R

更新日期：2019-03-01 00:00:00

abstract：:Although the cerebral cortical dopamine D(1) receptor is considered to play a role in normal and abnormal brain function, little information is available on its characteristics in human brain. We compared dopamine-stimulated adenylyl cyclase (AC) activity in homogenates of cerebral cortex (frontal, temporal, parietal,...

journal_title：Neurochemistry international

authors： Tong J,Ross BM,Sherwin AL,Kish SJ

更新日期：2001-08-01 00:00:00

abstract：:Cerebellar granule neurons produce homogenous cultures that provide a unique opportunity for quantifying the apoptosis by propidium iodide- and deoxynucleotidyl transferase-flow cytometry combined analysis and for studying its regulation by neurotrophins. Nerve growth factor (NGF) was found to promote postmitotic surv...

journal_title：Neurochemistry international

authors： Muller Y,Tangre K,Clos J

更新日期：1997-08-01 00:00:00

abstract：:The disposition of labelled [3H]GM1lactone, the inner ester of ganglioside GM1, was studied in the rat. After i.v. administration [3H]GM1lactone was quickly converted to its corresponding open form most likely by plasma esterases, and then displayed a pharmacokinetic profile identical to [3H]GM1. Following intramuscul...

journal_title：Neurochemistry international

authors： Bellato P,Milan F,Facchinetti E,Toffano G

更新日期：1992-04-01 00:00:00

abstract：:Diisopropyl phosphorofluoridate (DFP) produces Type I organophosphorus compound-induced delayed neurotoxicity (OPIDN) in adult female chickens. We have proposed that calcium/calmodulin protein kinase II (CaM kinase II) plays a role in the development of OPIDN by increasing the phosphorylation of cytoskeletal proteins....

journal_title：Neurochemistry international

authors： Abou-Donia MB,Viana ME,Gupta RP,Anderson JK

更新日期：1993-02-01 00:00:00

abstract：:Soluble guanylyl cyclase (sGC) is a key enzyme of the NO-cGMP pathway which is believed to mediate vasoprotective actions. In cardiovascular diseases such as hypercholesterolemia and atherosclerosis, these important functions of the vascular endothelium are strongly impaired. One of the major reasons for this so-calle...

journal_title：Neurochemistry international

authors： Francois M,Kojda G

更新日期：2004-11-01 00:00:00

abstract：:The opening of pannexin-1 (Px1) hemichannels is regulated by the activity of P2X(7) receptors (P2X(7)Rs). At present, however, little is known about how extracellular ATP-sensitive P2X(7)Rs regulates the opening and closure of Px1 hemichannels. Several lines of evidence suggest that P2X(7)Rs are activated under pathol...

journal_title：Neurochemistry international

authors： Iwabuchi S,Kawahara K

更新日期：2011-02-01 00:00:00

abstract：:Intact pieces or homogenates of rabbit retina were exposed to various established or putative retinal neurotransmitters for the study of receptors (or receptor-subtypes) linked to the production of cAMP. Since a dopamine-sensitive adenylate cyclase has been previously characterized in the retina of several species, th...

journal_title：Neurochemistry international

authors： Schorderet M

更新日期：1989-01-01 00:00:00

abstract：:The effects of cholesterol oxides on regular and neuronal PC12 cells were examined. Among the cholesterol oxides tested, 7-beta-, 22(R)- and 25-OH-cholesterol were very toxic to regular PC12 cells such that approximately 80% of cells were killed after a 3 day incubation with 20 micrograms/ml (50 microM) of these agent...

journal_title：Neurochemistry international

authors： Chang JY,Liu LZ

更新日期：1997-10-01 00:00:00

abstract：:A purification procedure to obtain peroxisomes (microperoxisomes) from the brain of suckling rats is reported. A P2 fraction, (crude light mitochondria) frozen and thawed seven times, was subfractionated yielding a P4 fraction, 4-fold enriched in catalase activity with respect to the cytoplasmic extract S1. The P4 fra...

