Disposition of exogenous tritium-labelled GM1lactone in the rat.

abstract：:The effect of different dietary fats with varying degrees of unsaturation and essential fatty acid composition, which are commonly consumed in India, on the activity of some important membrane-bound enzymes was assessed in different brain regions of rat. Four groups of male CFY weanling rats were fed nutritionally ade...

journal_title：Neurochemistry international

authors： Srinivasarao P,Narayanareddy K,Vajreswari A,Rupalatha M,Prakash PS,Rao P

更新日期：1997-12-01 00:00:00

abstract：:Age, sex, and gonadal hormones have profound effects on ischemic stroke outcomes, although how these factors impact basic stroke pathophysiology remains unclear. There is a plethora of inconsistent data reported throughout the literature, primarily due to differences in the species examined, the timing and methods use...

journal_title：Neurochemistry international

authors： Liu F,McCullough LD

更新日期：2012-12-01 00:00:00

abstract：:Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis associated with neuronal activity in the central nervous system, but the roles of AQP4 in adult neurogenesis remain largely unexplored. Based on preliminary evidences over the past years, AQP4 appears to emerge as an important player regula...

journal_title：Neurochemistry international

authors： Zheng GQ,Li Y,Gu Y,Chen XM,Zhou Y,Zhao SZ,Shen J

更新日期：2010-04-01 00:00:00

abstract：:INAD (infantile neuroaxonal dystrophy, OMIM#256600), an autosomal recessive inherited degenerative disease, is associated with PLA2G6 mutations. PLA2G6 encodes Ca2+-independent phospholipase A2 (VIA iPLA2). However, it is unclear how the PLA2G6-mutations lead to disease. Non-canonical functions, which were suggested f...

journal_title：Neurochemistry international

authors： Strokin M,Reiser G

更新日期：2017-09-01 00:00:00

abstract：:The neurotoxic beta-amyloid (Abeta) peptide fragment Abeta(25-35) has been suggested to exert its deleterious effects on cells via production of hydrogen peroxide. In human platelets and in the presence of DMSO to prevent production of hydroxyl radicals from hydrogen peroxide, both Abeta(25-35) and hydrogen peroxide w...

journal_title：Neurochemistry international

authors： Fowler CJ,Ando Y,Tiger G

更新日期：1998-08-01 00:00:00

abstract：:Adenosine is a neuromodulator that can control brain damage through activation of A(1), A(2A) and A(3) receptors, which are located in both neurons and other brain cells. We took advantage of cultured neurons to investigate the role of neuronal adenosine receptors in the control of neurotoxicity caused by kainate and ...

journal_title：Neurochemistry international

authors： Rebola N,Rodrigues RJ,Oliveira CR,Cunha RA

更新日期：2005-10-01 00:00:00

abstract：:Two polypeptides (designated DTX-A and DTX-B) were purified from crude snake venom of Dendroaspis angusticeps using gel filtration, cation exchange column chromatography and cation exchange high performance liquid chromatography, and their blocking actions of K+ channels were investigated in rat brain synaptosomes. Bo...

journal_title：Neurochemistry international

authors： Chaki S,Muramatsu M,Ushiyama Y,Otomo S

更新日期：1992-06-01 00:00:00

abstract：:The changes in intracellar Ca(2+)-concentration, which occur during stimulation of vascular smooth muscle cells with excitatory agonists, are discussed. The effects of these agonists on the membrane potential of these cells are indirect, and mainly due to an activation of K(+)- and Cl(?)-channels by the release of cal...

journal_title：Neurochemistry international

authors： Casteels R,Droogmans G,Missiaen L

更新日期：1990-01-01 00:00:00

abstract：:Excitotoxicity is the main event during neurological disorders producing drastic morphological and functional changes. Rac-GTPase is involved in cytoskeletal remodeling and survival. However, the role of Rac1 after cerebral ischemia has not been completely understood yet. In this study, we evaluated the activity of Ra...

journal_title：Neurochemistry international

authors： Johanna GV,Fredy CA,David VC,Natalia MV,Angel CR,Patricia CG

更新日期：2010-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, accounting for 60-70% of cases in subjects over 65 years of age. Several postulates have been put forward that relate AD neuropathology to intellectual and functional impairment. These range from free-radical-induced damage, through cholinergic dysfunction,...

journal_title：Neurochemistry international

authors： Hynd MR,Scott HL,Dodd PR

更新日期：2004-10-01 00:00:00

abstract：:Much attention has been paid to the connection between periodontitis and Alzheimer's disease (AD). We previously showed that infection of P. gingivalis, one of major periodontal pathogen causing periodontitis, induced migration and inflammatory responses in murine microglia through gingipain-induced activation of prot...

