The cognition-enhancer nefiracetam is protective in BDNF-independent neuronal cell death under the serum-free condition.

abstract：:Increased brain ammonia concentrations are a hallmark feature of several neurological disorders including congenital urea cycle disorders, Reye's syndrome and hepatic encephalopathy (HE) associated with liver failure. Over the last decade, increasing evidence suggests that hyperammonemia leads to alterations in the gl...

journal_title：Neurochemistry international

authors： Chan H,Butterworth RF

更新日期：2003-09-01 00:00:00

abstract：:It has been reported that skin/muscle incision and retraction (SMIR) in the thigh, produces mechanical allodynia in the hind paw, far from the site of incision/retraction. The mechanical allodynia lasts about 22 days, indicating chronic post-operative pain develops. The precise mechanisms, however, are largely unclear...

journal_title：Neurochemistry international

authors： Zhong X,Wang W,Mao Z,Gao F,Guo R,Wei X,Liu X,Wei X

更新日期：2019-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive and debilitating neurodegenerative disorder that affects over one million people in the United States. Previous studies, carried out in young adult rats, have shown that calcitriol, the active metabolite of vitamin D, can be neuroprotective in 6-hydroxydopamine (6-OHDA) models...

journal_title：Neurochemistry international

authors： Cass WA,Peters LE

更新日期：2017-09-01 00:00:00

abstract：:5,7-Dihydroxytryptamine (5,7-DHT) is a selective serotonergic neurotoxin by virtue of its selective uptake into 5-hydroxytryptamine neurons and its ability to undergo autoxidation. The mechanism by which 5,7-DHT induces neurodegenerative effects remains enigmatic. The mechanism of autoxidation of 5,7-DHT, which has be...

journal_title：Neurochemistry international

authors： Sinhababu AK,Borchardt RT

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:The major hallmark of Alzheimer's disease (AD) is the formation of amyloid aggregates, which are formed due to improper folding of proteins leading to the aggregation of amyloid beta (Aβ) 42 peptide. Inhibition of Aβ 42 aggregation using a drug such as carbenoxolone (Cbx), which has already been stated as ne...

journal_title：Neurochemistry international

authors： Sharma S,Nehru B,Saini A

更新日期：2017-09-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) affecting more than 2.5 million individuals worldwide. In the present study, myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) mice were treated with adenosine recept...

journal_title：Neurochemistry international

authors： Chen Y,Zhang ZX,Zheng LP,Wang L,Liu YF,Yin WY,Chen YY,Wang XS,Hou ST,Chen JF,Zheng RY

更新日期：2019-10-01 00:00:00

abstract：:Cholinergic neuroblastoma NS20Y cells were differentiated by the chicken gizzard extract. They were first inoculated into a glass culture bottle and the aggregated cells which grew in the suspension culture were collected. The aggregated cells (round and immature neuroblastoma cells) were seeded on a polyornithinecoat...

journal_title：Neurochemistry international

authors： Miki N,Higashida H,Hayashi Y,Akiyama M,Kuo CH

更新日期：1982-01-01 00:00:00

abstract：:Insulin receptors from rat brain regions were studied for insulin binding and receptor associated kinase activity, in alloxan induced short-term and long-term diabetes, and insulin induced hypoglycemia. Insulin receptor activity was assessed by [125I]insulin binding, and basal as well as insulin stimulated kinase acti...

journal_title：Neurochemistry international

authors： Gupta G,Azam M,Baquer NZ

更新日期：1992-06-01 00:00:00

abstract：:Ketone bodies serve as a source of energy and as precursors for lipid synthesis in developing brain. Neurons, astrocytes and oligodendroglia all have the necessary enzymes for metabolizing ketone bodies. In this in vivo study it was found that all three cell types were able to use ketone bodies as precursors for the s...

journal_title：Neurochemistry international

authors： Poduslo SE,Miller K

更新日期：1991-01-01 00:00:00

abstract：:The effect of the N-methylisoquinolinium ion (NMIQ(+)) on the activity of enzymes related to metabolism of dopamine was studied using a rat clonal pheochromocytoma PC12h cell line. The activities of tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase (AADC) and monoamine oxidase (MAO) were inhibited by NMIQ...

journal_title：Neurochemistry international

authors： Naoi M,Takahashi T,Parvez H,Kabeya R,Taguchi E,Yamaguchi K,Hirata Y,Minami M,Nagatsu T

更新日期：1989-01-01 00:00:00

abstract：:Neuroinflammation is an important factor contributing to cognitive impairment and neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), ischemic injury, and multiple sclerosis (MS). These diseases are characterized by inexorable progressive injur...

