Unchanged glutamine synthetase activity and increased NMDA receptor density in epileptic human neocortex: implications for the pathophysiology of epilepsy.

abstract：:In the present study, we investigated the neuroprotective role of p38 inhibition on experimental stroke in rats. p38 inhibition treatment alleviated the brain infarction volume and neurological deficits following ischemia, promoted the activation of Extracellular signal-regulated kinases (ERK1/2), suppressed the activ...

journal_title：Neurochemistry international

authors： Zhang XM,Zhang L,Wang G,Niu W,He Z,Ding L,Jia J

更新日期：2015-11-01 00:00:00

abstract：:This study aimed to examine the effects of Cacna1a mutation on the phenotype of Scn1a-associated epilepsy in rats. We used rats with an N1417H missense mutation in the Scn1a gene and others with an M251K mutation in the Cacna1a gene. Scn1a/Cacna1a double mutant rats were generated by mating both Scn1a and Cacna1a muta...

journal_title：Neurochemistry international

authors： Ohmori I,Kobayashi K,Ouchida M

更新日期：2020-12-01 00:00:00

abstract：:Patients with Parkinson's disease (PD) show a common progressive neurodegenerative movement disorder characterized by rigidity, tremors, postural instability, and bradykinesia due to the loss of dopaminergic neurons in the substantia nigra, and is often accompanied by several non-motor symptoms, called parkinsonism. S...

journal_title：Neurochemistry international

authors： Shimizu J,Kasai T,Yoshida H,Huynh AM,Nakao-Azuma Y,Shinomoto M,Tokuda T,Mizuno T,Yamaguchi M

更新日期：2020-10-01 00:00:00

abstract：:With their potent regenerative and protective capacities, stem cell-derived conditioned media emerged as an effective alternative to cell therapy, and have a prospect to be manufactured as pharmaceutical products for tissue regeneration applications. Our study investigates the neuroregenerative potential of human dent...

journal_title：Neurochemistry international

authors： Chouaib B,Collart-Dutilleul PY,Blanc-Sylvestre N,Younes R,Gergely C,Raoul C,Scamps F,Cuisinier F,Romieu O

更新日期：2021-01-16 00:00:00

abstract：:A procedure for studying 5-hydroxytryptamine synthesis by determining the rate of accumulation of 5-hydroxytryptophan after administering m-hydroxybenzylhydrazine, an inhibitor of aromatic-l-amino acid decarboxylase, and large doses of l-tryptophan was characterized. The utility of this method as an index of 5-hydroxy...

journal_title：Neurochemistry international

authors： Nielsen JA

更新日期：1986-01-01 00:00:00

abstract：:The effects of the peroxovanadium complex potassium bisperoxo(1,10-phenanthroline)-oxovanadate (bpV[phen]) have been studied on dopamine (DA) exocytosis in PC12 cells. Bisperoxo(1,10-phenanthroline)-oxovanadate does not elicit dopamine secretion in PC12 cells. However, treatment of PC12 cells with 30 microM bpV[phen] ...

journal_title：Neurochemistry international

authors： Bieger S,Morinville A,Maysinger D

更新日期：2002-04-01 00:00:00

abstract：:Exposure to high levels of manganese (Mn) results in a neurological disorder, termed manganism, which shares a similar phenotype to Parkinson's disease due to the involvement of the basal ganglia circuitry in both. The initial symptoms of manganism are likely due to the involvement of the globus pallidus, a region ric...

journal_title：Neurochemistry international

authors： Fitsanakis VA,Au C,Erikson KM,Aschner M

更新日期：2006-05-01 00:00:00

abstract：:A competitive RT-PCR assay was used to quantify the expression of the GABA(A) receptor beta(1), beta(2) and beta(3) isoform mRNA transcripts in the superior frontal cortex and motor cortex of 21 control and 22 alcoholic cases. A single set of primers was designed that permitted amplification of all three transcripts a...

journal_title：Neurochemistry international

authors： Buckley ST,Dodd PR

更新日期：2004-12-01 00:00:00

abstract：:Deficiency of 5-methyltetrahydrofolate (5-MTHF) in cerebrospinal fluid (CSF) is associated with a number of neurometabolic conditions including mitochondrial electron transport chain defects. Whilst failure of the active transport of 5-methyltetrahydrofolate (5-MTHF) into the CSF compartment has been proposed as a pot...

journal_title：Neurochemistry international

authors： Aylett SB,Neergheen V,Hargreaves IP,Eaton S,Land JM,Rahman S,Heales SJ

更新日期：2013-12-01 00:00:00

abstract：:Age-related and aged memory deficit changes in Nestin-immunoreactive (Nestin-IR) neurons were studied following recent evidence of distinct Nestin-IR neurons within adult rat basal forebrain. Morris water maze task assessed spatial learning capacity of 3- and 24-month rats (aged-impaired and aged-unimpaired groups). N...

