Enhanced calmodulin binding concurrent with increased kinase-dependent phosphorylation of cytoskeletal proteins following a single subcutaneous injection of diisopropyl phosphorofluoridate in hens.

abstract：:GM1 ganglioside, after intravenous injection into rats, is absorbed and taken up by various organs and tissues, including brain. The capacity of brain to take up gangliosides, referred to weight unit, is comparable to that of kidney and muscle. After injection of [Gal-(3)H]GM1 a relevant portion of brain associated ra...

journal_title：Neurochemistry international

authors： Ghidoni R,Fiorilli A,Trinchera M,Venerando B,Chigorno V,Tettamanti G

更新日期：1989-01-01 00:00:00

abstract：:The mediatory role of kinins in both acute and chronic inflammation within nervous tissues has been widely described. Bradykinin, the major representative of these bioactive peptides, is one of a few mediators of inflammation that directly stimulates afferent nerves due to the broad expression of specific kinin recept...

journal_title：Neurochemistry international

authors： Guevara-Lora I

更新日期：2012-07-01 00:00:00

abstract：:Vasogenic mechanism of brain edema in acute liver failure (ALF) remains poorly understood. Recent work demonstrates that matrix metalloproteinase-9 (MMP-9) contributes to the development of brain edema in experimental ALF (J Hepatol 44:1105, 2006). Importantly, MMP-9 blockage with specific monoclonal antibodies and/or...

journal_title：Neurochemistry international

authors： Nguyen JH

更新日期：2010-01-01 00:00:00

abstract：:The neonatal administration of 5,7-dihydroxytryptamine to rats (100 mg kg(?1) s.c. on the 1st and 2nd day after birth) resulted in marked reductions in serotoninergic presynaptic markers ([(3)H]-5-HT synaptosomal uptake, tryptophan hydroxylase activity and endogenous 5-HT content) in various forebrain areas, particula...

journal_title：Neurochemistry international

authors： Hamon M,Nelson DL,Mallat M,Bourgoin S

更新日期：1981-03-01 00:00:00

abstract：:Selective dopaminergic neurotoxicity induced by 1-methyl-4-phenylpyridine (MPP+) is believed to be due to the transmembrane uptake by the dopamine transporter and subsequent inhibition of mitochondrial complex I and/or production of free radicals. However, little is known about the molecular sequence of intracellular ...

journal_title：Neurochemistry international

authors： Storch A,Ludolph AC,Schwarz J

更新日期：1999-11-01 00:00:00

abstract：:Glial scar is a major impediment to axonal regeneration in central nervous system (CNS) disorders. Overcoming this physical and biochemical barrier might be crucial for axonal regeneration and functional compensation during the progression of CNS disorders. The mammalian target of rapamycin (mTOR) is an evolutionarily...

journal_title：Neurochemistry international

authors： Li CY,Li X,Liu SF,Qu WS,Wang W,Tian DS

更新日期：2015-04-01 00:00:00

abstract：:The formation of amyloid β-protein (1-42) (Aβ42) oligomers and Aβ42 oligomer cytotoxicity are two defining characteristics of the etiology of Alzheimer's disease (AD). In this study, we found that matrine (Mat) could maintain or even enhance the cytotrophic effect of Aβ42 monomers by inhibiting their aggregation and b...

journal_title：Neurochemistry international

authors： Yang B,Li H,Zhang T,Wang Z,Li H,Zhang Y

更新日期：2020-07-01 00:00:00

abstract：:In this report evidence is presented for a membrane-associated polypeptide that regulates ligand binding properties of a neuronal acetylcholine receptor. Removal of membrane-associated compounds reversibly increased the number of BGTX binding sites and decreased the number of binding sites for ACh in neuronal membrane...

journal_title：Neurochemistry international

authors： Benke D,Breer H

更新日期：1990-01-01 00:00:00

abstract：:Radial glial cells play a significant role in the repair of spinal cord injuries as they exert critical role in the neurogenesis and act as a scaffold for neuronal migration. Our previous study showed that mature astrocytes of spinal cord can undergo a de-differentiation process and further transform into pluripotenti...

journal_title：Neurochemistry international

authors： Yang H,Ling W,Vitale A,Olivera C,Min Y,You S

更新日期：2011-12-01 00:00:00

abstract：:Ketone bodies serve as a source of energy and as precursors for lipid synthesis in developing brain. Neurons, astrocytes and oligodendroglia all have the necessary enzymes for metabolizing ketone bodies. In this in vivo study it was found that all three cell types were able to use ketone bodies as precursors for the s...

