当前位置： SCI文献检索 > NEUROCHEMISTRY INTERNATIONAL期刊下所有文献 > Effects of nigral dopaminergic lesions and striatal excitotoxin lesions on brain converting enzyme.

Effects of nigral dopaminergic lesions and striatal excitotoxin lesions on brain converting enzyme.

Abstract：

:High levels of angiotensin converting enzyme (ACE) are found in the caudate-putamen (CPu), globus pallidus, entopeduncular nucleus and substantia nigra pars reticulata; these structures were connected by a continuous band of ACE. In order to investigate whether ACE was associated with dopaminergic projections from the substantia nigra or striatal projections, we performed unilateral excitotoxin lesions using N- methyl- d -asparate (NMDA) (500 nmol) into the CPu and 6-hydroxydopamine (60HDA) (8 ?g) lesions of the substantia nigra. One week after the nigral 60HDA lesions and 2 weeks after the striatal NMDA lesions, 20 ?m frozen brain sections were analysed by computerized quantitative in vitro autoradiography using the radioligand [(125)I]351A to label ACE. ACE was unchanged by nigral 60HDA lesions although a 67% decrease in the concentration of dopamine was detected in the CPu of the lesioned side. However, striatal NMDA lesions produced a significant decrease (36-54%) of ACE in the CPu, globus pallidus, entopeduncular nucleus and substantia nigra pars reticulata on the lesioned side. In these brains, ACE was unchanged in other remote regions such as the paraventricular and supraoptic nuclei. This study demonstrates that part of brain ACE is associated with neurones and terminals which descend from the CPu and globus pallidus to the substantia nigra. Since these pathways do not appear to contain angiotensin II, it is possible that ACE is involved in processing some other neuropeptide, possibly substance P, which has been shown to be a substrate for ACE and to exist in striato-nigral projections.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Chai SY,Christie MJ,Beart PM,Mendelsohn FA

doi

10.1016/0197-0186(87)90180-x

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

101-7

issue

1

eissn

0197-0186

issn

1872-9754

pii

0197-0186(87)90180-X

journal_volume

10

pub_type

杂志文章

相关文献

NEUROCHEMISTRY INTERNATIONAL文献大全
  • High-affinity choline uptake and acetylcholine-metabolizing enzymes in CNS white matter. A quantitative study.

    abstract：:The presence of nicotinic and muscarinic receptors suggests the occurrence of cholinergic neurotransmission in white matter; however no quantitative information exists on acetylcholine formation and breakdown in white matter. We compared white structures of pig brain (fimbria, corpus callosum, pyramidal tracts, and oc...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2008.06.008

    authors： Hassel B,Solyga V,Lossius A

    更新日期：2008-12-01 00:00:00

  • Molecular mechanism of biological action of the serotonergic neurotoxin 5,7-dihydroxytryptamine.

    abstract：:5,7-Dihydroxytryptamine (5,7-DHT) is a selective serotonergic neurotoxin by virtue of its selective uptake into 5-hydroxytryptamine neurons and its ability to undergo autoxidation. The mechanism by which 5,7-DHT induces neurodegenerative effects remains enigmatic. The mechanism of autoxidation of 5,7-DHT, which has be...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(88)90165-9

    authors： Sinhababu AK,Borchardt RT

    更新日期：1988-01-01 00:00:00

  • Bupropion and its photoreactive analog (±)-SADU-3-72 interact with luminal and non-luminal sites at human α4β2 nicotinic acetylcholine receptors.

    abstract：:The interaction of (±)-bupropion [(±)-BP] with the human (h) α4β2 nicotinic acetylcholine receptor (AChR) was compared to that for its photoreactive analog (±)-2-(N-tert-butylamino)-3'-iodo-4'-azidopropiophenone [(±)-SADU-3-72]. Ca2+ influx results indicated that (±)-SADU-3-72 and (±)-BP inhibit hα4β2 AChRs with pract...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2016.08.013

    authors： Arias HR,Feuerbach D,Ortells MO

    更新日期：2016-11-01 00:00:00

  • Intrastriatal kainic acid elicits functional supersensitivity of muscarinic receptors regulating dopamine release.