journal_title：Neurochemistry international

authors： Li D,Wang J,Yew DT,Lucy Forster E,Yao Z

更新日期：2008-12-01 00:00:00

abstract：:Whereas carbachol, noradrenaline, serotonin and memantine stimulated inositol phosphates production and calcium mobilization in 3-5 day old rabbit retinal cultures, only carbachol and noradrenaline were effective when 25-30 day old cultures were used. The older retinal cultures contain only Müller cells which shows th...

journal_title：Neurochemistry international

authors： Osborne NN,Quack G

更新日期：1992-10-01 00:00:00

abstract：:Focusing on development of novel drug candidates for the treatment of neurodegenerative diseases, we developed and synthesized a new compound, 2-(cyclohexylamino)-1-(4-cyclopentylpiperazin-1-yl)-2-methylpropan-1-one (amido-piperizine 1). The compound demonstrated robust neuroprotective properties after both glutamate ...

journal_title：Neurochemistry international

authors： Elbrønd-Bek H,Wellejus A,Kelly NM,Weidner MS,Jørgensen SH

更新日期：2011-11-01 00:00:00

abstract：:Neurosteroids are modulators of several receptors and ion channels and are implicated in the pathophysiology of several neuropsychiatric diseases including hepatic encephalopathy (HE). The neurosteroid, allopregnanolone, a positive allosteric modulator of GABA(A) receptors, accumulates in the brains of HE patients whe...

journal_title：Neurochemistry international

authors： Ahboucha S,Coyne L,Hirakawa R,Butterworth RF,Halliwell RF

更新日期：2006-06-01 00:00:00

abstract：:Many pharmacological and toxicological studies of centrally acting drugs are undertaken in animals at doses expressed in mg.kg-1, and the results extrapolated to the clinical dose in man. Safety margins based on such no or lowest effect levels may have little relevance since they do not take into account differences i...

journal_title：Neurochemistry international

authors： Campbell DB

更新日期：1995-02-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Rupture of lysosome is a major cellular stress condition leading to cell death in PD. We have previously shown that environmenta...

journal_title：Neurochemistry international

authors： Dong H,Qin Y,Huang Y,Ji D,Wu F

更新日期：2019-06-01 00:00:00

abstract：:Astrocytes, besides supporting metabolic and scaffolding functions, play a prominent role in the modulation of neuronal communication. In particular, they are responsible for clearing synaptically-released glutamate via highly specific transporters located on their plasma membrane. Since glutamate is the main excitato...

journal_title：Neurochemistry international

authors： Piet R,Poulain DA,Oliet SH

更新日期：2004-07-01 00:00:00

abstract：:Bindings of glutamate receptor agonists and related modulators were investigated in 10 discrete tissues from gerbil brain using a biochemical technique. There appeared considerable discrepancies, in respect of intrahippocampal profiles, from reported data by autoradiography on rat brain. In the gerbil, an almost equiv...

journal_title：Neurochemistry international

authors： Kataoka K,Mitani A,Andou Y,Enomoto R,Ogita K,Yoneda Y

更新日期：1993-01-01 00:00:00

abstract：:Depression is characterized by sadness, purposelessness, irritability, and impaired body functions. Depression causes severe symptoms for several weeks, and dysthymia, which may cause chronic, low-grade symptoms. Treatment of depression involves psychotherapy, medications, or phototherapy. Clinical and experimental ev...

journal_title：Neurochemistry international

authors： Shabbir F,Patel A,Mattison C,Bose S,Krishnamohan R,Sweeney E,Sandhu S,Nel W,Rais A,Sandhu R,Ngu N,Sharma S

更新日期：2013-02-01 00:00:00

abstract：:Microglia, the primary resident immune cells of the central nervous system (CNS), responds rapidly to pathogens and injury by secreting immune mediators including nitric oxide (NO). The reaction of NO with the anti-oxidant glutathione forms S-nitrosoglutathione (GSNO), the major pool of biologic NO in the body. GSNO i...

journal_title：Neurochemistry international

authors： Rossi-George A,Guo CJ

更新日期：2016-10-01 00:00:00

abstract：:To characterise ketamine-induced sympathomimetic action, we examined the effects of ketamine on in vivo cardiac sympathetic nerve endings function. Using adult cats given anaesthesia with pentobarbital, dialysis probes were implanted in the left ventricular myocardium and dialysate noradrenaline (NA) concentrations we...

journal_title：Neurochemistry international

authors： Kitagawa H,Yamazaki T,Akiyama T,Mori H,Sunagawa K

更新日期：2003-02-01 00:00:00

abstract：:Diabetic neuropathic pain (DNP) plays a major role in decreased life quality of diabetes patients, however, the neural mechanisms underlying DNP remain unclear. Endomorphins are the endogenous ligands for mu-opioid receptor. There is increasing evidence implicating the involvement of spinal endomorphin-2 (EM2) in neur...

