Abuse potential of 2-(4-iodo-2, 5-dimethoxyphenyl)N-(2-methoxybenzyl)ethanamine (25INBOMe); in vivo and ex vivo approaches.

abstract：:There has arisen considerable interest in the study of dopamine D(2/3) agonist binding sites by positron emission tomography (PET), based on the claim that agonist sites represent a functional subset of the total number of sites labeled by more conventional antagonist ligands. To test the basis of this claim, we used ...

journal_title：Neurochemistry international

authors： Minuzzi L,Cumming P

更新日期：2010-05-01 00:00:00

abstract：:Repeated exposure to addictive drugs enhances dopamine receptor (DR) signaling and the ultimate phosphorylation of the cyclic adenosine 5'-monophosphate (cAMP)-response element-binding protein (CREB)-regulated cocaine- and amphetamine-regulated transcript (CART) expression in the nucleus accumbens (NAcc). These effect...

journal_title：Neurochemistry international

authors： Peng Q,Sun X,Liu Z,Yang J,Oh KW,Hu Z

更新日期：2014-09-01 00:00:00

abstract：:Microglia, the primary resident immune cells of the central nervous system (CNS), responds rapidly to pathogens and injury by secreting immune mediators including nitric oxide (NO). The reaction of NO with the anti-oxidant glutathione forms S-nitrosoglutathione (GSNO), the major pool of biologic NO in the body. GSNO i...

journal_title：Neurochemistry international

authors： Rossi-George A,Guo CJ

更新日期：2016-10-01 00:00:00

abstract：:Variants in the gene encoding the enzyme glutamic acid decarboxylase like 1 (GADL1) have been associated with response to lithium therapy. Both GADL1 and the related enzyme cysteine sulfinic acid decarboxylase (CSAD) have been proposed to be involved in the pyridoxal-5'-phosphate (PLP)-dependent biosynthesis of taurin...

journal_title：Neurochemistry international

authors： Winge I,Teigen K,Fossbakk A,Mahootchi E,Kleppe R,Sköldberg F,Kämpe O,Haavik J

更新日期：2015-11-01 00:00:00

abstract：:Seizures are a serious and debilitating co-morbidity of primary brain tumors that affect most patients, yet their etiology is poorly understood. In many CNS pathologies, including epilepsy and brain injury, high levels of extracellular glutamate have been implicated in seizure generation. It has been shown that glioma...

journal_title：Neurochemistry international

authors： Buckingham SC,Robel S

更新日期：2013-12-01 00:00:00

abstract：:On the basis of the specific [(3)H]quinuclidinyl-benzilate binding, the transport of muscarinic cholinergic receptors has been demonstrated in the ventral horn, sciatic nerve and in the 3 mm segments proximal and distal to the ligature of rat sciatic nerves ligated for 24 h (a) without electrolytic lesion, (b) six day...

journal_title：Neurochemistry international

authors： Gulya K,Kása P

更新日期：1984-01-01 00:00:00

abstract：:In this study, the role of exogenous fatty acids in the regulation of proteolipid protein (PLP) gene expression was investigated using the following model culture system: C6 glioma cells expressing the green-fluorescent protein (eGFP) driven by different segments of PLP promoter. Eicosapentanoic acid (EPA; 20:5 n-3), ...

journal_title：Neurochemistry international

authors： Salvati S,Natali F,Attorri L,Raggi C,Di Biase A,Sanchez M

更新日期：2004-04-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress is linked to several neurological disorders, and neuronal injury cascades initiated by excessive ER stress are mediated, in part, via mitochondrial dysfunction. In the present study, we identified FAM3A as an important regulator of ER stress-induced cell death in neuronal HT22 cells. ...

journal_title：Neurochemistry international

authors： Song Q,Gou WL,Zhang R

更新日期：2016-03-01 00:00:00

abstract：:Age is the leading risk factor for many of the most prevalent and devastating diseases including neurodegenerative diseases. A number of herbal medicines have been used for centuries to ameliorate the deleterious effects of ageing-related diseases and increase longevity. Oxidative stress is believed to play a role in ...

journal_title：Neurochemistry international

authors： Steele ML,Truong J,Govindaraghavan S,Ooi L,Sucher NJ,Münch G

更新日期：2013-04-01 00:00:00

abstract：:Serotonin (5-HT) is a prime candidate for studies of the interaction between the nervous and immune systems, since it is both an important neurotransmitter and released at high concentrations at sites of inflammation. Serotonergic neurotransmission is regulated by the 5-HT transporter (5-HTT), which determines the mag...