    abstract：:Acetylcholine enhanced in a concentration-dependent way the K(+) (15 mM)-evoked release of [(3)H]dopamine from synaptosomes isolated from rat corpus striatum and prelabeled with the radioactive catecholamine. The concentration-effect curve of ACh obtained in presence of 1.2 mM Ca(2+) was progressively shifted to the l...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(87)90008-8

    authors： Versace P,Bocchieri P,Marchi M,Raiteri M

    更新日期：1987-01-01 00:00:00

  • Differential turnover rates of D1 dopamine receptors in the brain and retina of adult and senescent rats.

    abstract：:The present study was designed to investigate the turnover rates of D1 dopamine receptors in the brain and retina of adult and aged rats. To this aim, we monitored the increase in the density of 3H-SCH 23390 binding sites after the administration of the irreversible antagonist N-ethoxycarbonyl-2-ethoxy-1,2 dihydroquin...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(92)90233-h

    authors： Giorgi O,Pibiri MG,Dal Toso R,Toffano G,Biggio G

    更新日期：1992-03-01 00:00:00

  • Abnormal glycosylation of myelin-associated glycoprotein in quaking mouse brain.

    abstract：:Brain slices from actively myelinating (26-28 days) quaking and normal littermates were dual-labeled with radioactive mannose and fucose for 2 h. Following the incubation myelin was isolated by sucrose density gradient centrifugation and the incorporation of sugars into the major myelinassociated glycoprotein (MAG) de...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(87)90084-2

    authors： Konat G,Hogan EL,Leskawa KC,Gantt G,Singh I

    更新日期：1987-01-01 00:00:00

  • Neosurugatoxin blocks nicotinic acetylcholine receptors in the brain.

    abstract：:Neosurugatoxin, a neurotoxin isolated from the Japanese ivory mollusc (Babylonia japonica ) is a nicotinic antagonist with a specificity towards ganglionic nicotinic receptors. At low concentration (5 x 10(?8) M) neosurugatoxin inhibited the release of [(3)H]dopamine evoked by 1,1-dimethyl-4-phenylpiperazinium (DMPP) ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(85)90131-7

    authors： Rapier C,Harrison R,Lunt GG,Wonnacott S

    更新日期：1985-01-01 00:00:00

  • The effect of electroconvulsive therapy on blood glucose, creatinine levels, and lipid profile and its association with the type of psychiatric disorders.

    abstract：:Although the mechanism of electroconvulsive therapy (ECT) is not clearly known, its effects on hormones have been widely studied. However, there are controversies about the effect of ECT on blood glucose level. In addition, the possible effects of ECT on the blood cholesterol, LDL, HDL, and triglyceride levels are ign...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2012.07.013

    authors： Ghanizadeh A,Issaee M,Sigaroody MO,Kaviani K

    更新日期：2012-12-01 00:00:00

  • Long-term kainic acid exposure reveals compartmentation of glutamate and glutamine metabolism in cultured cerebellar neurons.

    abstract：:Glutamate neurotoxicity is implicated in most neurodegenerative diseases, and in the present study the long-term effects of the glutamate agonist kainic acid (KA) on cerebellar neurons are investigated. Primary cell cultures, mainly consisting of glutamatergic granule neurons, were cultured in medium containing 0.05 o...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2006.11.004

    authors： Olstad E,Qu H,Sonnewald U

    更新日期：2007-06-01 00:00:00

  • The negative coupling between serotonin and muscarinic receptor(s) for arachidonic acid and inositol phosphates release in brain cortex synaptoneurosomes. Effect of aging.

