Abstract:
:The 12/15-lipoxygenase (12/15-LOX) enzymes react with polyunsaturated fatty acids producing active lipid metabolites that are involved in plethora of human diseases including neurological disorders. A great many of elegant studies over the last decades have contributed to unraveling the mechanism how 12/15-lipoxygenase play a role in these diseases. And the way it works is mainly through apoptosis. However, recent years have found that the way 12/15-lipoxygenase works is also related to autophagy and ferroptosis, a newly defined type of cell death by Stockwell's lab in 2012. Figuring out how 12/15-lipoxygenase participate in these modes of cell death is of vital importance to understand its role in disease. The review aims to give a sight on our current knowledge on the role of this enzyme in apoptosis, autophagy and ferroptosis. And the relevant diseases that 12/15-lipoxygenase may be involved.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Li QQ,Li Q,Jia JN,Liu ZQ,Zhou HH,Mao XYdoi
10.1016/j.neuint.2018.04.002subject
Has Abstractpub_date
2018-09-01 00:00:00pages
34-41eissn
0197-0186issn
1872-9754pii
S0197-0186(17)30610-1journal_volume
118pub_type
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