journal_title：Neurochemistry international

authors： Nonaka S,Nakanishi H

更新日期：2020-11-01 00:00:00

abstract：:Several studies have indicated a functional differentiation across the septotemporal axis of rat hippocampus. Our previous results have shown that the alpha 1 beta 2 gamma 2-GABAA receptor subtype dominates in dorsal hippocampus (DH), while the alpha 2 beta 1 gamma 2-subtype prevails in ventral hippocampus (VH). We th...

journal_title：Neurochemistry international

authors： Sarantis K,Sotiriou E,Papatheodoropoulos C,Matsokis N,Angelatou F

更新日期：2008-05-01 00:00:00

abstract：:Dopaminergic dysregulation in nucleus accumbens has been implicated in the origin of schizophrenia. Accumbal cholinergic interneurons exert powerful modulatory control of local dopamine function, through nicotinic receptors located on dopamine terminals. Fast-scan cyclic voltammetry in rat brain slices in vitro was us...

journal_title：Neurochemistry international

authors： Yavas E,Young AMJ

更新日期：2020-11-01 00:00:00

abstract：:Acetylcholinesterase (AChE) hydrolyses acetylcholine to choline and acetate, playing an important role in terminating the neurotransmission in brain and muscle. Recently, the non-neuronal functions of AChE have been proposed in different tissues, in which there are various factors to regulate the expression of AChE. I...

journal_title：Neurochemistry international

authors： Wu Q,Bai P,Xia Y,Lai QWS,Guo MSS,Dai K,Zheng Z,Ling CSJ,Dong TTX,Pi R,Tsim KWK

更新日期：2020-12-01 00:00:00

abstract：:In this paper, two different aspects of growth hormone neuroregulation during aging were considered. Twenty-month-old male rats had decreased growth hormone-releasing hormone mRNA levels and a slight reduction of somatostatin mRNA levels in the hypothalamus when compared to 8-month-old counterparts. Short-term adminis...

journal_title：Neurochemistry international

authors： De Gennaro Colonna V,Cella SG,Parenti M,Locatelli V,Cocchi D,Müller EE

更新日期：1994-07-01 00:00:00

abstract：:The activities of the enzymes glutathione reductase (GRD), glutathione peroxidase (GPX), and glutathione S-transferase (GST) were studied in several rat brain areas following the aspirative transection of the septohippocampal pathway (fimbria fornix) and the administration of nerve growth factor (NGF) or cytochrome c....

journal_title：Neurochemistry international

authors： Cruz-Aguado R,Francis-Turner L,Díaz-Suárez CM,Bergado J

更新日期：1999-02-01 00:00:00

abstract：:Thromboxane A2(TxA2) is a potent vasoconstrictor associated with cerebrovascular disease and is thought to be synthesized within tissues of the brain. In order to determine the cellular sources of TxA2 in the central nervous system (CNS), we measured the release of the stable metabolite TxB2 in cultures of mixed or hi...

journal_title：Neurochemistry international

authors： Giulian D,Corpuz M,Richmond B,Wendt E,Hall ER

更新日期：1996-07-01 00:00:00

abstract：:In chicks submitted to light stimulation, the synthesis of gangliosides of the retina ganglion cell increases with respect to chicks maintained in the dark. In an attempt to elucidate if the activation of glycosyltransferases participates in the establishment of these light-dark differences detected in vivo, we examin...

journal_title：Neurochemistry international

authors： Bussolino DF,Guido ME,Caputto BL

更新日期：1997-07-01 00:00:00

abstract：:Acetylcholine enhanced in a concentration-dependent way the K(+) (15 mM)-evoked release of [(3)H]dopamine from synaptosomes isolated from rat corpus striatum and prelabeled with the radioactive catecholamine. The concentration-effect curve of ACh obtained in presence of 1.2 mM Ca(2+) was progressively shifted to the l...

journal_title：Neurochemistry international

authors： Versace P,Bocchieri P,Marchi M,Raiteri M

更新日期：1987-01-01 00:00:00

abstract：:D1 dopamine receptors have been localized using a radioactive form of a new specific antagonist, [3H]SCH39166. This compound has been shown, in in vitro binding studies, to be highly selective for the D1 receptor subtype; more so than its predecessor, [3H]SCH23390. These ligand binds saturably, reversibly and with hig...

