Are interspecies comparisons in the toxicity of centrally acting drugs valid without brain concentrations? A commentary.

abstract：:Glial (GLT-1 and GLAST) and neuronal (EAAC1) high-affinity transporters mediate the sodium dependent glutamate reuptake in mammalian brain. Their dysfunction leads to neuronal damage by allowing glutamate to remain in the synaptic cleft for a longer duration. The purpose of the present study is to understand their con...

journal_title：Neurochemistry international

authors： Raghavendra Rao VL,Rao AM,Dogan A,Bowen KK,Hatcher J,Rothstein JD,Dempsey RJ

更新日期：2000-05-01 00:00:00

abstract：:Initial studies demonstrated the loss of lysine and simultaneous appearance of glucitollysine in intracellular proteins following incubation with sugar. For example, when a crude nervous tissue cytoskeletal preparation was incubated in 100 mM glucose for 10 days, > 60% of the lysine residues were modified. Over 20% of...

journal_title：Neurochemistry international

authors： Brown MR,Keith TJ,Knull HR

更新日期：1992-09-01 00:00:00

abstract：:Serotonin2C receptor (5-HT2C) agonists are promising drugs for the treatment of neuropsychiatric diseases. However, their effect is not completely understood in part because they possibly affect several neurobiological networks simultaneously. We studied the effect of the 5-HT2C receptor agonist WAY-163909 (0.3 and 3 ...

journal_title：Neurochemistry international

authors： Chagraoui A,Whitestone S,Baassiri L,Manem J,Di Giovanni G,De Deurwaerdère P

更新日期：2019-03-01 00:00:00

abstract：INTRODUCTION:Primary pathology underlying Parkinson's disease (PD) is the loss of dopaminergic neurons in the substantia nigra (SN). A variety of genetic and environmental factors underlie this loss of dopaminergic neurons. However, recent studies have highlighted the role of elevated oxidative stress and the pro-infla...

journal_title：Neurochemistry international

authors： Sharma N,Nehru B

更新日期：2015-08-01 00:00:00

abstract：:Pediatric brain tumors are the leading cancer-related cause of death in children and adolescents in the United States, affecting on average 1 in 2000 children per year. Recent advances in cancer genomics have led to profound discoveries about the underlying molecular biology and ontogeny of these tumors. In particular...

journal_title：Neurochemistry international

authors： Alencastro Veiga Cruzeiro G,Rota C,Hack OA,Segal R,Filbin MG

更新日期：2020-12-15 00:00:00

abstract：:Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis associated with neuronal activity in the central nervous system, but the roles of AQP4 in adult neurogenesis remain largely unexplored. Based on preliminary evidences over the past years, AQP4 appears to emerge as an important player regula...

journal_title：Neurochemistry international

authors： Zheng GQ,Li Y,Gu Y,Chen XM,Zhou Y,Zhao SZ,Shen J

更新日期：2010-04-01 00:00:00

abstract：:To identify whether the process of apoptosis bears a topographic relationship to selected aspects of Alzheimer's disease (AD) pathology, we used an in situ nick translation method (TUNEL) to map DNA fragmentation in hippocampal sections immunostained for abnormally phosphorylated tau, which exists in the neurofibrilla...

journal_title：Neurochemistry international

authors： Sugaya K,Reeves M,McKinney M

更新日期：1997-08-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease in which pathogenic T cells play an important role, and an experimental autoimmune encephalomyelitis (EAE) is used as an animal model of MS. Galectins are β-galactoside-binding lectins and involved in various physiological and pathological events. Among fifteen members ...

journal_title：Neurochemistry international

authors： Itabashi T,Arima Y,Kamimura D,Higuchi K,Bando Y,Takahashi-Iwanaga H,Murakami M,Watanabe M,Iwanaga T,Nio-Kobayashi J

更新日期：2018-09-01 00:00:00

abstract：:Oxidative stress-induced neuronal death plays a pivotal role in pathogenesis of neurodegenerative disorders. Recently, 7,8-dihydroxyflavone (7,8-DHF) has been shown to exert neuroprotective effects by acting as a selective tyrosine kinase receptor B (TrkB) agonist. In addition, the antioxidant action of 7,8-DHF may pr...

journal_title：Neurochemistry international

authors： Han X,Zhu S,Wang B,Chen L,Li R,Yao W,Qu Z

更新日期：2014-01-01 00:00:00

abstract：:High levels of angiotensin converting enzyme (ACE) are found in the caudate-putamen (CPu), globus pallidus, entopeduncular nucleus and substantia nigra pars reticulata; these structures were connected by a continuous band of ACE. In order to investigate whether ACE was associated with dopaminergic projections from the...

