Abstract:
:Acyl-CoA synthetase activity was investigated in membrane fractions from normal and Trembler mouse sciatic nerves. Stearoyl-CoA synthesis in the Trembler assays was always about twice that observed in the control experiments under various conditions of CoA and ATP concentrations. In experiments using varying concentrations of fatty acid, the activation of stearate was very low in both systems (normal and Trembler), up to a substrate concentration of 20 mM, suggesting that fatty acid micelles are required for full activity. ATP, at concentrations of up to 1 mM, was totally (Trembler) or partially (control) hydrolyzed within 15 min, resulting in an apparently lower ligase activity in the mutant than in the control when an ATP-regenerating system was not added. The activation of saturated fatty acids decreased with increasing chain length. However, lignoceroyl-CoA formation was detected in the mutant but not in the control.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Boiron F,Heape AM,Cassagne Cdoi
10.1016/0197-0186(85)90035-xsubject
Has Abstractpub_date
1985-01-01 00:00:00pages
805-10issue
5eissn
0197-0186issn
1872-9754pii
0197-0186(85)90035-Xjournal_volume
7pub_type
杂志文章abstract::The effects of pretreatment of mice with some drugs which modify GABAergic neurotransmission on the convulsions and cerebellar cyclic nucelotide level changes induced by the subsequent intracerebroventricular administration of 4-isopropyl-2,6,7-trioxa-1-phosphabicyclo(2,2,2)octane-1-oxide (IPTBO) have been studied. Mu...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/0197-0186(84)90095-0
更新日期:1984-01-01 00:00:00
abstract::Transglutaminase (TGase) activity is increased in affected regions of brains from patients with Huntington's disease (HD). TGase activity is particularly elevated in the nucleus compared with the cytoplasm from these brains. Gamma-glutaminyl-lysyl cross-links have been detected in nuclear inclusions in HD brain, indic...
journal_title:Neurochemistry international
pub_type: 杂志文章,评审
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abstract::Monosialoganglioside (GM1) is a glycosphingolipid present in most cell membranes that displays antioxidant and neuroprotective properties. It has been recently described that GM1 induces vasodilation. However, the mechanisms underlying GM1-induced vasodilation were not evaluated to date. Therefore, in this study we in...
journal_title:Neurochemistry international
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更新日期:2008-12-01 00:00:00
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journal_title:Neurochemistry international
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更新日期:1987-01-01 00:00:00
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journal_title:Neurochemistry international
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doi:10.1016/j.neuint.2017.02.016
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/0197-0186(83)90114-6
更新日期:1983-01-01 00:00:00
abstract::Initial studies demonstrated the loss of lysine and simultaneous appearance of glucitollysine in intracellular proteins following incubation with sugar. For example, when a crude nervous tissue cytoskeletal preparation was incubated in 100 mM glucose for 10 days, > 60% of the lysine residues were modified. Over 20% of...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/0197-0186(92)90144-g
更新日期:1992-09-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2015.04.009
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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更新日期:1980-01-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2014.02.007
更新日期:2014-04-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2009.01.025
更新日期:2009-07-01 00:00:00
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journal_title:Neurochemistry international
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doi:10.1016/j.neuint.2005.10.012
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pub_type: 杂志文章
doi:10.1016/0197-0186(93)90133-p
更新日期:1993-11-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/0197-0186(83)90072-4
更新日期:1983-01-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/0197-0186(94)00110-g
更新日期:1995-02-01 00:00:00
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journal_title:Neurochemistry international
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更新日期:1989-01-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
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更新日期:2000-05-01 00:00:00
abstract::AMPA receptors are fast ligand-gated members of glutamate receptors in neuronal and many types of non-neuronal cells. The heterotetramer complexes are assembled from four subunits (GluR1-4) in region-, development- and function-selective patterns. Each subunit contains three extracellular domains (a large amino termin...
journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2007.07.002
更新日期:2008-01-01 00:00:00
abstract::Excessive glucocorticoid levels in depressed patients have been associated with atrophic changes in some brain regions, but only few studies suggest that some antidepressants can interfere with deleterious effect of glucocorticoids on neuronal cells. The aim of the present study was to examine the effect of dexamethas...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2013.07.007
更新日期:2013-11-01 00:00:00
abstract::The present studies were performed in order to examine the possible role of cyclic GMP-stimulated phosphodiesterase (cGMP-PDE) activity in the inhibitory action of the inflammatory peptide bradykinin on cyclic AMP (cAMP) accumulation in D384 cells. Bradykinin decreased the forskolin-stimulated cAMP accumulation in the...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/0197-0186(92)90149-l
更新日期:1992-09-01 00:00:00
abstract::Accumulating evidence indicates that various classes of non-coding RNAs (ncRNAs) including microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs) and long non-coding RNAs (lncRNAs) play important roles in normal state as well as the diseases of the CNS. Interestingly, ncRNAs have been shown to interact with messenger RNA,...
journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2017.01.015
更新日期:2017-12-01 00:00:00
abstract::In the last few years, several attempts were made for the setting up of specific methodologies aiming to evaluate steroid contents directly in nervous tissues. The main objective of these attempts was to determine accurately changes intervening in endogenous neuroactive steroid levels during pathological situations. T...
journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2007.09.010
更新日期:2008-03-01 00:00:00
abstract::Two signaling pathways, phosphoinositide 3-kinase (PI-3k)/Akt and Ras/MAPK, are major effectors triggered by nerve growth factor (NGF). Rac1, Cdc42 and GSK-3beta are reported to be targets of PI-3k in the signal transduction for neurite outgrowth. Immediately after NGF was added, broad ruffles were observed temporaril...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2007.04.032
更新日期:2007-07-01 00:00:00
abstract::D1 and D2 receptors are key mediators of dopaminergic signaling in the brain, and since the manifestations of pathologies related to dopamine are different in female and male patients, it is important to analyze if there are sex-related differences in dopaminergic markers. To contribute to the knowledge in this regard...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2016.09.001
更新日期:2016-11-01 00:00:00
abstract::The brain uses long-chain fatty acids (LCFAs) to a negligible extent as fuel for the mitochondrial energy generation, in contrast to other tissues that also demand high energy. Besides this generally accepted view, some studies using cultured neural cells or whole brain indicate a moderately active mitochondrial β-oxi...
journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2017.03.018
更新日期:2017-10-01 00:00:00