journal_title：Neurochemistry international

authors： Poduslo SE,Miller K

更新日期：1991-01-01 00:00:00

abstract：:The kinetics of oxidation of endogenous antioxidants such as vitamins C and E and thiols as well as membrane cholesterol in isolated rat brain mitochondria were studied. Oxidation was induced by incubating the mitochondria at 37 degrees C with the free radical generators 2,2' azobis (2'-amidinopropane) dihydrochloride...

journal_title：Neurochemistry international

authors： Vatassery GT,Smith WE,Quach HT,Lai JC

更新日期：1995-05-01 00:00:00

abstract：:The immunostains of GD3, c-pathway polysialogangliosides and gangliotetraosylgangliosides belonging to the a- and b-pathways were analyzed in embryo optic lobe cells. Cells were cultured in serum free media with, and without, bovine brain ganglioside mixture (largely gangliotetraosylgangliosides). Control cells differ...

journal_title：Neurochemistry international

authors： Cossy-Isasi S,Panzetta P

更新日期：1994-04-01 00:00:00

abstract：:Considerable evidence has been accumulated to suggests that blocking the inflammatory reaction promotes neuroprotection and shows therapeutic potential for clinical treatment of ischemic brain injury. Consequently, anti-inflammatory therapies are being explored for prevention and treatment of these diseases. Induction...

journal_title：Neurochemistry international

authors： Simão F,Matté A,Pagnussat AS,Netto CA,Salbego CG

更新日期：2012-10-01 00:00:00

abstract：:The amyloid precursor protein (APP) and presenilin-1 (PS-1) are not only of importance for the normal functioning of the various neurons, but also play central roles in the pathogenesis of Alzheimer's disease (AD). Through the use of immunohistochemical and Western blot techniques, the bidirectional axonal transport o...

journal_title：Neurochemistry international

authors： Papp H,Pakaski M,Kasa P

更新日期：2002-12-01 00:00:00

abstract：:Long-term potentiation (LTP) is a well-established experimental model used to investigate the synaptic basis of learning and memory. LTP at mossy fibre - CA3 synapses in the hippocampus is unusual because it is normally N-methyl-d-aspartate (NMDA) receptor-independent. Instead it seems that the trigger for mossy fibre...

journal_title：Neurochemistry international

authors： Sherwood JL,Amici M,Dargan SL,Culley GR,Fitzjohn SM,Jane DE,Collingridge GL,Lodge D,Bortolotto ZA

更新日期：2012-09-01 00:00:00

abstract：:The Mg(2+)-ATPase associated with highly purified cholinergic synaptic vesicles isolated from the Torpedo electric organ can be activated by millimolar concentrations of Ca(2+) only to a maximum of 46%. ATP is hydrolyzed in preference to other tri-nucleotides on Mg(2+)-activation but not on Ca(2+)-activation of the en...

journal_title：Neurochemistry international

authors： Stelzl H,Grondal EJ,Zimmermann H

更新日期：1987-01-01 00:00:00

abstract：:Transport activity of d-pipecolic acid and of l-pipecolic acid in mouse brain and peripheral tissues were tested, and the effect of immobilization stress was described, along with the method for preparative, enantiomeric resolution and purification of d,l-pipecolic acid using high performance liquid chromatography equ...

journal_title：Neurochemistry international

authors： Nishio H,Sogabe H,Segawa T

更新日期：1988-01-01 00:00:00

abstract：:Cytokines are a heterogenous group of polypeptide mediators that have been associated with activation of numerous functions, including the immune system and inflammatory responses. The cytokine families include, but are not limited to, interleukins (IL-I alpha, IL-I beta, ILIra and IL-2-IL-15), chemokines (IL-8/ NAP-I...

journal_title：Neurochemistry international

authors： Ebadi M,Bashir RM,Heidrick ML,Hamada FM,Refaey HE,Hamed A,Helal G,Baxi MD,Cerutis DR,Lassi NK

更新日期：1997-04-01 00:00:00

abstract：:We demonstrated that genetically modified fibroblasts can be encapsulated into biocompatible, biodegradable spheres retaining their viability and capacity to continuously secrete nerve growth factor (NGF) for at least two months. Genetically engineered rat fibroblasts producing NGF were encapsulated in an alginate-pol...

journal_title：Neurochemistry international

authors： Maysinger D,Piccardo P,Filipovic-Grcic J,Cuello AC

更新日期：1993-08-01 00:00:00

abstract：:The phosphorylation of proteins on tyrosine residues, initially believed to be primarily involved in cell growth and differentiation, is now recognized as having a critical role in regulating the function of mature cells. The brain exhibits one of the highest levels of tyrosine kinase activity in the adult animal and ...