journal_title：Neurochemistry international

authors： Mössner R,Heils A,Stöber G,Okladnova O,Daniel S,Lesch KP

更新日期：1998-09-01 00:00:00

abstract：:In the central nervous system, choline is an essential precursor of choline-containing phospholipids in neurons and glial cells and of acetylcholine in cholinergic neurons. In order to study choline transport and metabolism in the brain, we developed a comprehensive methodical procedure for the analysis of choline and...

journal_title：Neurochemistry international

authors： Klein J,Gonzalez R,Köppen A,Löffelholz K

更新日期：1993-03-01 00:00:00

abstract：:While nerve growth factor (NGF) activates various signaling cascades, the phosphatidylinositol 3-kinase (PI3-K)/Akt pathway plays a pivotal role in controlling the survival of neurons, although this activity declines during the aging process. We investigated the effect of forced moderate-intensity treadmill exercise o...

journal_title：Neurochemistry international

authors： Chae CH,Kim HT

更新日期：2009-09-01 00:00:00

abstract：:In this study we determined the changes in the intracellular free Ca2+ concentration, associated with the inhibitory modulation of the exocytotic release of GABA by GABAB receptor activation in rat cerebrocortical synaptosomes. We observed that SK&F 97541 and (-)baclofen both act as agonists of the presynaptic GABAB r...

journal_title：Neurochemistry international

authors： Santos AE,Carvalho CM,Macedo TA,Carvalho AP

更新日期：1995-10-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of (3S)-7-chloro-3-[2-((1R)-1-carboxyethoxy)-4-aminomethylphenyl]aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[c,d]indole-2-carboxylic acid hydrochloride (SM-31900), an antagonist with high selectivity and affinity for the NMDA receptor glycine-binding site, on the ...

journal_title：Neurochemistry international

authors： Ohtani K,Tanaka H,Ohno Y

更新日期：2003-04-01 00:00:00

abstract：:The mechanisms associated with cognitive decline in post-menopausal state driven by loss of ovarian function and reduced estrogen levels are not well understood. The aim of the present study is to investigate the role of mitochondrial dysfunctions in cognitive impairment in post-menopausal state and to evaluate the pr...

journal_title：Neurochemistry international

authors： Sandhir R,Sethi N,Aggarwal A,Khera A

更新日期：2014-07-01 00:00:00

abstract：:The disposition of labelled [3H]GM1lactone, the inner ester of ganglioside GM1, was studied in the rat. After i.v. administration [3H]GM1lactone was quickly converted to its corresponding open form most likely by plasma esterases, and then displayed a pharmacokinetic profile identical to [3H]GM1. Following intramuscul...

journal_title：Neurochemistry international

authors： Bellato P,Milan F,Facchinetti E,Toffano G

更新日期：1992-04-01 00:00:00

abstract：:The interaction of (±)-bupropion [(±)-BP] with the human (h) α4β2 nicotinic acetylcholine receptor (AChR) was compared to that for its photoreactive analog (±)-2-(N-tert-butylamino)-3'-iodo-4'-azidopropiophenone [(±)-SADU-3-72]. Ca2+ influx results indicated that (±)-SADU-3-72 and (±)-BP inhibit hα4β2 AChRs with pract...

journal_title：Neurochemistry international

authors： Arias HR,Feuerbach D,Ortells MO

更新日期：2016-11-01 00:00:00

abstract：:It has been shown recently that the N-terminal domain of the dopamine transporter (DAT) plays a role in several transporter functions. Here we provide evidence for a possible cellular mechanism of how the N-terminus of dopamine transporter might be removed in vivo. We isolated a recombinant N-terminal protein region o...

journal_title：Neurochemistry international

authors： Franekova V,Baliova M,Jursky F

更新日期：2008-06-01 00:00:00

abstract：:The discovery of nonsynaptic communication in the 1960s and 1970s was an important milestone in investigating the function of the nervous system, and it revolutionized our view about information transmission between neurons. In addition, nonsynaptic communication has a practical importance not only within the nervous ...

journal_title：Neurochemistry international

authors： Selmeczy Z,Vizi ES,Csóka B,Pacher P,Haskó G

更新日期：2008-01-01 00:00:00

abstract：:The oligosaccharides of rod and cone membranes were investigated with the aid of fluorescence and (125)I-labeled lectins. Additionally, the ability of lectins to cause agglutination in ROS suspensions was used as an index for the presence of the corresponding lectin receptors. The specificities of lectin-ligand intera...

journal_title：Neurochemistry international

authors： Bridges CD,Fong SL

更新日期：1980-01-01 00:00:00

abstract：:There is substantial evidence that hyperammonemia is one of the main factors contributing to the neurological alterations found in hepatic encephalopathy. The mechanisms by which chronic moderate hyperammonemia affects brain function involves alterations in neurotransmission at different steps. This article reviews th...

