Enhancement of serotonin transporter function by tumor necrosis factor alpha but not by interleukin-6.

abstract：:To characterise ketamine-induced sympathomimetic action, we examined the effects of ketamine on in vivo cardiac sympathetic nerve endings function. Using adult cats given anaesthesia with pentobarbital, dialysis probes were implanted in the left ventricular myocardium and dialysate noradrenaline (NA) concentrations we...

journal_title：Neurochemistry international

authors： Kitagawa H,Yamazaki T,Akiyama T,Mori H,Sunagawa K

更新日期：2003-02-01 00:00:00

abstract：:Recent in vitro studies have revealed that benzodiazepines, opiates, barbiturates and ethanol might influence GABA binding to CNS membrane sites. Further studies of such interactions might be helpful for explaining both the mechanisms of action of these psychoactive agents and the tolerance/dependence that might resul...

journal_title：Neurochemistry international

authors： Defeudis FV

更新日期：1983-01-01 00:00:00

abstract：:The aim of this study was to investigate the involvement of calmodulin in phospholipase D activation in SH-SY5Y cells. Cells prelabelled with [3H]-palmitic acid were incubated with calmodulin antagonists and/or other compounds. Phosphatidylethanol, a specific marker for phospholipase D activity, and phosphatidic acid ...

journal_title：Neurochemistry international

authors： del Carmen Boyano-Adánez M,Gustavsson L

更新日期：2002-03-01 00:00:00

abstract：:The worldwide prevalence of stroke continues to rise despite recent successes in treating acute ischemic stroke. With limited patient eligibility and associated risk of tPA and mechanical thrombectomy, new preventive and therapeutic modalities are needed to stave the rising wave of stroke. Inflammation plays a key rol...

journal_title：Neurochemistry international

authors： Benedek G,Vandenbark AA,Alkayed NJ,Offner H

更新日期：2017-07-01 00:00:00

abstract：:Alzheimer's disease as well as prion-related encephalopathies are neurodegenerative disorders of the central nervous system, which cause mental deterioration and progressive dementia. Both pathologies appear to be primarily associated with the pathological accumulation and deposit of β-amyloid or prion peptides in the...

journal_title：Neurochemistry international

authors： Morte B,Martínez T,Zambrano A,Pascual A

更新日期：2011-05-01 00:00:00

abstract：:Sprague-Dawley rats were made chronically vitamin D deficient (VDD) and hypocalcemic, or VDD and normocalcemic. Rickets, severely reduced body weight, hair shedding, lethargy, muscular paralysis and a high mortality rate are characteristic features of the male VDD/hypocalcemic animals. An assessment was made of the ne...

journal_title：Neurochemistry international

authors： Tenenhouse A,Warner M,Commissiong JW

更新日期：1991-01-01 00:00:00

abstract：:Receptors for transmitters, as varied as those expressed by neurons, have been described on primary astrocyte cultures prepared from new-born rats and mice. A variety of functional effects and considerable cell-to-cell and regional heterogeneity have been observed for such receptors in vitro. The various systems avail...

journal_title：Neurochemistry international

authors： Kimelberg HK

更新日期：1995-01-01 00:00:00

abstract：:The effects of cholesterol oxides on regular and neuronal PC12 cells were examined. Among the cholesterol oxides tested, 7-beta-, 22(R)- and 25-OH-cholesterol were very toxic to regular PC12 cells such that approximately 80% of cells were killed after a 3 day incubation with 20 micrograms/ml (50 microM) of these agent...

journal_title：Neurochemistry international

authors： Chang JY,Liu LZ

更新日期：1997-10-01 00:00:00

abstract：:The venom from the marine snail Conus pennaceus inhibits the binding of [3H]neuropeptide Y to calf brain membranes (Czerwiec et al., 1996a) and, in the present study, also to rat forebrain membranes. These membranes contain about 80% Y1- and 20% Y2-receptors. The inhibition by the venom was concentration-dependent wit...

journal_title：Neurochemistry international

authors： Diallo B,Vanderheyden PM,De Backer JP,Vauquelin G

更新日期：1998-01-01 00:00:00

abstract：:Brain slices from actively myelinating (26-28 days) quaking and normal littermates were dual-labeled with radioactive mannose and fucose for 2 h. Following the incubation myelin was isolated by sucrose density gradient centrifugation and the incorporation of sugars into the major myelinassociated glycoprotein (MAG) de...

