当前位置： SCI文献检索 > NEUROCHEMISTRY INTERNATIONAL期刊下所有文献 > Ferrous ion activates the less active form of human adrenal tyrosine hydroxylase.

Ferrous ion activates the less active form of human adrenal tyrosine hydroxylase.

Abstract：

:The less active form of human tyrosine hydroxylase has been previously reported but its physiological role is unknown. We partially purified the less active form of tyrosine hydroxylase from human adrenals, and examined differences in the properties of the active and less active forms. We succeeded in activation of the less active form of human tyrosine hydroxylase by addition of 100 ?M Fe(2+). Fe(2+) decreased the K(max) for pteridine cofactor in both the active and less active forms, but increased the V(max) only in the less active form. Fe(2+) changed the V(max) but not the K(m) of the less active form for tyrosine. These results suggest that Fe(2+) may regulate tyrosine hydroxylase activity in vivo as a result of activation of its less active form.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Ishii A,Kiuchi K,Matsuyama M,Satake T,Nagatsu T

doi

10.1016/0197-0186(90)90123-b

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

59-64

issue

1

eissn

0197-0186

issn

1872-9754

pii

0197-0186(90)90123-B

journal_volume

16

pub_type

杂志文章

相关文献

NEUROCHEMISTRY INTERNATIONAL文献大全
  • Molecular mechanism of biological action of the serotonergic neurotoxin 5,7-dihydroxytryptamine.

    abstract：:5,7-Dihydroxytryptamine (5,7-DHT) is a selective serotonergic neurotoxin by virtue of its selective uptake into 5-hydroxytryptamine neurons and its ability to undergo autoxidation. The mechanism by which 5,7-DHT induces neurodegenerative effects remains enigmatic. The mechanism of autoxidation of 5,7-DHT, which has be...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(88)90165-9

    authors： Sinhababu AK,Borchardt RT

    更新日期：1988-01-01 00:00:00

  • Effects of periodate oxidation and glycosidases on structural and functional properties of the acetylcholine receptor and the non-receptor, peripheral ?-polypeptide (M(r) 43,000).

    abstract：:NaIO(4) oxidation, exo- and endo-glycosidase treatments and combinations thereof have been applied to acetylcholine receptor from Torpedo marmorata in its membrane-bound and detergent-solubilised forms. The effects of these chemical and enzymatic treatments are made apparent in the electrophoretic properties of the fo...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(82)90066-3

    authors： Criado M,Barrantes FJ

    更新日期：1982-01-01 00:00:00

  • MK-801 partially protects against the acute MPP+ depleting effect on dopamine levels in rat striatal slices.

    abstract：:We tested the ability of the non-competitive N-methyl-D-aspartate (NMDA) antagonist, dizocilpine (MK-801), to promote protection against the acute effect of 1-methyl-4-phenylpyridinium ion (MPP+) in rat striatal slices. Pretreatment with MK-801 at concentrations higher than 15 microM partially prevented the dopamine (...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(95)00163-8

    authors： Venero JL,Santiago M,Machado A,Cano J

    更新日期：1996-10-01 00:00:00

  • Selective stimulation of excitatory amino acid receptor subtypes and the survival of granule cells in culture: effect of quisqualate and AMPA.

    abstract：:Differentiating granule cells develop survival requirements in vitro which can be met by treatment with high K+ or excitatory amino acids. Promotion of cell survival by N-methyl-D-aspartate (NMDA) or kainate has already been established and here we report that treatment of the cells with alpha-amino-3-hydroxy-5-methyl...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(94)90067-1

    authors： Hack N,Balázs R

    更新日期：1994-09-01 00:00:00

  • Cyclothiazide binding to functionally active AMPA receptor reveals genuine allosteric interaction with agonist binding sites.

    abstract：:The agonist, [3H](-)[S]-1-(2-amino-2-carboxyethyl)-5-fluoro-pyrimidine-2,4-dione ([3H](S)F-Willardiine) binding to functional alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors of resealed plasma membrane vesicles and nerve endings freshly isolated from the rat cerebral cortex displayed two bind...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(03)00137-2

    authors： Kovács I,Simon A,Szárics E,Barabás P,Héja L,Nyikos L,Kardos J

    更新日期：2004-03-01 00:00:00

  • High concentrations of calmodulin antagonists inhibit accumulation and binding activities of [(3)H]glutamate in rat brain.