journal_title：Neurochemistry international

authors： de Araújo Boleti AP,de Oliveira Flores TM,Moreno SE,Anjos LD,Mortari MR,Migliolo L

更新日期：2020-06-01 00:00:00

abstract：:Whereas carbachol, noradrenaline, serotonin and memantine stimulated inositol phosphates production and calcium mobilization in 3-5 day old rabbit retinal cultures, only carbachol and noradrenaline were effective when 25-30 day old cultures were used. The older retinal cultures contain only Müller cells which shows th...

journal_title：Neurochemistry international

authors： Osborne NN,Quack G

更新日期：1992-10-01 00:00:00

abstract：:Exposure to high levels of manganese (Mn) results in a neurological disorder, termed manganism, which shares a similar phenotype to Parkinson's disease due to the involvement of the basal ganglia circuitry in both. The initial symptoms of manganism are likely due to the involvement of the globus pallidus, a region ric...

journal_title：Neurochemistry international

authors： Fitsanakis VA,Au C,Erikson KM,Aschner M

更新日期：2006-05-01 00:00:00

abstract：:Streptozotocin (STZ) is a glucosamine-nitrosourea commonly used to induce long-lasting models of diabetes mellitus and Alzheimer's disease. Direct toxicity of STZ on the pancreas and kidneys has been well characterized, but the acute effect of this compound on brain tissue has received less attention. Herein, we inves...

journal_title：Neurochemistry international

authors： Rodrigues L,Wartchow KM,Suardi LZ,Federhen BC,Selistre NG,Gonçalves CA

更新日期：2019-09-01 00:00:00

abstract：:Intoxication with inorganic arsenicals leads to neuropathies and impaired cognitive functions. However, little is known so far on the cellular targets that are involved in the adverse effects of arsenite to brain cells. To test whether arsenite may affect neural glucose and glutathione (GSH) metabolism, primary astroc...

journal_title：Neurochemistry international

authors： Tadepalle N,Koehler Y,Brandmann M,Meyer N,Dringen R

更新日期：2014-10-01 00:00:00

abstract：:We demonstrate the feasibility and usefulness of the histoblot immunostaining of cryosections of whole hemispheres of healthy and Alzheimer diseased (AD) human brains by localizing a neuron-specific marker, the anti-neuronal nuclei (NeuN) antigen. As expected, cortical NeuN-immunopositive regions were generally thinne...

journal_title：Neurochemistry international

authors： Beliczai Z,Varszegi S,Gulyas B,Halldin C,Kasa P,Gulya K

更新日期：2008-12-01 00:00:00

abstract：:Spinal muscular atrophy (SMA), the leading genetic cause of infant mortality worldwide, is characterised by the homozygous loss of the survival motor neuron 1 (SMN1) gene. The consequent degeneration of spinal motor neurons and progressive atrophy of voluntary muscle groups results in paralysis and eventually prematur...

journal_title：Neurochemistry international

authors： Farrelly-Rosch A,Lau CL,Patil N,Turner BJ,Shabanpoor F

更新日期：2017-09-01 00:00:00

abstract：:A significant increase in the number of measurable [3H]Ro 5-4864 receptors was found in forebrain membranes of chicks submitted to 15 min of acute swim stress compared to non-stressed chicks. In addition, low subsolubilizing concentrations of Triton X-100 caused a significant increase in the measurable [3H]Ro 5-4864 r...

journal_title：Neurochemistry international

authors： Marín RH,Arce A,Martijena ID

更新日期：1996-04-01 00:00:00

abstract：:In the present study we investigated the effects of a single injection of reserpine on dopamine receptor function in rat striatum. The measurement of adenylate cyclase activity indicated that cAMP formation induced by the selective D-1 agonist SKF 82526 was greatly increased 2 and 20 h after reserpine; in contrast, th...

journal_title：Neurochemistry international

authors： Liberini P,Nisoli E,Missale C,Memo M,Buonamici M,Rossi A,Spano PF

更新日期：1989-01-01 00:00:00

abstract：:The results of the present study showed the presence of a high-affinity and saturable binding of [3H]-ketanserin to frontal and parietal brain membranes obtained postmortem from bipolar, depressed, schizophrenic patients and normal controls. The human brain samples (60 frontal cortex and 51 parietal cortex), were dona...

journal_title：Neurochemistry international

authors： Marazziti D,Giannaccini G,Giromella A,Betti L,Pesce D,Nardi I,Rossi A,Lucacchini A,Cassano GB

