Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats.

abstract：:Many studies indicate that chronic stress and excessive stress hormone can cause an inflammatory response. Thioredoxin-interacting protein (Txnip) as an endogenous thioredoxin inhibitor suppresses thioredoxin-produced antioxidant effects. Txnip was also found to interact with nucleotide-binding oligomerization domain-...

journal_title：Neurochemistry international

authors： Bharti V,Tan H,Zhou H,Wang JF

更新日期：2019-12-01 00:00:00

abstract：:Cortical cells from embryonic mice (E17) showed a rapid cell-death under the serum-free condition. The addition of nefiracetam at 0.1-10 microM increased the survival activity, while aniracetam at the same concentrations did not. The cell death was characterized to be apoptotic, since dead cells showed nuclear condens...

journal_title：Neurochemistry international

authors： Fujita R,Takayama N,Ueda H

更新日期：2002-02-01 00:00:00

abstract：:Recent studies suggest that the behavioral effects of chronic antidepressant treatment are mediated by stimulation of hippocampal neuronal plasticity and neurogenesis. The present study was designed to examine the effects of 3,6'-disinapoyl sucrose (DISS), a bioactive component of Polygala tenuifolia Willd, on the exp...

journal_title：Neurochemistry international

authors： Hu Y,Liao HB,Dai-Hong G,Liu P,Wang YY,Rahman K

更新日期：2010-02-01 00:00:00

abstract：:The effect of different dietary fats with varying degrees of unsaturation and essential fatty acid composition, which are commonly consumed in India, on the activity of some important membrane-bound enzymes was assessed in different brain regions of rat. Four groups of male CFY weanling rats were fed nutritionally ade...

journal_title：Neurochemistry international

authors： Srinivasarao P,Narayanareddy K,Vajreswari A,Rupalatha M,Prakash PS,Rao P

更新日期：1997-12-01 00:00:00

abstract：:Ischemic neuronal injury is associated with several life- and vision-threatening diseases. Neuroprotection is essential in the treatment of these diseases. Here, we identified and characterized a novel peptide, FK18, from basic fibroblast growth factor (bFGF). We further assessed the neuroprotective effects of this pe...

journal_title：Neurochemistry international

authors： Xiong S,Xu Y,Ma M,Wang H,Wei F,Gu Q,Xu X

更新日期：2017-09-01 00:00:00

abstract：:Nitrite therapy is more effective in cerebral ischemia when administered earlier. It would be beneficial during the hyperacute stages of stroke if the nitrite effect is demonstrated in intracerebral hemorrhage (ICH). When nitrite is injected intravenously 3h after ICH induction in rats, most doses of nitrite provided ...

journal_title：Neurochemistry international

authors： Jung KH,Chu K,Lee ST,Kim JM,Park DK,Kim M,Lee SK,Roh JK

更新日期：2011-08-01 00:00:00

abstract：:In order to compare the incorporation of several saturated fatty acids into the brain, radioactive palmitic, stearic and lignoceric acids were injected into mice. The radioactivity was measured in lipids from isolated neurons, astrocytes and myelin. Our data indicate that specific radioactivity of lignoceric acid afte...

journal_title：Neurochemistry international

authors： Morand O,Masson M,Baumann N,Bourre JM

更新日期：1981-01-01 00:00:00

abstract：:Specific binding of [(3)H]d- fenfluramine , an anorectic agent acting on serotonergic system, was characterized in rat total brain minus cerebellum. The binding was reversible, stereospecific and with high affinity (K(d) about 80 nM). The receptor density in total brain was about 32 pmol/g tissue. Subcellular distribu...

journal_title：Neurochemistry international

authors： Mennini T,Gobbi M,Taddei C,Garattini S

更新日期：1988-01-01 00:00:00

abstract：:Essential metals are crucial for the maintenance of cell homeostasis. Among the 23 elements that have known physiological functions in humans, 12 are metals, including iron (Fe) and manganese (Mn). Nevertheless, excessive exposure to these metals may lead to pathological conditions, including neurodegeneration. Simila...

journal_title：Neurochemistry international

authors： Farina M,Avila DS,da Rocha JB,Aschner M

更新日期：2013-04-01 00:00:00

abstract：:Rapid eye movement sleep deprivation is associated with an increase in Na-K ATPase activity. In order to understand the possible biochemical mechanism of this increase, the kinetics of Na-K ATPase was studied. Although the enzyme activity increased after the deprivation, the catalytic efficiency of the enzyme remained...

journal_title：Neurochemistry international

authors： Adya HV,Mallick BN

更新日期：2000-03-01 00:00:00

abstract：:Although microvascular cell death is a well established hallmark of diabetic retinopathy, which is a major cause of vision loss, much remains to be learned about the functional changes that precede the onset of morphological damage to retinal blood vessels. Early alterations of function are of interest since they may ...