    abstract：:Sodium- and energy-dependent accumulation of [(3)H]l-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 ?M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, in concentration-de...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(89)90071-5

    authors： Yoneda Y,Ogita K,Yamada K,Kouda T,Ohgaki T,Uchida S,Meguri H

    更新日期：1989-01-01 00:00:00

  • Inhibition of mTOR pathway restrains astrocyte proliferation, migration and production of inflammatory mediators after oxygen-glucose deprivation and reoxygenation.

    abstract：:Glial scar is a major impediment to axonal regeneration in central nervous system (CNS) disorders. Overcoming this physical and biochemical barrier might be crucial for axonal regeneration and functional compensation during the progression of CNS disorders. The mammalian target of rapamycin (mTOR) is an evolutionarily...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2015.03.001

    authors： Li CY,Li X,Liu SF,Qu WS,Wang W,Tian DS

    更新日期：2015-04-01 00:00:00

  • Norepinephrine acts as D1-dopaminergic agonist in the embryonic avian retina: late expression of beta1-adrenergic receptor shifts norepinephrine specificity in the adult tissue.

    abstract：:Dopamine is the main catecholamine found in the chick retina whereas norepinephrine is only found in trace amounts. We compared the effectiveness of dopamine and norepinephrine in promoting cyclic AMP accumulation in retinas at embryonic day 13 (E13) and from post-hatched chicken (P15). Dopamine (EC(50)=10microM) and ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2006.08.004

    authors： Kubrusly RC,Ventura AL,de Melo Reis RA,Serra GC,Yamasaki EN,Gardino PF,de Mello MC,de Mello FG

    更新日期：2007-01-01 00:00:00

  • Electromagnetic fields induce neural differentiation of human bone marrow derived mesenchymal stem cells via ROS mediated EGFR activation.

    abstract：:Even though the inducing effect of electromagnetic fields (EMF) on the neural differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) is a distinctive, the underlying mechanism of differentiation remains unclear. To find out the signaling pathways involved in the neural differentiation of BM-MSCs by EMF...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2013.02.002

    authors： Park JE,Seo YK,Yoon HH,Kim CW,Park JK,Jeon S

    更新日期：2013-03-01 00:00:00

  • Increased oxidative stress during hyperglycemic cerebral ischemia.

    abstract：:In this review, we summarize the role of hyperglycemia during cerebral ischemia. Hyperglycemia occurring during experimental and clinical stroke has been associated with increased cerebral damage. Increased oxidative stress resulting from hyperglycemia is believed to contribute to the exacerbated damage. More specific...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuint.2007.03.002

    authors： Bémeur C,Ste-Marie L,Montgomery J

    更新日期：2007-06-01 00:00:00

  • Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells.

    abstract：:Gliomas are the most common and malignant primary brain tumours and are associated with a poor prognosis despite the availability of multiple therapeutic options. Quercetin, a traditional Chinese medicinal herb, is an important flavonoid and has anti-cancer activity. Here, we evaluated whether quercetin could inhibit ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2014.12.001

    authors： Pan HC,Jiang Q,Yu Y,Mei JP,Cui YK,Zhao WJ

    更新日期：2015-01-01 00:00:00

  • BMY 7378: Partial agonist at spinal cord 5-HT(1A) receptors.

    abstract：:Recent data indicate that BMY 7378 demonstrates high affinity, selectivity and low intrinsic activity at hippocampal 5-HT(1A) receptors, suggesting that BMY 7378 may represent the first selective 5-HT(1A) functional antagonist. The present study examined the agonist and antagonist properties of BMY 7378 at spinal cord...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(90)90011-h

    authors： Zemlan FP,Zieleniewski-Murphy A,Maureen Murphy R,Behbehani MM

    更新日期：1990-01-01 00:00:00

  • Electrical high frequency stimulation modulates GABAergic activity in the nucleus accumbens of freely moving rats.

    abstract：:Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is an effective treatment option for those affected by obsessive compulsive disorder, who do not respond to pharmacological treatment strategies. Yet, little is known about the mechanism by which DBS achieve its therapeutic effects. Previous studies have show...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2015.10.002

    authors： Varatharajan R,Joseph K,Neto SC,Hofmann UG,Moser A,Tronnier V

    更新日期：2015-11-01 00:00:00

  • Uncompetitive stimulation of rat brain Na-K ATPase activity by rapid eye movement sleep deprivation.

    abstract：:Rapid eye movement sleep deprivation is associated with an increase in Na-K ATPase activity. In order to understand the possible biochemical mechanism of this increase, the kinetics of Na-K ATPase was studied. Although the enzyme activity increased after the deprivation, the catalytic efficiency of the enzyme remained...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(99)00121-7

    authors： Adya HV,Mallick BN

    更新日期：2000-03-01 00:00:00

  • Metabolomic analyses of vigabatrin (VGB)-treated mice: GABA-transaminase inhibition significantly alters amino acid profiles in murine neural and non-neural tissues.

