PnTx3-6 a spider neurotoxin inhibits K+-evoked increase in [Ca2+](i) and Ca2+-dependent glutamate release in synaptosomes.

abstract：BACKGROUND:Axonal injury is the correlate of disease progression in NMO and MS. Neurofilament (Nf) belongs to neuron specific intermediate filaments located in axons. Nf protein subunits are potential biomarkers in cerebrospinal fluid (CSF) for acute axonal injury. However, whether CSF NfH and NfL levels are elevated i...

journal_title：Neurochemistry international

authors： Wang H,Wang C,Qiu W,Lu Z,Hu X,Wang K

更新日期：2013-12-01 00:00:00

abstract：:There is a growing body of evidence on the role of nitric oxide (NO) in retinal physiology. Recently, interest has developed in the functional role of an alternative redox form of NO, namely nitroxyl (HNO/NO(-)), because it is formed by a number of diverse biochemical reactions. The aim of the present report was to co...

journal_title：Neurochemistry international

authors： Sáenz DA,Bari SE,Salido E,Chianelli M,Rosenstein RE

更新日期：2007-11-01 00:00:00

abstract：:Striatal quinolinic acid lesions have been used as a model for the pathology seen in Huntington's disease. Seven days following a unilateral injection of 100 nmol of quinolinic acid into the rat caudate-putamen (striatum), a large increase in the binding of [3H]WIN 35,428 to the lesioned caudate-putamen was seen when ...

journal_title：Neurochemistry international

authors： Gehlert DR,Schoepp DD

更新日期：1992-12-01 00:00:00

abstract：:Long-term potentiation (LTP) is a well-established experimental model used to investigate the synaptic basis of learning and memory. LTP at mossy fibre - CA3 synapses in the hippocampus is unusual because it is normally N-methyl-d-aspartate (NMDA) receptor-independent. Instead it seems that the trigger for mossy fibre...

journal_title：Neurochemistry international

authors： Sherwood JL,Amici M,Dargan SL,Culley GR,Fitzjohn SM,Jane DE,Collingridge GL,Lodge D,Bortolotto ZA

更新日期：2012-09-01 00:00:00

abstract：:NADPH derived from glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, has been implicated not only to promote reduced glutathione (GSH) but also enhance oxidative stress in specific cellular conditions. In this study, the effects of G6PD antisense oligodeoxynucleotides...

journal_title：Neurochemistry international

authors： Zhao G,Zhao Y,Wang X,Xu Y

更新日期：2012-07-01 00:00:00

abstract：:In order to elucidate the effects of MPTP on enkephalinergic neurons, dopamine (DA), norepinephrine (NE), proenkephalin (PE) mRNA and met-enkephalin (ME) were measured in striatum, olfactory tubercle, and prefrontal cortex of C57/B16 mice 1 day-2 weeks following treatment with 96 mg/kg MPTP HCl (24 mg/kg i.p., twice/d...

journal_title：Neurochemistry international

authors： Mitsuo K,Cosi C,Harvey-White JD,Schwartz JP

更新日期：1993-02-01 00:00:00

abstract：:AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) excitotoxicity was examined in cultured neocortical neurons using the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to measure cell viability. Neurons were exposed to AMPA at different culture periods during development o...

journal_title：Neurochemistry international

authors： Jensen JB,Schousboe A,Pickering DS

更新日期：1998-05-01 00:00:00

abstract：:Using native plasma membrane vesicle suspensions from the rat cerebral cortex under conditions designed to alter intravesicular [Ca2+], we found that Ca2+ induced 47 +/- 5% more influx of [3H]GABA, [3H]D-aspartate and [3H]glycine at 37 degrees C with half-times 1.7 +/- 0.5, 1.3 +/- 0.4 and 1.3 +/- 0.4 min, respectivel...

journal_title：Neurochemistry international

authors： Kovács I,Szárics E,Nyitrai G,Blandl T,Kardos J

更新日期：1998-11-01 00:00:00

abstract：:Flavonoids that are found in nutraceuticals have many and varied effects on the activation of ionotropic receptors for GABA, the major inhibitory neurotransmitter in our brains. They can act as positive or negative modulators enhancing or reducing the effect of GABA. They can act as allosteric agonists. They can act t...

journal_title：Neurochemistry international

authors： Johnston GA

更新日期：2015-10-01 00:00:00

abstract：:In recent years there has been a great deal of research within the stem cell field which has led to the definition and classification of a range of stem cells from a plethora of tissues and organs. Stem cells, by classification, are considered to be pluri- or multipotent and have both self-renewal and multi-differenti...

