Ligand interactions of crustacean axonal membranes.

abstract：:Free radicals have been implicated in the pathogenesis of vasogenic brain edema caused by ischemic or traumatic injury. It has been reported that in transgenic mice overexpressing the human CuZn-superoxide dismutase, brain edema is decreased in many cerebral disorders. To investigate the effects of free radicals on th...

journal_title：Neurochemistry international

authors： Imaizumi S,Kondo T,Deli MA,Gobbel G,Joó F,Epstein CJ,Yoshimoto T,Chan PH

更新日期：1996-08-01 00:00:00

abstract：:The neuromodulator adenosine, has been shown to have the highest density of central uptake sites in the nucleus tractus solitarius in the dorsal brain stem. The nucleus tractus solitarius is involved in the central regulation of reflex cardiovascular activity suggesting that adenosine may also be involved in central c...

journal_title：Neurochemistry international

authors： Lawrence AJ,Castillo-Meléndez M,Jarrott B

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Axonal injury is the correlate of disease progression in NMO and MS. Neurofilament (Nf) belongs to neuron specific intermediate filaments located in axons. Nf protein subunits are potential biomarkers in cerebrospinal fluid (CSF) for acute axonal injury. However, whether CSF NfH and NfL levels are elevated i...

journal_title：Neurochemistry international

authors： Wang H,Wang C,Qiu W,Lu Z,Hu X,Wang K

更新日期：2013-12-01 00:00:00

abstract：:Cerebral edema is a potentially life-threatening complication shared by diseases of different etiology, such as diabetic ketoacidosis, acute liver failure, high altitude exposure, dialysis disequilibrium syndrome, and salicylate intoxication. Pulmonary edema is also habitually present in these disorders, indicating th...

journal_title：Neurochemistry international

authors： Adeva MM,Souto G,Donapetry C,Portals M,Rodriguez A,Lamas D

更新日期：2012-07-01 00:00:00

abstract：:Malfunctioning of high-affinity glutamate transporters is believed to contribute to the accumulation of toxic concentrations of glutamate and, thus, trigger the cellular mechanisms of neurodegeneration. Emerging data point to the presence of excitotoxic component in Alzheimer's disease (AD) and aberrant expression of ...

journal_title：Neurochemistry international

authors： Rodriguez-Kern A,Gegelashvili M,Schousboe A,Zhang J,Sung L,Gegelashvili G

更新日期：2003-09-01 00:00:00

abstract：:Ligand-induced changes in the conformation of extracellular loop (EL) 2 in the rat (r) dopamine transporter (DAT) were examined using limited proteolysis with endoproteinase Asp-N and detection of cleavage products by epitope-specific immunoblotting. The principle N-terminal fragment produced by Asp-N was a 19kDa pept...

journal_title：Neurochemistry international

authors： Gaffaney JD,Shetty M,Felts B,Pramod AB,Foster JD,Henry LK,Vaughan RA

更新日期：2014-07-01 00:00:00

abstract：:A low density of brain IR2-imidazoline receptive sites has previously been linked to depression. In this study we evaluated brain IR2-binding sites in a rat model of depression, olfactory bulbectomy, and determined the effects of chronic imipramine treatment in vivo on these sites. Compared with sham-operated controls...

journal_title：Neurochemistry international

authors： Zhu H,Paul IA,McNamara M,Redmond A,Nowak G,Piletz JE

更新日期：1997-01-01 00:00:00

abstract：:Excitable membranes appear to be biochemically characterized by the presence of a highly specific receptor protein, which undergoes conformational changes upon stimulation and returns to its original conformation for renewed excitability. Our present knowledge of the disk membrane and its receptor protein rhodopsin is...

journal_title：Neurochemistry international

authors： Daemen FJ,de Grip WJ

更新日期：1980-01-01 00:00:00

abstract：:Axonal transport of tripeptidyl peptidase II, a putative cholecystokinin inactivating serine peptidase, was examined in the proximal, middle, and distal segments of rat sciatic nerves using a double ligation technique. Enzyme activity significantly increased not only in the proximal segment but also in the distal segm...

journal_title：Neurochemistry international

authors： Chikuma T,Shimizu M,Tsuchiya Y,Kato T,Hojo H

更新日期：2007-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARα, -β/δ and -γ) are lipid-activated transcription factors. Synthetic PPARα and PPARγ ligands have neuroprotective properties. Recently, PPARβ/δ activation emerged as the focus of a novel approach for the treatment of a wide range of neurodegenerative diseases. To fill t...