journal_title：Neurochemistry international

authors： Gurd JW

更新日期：1997-11-01 00:00:00

abstract：:Precise anatomical distribution of 5HT1 binding sites has been investigated in the nuclei raphe dorsalis, raphe centralis and locus caeruleus of the rat brain. An original pattern of distribution was observed in the raphe nuclei, closely correlated to the already known distribution of 5HT containing elements. This pat...

journal_title：Neurochemistry international

authors： Weissmann-Nanopoulos D,Mach E,Magre J,Demassey Y,Pujol JF

更新日期：1985-01-01 00:00:00

abstract：:In the present investigation we address the question of whether one of the responses to increased neuronal activity is a modification of the expression of the different subunits of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-selective glutamate receptors (GluR-1, GluR-2, GluR-3). Thus, we used two dif...

journal_title：Neurochemistry international

authors： Condorelli DF,Belluardo N,Mudò G,Dell'Albani P,Jiang X,Giuffrida-Stella AM

更新日期：1994-10-01 00:00:00

abstract：:Astroglial cells have a variety of roles in the central nervous system (CNS), providing a homeostasis for the proper functioning of neuronal cells. The classical view concerning the supportive role of astroglia towards associated neurons has to be extended. A great number of new evidences suggest that astrocytes inter...

journal_title：Neurochemistry international

authors： Struzyńska L

更新日期：2009-07-01 00:00:00

abstract：:High-affinity binding sites for tritiated hemicholinium-3, a potent and selective inhibitor of the sodium-dependent high-affinity choline transport, have been found in synaptosomal membranes from insect ganglia. The binding of hemicholinium to ganglionic membrane preparations was saturable and specific with an apparen...

journal_title：Neurochemistry international

authors： Knipper M,Krieger J,Breer H

更新日期：1989-01-01 00:00:00

abstract：:The activities of the enzymes glutathione reductase (GRD), glutathione peroxidase (GPX), and glutathione S-transferase (GST) were studied in several rat brain areas following the aspirative transection of the septohippocampal pathway (fimbria fornix) and the administration of nerve growth factor (NGF) or cytochrome c....

journal_title：Neurochemistry international

authors： Cruz-Aguado R,Francis-Turner L,Díaz-Suárez CM,Bergado J

更新日期：1999-02-01 00:00:00

abstract：:To identify whether the process of apoptosis bears a topographic relationship to selected aspects of Alzheimer's disease (AD) pathology, we used an in situ nick translation method (TUNEL) to map DNA fragmentation in hippocampal sections immunostained for abnormally phosphorylated tau, which exists in the neurofibrilla...

journal_title：Neurochemistry international

authors： Sugaya K,Reeves M,McKinney M

更新日期：1997-08-01 00:00:00

abstract：:Zinc transporter 3 (ZNT3) has been shown to transport zinc ions from the cytosol into presynaptic vesicles in the mammalian brain. Several studies have stated that the zinc ion containing synaptic vesicles of zinc-enriched neurons (ZEN) are loaded with ZNT3 proteins in their membranes. This fact makes it possible to t...

journal_title：Neurochemistry international

authors： Chi ZH,Wang X,Cai JQ,Stoltenberg M,Danscher G,Wang ZY

更新日期：2008-06-01 00:00:00

abstract：:The release of [(3)H]GABA which is newly synthesized from [(3)H]l-glutamic acid (GLU) has been examined using striatal slices obtained from the rat brain. It was found that 8-10% of [(3)H]GLU transported was converted to [(3)H]GABA during the incubation of striatal slices in the presence of nipecotic acid (5 x 10(?5) ...

journal_title：Neurochemistry international

authors： Yoneda Y,Kanmori K,Takahashi M,Zuo PP,Paik IH,Kuriyama K

更新日期：1984-01-01 00:00:00

abstract：:Depression is highly comorbid with anxiety disorders and associated with profound cognitive impairment. Moreover, cognitive deficits associated with hippocampal dysfunction are central in depression and anxiety disorders. Furthermore, depression is accompanied by glutamatergic dysfunction which can further impair the ...

journal_title：Neurochemistry international

authors： Chakraborty S,Tripathi SJ,Srikumar BN,Raju TR,Shankaranarayana Rao BS

更新日期：2020-01-01 00:00:00

abstract：:Quantitative autoradiography analysis of neurotensin (NT) and somatostatin (SS) binding sites was performed on coronal sections of the medulla oblongata from 2 fetuses, 6 controls and 7 victims of Sudden Infant Death Syndrome (SIDS). Throughout the first postnatal year, mean SS binding site density was similar in cont...

journal_title：Neurochemistry international

authors： Chigr F,Jordan D,Najimi M,Denoroy L,Sarrieau A,de Broca A,Rostene W,Epelbaum J,Kopp N

更新日期：1992-01-01 00:00:00