journal_title：Neurochemistry international

authors： Lindsay SL,Barnett SC

更新日期：2017-06-01 00:00:00

abstract：:The effects of the GABA agonist, muscimol on [(3)H]flunitrazepam binding were examined in cerebellum and hippocampus regions proposed to contain different populations of benzodiazepine binding site subtypes. Quantitative analysis was made of the contribution of different components of [(3)H]flunitrazepam binding by ut...

journal_title：Neurochemistry international

authors： Mitchell R,Wilson L

更新日期：1984-01-01 00:00:00

abstract：:Development of tissue structure and three-dimensional microenvironment is crucial for regeneration of axons in the peripheral nerve repair. In this study we aimed to evaluate the efficacy of nerve regeneration by using an acellular nerve allograft (ANA) injected with allogenic skin-derived precursor differentiated Sch...

journal_title：Neurochemistry international

authors： Wang H,Wu J,Zhang X,Ding L,Zeng Q

更新日期：2016-07-01 00:00:00

abstract：:We have used an in vitro system to monitor the effects of high levels of ammonia and ethanol on glial cells. Nuclei were isolated and the protein profiles examined by two-dimensional gel electrophoresis. Acute exposure of rat astrocyte cell cultures to ammonia or ethanol resulted in changes in cellular morphology and ...

journal_title：Neurochemistry international

authors： Lipsky RH,Vemuri MC,Silverman SJ

更新日期：1988-01-01 00:00:00

abstract：:A decrease in the osmolarity of incubation medium is accompanied by calcium influx in neuronal presynaptic endings. We studied the influence of Ca2+ on exocytosis induced by hypotonic shock using the hydrophilic fluorescent dye acridine orange and the hydrophobic fluorescent dye FM2-10. It was shown using acridine ora...

journal_title：Neurochemistry international

authors： Waseem TV,Rakovich AA,Lavrukevich TV,Konev SV,Fedorovich SV

更新日期：2005-02-01 00:00:00

abstract：:Monosialoganglioside (GM1) is a glycosphingolipid present in most cell membranes that displays antioxidant and neuroprotective properties. It has been recently described that GM1 induces vasodilation. However, the mechanisms underlying GM1-induced vasodilation were not evaluated to date. Therefore, in this study we in...

journal_title：Neurochemistry international

authors： Furian AF,Oliveira MS,Magni DV,Souza MA,Bortoluzzi VT,Bueno LM,Royes LF,Mello CF

更新日期：2008-12-01 00:00:00

abstract：:Human neuroblastoma GOTO cell lines were established that stably express recombinant human lysosomal protective protein/cathepsin A (PPCA) cDNA by transfection. Intracellular cathepsin A (acid serine carboxypeptidase) activity increased four-fold compared with in those of the parent and mock-transfected cell lines. Th...

journal_title：Neurochemistry international

authors： Itoh K,Satoh Y,Kadota Y,Oheda Y,Kuwahara J,Shimmoto M,Sakuraba H

更新日期：2004-05-01 00:00:00

abstract：:Aging is a biological process characterized by impairment of cellular bioenergetic function, increased oxidative stress, attenuated ability to respond to stresses, increased risk of contracting age-associated disorders that affects many tissues, with a more marked effect on brain and heart function. Oxidative stress i...

journal_title：Neurochemistry international

authors： Paradies G,Petrosillo G,Paradies V,Ruggiero FM

更新日期：2011-03-01 00:00:00

abstract：:Intact pieces or homogenates of rabbit retina were exposed to various established or putative retinal neurotransmitters for the study of receptors (or receptor-subtypes) linked to the production of cAMP. Since a dopamine-sensitive adenylate cyclase has been previously characterized in the retina of several species, th...

journal_title：Neurochemistry international

authors： Schorderet M

更新日期：1989-01-01 00:00:00

abstract：:Metabotropic glutamate receptors (mGluRs) are expressed in neural progenitor cells (NPCs) and may play important roles in the neurogenesis during embryonic development and adult brain repair following injuries. In the present study, we investigated the expression of metabotropic glutamate receptor 7 (mGluR7) and the p...

journal_title：Neurochemistry international

authors： Tian Y,Liu Y,Chen X,Kang Q,Zhang J,Shi Q,Zhang H

更新日期：2010-08-01 00:00:00

abstract：:We investigated whether alterations in glutamate metabolising glutamine synthetase activity occur in human epileptic neocortex, as shown previously for human epileptic hippocampus [Eid, T., Thomas, M.J., Spencer, D.D., Rundén-Pran, E., Lai, J.C.K., Malthankar, G.V., Kim, J.H., Danbolt, N.C., Ottersen, O.P., de Lanerol...

