Dephosphorylation of purified brain tyrosine hydroxylase by rat striatal extracts.

abstract：:Bindings of glutamate receptor agonists and related modulators were investigated in 10 discrete tissues from gerbil brain using a biochemical technique. There appeared considerable discrepancies, in respect of intrahippocampal profiles, from reported data by autoradiography on rat brain. In the gerbil, an almost equiv...

journal_title：Neurochemistry international

authors： Kataoka K,Mitani A,Andou Y,Enomoto R,Ogita K,Yoneda Y

更新日期：1993-01-01 00:00:00

abstract：:A pre-requisite to understanding the physiological mechanisms of action of melatonin is the identification of the target sites where the hormone acts. The radioligand 2-[125I]iodo-melatonin has been used extensively to localize binding sites in both the brain and peripheral tissues. In general these binding sites have...

journal_title：Neurochemistry international

authors： Morgan PJ,Barrett P,Howell HE,Helliwell R

更新日期：1994-02-01 00:00:00

abstract：:A novel copper-containing protein has been isolated in electrophoretically homogeneous state from bovine brain extracts. Some physico-chemical properties of the protein are determined (molecular weight, copper content, isoelectric point, amino acid composition, optical and EPR spectra), and they are compared with thos...

journal_title：Neurochemistry international

authors： Mikaelyan MV,Nalbandyan RM

更新日期：1988-01-01 00:00:00

abstract：:A procedure for studying 5-hydroxytryptamine synthesis by determining the rate of accumulation of 5-hydroxytryptophan after administering m-hydroxybenzylhydrazine, an inhibitor of aromatic-l-amino acid decarboxylase, and large doses of l-tryptophan was characterized. The utility of this method as an index of 5-hydroxy...

journal_title：Neurochemistry international

authors： Nielsen JA

更新日期：1986-01-01 00:00:00

abstract：:Specific binding of [(3)H]d- fenfluramine , an anorectic agent acting on serotonergic system, was characterized in rat total brain minus cerebellum. The binding was reversible, stereospecific and with high affinity (K(d) about 80 nM). The receptor density in total brain was about 32 pmol/g tissue. Subcellular distribu...

journal_title：Neurochemistry international

authors： Mennini T,Gobbi M,Taddei C,Garattini S

更新日期：1988-01-01 00:00:00

abstract：:Long term consequence of non-fatal overdose in people who use opioids are not well understood. The intermittent exposure to non-fatal overdose leads to a tauopathy that is often accompanied by abrogated neuroprotective response, abnormal amyloid processing and other pathologies. The scope and limitations of available ...

journal_title：Neurochemistry international

authors： Voronkov M,Cocchiaro B,Stock JB

更新日期：2020-12-10 00:00:00

abstract：:Superfused rat cerebral cortex slices were submitted to a continuous electrical (5 Hz) stimulation and treated with sodium azide (1-10 mM) in the presence of 2 mM 2-deoxyglucose ("chemical ischemia"). Presynaptic cholinergic activity, evaluated as acetylcholine release, was inhibited depending on the sodium azide conc...

journal_title：Neurochemistry international

authors： Cavallini S,Marti M,Marino S,Selvatici R,Beani L,Bianchi C,Siniscalchi A

更新日期：2005-12-01 00:00:00

abstract：:We investigated whether alterations in glutamate metabolising glutamine synthetase activity occur in human epileptic neocortex, as shown previously for human epileptic hippocampus [Eid, T., Thomas, M.J., Spencer, D.D., Rundén-Pran, E., Lai, J.C.K., Malthankar, G.V., Kim, J.H., Danbolt, N.C., Ottersen, O.P., de Lanerol...

journal_title：Neurochemistry international

authors： Steffens M,Huppertz HJ,Zentner J,Chauzit E,Feuerstein TJ

更新日期：2005-11-01 00:00:00

abstract：:Iron accumulation is considered to be involved in the pathogenesis of Parkinson's disease. To demonstrate the relationship between peripheral iron overload and dopaminergic neuron loss in rat substantia nigra (SN), in the present study we used fast cyclic voltammetry, tyrosine hydroxylase (TH) immunohistochemistry, Pe...

journal_title：Neurochemistry international

authors： Jiang H,Song N,Wang J,Ren LY,Xie JX

更新日期：2007-07-01 00:00:00

abstract：:Adenosine is a neuromodulator that can control brain damage through activation of A(1), A(2A) and A(3) receptors, which are located in both neurons and other brain cells. We took advantage of cultured neurons to investigate the role of neuronal adenosine receptors in the control of neurotoxicity caused by kainate and ...