    abstract：:In the present study we have investigated the relationship between serotonergic receptor(s) (5-HTR) and muscarinic cholinergic receptor (mAChR) activation, leading to the arachidonic acid (AA) release and inositol phosphates (IPs) formation in adult and aged brain cortex synaptoneurosomes. It was observed that seroton...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(95)00001-o

    authors： Samochocki M,Strosznajder J

    更新日期：1995-06-01 00:00:00

  • The significance of dendritic release of transmitter and protein in the substantia nigra.

    abstract：:The transmitter dopamine and the protein acetylcholinesterase are released within the substantia nigra from the dendrites of nigrostriatal neurons. These phenomena do not correspond to the familiar events involved in information transfer at the classic axons synapse. It is possible that both dopamine and acetylcholine...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(85)90136-6

    authors： Greenfield SA

    更新日期：1985-01-01 00:00:00

  • Regulation of GABAA receptors by prolonged exposure to endogenous and exogenous ligands.

    abstract：:GABAA receptors mediate most of the fast inhibitory transmissions in the central nervous system. These receptors are pentameric complexes that exhibit high structural and pharmacological heterogeneity, as they can be constructed from 19 distinct subunits. GABAA receptors are the targets of numerous clinically relevant...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuint.2018.05.015

    authors： Gravielle MC

    更新日期：2018-09-01 00:00:00

  • Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones.

    abstract：:Whereas carbachol, noradrenaline, serotonin and memantine stimulated inositol phosphates production and calcium mobilization in 3-5 day old rabbit retinal cultures, only carbachol and noradrenaline were effective when 25-30 day old cultures were used. The older retinal cultures contain only Müller cells which shows th...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(92)90183-r

    authors： Osborne NN,Quack G

    更新日期：1992-10-01 00:00:00

  • Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in adrenal chromaffin cells.

    abstract：:Multiple signaling pathways via insulin receptor substrate-1 and -2 play crucial roles in health, diseases, and therapeutics (i.e., longevity, tumorigenesis, and neuroprotection). The 90-kDa heat-shock protein (Hsp90) is an emerging target molecule of therapeutics, Hsp90 inhibitors being promising against various dise...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2009.08.013

    authors： Yoshikawa N,Nemoto T,Satoh S,Maruta T,Yanagita T,Chosa E,Wada A

    更新日期：2010-01-01 00:00:00

  • Adult development of the hippocampal-serotonin system of C57BL/6N mice; analysis of high-affinity uptake of (3)H-5HT in slices and synaptosomes.

    abstract：:The saturable and specific high-affinity uptake of [(3)H]serotonin ([(3)H]5HT) (5 x 10(?8) M) was studied in slices from the hippocampus, parietal cortex, septum-preoptic area, and hypothalamus of male 2, 6, 12 and 24-32 month old C57BL/6N mice. Hippocampal [(3)H]5-HT uptake showed a significant biphasic relationship ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(83)90006-2

    authors： Azmitia E,Brennan MJ,Quartermain D

    更新日期：1983-01-01 00:00:00

  • Retinal protein kinase C.

    abstract：:The protein kinase C (PKC) family of serine/threonine kinase isoenzymes are universally expressed in vertebrate tissues where they control vital cellular functioning. PKC comprises twelve currently identified mammalian isoenzymes, described in three distinct groups according to their need for different effector stimul...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/s0197-0186(96)00049-6

    authors： Wood JP,McCord RJ,Osborne NN

    更新日期：1997-02-01 00:00:00

  • Alterations of purine and pyrimidine nucleotide contents in rat corticoencephalic cell cultures following metabolic damage and treatment with openers and blockers of ATP-sensitive potassium channels.