    abstract：:The anticonvulsant vigabatrin (VGB; SabrilR) irreversibly inhibits GABA transaminase to increase neural GABA, yet its mechanism of retinal toxicity remains unclear. VGB is suggested to alter several amino acids, including homocarnosine, β-alanine, ornithine, glycine, taurine, and 2-aminoadipic acid (AADA), the latter ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2019.02.015

    authors： Walters DC,Arning E,Bottiglieri T,Jansen EEW,Salomons GS,Brown MN,Schmidt MA,Ainslie GR,Roullet JB,Gibson KM

    更新日期：2019-05-01 00:00:00

  • Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products.

    abstract：:The increasing incidence of autism suggests a major environmental influence. Epidemiology has implicated many candidates and genetics many susceptibility genes. Gene/environment interactions in autism were analysed using 206 autism susceptibility genes (ASG's) from the Autworks database to interrogate ∼1 million chemi...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuint.2016.10.011

    authors： Carter CJ,Blizard RA

    更新日期：2016-10-27 00:00:00

  • Are nestin-positive mesenchymal stromal cells a better source of cells for CNS repair?

    abstract：:In recent years there has been a great deal of research within the stem cell field which has led to the definition and classification of a range of stem cells from a plethora of tissues and organs. Stem cells, by classification, are considered to be pluri- or multipotent and have both self-renewal and multi-differenti...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuint.2016.08.001

    authors： Lindsay SL,Barnett SC

    更新日期：2017-06-01 00:00:00

  • Neuroendocrine aging: its impact on somatotrophic function.

    abstract：:In this paper, two different aspects of growth hormone neuroregulation during aging were considered. Twenty-month-old male rats had decreased growth hormone-releasing hormone mRNA levels and a slight reduction of somatostatin mRNA levels in the hypothalamus when compared to 8-month-old counterparts. Short-term adminis...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(94)90045-0

    authors： De Gennaro Colonna V,Cella SG,Parenti M,Locatelli V,Cocchi D,Müller EE

    更新日期：1994-07-01 00:00:00

  • PDE9 inhibition promotes proliferation of neural stem cells via cGMP-PKG pathway following oxygen-glucose deprivation/reoxygenation injury in vitro.

    abstract：:Cerebral ischemia is one of leading causes of death and long-term disability worldwide. Stem cell-based therapy is promising some valuable strategies for the structural and functional recovery after ischemic insult. The inhibition of phosphodiesterases (PDEs) has wide spectrum neuroprotective properties by stimulating...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2019.104630

    authors： Huan X,Oumei C,Hongmei Q,Junxia Y,Xiaojiao M,Qingsong J

    更新日期：2020-02-01 00:00:00

  • Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemia.

    abstract：:Excitotoxicity is the main event during neurological disorders producing drastic morphological and functional changes. Rac-GTPase is involved in cytoskeletal remodeling and survival. However, the role of Rac1 after cerebral ischemia has not been completely understood yet. In this study, we evaluated the activity of Ra...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2010.08.014

    authors： Johanna GV,Fredy CA,David VC,Natalia MV,Angel CR,Patricia CG

    更新日期：2010-12-01 00:00:00

  • Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague-Dawley rats.

    abstract：:The influence of citalopram on regional 5-hydroxytryptamine (serotonin, 5-HT) synthesis, one of the most important presynaptic parameters of serotonergic neurotransmission, was studied. Sprague-Dawley (SPD) rats were used as the controls, and Flinders Resistant Line (FRL) rats were used as auxiliary controls, to hopef...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2009.01.005

    authors： Kanemaru K,Nishi K,Hasegawa S,Diksic M

    更新日期：2009-05-01 00:00:00

  • Regulation of ganglioside and sialoglycoprotein biosynthesis-Effect of drugs affecting membrane flow.

    abstract：:The labelling of gangliosides and sialoglycoproteins (SGP) after injecting intraocularly 30 ?Ci of [(3)H]ManNAc was studied in chickens that had previously received, also intraocularly, 30 or 70 nmol of monensin in 10 ?l of ethanol or 24 ?g of colchicine in 10 ?l saline. Controls received ethanol or saline only. Colch...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(86)90183-x

    authors： Nores GA,Caputto R

    更新日期：1986-01-01 00:00:00

  • 2-(Cyclohexylamino)-1-(4-cyclopentylpiperazin-1-yl)-2-methylpropan-1-one, a novel compound with neuroprotective and neurotrophic effects in vitro.

