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Functional coupling of Gi subtype with GABAB receptor/adenylyl cyclase system: analysis using a reconstituted system with purified GTP-binding protein from bovine cerebral cortex.

Abstract：

:A single molecular species of GTP-binding protein (G protein) has been purified from the bovine cerebral cortex. The immunoblot analysis indicated that the isolated G protein might be Gi1 or Gi2 but not Go, since it was reacted by specific antibodies, anti-Gi alpha 1-2 and anti-Gi alpha 1-1, but not anti-Go alpha. When the Gi protein was reconstituted into phospholipid vesicles with partially purified GABAB receptor and adenylyl cyclase, the stimulation of GABAB receptor by its agonists induced the inhibition of forskolin-stimulated cAMP accumulation. This GABA-induced inhibition was abolished by CGP 55845A, an antagonist of GABAB receptor. These results suggest that a Gi subtype, which was suggested to correspond to Gi1 or Gi2 may be functionally coupled with GABAB receptor/adenylyl cyclase system.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Nishikawa M,Hirouchi M,Kuriyama K

doi

10.1016/s0197-0186(96)00138-6

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

21-5

issue

1

eissn

0197-0186

issn

1872-9754

pii

S0197-0186(96)00138-6

journal_volume

31

pub_type

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