    abstract：:Rat corticoencephalic cell cultures were investigated by high performance liquid chromatography for changes in the levels of adenosine 5'-triphosphate (ATP), guanosine 5'-triphosphate (GTP), uridine 5'-triphosphate (UTP), cytidine 5'-triphosphate (CTP), and the respective nucleoside diphosphates. Hypoxia was induced b...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(01)00102-4

    authors： Reinhardt R,Manaenko A,Pissarek M,Wagner A,Illes P

    更新日期：2002-04-01 00:00:00

  • Sildenafil treatment of vascular dementia in aged rats.

    abstract：BACKGROUND:and purpose: In this study, we employed a multiple microinfarction (MMI) based vascular dementia (VaD) model in aged rats and tested the therapeutic effects of Sildenafil, a phosphodiesterase type 5 inhibitor, on cognitive decline, white matter damage, autophagy and inflammatory response associated with VaD....

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2018.12.015

    authors： Venkat P,Chopp M,Zacharek A,Cui C,Landschoot-Ward J,Qian Y,Chen Z,Chen J

    更新日期：2019-07-01 00:00:00

  • Concerted action of antiepileptic and antidepressant agents to depress spinal neurotransmission: Possible use in the therapy of spasticity and chronic pain.

    abstract：:Chronic pain states and epilepsies are common therapeutic targets of voltage-gated sodium channel blockers. Inhibition of sodium channels results in central muscle relaxant activity as well. Selective serotonin reuptake inhibitors are also applied in the treatment of pain syndromes. Here, we investigate the pharmacody...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2006.12.008

    authors： Thán M,Kocsis P,Tihanyi K,Fodor L,Farkas B,Kovács G,Kis-Varga A,Szombathelyi Z,Tarnawa I

    更新日期：2007-03-01 00:00:00

  • Immunocytochemical demonstration of taurine in the retina and pineal organ of the pigeon.

    abstract：:Taurine-like immunoreactivity (TLI) is found in the pigeon retina at high levels within cones, in select cells of the inner nuclear layer and in sublaminae of the inner plexiform layer. At the ultrastructural level a high density of immuno-gold particles in visualized in the ellipsoid, but not in the paraboloid area o...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(95)00043-8

    authors： Ueck M,Hach A,Verdone-Smith C,Lake N

    更新日期：1995-12-01 00:00:00

  • Bioactive lipids in excitatory neurotransmission and neuronal plasticity.

    abstract：:Long-term potentiation (LTP), a model of activity-dependent synaptic plasticity and of certain forms of memory, comprises the persistent enhancement of excitatory neurotransmission that results from high-frequency activation. A presynaptic component of LTP is thought to be modulated by a retrograde messenger generated...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/s0197-0186(96)00020-4

    authors： Bazan NG,Packard MG,Teather L,Allan G

    更新日期：1997-02-01 00:00:00

  • Study of a 53 kDa cell surface antigen of oligodendrocytes in culture.

    abstract：:It was shown previously that pure oligodendrocytes release proteins when maintained in a chemically defined medium. Among these proteins, a 53 kDa glycoprotein was characterized as a component accessible from the external surface of these glial cells. Specific antibodies directed against this glycoprotein were obtaine...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(88)90101-5

    authors： Pari FM,Roussel G,Nussbaum F,Nussbaum JL

    更新日期：1988-01-01 00:00:00

  • Na+K+ ATPase activity in the rat hippocampus: a study in the pilocarpine model of epilepsy.

    abstract：:Biochemical abnormalities have been implicated in possible mechanisms underlying the epileptic phenomena. Some of these alterations include changes in the activity of several enzymes present in epileptic tissues. Systemic administration of pilocarpine in rats induces electrographic and behavioral limbic seizures and s...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(95)00153-0

    authors： Fernandes MJ,Naffah-Mazzacoratti MG,Cavalheiro EA

    更新日期：1996-05-01 00:00:00

  • Induction of conditioned place preference and dopamine release by salsolinol in posterior VTA of rats: involvement of μ-opioid receptors.

