Abstract：
:The inflammatory central nervous system response that involves activated microglia and reactive astrocytes may both heal and harm neurons, as inflammatory mediators lead to neuroprotection or excitation at one dose but to injury at a different concentration. To investigate these complex cellular interactions, L-trans-pyrrolidine-2,4-dicarboxylate (PDC), a selective substrate inhibitor of glutamate transport, was infused during 14 days in the rat hippocampus at three different rates: 5, 10 and 25 nmol/h. A microglial reaction appeared at the 5 nmol/h PDC rate in absence of astroglial reaction and neuronal loss. Microgliosis and neuronal death were observed at PDC 10 nmol/h in absence of astrogliosis and calcium precipitation, whereas all four aspects were present at the highest rate. This dissociation between neuronal loss and astroglial reactivity took place in presence of a permanent microglial reaction. These data suggest a specific response of microglia to PDC whose neuronal effects may differ with the infused dose.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
de Yebra L,Malpesa Y,Ursu G,Pugliese M,Liévens JC,Kerkerian-Le Goff L,Mahy Ndoi
10.1016/j.neuint.2006.06.008subject
Has Abstractpub_date
2006-12-01 00:00:00pages
691-7issue
7eissn
0197-0186issn
1872-9754pii
S0197-0186(06)00218-Xjournal_volume
49pub_type
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