Abstract：
:In the past few years, several studies have demonstrated in the rat subcommissural organ the presence of nerve endings and modified ependymocytes showing an uptake of [(3)H]GABA. The present work was performed to demonstrate in this cerebral zone the possibility of a GABA synthesis by the immunohistochemical localization of glutamate decarboxylase (GAD). GAD-positive reaction was detected with unlabelled antibody-enzyme peroxidase anti-peroxidase. Some nerve terminals containing either clear round vesicles, or sometimes clear round vesicles and some large granular vesicles, exhibited a positive staining. These terminals could belong to GABAergic inputs in the subcommissural organ. The few reactive terminals containing some granular vesicles could be related to the serotoninergic input as suggested previously (Gamrani et al., 1981). Several ependymocytes of this structure contained GAD-like positive reaction; these cells are also capable of taking up [(3)H]GABA (Gamrani et al., 1981) and present neuronal properties with regard to GABA. However, the presence in their cytoplasm of ?? enolase, a specific glial marker, related them to glial elements. The presence of GABA in these ependymocytes suggests a modulating function of GABA on the secretory activity of the subcommissural organ.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Weissmann-Nanopoulos D,Belin MF,Didier M,Aguera M,Partisani M,Maitre M,Pujol JFdoi
10.1016/0197-0186(83)90105-5subject
Has Abstractpub_date
1983-01-01 00:00:00pages
785-91issue
6eissn
0197-0186issn
1872-9754pii
0197-0186(83)90105-5journal_volume
5pub_type
杂志文章abstract：:We demonstrate the feasibility and usefulness of the histoblot immunostaining of cryosections of whole hemispheres of healthy and Alzheimer diseased (AD) human brains by localizing a neuron-specific marker, the anti-neuronal nuclei (NeuN) antigen. As expected, cortical NeuN-immunopositive regions were generally thinne...
journal_title：Neurochemistry international
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journal_title：Neurochemistry international
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更新日期：1995-01-01 00:00:00
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