journal_title：Neurochemistry international

authors： Aleshin S,Strokin M,Sergeeva M,Reiser G

更新日期：2013-10-01 00:00:00

abstract：:Pregabalin is effective in treating many neuropathic pain conditions. However, the mechanisms of its analgesic effects remain poorly understood. The aim of the present study was to determine whether pregabalin suppresses facial mechanical hypersensitivity and evoked glutamate release in the medullary dorsal horn (MDH)...

journal_title：Neurochemistry international

authors： Kumar N,Cherkas PS,Varathan V,Miyamoto M,Chiang CY,Dostrovsky JO,Sessle BJ,Coderre TJ

更新日期：2013-05-01 00:00:00

abstract：:The expression of 5-hydroxytryptamine-2B (5-HT2B) receptor mRNA has recently been shown in cultured astrocytes. Here the expression of functional 5-HT2B receptors has been studied in cultured astrocytes from rat cerebral cortex, hippocampus, and brain stem. Fluo-3- and fura-2-based microspectrofluorometry was used for...

journal_title：Neurochemistry international

authors： Sandén N,Thorlin T,Blomstrand F,Persson PA,Hansson E

更新日期：2000-04-01 00:00:00

abstract：:Nerve terminals from the head ganglia of Locusta migratoria were isolated by means of a modified microscale flotation technique. Enzymatic, ultrastructural and chemical analysis revealed that the synaptosomal fraction was highly enriched in well-preserved nerve endings containing almost no free mitochondria. Cholinerg...

journal_title：Neurochemistry international

authors： Breer H

更新日期：1981-01-01 00:00:00

abstract：:A possible modulatory role of kinases on voltage sensitive Na+ channels of presynaptic brain nerve endings was investigated by testing the effect of several kinase activators and inhibitors on the elevation of [Nai] induced by veratridine in mouse brain synaptosomes loaded with a selective Na+ indicator dye. Veratridi...

journal_title：Neurochemistry international

authors： Sitges M,Peña F,Chiu LM,Guarneros A

更新日期：1998-02-01 00:00:00

abstract：:Age, sex, and gonadal hormones have profound effects on ischemic stroke outcomes, although how these factors impact basic stroke pathophysiology remains unclear. There is a plethora of inconsistent data reported throughout the literature, primarily due to differences in the species examined, the timing and methods use...

journal_title：Neurochemistry international

authors： Liu F,McCullough LD

更新日期：2012-12-01 00:00:00

abstract：:Oxidative stress-induced neuronal death due to hydrogen peroxide overload plays a critical role in the pathogenesis of numerous neurological diseases. Insulin-like growth factor-1 (IGF-1) is important in maintaining neuronal survival, proliferation, and differentiation in the central nervous system. We now report that...

journal_title：Neurochemistry international

authors： Zhong J,Lee WH

更新日期：2007-11-01 00:00:00

abstract：:The observation that autophosphorylation converts CaM kinase II from the Ca(2+)-dependent form to the Ca(2+)-independent form has led to speculation that the formation of the Ca(2+)-independent form of the enzyme could encode frequency of synaptic usage and serve as a molecular explanation of "memory". In cultured rat...

journal_title：Neurochemistry international

authors： Fukunaga K,Muller D,Miyamoto E

更新日期：1996-04-01 00:00:00

abstract：:Tyrosine hydroxylase (TH) was purified from bovine brain and enzymatically phosphorylated in vitro. Radioactively phosphorylated TH was dephosphorylated by rat tissue extracts. Of tissues examined, rat corpus striatal extracts were highest in specific activity in the TH dephosphorylating assay. Phosphorylated histone ...

journal_title：Neurochemistry international

authors： Lazar MA,Raese JD,Barchas JD

更新日期：1983-01-01 00:00:00

abstract：:Recent studies suggest that the behavioral effects of chronic antidepressant treatment are mediated by stimulation of hippocampal neuronal plasticity and neurogenesis. The present study was designed to examine the effects of 3,6'-disinapoyl sucrose (DISS), a bioactive component of Polygala tenuifolia Willd, on the exp...

journal_title：Neurochemistry international

authors： Hu Y,Liao HB,Dai-Hong G,Liu P,Wang YY,Rahman K

更新日期：2010-02-01 00:00:00

abstract：:Minocycline is neuroprotective in animal models of a number of acute CNS injuries, neurodegenerative diseases and CNS infection. While anti-inflammatory and anti-apoptotic effects of Minocycline have been characterized, the molecular basis for the neuroprotective effects of Minocycline remains unclear. We report here ...

journal_title：Neurochemistry international

authors： Mishra MK,Ghosh D,Duseja R,Basu A

更新日期：2009-06-01 00:00:00

abstract：:Age is the leading risk factor for many of the most prevalent and devastating diseases including neurodegenerative diseases. A number of herbal medicines have been used for centuries to ameliorate the deleterious effects of ageing-related diseases and increase longevity. Oxidative stress is believed to play a role in ...