journal_title：Neurochemistry international

authors： Konat G,Hogan EL,Leskawa KC,Gantt G,Singh I

更新日期：1987-01-01 00:00:00

abstract：:The correlation between rotational behaviors and neurochemical changes associated with the striatal damage induced by an unilateral microinjection of kainic acid were investigated. Shortly after the unilateral striatal injection of kainic acid, rats exhibited contralateral rotational behaviors, and these changes were ...

journal_title：Neurochemistry international

authors： Kuriyama K,Kurihara E

更新日期：1982-01-01 00:00:00

abstract：:Prenatal exposure to diazepam (DZ), a positive allosteric modulator of the gamma-aminobutyric acid(A) (GABA(A)) receptor complex, exerts profound effects that become more evident during puberty and in many cases are sex-specific, suggesting that such exposure interferes with the activity of steroid hormones. Apart fro...

journal_title：Neurochemistry international

authors： Cannizzaro C,D'Amico M,Altobelli D,Preziosi P,Martire M

更新日期：2003-07-01 00:00:00

abstract：:To elucidate the role of Ca(2+)-activated K(+) (K(Ca)) channels in the presynaptic acetylcholine (ACh) release from splanchnic nerve endings and the postsynaptic catecholamine release from chromaffin cells, we applied microdialysis technique to the left adrenal medulla of anesthetized rats and investigated the effects...

journal_title：Neurochemistry international

authors： Akiyama T,Yamazaki T,Kawada T,Shimizu S,Sugimachi M,Shirai M

更新日期：2010-01-01 00:00:00

abstract：:Oxidative stress-induced neuronal death plays a pivotal role in pathogenesis of neurodegenerative disorders. Recently, 7,8-dihydroxyflavone (7,8-DHF) has been shown to exert neuroprotective effects by acting as a selective tyrosine kinase receptor B (TrkB) agonist. In addition, the antioxidant action of 7,8-DHF may pr...

journal_title：Neurochemistry international

authors： Han X,Zhu S,Wang B,Chen L,Li R,Yao W,Qu Z

更新日期：2014-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) affecting more than 2.5 million individuals worldwide. In the present study, myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) mice were treated with adenosine recept...

journal_title：Neurochemistry international

authors： Chen Y,Zhang ZX,Zheng LP,Wang L,Liu YF,Yin WY,Chen YY,Wang XS,Hou ST,Chen JF,Zheng RY

更新日期：2019-10-01 00:00:00

abstract：:The present study was carried out to clarify whether the imidazolines clonidine, moxonidine and cirazoline as well as the guanidine aganodine inhibit noradrenaline release in the rat and rabbit brain via imidazoline receptors, alpha 2-adrenoceptors and/or histamine H3 receptors. Slices or synaptosomes from the rat or ...

journal_title：Neurochemistry international

authors： Schlicker E,Fink K,Kathmann M,Molderings GJ,Göthert M

更新日期：1997-01-01 00:00:00

abstract：:Cerebellar granule neurons produce homogenous cultures that provide a unique opportunity for quantifying the apoptosis by propidium iodide- and deoxynucleotidyl transferase-flow cytometry combined analysis and for studying its regulation by neurotrophins. Nerve growth factor (NGF) was found to promote postmitotic surv...

journal_title：Neurochemistry international

authors： Muller Y,Tangre K,Clos J

更新日期：1997-08-01 00:00:00

abstract：:Air pollution is an important contributor to the global burden of disease, particularly to respiratory and cardiovascular diseases. In recent years, evidence is accumulating that air pollution may adversely affect the nervous system as shown by human epidemiological studies and by animal models. Age appears to play a ...

journal_title：Neurochemistry international

authors： Costa LG,Cole TB,Dao K,Chang YC,Garrick JM

更新日期：2019-12-01 00:00:00

abstract：:In the present study we have investigated the relationship between serotonergic receptor(s) (5-HTR) and muscarinic cholinergic receptor (mAChR) activation, leading to the arachidonic acid (AA) release and inositol phosphates (IPs) formation in adult and aged brain cortex synaptoneurosomes. It was observed that seroton...

journal_title：Neurochemistry international

authors： Samochocki M,Strosznajder J

更新日期：1995-06-01 00:00:00

abstract：:Repeated exposure to classical psychomotor stimulants, like amphetamine (AMPH), produces locomotor sensitization and accompanied structural plasticity of dendritic spines in the nucleus accumbens (NAcc). Following our previous report that repeated administration of methiopropamine (MPA), a structural analog to meth-AM...