    abstract：:Salsolinol (Sal), locally administered into the posterior VTA (pVTA) of rats, produces psychomotor responses and reinforcing effects, probably, through the activation of μ-opioid receptors (MORs). The neurochemical correlates of these phenomena are, however, practically unknown. In this paper, we explore the neurochem...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2011.04.014

    authors： Hipólito L,Martí-Prats L,Sánchez-Catalán MJ,Polache A,Granero L

    更新日期：2011-10-01 00:00:00

  • Electrophoretic pattern and distribution of cytoskeletal proteins in flat-epitheloid and stellate process-bearing astrocytes in primary culture.

    abstract：:One- and two-dimensional electrophoresis patterns and distribution of major cytoskeletal proteins were studied in primary astrocytes with either flat-epitheloid or stellate appearance. No major differences in the electrophoretic patterns of actin, tubulin, glial fibrillary acidic protein (GFAP) and vimentin were detec...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(84)90126-8

    authors： Ciesielski-Treska J,Ulrich G,Mensch C,Aunis D

    更新日期：1984-01-01 00:00:00

  • 12/15 lipoxygenase: A crucial enzyme in diverse types of cell death.

    abstract：:The 12/15-lipoxygenase (12/15-LOX) enzymes react with polyunsaturated fatty acids producing active lipid metabolites that are involved in plethora of human diseases including neurological disorders. A great many of elegant studies over the last decades have contributed to unraveling the mechanism how 12/15-lipoxygenas...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuint.2018.04.002

    authors： Li QQ,Li Q,Jia JN,Liu ZQ,Zhou HH,Mao XY

    更新日期：2018-09-01 00:00:00

  • Neurotransmitters in the CNS of the vitamin D deficient, hypocalcemic rat.

    abstract：:Sprague-Dawley rats were made chronically vitamin D deficient (VDD) and hypocalcemic, or VDD and normocalcemic. Rickets, severely reduced body weight, hair shedding, lethargy, muscular paralysis and a high mortality rate are characteristic features of the male VDD/hypocalcemic animals. An assessment was made of the ne...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(91)90192-g

    authors： Tenenhouse A,Warner M,Commissiong JW

    更新日期：1991-01-01 00:00:00

  • Cerebrospinal fluid light and heavy neurofilaments in neuromyelitis optica.

    abstract：BACKGROUND:Axonal injury is the correlate of disease progression in NMO and MS. Neurofilament (Nf) belongs to neuron specific intermediate filaments located in axons. Nf protein subunits are potential biomarkers in cerebrospinal fluid (CSF) for acute axonal injury. However, whether CSF NfH and NfL levels are elevated i...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2013.10.008

    authors： Wang H,Wang C,Qiu W,Lu Z,Hu X,Wang K

    更新日期：2013-12-01 00:00:00

  • Neurosteroid modulation of the presynaptic NMDA receptors regulating hippocampal noradrenaline release in normal rats and those exposed prenatally to diazepam.

    abstract：:Prenatal exposure to diazepam (DZ), a positive allosteric modulator of the gamma-aminobutyric acid(A) (GABA(A)) receptor complex, exerts profound effects that become more evident during puberty and in many cases are sex-specific, suggesting that such exposure interferes with the activity of steroid hormones. Apart fro...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(02)00226-7

    authors： Cannizzaro C,D'Amico M,Altobelli D,Preziosi P,Martire M

    更新日期：2003-07-01 00:00:00

  • The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain.

    abstract：:P2Y purinergic receptors expressed in neurons and satellite glial cells (SGCs) of the trigeminal ganglion (TG) contribute to inflammatory and neuropathic pain. P2Y14 receptor expression is reported in the spinal cord, dorsal root ganglion (DRG), and TG. In present study, the role of P2Y14 receptor in the TG in inflamm...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2019.104567

    authors： Lin J,Zhang YY,Liu F,Fang XY,Liu MK,Huang CL,Wang H,Liao DQ,Zhou C,Shen JF

    更新日期：2019-12-01 00:00:00