journal_title：Neurochemistry international

authors： Chai SY,Christie MJ,Beart PM,Mendelsohn FA

更新日期：1987-01-01 00:00:00

abstract：:The present experiments investigated the effect of a neurotoxin purified from the venom of the spider Phoneutria nigriventer. This toxic component, P. nigriventer toxin 3-6 (PnTx3-6), abolished Ca(2+)-dependent glutamate release with an IC(50) of 74.4nM but did not alter Ca(2+)-independent secretion of glutamate when ...

journal_title：Neurochemistry international

authors： Vieira LB,Kushmerick C,Reis HJ,Diniz CR,Cordeiro MN,Prado MA,Kalapothakis E,Romano-Silva MA,Gomez MV

更新日期：2003-03-01 00:00:00

abstract：:Aging is a biological process characterized by impairment of cellular bioenergetic function, increased oxidative stress, attenuated ability to respond to stresses, increased risk of contracting age-associated disorders that affects many tissues, with a more marked effect on brain and heart function. Oxidative stress i...

journal_title：Neurochemistry international

authors： Paradies G,Petrosillo G,Paradies V,Ruggiero FM

更新日期：2011-03-01 00:00:00

abstract：:Immunoglobulin G (IgG) antibodies against myelin oligodendrocyte glycoprotein (MOG) are detected in the serum of some patients with demyelinating diseases. These patients are known to show repeated clinical episodes of inflammatory demyelinating attacks in the central nervous system. Although the associated pathogenic...

journal_title：Neurochemistry international

authors： Akaishi T,Sato DK,Takahashi T,Nakashima I

更新日期：2019-11-01 00:00:00

abstract：:Age is the leading risk factor for many of the most prevalent and devastating diseases including neurodegenerative diseases. A number of herbal medicines have been used for centuries to ameliorate the deleterious effects of ageing-related diseases and increase longevity. Oxidative stress is believed to play a role in ...

journal_title：Neurochemistry international

authors： Steele ML,Truong J,Govindaraghavan S,Ooi L,Sucher NJ,Münch G

更新日期：2013-04-01 00:00:00

abstract：:Nitrite therapy is more effective in cerebral ischemia when administered earlier. It would be beneficial during the hyperacute stages of stroke if the nitrite effect is demonstrated in intracerebral hemorrhage (ICH). When nitrite is injected intravenously 3h after ICH induction in rats, most doses of nitrite provided ...

journal_title：Neurochemistry international

authors： Jung KH,Chu K,Lee ST,Kim JM,Park DK,Kim M,Lee SK,Roh JK

更新日期：2011-08-01 00:00:00

abstract：:Monocarboxylate transporter (MCT1) levels in brains of adult Long-Evans rats on a high-fat (ketogenic) diet were investigated using light and electron microscopic immunocytochemical methods. Rats given the ketogenic diet (91% fat and 9% protein) for up to 6 weeks had increased levels of the monocarboxylate transporter...

journal_title：Neurochemistry international

authors： Leino RL,Gerhart DZ,Duelli R,Enerson BE,Drewes LR

更新日期：2001-05-01 00:00:00

abstract：:L-serine-O-sulphate is a member of a group of amino acids collectively called gliotoxins and is a substrate for the high affinity sodium-dependent glutamate transporters. Previous studies have shown that it is toxic to primary cultures of astrocytes but the mode of toxicity is unknown. The current study demonstrates t...

journal_title：Neurochemistry international

authors： Brennan L,Alves PM,Hewage C,Malthouse JP,McBean GJ

更新日期：2006-06-01 00:00:00

abstract：:To characterise ketamine-induced sympathomimetic action, we examined the effects of ketamine on in vivo cardiac sympathetic nerve endings function. Using adult cats given anaesthesia with pentobarbital, dialysis probes were implanted in the left ventricular myocardium and dialysate noradrenaline (NA) concentrations we...

journal_title：Neurochemistry international

authors： Kitagawa H,Yamazaki T,Akiyama T,Mori H,Sunagawa K

更新日期：2003-02-01 00:00:00

abstract：:The changes in intracellar Ca(2+)-concentration, which occur during stimulation of vascular smooth muscle cells with excitatory agonists, are discussed. The effects of these agonists on the membrane potential of these cells are indirect, and mainly due to an activation of K(+)- and Cl(?)-channels by the release of cal...

journal_title：Neurochemistry international

authors： Casteels R,Droogmans G,Missiaen L

更新日期：1990-01-01 00:00:00

abstract：:With their potent regenerative and protective capacities, stem cell-derived conditioned media emerged as an effective alternative to cell therapy, and have a prospect to be manufactured as pharmaceutical products for tissue regeneration applications. Our study investigates the neuroregenerative potential of human dent...

journal_title：Neurochemistry international

authors： Chouaib B,Collart-Dutilleul PY,Blanc-Sylvestre N,Younes R,Gergely C,Raoul C,Scamps F,Cuisinier F,Romieu O