journal_title：Neurochemistry international

authors： Cimini AM,Moreno S,Giorgi M,Serafini B,Cerú MP

更新日期：1993-09-01 00:00:00

abstract：:This study aimed to examine the effects of Cacna1a mutation on the phenotype of Scn1a-associated epilepsy in rats. We used rats with an N1417H missense mutation in the Scn1a gene and others with an M251K mutation in the Cacna1a gene. Scn1a/Cacna1a double mutant rats were generated by mating both Scn1a and Cacna1a muta...

journal_title：Neurochemistry international

authors： Ohmori I,Kobayashi K,Ouchida M

更新日期：2020-12-01 00:00:00

abstract：:Oxidative stress-induced neuronal death plays a pivotal role in pathogenesis of neurodegenerative disorders. Recently, 7,8-dihydroxyflavone (7,8-DHF) has been shown to exert neuroprotective effects by acting as a selective tyrosine kinase receptor B (TrkB) agonist. In addition, the antioxidant action of 7,8-DHF may pr...

journal_title：Neurochemistry international

authors： Han X,Zhu S,Wang B,Chen L,Li R,Yao W,Qu Z

更新日期：2014-01-01 00:00:00

abstract：:Human glutamate dehydrogenase (GDH) gene was fused with a gene fragment encoding the nine amino acid (RKKRRQRRR) protein transduction domain of human immunodeficiency virus TAT protein in bacterial expression vector to produce genetic in-frame TAT-GDH fusion protein. The TAT-GDH protein can enter PC12 cells efficientl...

journal_title：Neurochemistry international

authors： Yoon HY,Lee SH,Cho SW,Lee JE,Yoon CS,Park J,Kim TU,Choi SY

更新日期：2002-07-01 00:00:00

abstract：:The less active form of human tyrosine hydroxylase has been previously reported but its physiological role is unknown. We partially purified the less active form of tyrosine hydroxylase from human adrenals, and examined differences in the properties of the active and less active forms. We succeeded in activation of th...

journal_title：Neurochemistry international

authors： Ishii A,Kiuchi K,Matsuyama M,Satake T,Nagatsu T

更新日期：1990-01-01 00:00:00

abstract：:The function of PMP70, one of the four ABC half-transporters of mammalian peroxisomes, encoded by ABCD3 gene, is still unclear. The finding that PMP70 over-expression partially corrected very long-chain fatty acid oxidation defects in fibroblasts of X-linked adrenoleukodystrophy patients, has unveiled its potential cl...

journal_title：Neurochemistry international

authors： Di Benedetto R,Denti MA,Salvati S,Sanchez M,Attorri L,David G,Di Biase A

更新日期：2008-05-01 00:00:00

abstract：:Taurine-like immunoreactivity (TLI) is found in the pigeon retina at high levels within cones, in select cells of the inner nuclear layer and in sublaminae of the inner plexiform layer. At the ultrastructural level a high density of immuno-gold particles in visualized in the ellipsoid, but not in the paraboloid area o...

journal_title：Neurochemistry international

authors： Ueck M,Hach A,Verdone-Smith C,Lake N

更新日期：1995-12-01 00:00:00

abstract：:Acyl-CoA synthetase activity was investigated in membrane fractions from normal and Trembler mouse sciatic nerves. Stearoyl-CoA synthesis in the Trembler assays was always about twice that observed in the control experiments under various conditions of CoA and ATP concentrations. In experiments using varying concentra...

journal_title：Neurochemistry international

authors： Boiron F,Heape AM,Cassagne C

更新日期：1985-01-01 00:00:00

abstract：:Resistance to inhibitors of cholinesterase (RIC) -3 promotes the maturation (folding and assembly) of neuronal nicotinic acetylcholine receptors (nAChRs) as a molecular chaperone. The modulation effects of RIC-3 on homomeric α7 nAChRs are always positive, but its effects on heteromeric subtypes are inconsistent among ...