更新日期：2003-05-01 00:00:00

abstract：:Recent in vitro studies have revealed that benzodiazepines, opiates, barbiturates and ethanol might influence GABA binding to CNS membrane sites. Further studies of such interactions might be helpful for explaining both the mechanisms of action of these psychoactive agents and the tolerance/dependence that might resul...

journal_title：Neurochemistry international

authors： Defeudis FV

更新日期：1983-01-01 00:00:00

abstract：:The opening of pannexin-1 (Px1) hemichannels is regulated by the activity of P2X(7) receptors (P2X(7)Rs). At present, however, little is known about how extracellular ATP-sensitive P2X(7)Rs regulates the opening and closure of Px1 hemichannels. Several lines of evidence suggest that P2X(7)Rs are activated under pathol...

journal_title：Neurochemistry international

authors： Iwabuchi S,Kawahara K

更新日期：2011-02-01 00:00:00

abstract：:Serotonin (5-HT) is a prime candidate for studies of the interaction between the nervous and immune systems, since it is both an important neurotransmitter and released at high concentrations at sites of inflammation. Serotonergic neurotransmission is regulated by the 5-HT transporter (5-HTT), which determines the mag...

journal_title：Neurochemistry international

authors： Mössner R,Heils A,Stöber G,Okladnova O,Daniel S,Lesch KP

更新日期：1998-09-01 00:00:00

abstract：:To elucidate the role of Ca(2+)-activated K(+) (K(Ca)) channels in the presynaptic acetylcholine (ACh) release from splanchnic nerve endings and the postsynaptic catecholamine release from chromaffin cells, we applied microdialysis technique to the left adrenal medulla of anesthetized rats and investigated the effects...

journal_title：Neurochemistry international

authors： Akiyama T,Yamazaki T,Kawada T,Shimizu S,Sugimachi M,Shirai M

更新日期：2010-01-01 00:00:00

abstract：:The brain uses long-chain fatty acids (LCFAs) to a negligible extent as fuel for the mitochondrial energy generation, in contrast to other tissues that also demand high energy. Besides this generally accepted view, some studies using cultured neural cells or whole brain indicate a moderately active mitochondrial β-oxi...

journal_title：Neurochemistry international

authors： Schönfeld P,Reiser G

更新日期：2017-10-01 00:00:00

abstract：:Chronic variate stress was seen to decrease the ingestion of sweet food when compared to control rats. Brain monoamines are known to be involved in the control of food intake, serotonin appears to be involved in the mechanisms of satiety, and dopamine in mediating appetite or approach behaviors triggered by incentive ...

journal_title：Neurochemistry international

authors： Gamaro GD,Manoli LP,Torres IL,Silveira R,Dalmaz C

更新日期：2003-01-01 00:00:00

abstract：:Neural stem cells (NSCs) play a crucial role in the development and maturation of the central nervous system. Recently studies suggest that antipsychotic drugs regulate the activities of NSCs. However, the molecular mechanisms underlying antipsychotic-induced changes of the activity of NSCs, particularly protein expre...

journal_title：Neurochemistry international

authors： Kashem MA,Ummehany R,Ukai W,Hashimoto E,Saito T,Mcgregor IS,Matsumoto I

更新日期：2009-12-01 00:00:00

abstract：:The immunostains of GD3, c-pathway polysialogangliosides and gangliotetraosylgangliosides belonging to the a- and b-pathways were analyzed in embryo optic lobe cells. Cells were cultured in serum free media with, and without, bovine brain ganglioside mixture (largely gangliotetraosylgangliosides). Control cells differ...

journal_title：Neurochemistry international

authors： Cossy-Isasi S,Panzetta P

更新日期：1994-04-01 00:00:00

abstract：:We demonstrated that genetically modified fibroblasts can be encapsulated into biocompatible, biodegradable spheres retaining their viability and capacity to continuously secrete nerve growth factor (NGF) for at least two months. Genetically engineered rat fibroblasts producing NGF were encapsulated in an alginate-pol...

journal_title：Neurochemistry international

authors： Maysinger D,Piccardo P,Filipovic-Grcic J,Cuello AC

更新日期：1993-08-01 00:00:00

abstract：:The binding kinetics of the specific dopamine D2 antagonist [3H]raclopride to dopamine D2 receptors in rat neostriatum were studied. The pseudo-first-order rate constants of [3H]raclopride binding with these membranes revealed a hyperbolic dependence upon the antagonist concentration, indicating that the reaction had ...

journal_title：Neurochemistry international

authors： Lepiku M,Rinken A,Järv J,Fuxe K

更新日期：1996-05-01 00:00:00