journal_title：Neurochemistry international

authors： Steffens M,Huppertz HJ,Zentner J,Chauzit E,Feuerstein TJ

更新日期：2005-11-01 00:00:00

abstract：:Many peripheral substances, including ghrelin, induce neuronal activation in the brain. In the present study, we compared the effect of subcutaneously administered ghrelin and its three stable agonists: Dpr(3)ghr ([Dpr(N-octanoyl)(3)] ghrelin) (Dpr - diaminopropionic acid), YA GHRP-6 (H-Tyr-Ala-His-DTrp-Ala-Trp-DPhe-L...

journal_title：Neurochemistry international

authors： Pirnik Z,Bundziková J,Holubová M,Pýchová M,Fehrentz JA,Martinez J,Zelezná B,Maletínská L,Kiss A

更新日期：2011-11-01 00:00:00

abstract：:Acetylcholine is an excitatory neurotransmitter in the central nervous system of insects and the nicotinic acetylcholine receptor (nAChR) is a target for neonicotinoid insecticides. Functional insect nAChRs are difficult to express in host cells, and hence difficult to study. In mammals, acetylcholine and nicotine evo...

journal_title：Neurochemistry international

authors： Pyakurel P,Shin M,Venton BJ

更新日期：2018-03-01 00:00:00

abstract：:Glutathione (GSH) is an essential component of intracellular antioxidant systems that plays a primordial role in the protection of cells against oxidative stress, maintaining redox homeostasis and xenobiotic detoxification. GSH synthesis in the brain is limited by the availability of cysteine and glutamate. Cystine, t...

journal_title：Neurochemistry international

authors： Garza-Lombó C,Petrosyan P,Tapia-Rodríguez M,Valdovinos-Flores C,Gonsebatt ME

更新日期：2018-12-01 00:00:00

abstract：:The effects of a cerebral anti-ischemic drug ifenprodil on the receptor ionophore complex of an N-methyl-D-aspartate (NMDA)-sensitive subclass of central excitatory amino acid receptors were examined using [3H](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10- imine (MK-801) binding in rat brain synaptic memb...

journal_title：Neurochemistry international

authors： Ogita K,Ohkawara A,Suzuki T,Ohgaki T,Uchida S,Meguri H,Yoneda Y

更新日期：1992-07-01 00:00:00

abstract：:Guanylate cyclase in the membrane fraction of rod outer segments (ROS-membrane) from the frog retina showed an extremely high activity but had no responsiveness to NaN(3) (+catalase), nitrosoguanidine or superoxide dismutase. These compounds, however, markedly activated the enzyme in a soluble fraction from the retina...

journal_title：Neurochemistry international

authors： Yoshikawa K,Nishimura C,Kuriyama K

更新日期：1982-01-01 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) are considered as a powerful tool for drug and chemical screening and development of new in vitro testing strategies in the field of toxicology, including neurotoxicity evaluation. These cells are able to expand and efficiently differentiate into different types of neurona...

journal_title：Neurochemistry international

authors： Zagoura D,Canovas-Jorda D,Pistollato F,Bremer-Hoffmann S,Bal-Price A

更新日期：2017-06-01 00:00:00

abstract：:ATPase activities in CNS membranes were studied after administration of desipramine (DMI), a noradrenaline (NA) uptake inhibitor. In a previous paper we reported that Na+,K(+)-ATPase activity significantly increased 3 h after DMI administration (10 mg/kg) in hypothalamus and mesencephalus but not in cerebral cortex an...

journal_title：Neurochemistry international

authors： Viola MS,Rodríguez de Lores Arnaiz G,Enero MA

更新日期：1994-01-01 00:00:00

abstract：:The effects of mechanoreceptor stimulation and subsequent ATP release in cyclophosphamide evoked chronic bladder inflammation was examined to demonstrate: (1) whether inflammation modulates ATP release from bladder urothelium and (2) whether intravesical botulinum toxin A administration inhibits urothelial ATP release...

journal_title：Neurochemistry international

authors： Smith CP,Vemulakonda VM,Kiss S,Boone TB,Somogyi GT

更新日期：2005-09-01 00:00:00

abstract：:RBFox proteins are well-known alternative splicing regulators. We have shown previously that during neuronal differentiation of P19 cells induced by all-trans retinoic acid and cell aggregation, RBFox1 shows markedly increased temporal expression. To find its key splicing regulation, we examined the effect of RBFox1 o...

journal_title：Neurochemistry international

authors： Alam S,Suzuki H,Tsukahara T

更新日期：2014-12-01 00:00:00

abstract：:The effect of aging and CDP-choline treatment (20 mg kg⁻¹ body weight i.p. for 28 days) on the maximal rates (V(max)) of representative mitochondrial enzyme activities related to Krebs' cycle (citrate synthase, α-ketoglutarate dehydrogenase, malate dehydrogenase), glutamate and related amino acid metabolism (glutamate...

journal_title：Neurochemistry international

authors： Villa RF,Ferrari F,Gorini A

更新日期：2012-12-01 00:00:00