journal_title：Neurochemistry international

authors： Rebola N,Rodrigues RJ,Oliveira CR,Cunha RA

更新日期：2005-10-01 00:00:00

abstract：:One hour of ischemia significantly increased protein S100B release from rat brain slices without altering lactate dehydrogenase leakage. Reoxygenation of the ischemic slices, however, increased the levels of these biochemical markers in the medium. Although removal of extracellular Ca(+2) ions from the medium did not ...

journal_title：Neurochemistry international

authors： Büyükuysal RL

更新日期：2005-12-01 00:00:00

abstract：:The transmitter dopamine and the protein acetylcholinesterase are released within the substantia nigra from the dendrites of nigrostriatal neurons. These phenomena do not correspond to the familiar events involved in information transfer at the classic axons synapse. It is possible that both dopamine and acetylcholine...

journal_title：Neurochemistry international

authors： Greenfield SA

更新日期：1985-01-01 00:00:00

abstract：:A simple procedure for isolating a fraction enriched in synaptic plasma membrane (SPM) vesicles from sheep brain cortex is described and is used in studying uptake and release of [(3)H]GABA. The crude synaptosomal fraction was subjected to osmotic shock and the lysate was subfractioned in a discontinuous density gradi...

journal_title：Neurochemistry international

authors： Gonçalves PP,Santos MS,Carvalho AP

更新日期：1990-01-01 00:00:00

abstract：:The effects of mechanoreceptor stimulation and subsequent ATP release in cyclophosphamide evoked chronic bladder inflammation was examined to demonstrate: (1) whether inflammation modulates ATP release from bladder urothelium and (2) whether intravesical botulinum toxin A administration inhibits urothelial ATP release...

journal_title：Neurochemistry international

authors： Smith CP,Vemulakonda VM,Kiss S,Boone TB,Somogyi GT

更新日期：2005-09-01 00:00:00

abstract：:Recent data indicate that BMY 7378 demonstrates high affinity, selectivity and low intrinsic activity at hippocampal 5-HT(1A) receptors, suggesting that BMY 7378 may represent the first selective 5-HT(1A) functional antagonist. The present study examined the agonist and antagonist properties of BMY 7378 at spinal cord...

journal_title：Neurochemistry international

authors： Zemlan FP,Zieleniewski-Murphy A,Maureen Murphy R,Behbehani MM

更新日期：1990-01-01 00:00:00

abstract：:The discovery of nonsynaptic communication in the 1960s and 1970s was an important milestone in investigating the function of the nervous system, and it revolutionized our view about information transmission between neurons. In addition, nonsynaptic communication has a practical importance not only within the nervous ...

journal_title：Neurochemistry international

authors： Selmeczy Z,Vizi ES,Csóka B,Pacher P,Haskó G

更新日期：2008-01-01 00:00:00

abstract：:Rabbit retinas were maintained in vitro in medium resembling cerebrospinal fluid and were exposed to (3)H-leucine or (14)C-leucine in double-labeling experiments designed to measure rates of protein turnover and to determine the effects of photic stimulation on protein synthesis and degradation. The retinas were solub...

journal_title：Neurochemistry international

authors： Ames A 3rd,Parks JM,Nesbett FB

更新日期：1980-01-01 00:00:00

abstract：:We have previously demonstrated that acute hyperhomocysteinemia induces oxidative stress in rat brain. In the present study, we initially investigated the effect of chronic hyperhomocysteinemia on some parameters of oxidative damage, namely total radical-trapping antioxidant potential and activities of antioxidant enz...

journal_title：Neurochemistry international

authors： Matté C,Mackedanz V,Stefanello FM,Scherer EB,Andreazza AC,Zanotto C,Moro AM,Garcia SC,Gonçalves CA,Erdtmann B,Salvador M,Wyse AT

更新日期：2009-01-01 00:00:00

abstract：:Following intravitreal injections of (35)S-amino acids to label axonally transported proteins, calpain I and II from the superior colliculi and the lateral geniculate bodies were isolated via hydrophobic interaction chromatography, anion exchange HPLC and sodium-dodecyl sulphate electrophoresis. Among the slowly trans...

journal_title：Neurochemistry international

authors： Nilsson E,Karlsson JO

更新日期：1990-01-01 00:00:00

abstract：:Two signaling pathways, phosphoinositide 3-kinase (PI-3k)/Akt and Ras/MAPK, are major effectors triggered by nerve growth factor (NGF). Rac1, Cdc42 and GSK-3beta are reported to be targets of PI-3k in the signal transduction for neurite outgrowth. Immediately after NGF was added, broad ruffles were observed temporaril...