更新日期：2021-01-16 00:00:00

abstract：:Many peripheral substances, including ghrelin, induce neuronal activation in the brain. In the present study, we compared the effect of subcutaneously administered ghrelin and its three stable agonists: Dpr(3)ghr ([Dpr(N-octanoyl)(3)] ghrelin) (Dpr - diaminopropionic acid), YA GHRP-6 (H-Tyr-Ala-His-DTrp-Ala-Trp-DPhe-L...

journal_title：Neurochemistry international

authors： Pirnik Z,Bundziková J,Holubová M,Pýchová M,Fehrentz JA,Martinez J,Zelezná B,Maletínská L,Kiss A

更新日期：2011-11-01 00:00:00

abstract：:Astrocytes play an important role in chemical signalling, acting as receptive as well as secretory elements. They can express receptors for essentially all classical neurotransmitter substances and for a large variety of peptides. Recent evidence indicates that astrocytes are involved in the information processing wit...

journal_title：Neurochemistry international

authors： Volknandt W

更新日期：2002-11-01 00:00:00

abstract：:Depression is characterized by sadness, purposelessness, irritability, and impaired body functions. Depression causes severe symptoms for several weeks, and dysthymia, which may cause chronic, low-grade symptoms. Treatment of depression involves psychotherapy, medications, or phototherapy. Clinical and experimental ev...

journal_title：Neurochemistry international

authors： Shabbir F,Patel A,Mattison C,Bose S,Krishnamohan R,Sweeney E,Sandhu S,Nel W,Rais A,Sandhu R,Ngu N,Sharma S

更新日期：2013-02-01 00:00:00

abstract：:Parkinson's disease (PD), a progressive neurodegenerative disorder, has long been associated with mitochondrial dysfunction in both sporadic and familial forms of the disease. Mitochondria are crucial for maintaining cellular homeostasis, and their dysfunction is detrimental to dopaminergic neurons. These neurons are ...

journal_title：Neurochemistry international

authors： Müller-Nedebock AC,Brennan RR,Venter M,Pienaar IS,van der Westhuizen FH,Elson JL,Ross OA,Bardien S

更新日期：2019-10-01 00:00:00

abstract：:Therapeutic hypothermia as a physical method to lower the brain temperature of patients has been widely used in clinics as an effective and necessary step during the treatment of acute brain injury or edema. However, due to limitations of the ocular structure, the application of hypothermia in retinal neuroprotection ...

journal_title：Neurochemistry international

authors： Sun YJ,Ma S,Fan B,Wang Y,Wang SR,Li GY

更新日期：2019-06-01 00:00:00

abstract：:The Xenopus oocyte expression and recording system has allowed a detailed analysis of the physiology and pharmacology of neuronal ion channels including their sensitivity to ethanol. It is important however, to ascertain the effects of a particular drug on the channels inherently expressed by oocytes to ensure that dr...

journal_title：Neurochemistry international

authors： Clayton R,Woodward JJ

更新日期：2000-01-01 00:00:00

abstract：:The accumulation of extracellular amyloid beta (Abeta42) both in brain and in cerebral vessels characterizes Alzheimer's disease (AD) pathogenesis. Recently, the possibility to functionalize nanoparticles (NPs) surface with Abeta42 binding molecules, making them suitable tools for reducing Abeta42 burden has been show...

journal_title：Neurochemistry international

authors： Conti E,Gregori M,Radice I,Da Re F,Grana D,Re F,Salvati E,Masserini M,Ferrarese C,Zoia CP,Tremolizzo L

更新日期：2017-09-01 00:00:00

abstract：:The results of the present study showed the presence of a high-affinity and saturable binding of [3H]-ketanserin to frontal and parietal brain membranes obtained postmortem from bipolar, depressed, schizophrenic patients and normal controls. The human brain samples (60 frontal cortex and 51 parietal cortex), were dona...

journal_title：Neurochemistry international

authors： Marazziti D,Giannaccini G,Giromella A,Betti L,Pesce D,Nardi I,Rossi A,Lucacchini A,Cassano GB

更新日期：2003-05-01 00:00:00

abstract：:Superfused rat cerebral cortex slices were submitted to a continuous electrical (5 Hz) stimulation and treated with sodium azide (1-10 mM) in the presence of 2 mM 2-deoxyglucose ("chemical ischemia"). Presynaptic cholinergic activity, evaluated as acetylcholine release, was inhibited depending on the sodium azide conc...

journal_title：Neurochemistry international

authors： Cavallini S,Marti M,Marino S,Selvatici R,Beani L,Bianchi C,Siniscalchi A

更新日期：2005-12-01 00:00:00

abstract：:The worldwide prevalence of stroke continues to rise despite recent successes in treating acute ischemic stroke. With limited patient eligibility and associated risk of tPA and mechanical thrombectomy, new preventive and therapeutic modalities are needed to stave the rising wave of stroke. Inflammation plays a key rol...

journal_title：Neurochemistry international

authors： Benedek G,Vandenbark AA,Alkayed NJ,Offner H

更新日期：2017-07-01 00:00:00