Abstract：
:Alzheimer's disease as well as prion-related encephalopathies are neurodegenerative disorders of the central nervous system, which cause mental deterioration and progressive dementia. Both pathologies appear to be primarily associated with the pathological accumulation and deposit of β-amyloid or prion peptides in the brain, and it has been even suggested that neurotoxicity induced by these peptides would be associated to essentially similar pathogenic mechanisms, in particular to those that follow the activation of microglial cells. To probe whether the neurotoxic effects induced by the β-amyloid and prion peptides are actually mediated by similar glial-associated mechanisms, we have examined the differential expression of genes in SH-SY5Y neuroblastoma cells incubated with conditioned media from β-amyloid or prion-stimulated THP-1 monocytic cells. According to microarray analysis, not many coincidences are observed and only four genes (Hint3, Psph, Daam1 and c-Jun) appear to be commonly upregulated by both peptides. Furthermore, c-Jun appears to be involved in the cell death mediated by both peptides.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Morte B,Martínez T,Zambrano A,Pascual Adoi
10.1016/j.neuint.2011.01.019subject
Has Abstractpub_date
2011-05-01 00:00:00pages
613-9issue
6eissn
0197-0186issn
1872-9754pii
S0197-0186(11)00040-4journal_volume
58pub_type
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