journal_title：Neurochemistry international

authors： Wamsley JK,Alburges ME,McQuade RD,Hunt M

更新日期：1992-03-01 00:00:00

abstract：:Patients with Parkinson's disease (PD) show a common progressive neurodegenerative movement disorder characterized by rigidity, tremors, postural instability, and bradykinesia due to the loss of dopaminergic neurons in the substantia nigra, and is often accompanied by several non-motor symptoms, called parkinsonism. S...

journal_title：Neurochemistry international

authors： Shimizu J,Kasai T,Yoshida H,Huynh AM,Nakao-Azuma Y,Shinomoto M,Tokuda T,Mizuno T,Yamaguchi M

更新日期：2020-10-01 00:00:00

abstract：:The phosphorylation of proteins on tyrosine residues, initially believed to be primarily involved in cell growth and differentiation, is now recognized as having a critical role in regulating the function of mature cells. The brain exhibits one of the highest levels of tyrosine kinase activity in the adult animal and ...

journal_title：Neurochemistry international

authors： Gurd JW

更新日期：1997-11-01 00:00:00

abstract：:SN1, a system N amino acid transporter specific for astrocytes, is mainly responsible for export of newly synthesized L-glutamine from the cells. Astrocytic retention of L-glutamine which plays a critical role in ammonia-induced astrocytic swelling resulting in brain edema, could be tentatively attributed to the impai...

journal_title：Neurochemistry international

authors： Dąbrowska K,Albrecht J,Zielińska M

更新日期：2018-09-01 00:00:00

abstract：:A biochemical study of the endogenous levels of serotonin (5-HT), noradrenaline (NA) and the activity of choline acetyltransferase (CAT) was carried out in the intestinal tract of the rat. High levels of 5-HT and NA were detected in the caecum and the colon. These anatomical regions also presented the highest activity...

journal_title：Neurochemistry international

authors： Legay C,Faudon M,Ternaux JP

更新日期：1983-01-01 00:00:00

abstract：:Acyl-CoA synthetase activity was investigated in membrane fractions from normal and Trembler mouse sciatic nerves. Stearoyl-CoA synthesis in the Trembler assays was always about twice that observed in the control experiments under various conditions of CoA and ATP concentrations. In experiments using varying concentra...

journal_title：Neurochemistry international

authors： Boiron F,Heape AM,Cassagne C

更新日期：1985-01-01 00:00:00

abstract：:An endogenous Na+, K+-ATPase inhibitor termed endobain E has been isolated from rat brain which shares several biological properties with ouabain. This cardiac glycoside possesses neurotoxic properties attributable to Na+, K+-ATPase inhibition, which leads to NMDA receptor activation, thus supporting the concept that ...

journal_title：Neurochemistry international

authors： Reinés A,Peña C,Rodríguez de Lores Arnaiz G

更新日期：2001-10-01 00:00:00

abstract：:Intrauterine growth retardation induced by ligation of the uterine vessels in pregnant rats on the 5th day before delivery was associated with brain and body weights of hypotrophic offspring significantly lower than those of pair-aged control rats, even after 6 weeks of postnatal rearing under normal conditions. In vi...

journal_title：Neurochemistry international

authors： Chanez C,Flexor MA,Hamon M

更新日期：1985-01-01 00:00:00

abstract：:Glycine transporter GlyT1 plays important role in maintaining accurate glycine concentration in local brain microenvironment. Transporting efficiency of GlyT1 is strongly affected by the state of its distal C-terminus, which regulates transporter trafficking and cellular surface density. Using selected range of antibo...

journal_title：Neurochemistry international

authors： Baliova M,Jursky F

更新日期：2010-10-01 00:00:00

abstract：:The molecular mechanism responsible for hyperphosphorylated tau accumulation in dendrites of Alzheimer's disease (AD) neurons has not been fully clarified. Recently, we reported that tau mRNA is distributed into dendrites, and that translation and phosphorylation of tau protein are immediately enhanced in response to ...

journal_title：Neurochemistry international

authors： Tanaka T,Ohashi S,Takashima A,Kobayashi S

更新日期：2020-10-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of (3S)-7-chloro-3-[2-((1R)-1-carboxyethoxy)-4-aminomethylphenyl]aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[c,d]indole-2-carboxylic acid hydrochloride (SM-31900), an antagonist with high selectivity and affinity for the NMDA receptor glycine-binding site, on the ...

journal_title：Neurochemistry international

authors： Ohtani K,Tanaka H,Ohno Y

更新日期：2003-04-01 00:00:00