journal_title：Neurochemistry international

authors： Cai WT,Yoon HS,Lee S,Kim JH

更新日期：2019-10-01 00:00:00

abstract：:The brain uses long-chain fatty acids (LCFAs) to a negligible extent as fuel for the mitochondrial energy generation, in contrast to other tissues that also demand high energy. Besides this generally accepted view, some studies using cultured neural cells or whole brain indicate a moderately active mitochondrial β-oxi...

journal_title：Neurochemistry international

authors： Schönfeld P,Reiser G

更新日期：2017-10-01 00:00:00

abstract：:Many pharmacological and toxicological studies of centrally acting drugs are undertaken in animals at doses expressed in mg.kg-1, and the results extrapolated to the clinical dose in man. Safety margins based on such no or lowest effect levels may have little relevance since they do not take into account differences i...

journal_title：Neurochemistry international

authors： Campbell DB

更新日期：1995-02-01 00:00:00

abstract：:The effects of N-methyl-norsalsolinol on basal and inhibited activity of monoamine oxidase (MAO) in membrane preparations from the caudate nucleus of the rat have been studied. For the first time, the physiological step of dopamine oxidation to 3, 4 dihydroxyphenylacetic aldehyde (DPAA) was examined. N-methyl-norsalso...

journal_title：Neurochemistry international

authors： Moser A,Scholz J,Bamberg H,Böhme V

更新日期：1996-01-01 00:00:00

abstract：:Succinyl-Leu-Leu-Val-Tyr-4-methylcoumaryl-7-amide (Suc-LLVY-MCA) hydrolyzing activities of the 20S and 26S proteasomes in the gerbil cortex following transient forebrain ischemia were examined. Using extraction solutions without ATP, only 20S proteasome activity was noted after separation with glycerol gradient centri...

journal_title：Neurochemistry international

authors： Kamikubo T,Hayashi T

更新日期：1996-02-01 00:00:00

abstract：:Neurones are dependent on their mitochondria to produce the necessary amounts of ATP for survival. Retinal ganglion cells (RGCs) have a particularly large number of mitochondria which-unlike neurones in the brain-are exposed to visual light of 400-850 nm. Here we demonstrate that short wavelength visual blue light neg...

journal_title：Neurochemistry international

authors： Núñez-Álvarez C,Osborne NN

更新日期：2019-05-01 00:00:00

abstract：:Monosialoganglioside (GM1) is a glycosphingolipid present in most cell membranes that displays antioxidant and neuroprotective properties. It has been recently described that GM1 induces vasodilation. However, the mechanisms underlying GM1-induced vasodilation were not evaluated to date. Therefore, in this study we in...

journal_title：Neurochemistry international

authors： Furian AF,Oliveira MS,Magni DV,Souza MA,Bortoluzzi VT,Bueno LM,Royes LF,Mello CF

更新日期：2008-12-01 00:00:00

abstract：:The precise function of activated microglia and their secretory products remains controversial. In order to assess the role of microglial secretion products, we established an in vitro model of an inflammatory reaction in the brain by co-culturing microglial and neuronal cell lines. Upon stimulation with interferon-ga...

journal_title：Neurochemistry international

authors： Hemmer K,Fransen L,Vanderstichele H,Vanmechelen E,Heuschling P

更新日期：2001-06-01 00:00:00

abstract：:Tryptophan hydroxylation in cockroach (Periplaneta americana) nervous tissue was measured and compared to the hydroxylation of tryptophan in rat brain. Tryptophan hydroxylation in both tissues requires a pterine cofactor, and is inhibited by p-chlorophenylalanine. The molecular weight of the protein responsible for hy...

journal_title：Neurochemistry international

authors： Sloley BD,Yu PH

更新日期：1987-01-01 00:00:00

abstract：:Parkinson's disease (PD), a progressive neurodegenerative disorder, has long been associated with mitochondrial dysfunction in both sporadic and familial forms of the disease. Mitochondria are crucial for maintaining cellular homeostasis, and their dysfunction is detrimental to dopaminergic neurons. These neurons are ...

journal_title：Neurochemistry international

authors： Müller-Nedebock AC,Brennan RR,Venter M,Pienaar IS,van der Westhuizen FH,Elson JL,Ross OA,Bardien S

更新日期：2019-10-01 00:00:00

abstract：:Radial glial cells play a significant role in the repair of spinal cord injuries as they exert critical role in the neurogenesis and act as a scaffold for neuronal migration. Our previous study showed that mature astrocytes of spinal cord can undergo a de-differentiation process and further transform into pluripotenti...

journal_title：Neurochemistry international

authors： Yang H,Ling W,Vitale A,Olivera C,Min Y,You S

更新日期：2011-12-01 00:00:00