journal_title：Neurochemistry international

authors： Niu L,Dai GH,He GL,Yang M,Hu HM,Liu ZK,Qian NS,Chen YL

更新日期：2017-09-01 00:00:00

abstract：:A novel copper-containing protein has been isolated in electrophoretically homogeneous state from bovine brain extracts. Some physico-chemical properties of the protein are determined (molecular weight, copper content, isoelectric point, amino acid composition, optical and EPR spectra), and they are compared with thos...

journal_title：Neurochemistry international

authors： Mikaelyan MV,Nalbandyan RM

更新日期：1988-01-01 00:00:00

abstract：:Resistance to inhibitors of cholinesterase (RIC) -3 promotes the maturation (folding and assembly) of neuronal nicotinic acetylcholine receptors (nAChRs) as a molecular chaperone. The modulation effects of RIC-3 on homomeric α7 nAChRs are always positive, but its effects on heteromeric subtypes are inconsistent among ...

journal_title：Neurochemistry international

authors： Bao H,Xu X,Liu W,Yu N,Liu Z

更新日期：2018-05-01 00:00:00

abstract：:The less active form of human tyrosine hydroxylase has been previously reported but its physiological role is unknown. We partially purified the less active form of tyrosine hydroxylase from human adrenals, and examined differences in the properties of the active and less active forms. We succeeded in activation of th...

journal_title：Neurochemistry international

authors： Ishii A,Kiuchi K,Matsuyama M,Satake T,Nagatsu T

更新日期：1990-01-01 00:00:00

abstract：:Neural stem cells (NSCs) play a crucial role in the development and maturation of the central nervous system. Recently studies suggest that antipsychotic drugs regulate the activities of NSCs. However, the molecular mechanisms underlying antipsychotic-induced changes of the activity of NSCs, particularly protein expre...

journal_title：Neurochemistry international

authors： Kashem MA,Ummehany R,Ukai W,Hashimoto E,Saito T,Mcgregor IS,Matsumoto I

更新日期：2009-12-01 00:00:00

abstract：:Intense glucose-based energy metabolism and glutamate synthesis by astrocytes require malate-aspartate-shuttle (MAS) activity to regenerate NAD⁺ from NADH formed during glycolysis, since brain lacks significant glycerophosphate shuttle activity. Aralar is a necessary aspartate/glutamate exchanger for MAS function in b...

journal_title：Neurochemistry international

authors： Li B,Hertz L,Peng L

更新日期：2012-12-01 00:00:00

abstract：:The anticonvulsant vigabatrin (VGB; SabrilR) irreversibly inhibits GABA transaminase to increase neural GABA, yet its mechanism of retinal toxicity remains unclear. VGB is suggested to alter several amino acids, including homocarnosine, β-alanine, ornithine, glycine, taurine, and 2-aminoadipic acid (AADA), the latter ...

journal_title：Neurochemistry international

authors： Walters DC,Arning E,Bottiglieri T,Jansen EEW,Salomons GS,Brown MN,Schmidt MA,Ainslie GR,Roullet JB,Gibson KM

更新日期：2019-05-01 00:00:00

abstract：:The concentrations of histamine reported vary considerably from species to species. The present studies sought to determine if blood sampling techniques were at least in part responsible for this large variability. Since plasma catecholamines are influenced by the stress associated with blood sampling, these biogenic ...

journal_title：Neurochemistry international

authors： Head RJ,Jarrott B,Libys J,Robinson RL,Stitzel RE,Zavisca F

更新日期：1985-01-01 00:00:00

abstract：:Immunoglobulin G (IgG) antibodies against myelin oligodendrocyte glycoprotein (MOG) are detected in the serum of some patients with demyelinating diseases. These patients are known to show repeated clinical episodes of inflammatory demyelinating attacks in the central nervous system. Although the associated pathogenic...

journal_title：Neurochemistry international

authors： Akaishi T,Sato DK,Takahashi T,Nakashima I

更新日期：2019-11-01 00:00:00

abstract：:Amyloid β (Aβ) oligomers are presumed to be one of the causes of Alzheimer's disease (AD). Previously, we identified the E693Δ mutation in amyloid precursor protein (APP) in patients with AD who displayed almost no signals of amyloid plaques in amyloid imaging. We generated APP-transgenic mice expressing the E693Δ mut...

journal_title：Neurochemistry international

authors： Takano M,Maekura K,Otani M,Sano K,Nakamura-Hirota T,Tokuyama S,Min KS,Tomiyama T,Mori H,Matsuyama S

更新日期：2012-08-01 00:00:00