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High concentrations of calmodulin antagonists inhibit accumulation and binding activities of [(3)H]glutamate in rat brain.

Abstract：

:Sodium- and energy-dependent accumulation of [(3)H]l-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 ?M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, in concentration-dependent and noncompetitive manners. The latter antagonist not only diminished the basal binding activity of [(3)H]Glu in synaptic membranes of the rat brain, but also eliminated the activities found in the presence of Cl(?) and Cl(?)/Ca(2+) ions. However, N- methyl- d -aspartate-sensitive [(3)H]Glu binding was not affected by these antagonists. These results suggest the possible involvement of the calmodulin system in glutamatergic neurotransmission in the brain.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Yoneda Y,Ogita K,Yamada K,Kouda T,Ohgaki T,Uchida S,Meguri H

doi

10.1016/0197-0186(89)90071-5

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

17-23

issue

1

eissn

0197-0186

issn

1872-9754

pii

0197-0186(89)90071-5

journal_volume

15

pub_type

杂志文章

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