    abstract：:Focusing on development of novel drug candidates for the treatment of neurodegenerative diseases, we developed and synthesized a new compound, 2-(cyclohexylamino)-1-(4-cyclopentylpiperazin-1-yl)-2-methylpropan-1-one (amido-piperizine 1). The compound demonstrated robust neuroprotective properties after both glutamate ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2011.08.003

    authors： Elbrønd-Bek H,Wellejus A,Kelly NM,Weidner MS,Jørgensen SH

    更新日期：2011-11-01 00:00:00

  • Guanylate cyclase in synaptosomal soluble fraction from rat brain: possible involvement of free radical acceptor in endogenous activation mechanisms.

    abstract：:Guanylate cyclase (GTP pyrophosphate-lyase (cyclizing); EC 4.6.1.2), in the crude synaptosomal soluble (P(2)-soluble) fraction obtained by hypo-osmotic treatment and subsequent centrifugation of crude synaptosomal (P(2)) fraction from the rat brain, showed a significantly high activity when assayed in the presence of ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(81)90008-5

    authors： Yoshikawa K,Kuriyama K

    更新日期：1981-01-01 00:00:00

  • Subtle BBB alterations in brain edema associated with acute liver failure.

    abstract：:Vasogenic mechanism of brain edema in acute liver failure (ALF) remains poorly understood. Recent work demonstrates that matrix metalloproteinase-9 (MMP-9) contributes to the development of brain edema in experimental ALF (J Hepatol 44:1105, 2006). Importantly, MMP-9 blockage with specific monoclonal antibodies and/or...

    journal_title：Neurochemistry international

    pub_type： 评论,信件

    doi：10.1016/j.neuint.2009.07.013

    authors： Nguyen JH

    更新日期：2010-01-01 00:00:00

  • Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridge.

    abstract：:Ligand-induced changes in the conformation of extracellular loop (EL) 2 in the rat (r) dopamine transporter (DAT) were examined using limited proteolysis with endoproteinase Asp-N and detection of cleavage products by epitope-specific immunoblotting. The principle N-terminal fragment produced by Asp-N was a 19kDa pept...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2013.11.003

    authors： Gaffaney JD,Shetty M,Felts B,Pramod AB,Foster JD,Henry LK,Vaughan RA

    更新日期：2014-07-01 00:00:00

  • Tryptophan and serotonin turnover rate in the brain of genetically hyperammonemic mice.

    abstract：:An investigation was made into the effects of hyperammonemia on the metabolism of brain serotonin (5-HT). The animal model used was the sparse fur (spf) mouse, which possesses an inborn error of the urea cycle, i.e. an abnormal form of ornithine transcarbamylase. Several indoles were measured in brain and plasma using...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(85)90019-1

    authors： Chaouloff F,Laude D,Mignot E,Kamoun P,Elghozi JL

    更新日期：1985-01-01 00:00:00

  • Transport of muscarinic cholinergic receptors in the sciatic nerve of rat.

    abstract：:On the basis of the specific [(3)H]quinuclidinyl-benzilate binding, the transport of muscarinic cholinergic receptors has been demonstrated in the ventral horn, sciatic nerve and in the 3 mm segments proximal and distal to the ligature of rat sciatic nerves ligated for 24 h (a) without electrolytic lesion, (b) six day...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(84)90036-6

    authors： Gulya K,Kása P

    更新日期：1984-01-01 00:00:00

  • Evidence of sexual dimorphism in D1 and D2 dopaminergic receptors expression in frontal cortex and striatum of young rats.

    abstract：:D1 and D2 receptors are key mediators of dopaminergic signaling in the brain, and since the manifestations of pathologies related to dopamine are different in female and male patients, it is important to analyze if there are sex-related differences in dopaminergic markers. To contribute to the knowledge in this regard...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2016.09.001

    authors： Orendain-Jaime EN,Ortega-Ibarra JM,López-Pérez SJ

    更新日期：2016-11-01 00:00:00

  • Functional characterization of endothelin receptors on cultured brain capillary endothelial cells of the rat.

    abstract：:This report describes the effects of endothelins (ET-1 and ET-3) on ion transport systems expressed on cultured rat brain capillary endothelial cells (RBEC) and includes investigation of pharmacological properties of ET receptors, their reactivity and induction of signal transduction pathways. ET-1 stimulated IP3 form...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(97)00018-1

    authors： Kawai N,Yamamoto T,Yamamoto H,McCarron RM,Spatz M

    更新日期：1997-10-01 00:00:00