journal_title：Neurochemistry international

authors： Nakaizumi A,Zhang T,Puro DG

更新日期：2012-11-01 00:00:00

abstract：:Methamphetamine is a widely abused psychostimulant. It reverses transport through the dopamine transporter, thereby increasing the extracellular level of dopamine in the brain, which is associated with the rewarding effect. Repeated intake of methamphetamine leads to drug addiction, a chronically relapsing disorder ch...

journal_title：Neurochemistry international

authors： Mizoguchi H,Yamada K

更新日期：2019-03-01 00:00:00

abstract：:Recent studies have suggested that neurosteroids such as pregnenolone, progesterone (PG) and their derivatives, have a role in activating autophagy in addition to diverse other functions. In our previous studies, we demonstrated that cellular free Zn(2+) is involved in oxidative stress-induced autophagy and autophagic...

journal_title：Neurochemistry international

authors： Kim HN,Lee SJ,Koh JY

更新日期：2012-01-01 00:00:00

abstract：:Previously, we revealed that the state of the actin cytoskeleton affects the uptake activity of the serotonin transporter (SERT). Recently, it was reported that the C-terminus of SERT interacts with MacMARCKS, a substrate of PKC that can bind to the actin cytoskeleton. To elucidate the importance of the C-terminal reg...

journal_title：Neurochemistry international

authors： Mochizuki H,Amano T,Seki T,Matsubayashi H,Mitsuhata C,Morita K,Kitayama S,Dohi T,Mishima HK,Sakai N

更新日期：2005-01-01 00:00:00

abstract：:Uridine was administered in the drinking water (0.5 mg/ml) in adult 6 month-old rats for 6 months. The mean daily dose of uridine was 12.5 mg/rat. The effects of this treatment on tyrosine hydroxylase, galanin, somatostatin, neuropeptide Y and cholecystokinin-like immunoreactivities were studied by means of semiquanti...

journal_title：Neurochemistry international

authors： Zoli M,Agnat LF,Fuxe K,Cintra A,Grimaldi R,Vanderhaeghen JJ,Eneroth P,Goldstein M

更新日期：1988-01-01 00:00:00

abstract：:Rat corticoencephalic cell cultures were investigated by high performance liquid chromatography for changes in the levels of adenosine 5'-triphosphate (ATP), guanosine 5'-triphosphate (GTP), uridine 5'-triphosphate (UTP), cytidine 5'-triphosphate (CTP), and the respective nucleoside diphosphates. Hypoxia was induced b...

journal_title：Neurochemistry international

authors： Reinhardt R,Manaenko A,Pissarek M,Wagner A,Illes P

更新日期：2002-04-01 00:00:00

abstract：:alpha(2)-Adrenoceptors are involved in various physiological functions, particularly in the cardiovascular system and the central nervous system. Different adrenoceptor subtypes (alpha(2A), alpha(2B) and alpha(2C)) have been recognised and the different subtypes may have role in activation of distinct physiological an...

journal_title：Neurochemistry international

authors： Gyires K,Zádori ZS,Török T,Mátyus P

更新日期：2009-12-01 00:00:00

abstract：:The ultrastructural localization of AChE and BuChE was studied in motor endplates of the rat and mouse diaphragms, using the CNS(?) modification of the one-step Cu-thiocholine procedure. AChE activity was observed on pre- and postsynaptic membranes, in the basal lamina and in the Schwann cell-nerve terminal interspace...

journal_title：Neurochemistry international

authors： Brzin M,Sketelj J,Grubi Z,Kiauta T

更新日期：1980-01-01 00:00:00

abstract：:Alzheimer's disease as well as prion-related encephalopathies are neurodegenerative disorders of the central nervous system, which cause mental deterioration and progressive dementia. Both pathologies appear to be primarily associated with the pathological accumulation and deposit of β-amyloid or prion peptides in the...

journal_title：Neurochemistry international

authors： Morte B,Martínez T,Zambrano A,Pascual A

更新日期：2011-05-01 00:00:00

abstract：:Esters of dimethylcarbamic acid are known to be poor substrates of acetylcholinesterase. They carbamylate the active catalytic site of the enzyme and the subsequent decarbamylation is a slow but measurable process. Similarly, acetylcholinesterase can be phosphonylated, and the dephosphonylation is extremely slow. Rapi...

journal_title：Neurochemistry international

authors： Dawson RM,Poretski M,Upsher CM

更新日期：1981-01-01 00:00:00

abstract：:Much attention has been paid to the connection between periodontitis and Alzheimer's disease (AD). We previously showed that infection of P. gingivalis, one of major periodontal pathogen causing periodontitis, induced migration and inflammatory responses in murine microglia through gingipain-induced activation of prot...