journal_title：Neurochemistry international

authors： Steele ML,Truong J,Govindaraghavan S,Ooi L,Sucher NJ,Münch G

更新日期：2013-04-01 00:00:00

abstract：:Soluble guanylyl cyclase (sGC) is a key enzyme of the NO-cGMP pathway which is believed to mediate vasoprotective actions. In cardiovascular diseases such as hypercholesterolemia and atherosclerosis, these important functions of the vascular endothelium are strongly impaired. One of the major reasons for this so-calle...

journal_title：Neurochemistry international

authors： Francois M,Kojda G

更新日期：2004-11-01 00:00:00

abstract：:We assessed the diagnostic accuracy of cerebrospinal fluid (CSF) neurofilament light chain (NFL) protein in the classification of patients with Alzheimer's disease (AD) and cognitively healthy control individuals (HCs) and patients with frontotemporal dementia (FTD) as comparisons. Particularly, we tested the performa...

journal_title：Neurochemistry international

authors： Lista S,Toschi N,Baldacci F,Zetterberg H,Blennow K,Kilimann I,Teipel SJ,Cavedo E,Dos Santos AM,Epelbaum S,Lamari F,Dubois B,Floris R,Garaci F,Hampel H,Alzheimer Precision Medicine Initiative (APMI).

更新日期：2017-09-01 00:00:00

abstract：:Astrocytes, besides supporting metabolic and scaffolding functions, play a prominent role in the modulation of neuronal communication. In particular, they are responsible for clearing synaptically-released glutamate via highly specific transporters located on their plasma membrane. Since glutamate is the main excitato...

journal_title：Neurochemistry international

authors： Piet R,Poulain DA,Oliet SH

更新日期：2004-07-01 00:00:00

abstract：:Diabetic neuropathic pain (DNP) plays a major role in decreased life quality of diabetes patients, however, the neural mechanisms underlying DNP remain unclear. Endomorphins are the endogenous ligands for mu-opioid receptor. There is increasing evidence implicating the involvement of spinal endomorphin-2 (EM2) in neur...

journal_title：Neurochemistry international

authors： Niu L,Dai GH,He GL,Yang M,Hu HM,Liu ZK,Qian NS,Chen YL

更新日期：2017-09-01 00:00:00

abstract：:5,7-Dihydroxytryptamine (5,7-DHT) is a selective serotonergic neurotoxin by virtue of its selective uptake into 5-hydroxytryptamine neurons and its ability to undergo autoxidation. The mechanism by which 5,7-DHT induces neurodegenerative effects remains enigmatic. The mechanism of autoxidation of 5,7-DHT, which has be...

journal_title：Neurochemistry international

authors： Sinhababu AK,Borchardt RT

更新日期：1988-01-01 00:00:00

abstract：:Homozygous deletion or mutation in the survival motor neuron (SMN)1 gene causes proximal spinal muscular atrophy (SMA), whereas SMN2 acts as a modifying gene that can influence the severity of SMA. It has been suggested that restoration of the SMN protein level in neuronal cells may prevent cell loss and may be helpfu...

journal_title：Neurochemistry international

authors： Chang HC,Hung WC,Chuang YJ,Jong YJ

更新日期：2004-12-01 00:00:00

abstract：:A simple procedure for isolating a fraction enriched in synaptic plasma membrane (SPM) vesicles from sheep brain cortex is described and is used in studying uptake and release of [(3)H]GABA. The crude synaptosomal fraction was subjected to osmotic shock and the lysate was subfractioned in a discontinuous density gradi...

journal_title：Neurochemistry international

authors： Gonçalves PP,Santos MS,Carvalho AP

更新日期：1990-01-01 00:00:00

abstract：:Antibodies to electrolectin, a lectin endogenous to embryonic skeletal muscle, have been used to study the distribution of lectin during myogenesis in L(6) cells by using immunohistofluorescence microscopy. Evidence for both surface and cytoplasmic forms of lectin is presented. Cytoplasmic lectin does not appear to be...

journal_title：Neurochemistry international

authors： Podleski TR

更新日期：1980-01-01 00:00:00

abstract：:Diabetic neuropathy (DN) is a common form of peripheral neuropathy, yet the mechanisms responsible for chronic pain in this disease are poorly understood. The up-regulation of the expression and function of voltage-gated sodium channel Nav1.7 has been implicated in DN, however, the exact mechanism is unclear. In the p...

journal_title：Neurochemistry international

authors： Huang Y,Zang Y,Zhou L,Gui W,Liu X,Zhong Y

更新日期：2014-09-01 00:00:00