Abstract:
:Salsolinol (Sal), locally administered into the posterior VTA (pVTA) of rats, produces psychomotor responses and reinforcing effects, probably, through the activation of μ-opioid receptors (MORs). The neurochemical correlates of these phenomena are, however, practically unknown. In this paper, we explore the neurochemical events and the mechanisms involved in these behaviors. To do that, we test the ability of Sal, directly microinjected into the pVTA, to induce conditioned place preference (CPP) and to increase dopamine levels in the nucleus accumbens shell. Bilateral injections of 30 pmol of Sal induced a strong CPP (rats spent around 70% of the total test time), a result that could be explained by the fact that Sal microinjected into the pVTA increased DA levels in the ipsilateral accumbens up to 141% of baseline. The local pretreatment with β-FNA, an antagonist of MORs, prevented this increase, supporting our hypothesis on the involvement of MORs in the Sal-derived effects.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Hipólito L,Martí-Prats L,Sánchez-Catalán MJ,Polache A,Granero Ldoi
10.1016/j.neuint.2011.04.014subject
Has Abstractpub_date
2011-10-01 00:00:00pages
559-62issue
5eissn
0197-0186issn
1872-9754pii
S0197-0186(11)00172-0journal_volume
59pub_type
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