journal_title：Neurochemistry international

authors： Bao H,Xu X,Liu W,Yu N,Liu Z

更新日期：2018-05-01 00:00:00

abstract：:The present study confirmed our previous assumption on the crucial role of central alpha2B-like adrenoceptor subtype in gastric mucosal defense. It was found that beside clonidine, rilmenidine, an alpha2/imidazoline receptor agonist and ST-91, an alpha2B-adrenoceptor preferring agonist inhibited the mucosal lesions in...

journal_title：Neurochemistry international

authors： Gyires K,Zádori ZS,Shujaa N,Minorics R,Falkay G,Mátyus P

更新日期：2007-10-01 00:00:00

abstract：:Following intravitreal injections of (35)S-amino acids to label axonally transported proteins, calpain I and II from the superior colliculi and the lateral geniculate bodies were isolated via hydrophobic interaction chromatography, anion exchange HPLC and sodium-dodecyl sulphate electrophoresis. Among the slowly trans...

journal_title：Neurochemistry international

authors： Nilsson E,Karlsson JO

更新日期：1990-01-01 00:00:00

abstract：:DJ-1 (also known as PARK7) is a redox-active protein that protects against oxidative stress. This study evaluated the hypothesis that DJ-1 sustains brainstem cardiovascular regulation via maintaining mitochondrial function in the rostral ventrolateral medulla (RVLM), a brainstem site known to maintain blood pressure a...

journal_title：Neurochemistry international

authors： Tsai CY,Wu CJ,Wu JCC,Fang C,Huang YH,Dai KY

更新日期：2020-10-01 00:00:00

abstract：:In the present study, we investigated the neuroprotective role of p38 inhibition on experimental stroke in rats. p38 inhibition treatment alleviated the brain infarction volume and neurological deficits following ischemia, promoted the activation of Extracellular signal-regulated kinases (ERK1/2), suppressed the activ...

journal_title：Neurochemistry international

authors： Zhang XM,Zhang L,Wang G,Niu W,He Z,Ding L,Jia J

更新日期：2015-11-01 00:00:00

abstract：:Na+-dependent uptake of excitatory neurotransmitter glutamate in astrocytes increases cell energy demands primarily due to the elevated ATP consumption by glutamine synthetase and Na+, K+-ATPase. The major pool of GLAST/EAAT1, the only glutamate transporter subtype expressed by human fetal astrocytes in undifferentiat...

journal_title：Neurochemistry international

authors： Gegelashvili M,Rodriguez-Kern A,Sung L,Shimamoto K,Gegelashvili G

更新日期：2007-06-01 00:00:00

abstract：:Chronic pain states and epilepsies are common therapeutic targets of voltage-gated sodium channel blockers. Inhibition of sodium channels results in central muscle relaxant activity as well. Selective serotonin reuptake inhibitors are also applied in the treatment of pain syndromes. Here, we investigate the pharmacody...

journal_title：Neurochemistry international

authors： Thán M,Kocsis P,Tihanyi K,Fodor L,Farkas B,Kovács G,Kis-Varga A,Szombathelyi Z,Tarnawa I

更新日期：2007-03-01 00:00:00

abstract：:High-affinity binding sites for tritiated hemicholinium-3, a potent and selective inhibitor of the sodium-dependent high-affinity choline transport, have been found in synaptosomal membranes from insect ganglia. The binding of hemicholinium to ganglionic membrane preparations was saturable and specific with an apparen...

journal_title：Neurochemistry international

authors： Knipper M,Krieger J,Breer H

更新日期：1989-01-01 00:00:00

abstract：:The present experiments investigated the effect of a neurotoxin purified from the venom of the spider Phoneutria nigriventer. This toxic component, P. nigriventer toxin 3-6 (PnTx3-6), abolished Ca(2+)-dependent glutamate release with an IC(50) of 74.4nM but did not alter Ca(2+)-independent secretion of glutamate when ...

journal_title：Neurochemistry international

authors： Vieira LB,Kushmerick C,Reis HJ,Diniz CR,Cordeiro MN,Prado MA,Kalapothakis E,Romano-Silva MA,Gomez MV

更新日期：2003-03-01 00:00:00