journal_title：Neurochemistry international

authors： Corbalán R,Hernández-Viadel M,Llansola M,Montoliu C,Felipo V

更新日期：2002-08-01 00:00:00

abstract：:Adenosine is a neuromodulator that can control brain damage through activation of A(1), A(2A) and A(3) receptors, which are located in both neurons and other brain cells. We took advantage of cultured neurons to investigate the role of neuronal adenosine receptors in the control of neurotoxicity caused by kainate and ...

journal_title：Neurochemistry international

authors： Rebola N,Rodrigues RJ,Oliveira CR,Cunha RA

更新日期：2005-10-01 00:00:00

abstract：:The effects of cholesterol oxides on regular and neuronal PC12 cells were examined. Among the cholesterol oxides tested, 7-beta-, 22(R)- and 25-OH-cholesterol were very toxic to regular PC12 cells such that approximately 80% of cells were killed after a 3 day incubation with 20 micrograms/ml (50 microM) of these agent...

journal_title：Neurochemistry international

authors： Chang JY,Liu LZ

更新日期：1997-10-01 00:00:00

abstract：:Human atrial natriuretic peptide (Ser 99-Tyr 126) was rapidly degraded by both choroid plexus and hypothalamic membranes with a complex pattern of cleavage. The use of protease inhibitors allowed a preliminary characterization of the enzymes involved in the hydrolysis of the Ser-Phe and Phe-Arg bonds of iodine-labelle...

journal_title：Neurochemistry international

authors： Deschodt-Lanckman M,Vanneste Y,Michaux F

更新日期：1988-01-01 00:00:00

abstract：:Vinpocetine (ethyl apovincaminate), a synthetic derivative of the Vinca minor alkaloid vincamine, is widely used for the treatment of cerebrovascular-related diseases. One of the proposed mechanisms underlying its action is to protect against the cytotoxic effects of glutamate overexposure. Glutamate excitotoxicity le...

journal_title：Neurochemistry international

authors： Tárnok K,Kiss E,Luiten PG,Nyakas C,Tihanyi K,Schlett K,Eisel UL

更新日期：2008-12-01 00:00:00

abstract：:This study aimed to elucidate locomotor activity changes in 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) and investigate the possible beneficial effects of melatonin on altered levels of locomotor activity, cyclooxygenase (COX), prostaglandin E2 (PGE2), nuclear factor kappa-B (NF-κB), nitrate/nitrite an...

journal_title：Neurochemistry international

authors： Yildirim FB,Ozsoy O,Tanriover G,Kaya Y,Ogut E,Gemici B,Dilmac S,Ozkan A,Agar A,Aslan M

更新日期：2014-12-01 00:00:00

abstract：:Cytokines are a heterogenous group of polypeptide mediators that have been associated with activation of numerous functions, including the immune system and inflammatory responses. The cytokine families include, but are not limited to, interleukins (IL-I alpha, IL-I beta, ILIra and IL-2-IL-15), chemokines (IL-8/ NAP-I...

journal_title：Neurochemistry international

authors： Ebadi M,Bashir RM,Heidrick ML,Hamada FM,Refaey HE,Hamed A,Helal G,Baxi MD,Cerutis DR,Lassi NK

更新日期：1997-04-01 00:00:00

abstract：:AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) excitotoxicity was examined in cultured neocortical neurons using the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to measure cell viability. Neurons were exposed to AMPA at different culture periods during development o...

journal_title：Neurochemistry international

authors： Jensen JB,Schousboe A,Pickering DS

更新日期：1998-05-01 00:00:00

abstract：:An endogenous modulator(s) of the dopamine receptor(s) in bovine and rat brain striatum was detected by demonstrating that water extracts of the striatum inhibited [(3)H]apomorphine binding. This modulator(s) was partially purified by methanol extraction and then successive ion exchange chromatographies on SP-Sephadex...

journal_title：Neurochemistry international

authors： Hirata A,Yamada I,Fujita N,Saito K,Nakahiro M,Yoshida H

更新日期：1986-01-01 00:00:00

abstract：INTRODUCTION:Primary pathology underlying Parkinson's disease (PD) is the loss of dopaminergic neurons in the substantia nigra (SN). A variety of genetic and environmental factors underlie this loss of dopaminergic neurons. However, recent studies have highlighted the role of elevated oxidative stress and the pro-infla...

journal_title：Neurochemistry international

authors： Sharma N,Nehru B

更新日期：2015-08-01 00:00:00