journal_title：Neurochemistry international

authors： Nonaka S,Nakanishi H

更新日期：2020-11-01 00:00:00

abstract：:Age-related and aged memory deficit changes in Nestin-immunoreactive (Nestin-IR) neurons were studied following recent evidence of distinct Nestin-IR neurons within adult rat basal forebrain. Morris water maze task assessed spatial learning capacity of 3- and 24-month rats (aged-impaired and aged-unimpaired groups). N...

journal_title：Neurochemistry international

authors： Li D,Wang J,Yew DT,Lucy Forster E,Yao Z

更新日期：2008-12-01 00:00:00

abstract：:5,7-Dihydroxytryptamine (5,7-DHT) is a selective serotonergic neurotoxin by virtue of its selective uptake into 5-hydroxytryptamine neurons and its ability to undergo autoxidation. The mechanism by which 5,7-DHT induces neurodegenerative effects remains enigmatic. The mechanism of autoxidation of 5,7-DHT, which has be...

journal_title：Neurochemistry international

authors： Sinhababu AK,Borchardt RT

更新日期：1988-01-01 00:00:00

abstract：:There has been limited success with blood-based biomarkers of neurodegeneration. One perceived reason is that blood has no direct contact to the brain. Recently developed blood-based biomarkers of tau-degradation have shown promise as potential tools for peripheral assessment of neurodegeneration; however, factors con...

journal_title：Neurochemistry international

authors： Neergaard JS,Dragsbæk K,Christiansen C,Nielsen HB,Workman CT,Brix S,Henriksen K,Karsdal MA

更新日期：2017-09-01 00:00:00

abstract：:On the basis of abnormal neuropsychological behavior in the open-field test after 2-week zinc deprivation, neurochemical response was examined in young mice fed a zinc-deficient diet for 2 weeks. Serum corticosterone concentration was markedly higher in zinc-deficient mice than in the control mice. Basal signals of in...

journal_title：Neurochemistry international

authors： Takeda A,Yamada K,Tamano H,Fuke S,Kawamura M,Oku N

更新日期：2008-01-01 00:00:00

abstract：:The mechanisms of intracellular calcium store depletion and store-related Ca(2+) dysregulation in relation to apoptotic cell death in PC12 cells were investigated at physiological temperatures with a leak-resistant fluorescent indicator dye Fura-PE3/AM by a cooled CCD imaging analysis system. Electron microscopic obse...

journal_title：Neurochemistry international

authors： Yoshida I,Monji A,Tashiro K,Nakamura K,Inoue R,Kanba S

更新日期：2006-06-01 00:00:00

abstract：:The integrity of hippocampal G-protein mediated signalling following ibotenate induced lesion of the medial septum was examined. The lesion was confined histologically to the septum and induced a 23% reduction in hippocampal choline acetyltransferase (ChAT) activity and G-proteins levels and related enzyme activities ...

journal_title：Neurochemistry international

authors： McLaughlin M,Inglis FM,Ross BM,Breen KC,McCulloch J

更新日期：1999-07-01 00:00:00

abstract：:Amyloid β (Aβ) oligomers are presumed to be one of the causes of Alzheimer's disease (AD). Previously, we identified the E693Δ mutation in amyloid precursor protein (APP) in patients with AD who displayed almost no signals of amyloid plaques in amyloid imaging. We generated APP-transgenic mice expressing the E693Δ mut...

journal_title：Neurochemistry international

authors： Takano M,Maekura K,Otani M,Sano K,Nakamura-Hirota T,Tokuyama S,Min KS,Tomiyama T,Mori H,Matsuyama S

更新日期：2012-08-01 00:00:00

abstract：:Selective dopaminergic neurotoxicity induced by 1-methyl-4-phenylpyridine (MPP+) is believed to be due to the transmembrane uptake by the dopamine transporter and subsequent inhibition of mitochondrial complex I and/or production of free radicals. However, little is known about the molecular sequence of intracellular ...

journal_title：Neurochemistry international

authors： Storch A,Ludolph AC,Schwarz J

更新日期：1999-11-01 00:00:00

abstract：:We examined the vesicular accumulation of the excitatory amino-acid (EAA) neurotransmitters, L-glutamate and L-aspartate, together with the non-metabolisable EAA analogue D-aspartate. Synaptosomes derived from whole brain were incubated in various concentrations of [3H]-amino acids under conditions to facilitate vesic...

journal_title：Neurochemistry international

authors： Fleck MW,Barrionuevo G,Palmer AM

更新日期：2001-09-01 00:00:00