journal_title：Neurochemistry international

authors： Jin E,Nosaka K,Sano M

更新日期：2007-07-01 00:00:00

abstract：:GM1 ganglioside, after intravenous injection into rats, is absorbed and taken up by various organs and tissues, including brain. The capacity of brain to take up gangliosides, referred to weight unit, is comparable to that of kidney and muscle. After injection of [Gal-(3)H]GM1 a relevant portion of brain associated ra...

journal_title：Neurochemistry international

authors： Ghidoni R,Fiorilli A,Trinchera M,Venerando B,Chigorno V,Tettamanti G

更新日期：1989-01-01 00:00:00

abstract：:The possible influence of cholinergic and dopaminergic mechanisms on neurotensin-containing neurones was examined at two different levels; nucleus accumbens and striatum in the rat brain. The acute treatment with the anticholinergic drugs atropine and scopolamine increased neurotensin concentrations in the striatum an...

journal_title：Neurochemistry international

authors： Frey P,Lis M,Coward DM

更新日期：1988-01-01 00:00:00

abstract：:A single molecular species of GTP-binding protein (G protein) has been purified from the bovine cerebral cortex. The immunoblot analysis indicated that the isolated G protein might be Gi1 or Gi2 but not Go, since it was reacted by specific antibodies, anti-Gi alpha 1-2 and anti-Gi alpha 1-1, but not anti-Go alpha. Whe...

journal_title：Neurochemistry international

authors： Nishikawa M,Hirouchi M,Kuriyama K

更新日期：1997-07-01 00:00:00

abstract：:Zellweger syndrome (ZS) is a neonatal-lethal genetic disease that affects all tissues, and features neuropathology that involves primary developmental defects as well as neurodegeneration. Neuropathological changes include abnormal neuronal migration affecting the cerebral hemispheres, cerebellum and inferior olivary ...

journal_title：Neurochemistry international

authors： Crane DI

更新日期：2014-04-01 00:00:00

abstract：:Malfunctioning of high-affinity glutamate transporters is believed to contribute to the accumulation of toxic concentrations of glutamate and, thus, trigger the cellular mechanisms of neurodegeneration. Emerging data point to the presence of excitotoxic component in Alzheimer's disease (AD) and aberrant expression of ...

journal_title：Neurochemistry international

authors： Rodriguez-Kern A,Gegelashvili M,Schousboe A,Zhang J,Sung L,Gegelashvili G

更新日期：2003-09-01 00:00:00

abstract：:In the present study we have investigated the relationship between serotonergic receptor(s) (5-HTR) and muscarinic cholinergic receptor (mAChR) activation, leading to the arachidonic acid (AA) release and inositol phosphates (IPs) formation in adult and aged brain cortex synaptoneurosomes. It was observed that seroton...

journal_title：Neurochemistry international

authors： Samochocki M,Strosznajder J

更新日期：1995-06-01 00:00:00

abstract：:Microglial activation has been implicated in neurodegenerative diseases. Therefore, inhibition of inflammation mediated by microglia is a strategy in neurodegenerative disease therapy. In this study, we isolated cryptotanshinone and 15,16-dihydrotanshinone I from Salvia miltiorrhiza, a traditional Korean herb medicine...

journal_title：Neurochemistry international

authors： Lee P,Hur J,Lee J,Kim J,Jeong J,Kang I,Kim SY,Kim H

更新日期：2006-01-01 00:00:00

abstract：:In the past few years, several studies have demonstrated in the rat subcommissural organ the presence of nerve endings and modified ependymocytes showing an uptake of [(3)H]GABA. The present work was performed to demonstrate in this cerebral zone the possibility of a GABA synthesis by the immunohistochemical localizat...

journal_title：Neurochemistry international

authors： Weissmann-Nanopoulos D,Belin MF,Didier M,Aguera M,Partisani M,Maitre M,Pujol JF

更新日期：1983-01-01 00:00:00

abstract：:Recent in vivo studies have established astrocytes as a major target for locus coeruleus activation (Bekar et al., 2008), renewing interest in cell culture studies on noradrenergic effects on astrocytes in primary cultures and calling for additional information about the expression of adrenoceptor subtypes on differen...

journal_title：Neurochemistry international

authors： Hertz L,Lovatt D,Goldman SA,Nedergaard M

更新日期：2010-11-01 00:00:00

abstract：:Ghrelin, a 28 amino acid brain-gut peptide, has attracted increasing attention for its neuroprotective effect in Parkinson's disease (PD). In view of the pivotal role of excitability of dopaminergic neurons in substantia nigra pars compacta (SNc) in the function of nigrostriatal system, it is of great significance to ...

journal_title：Neurochemistry international

authors： Chang X,Ma Z,Shi L,Xie J

更新日期：2020-09-01 00:00:00