当前位置： SCI文献检索 > NEUROCHEMISTRY INTERNATIONAL期刊下所有文献 > The negative coupling between serotonin and muscarinic receptor(s) for arachidonic acid and inositol phosphates release in brain cortex synaptoneurosomes. Effect of aging.

The negative coupling between serotonin and muscarinic receptor(s) for arachidonic acid and inositol phosphates release in brain cortex synaptoneurosomes. Effect of aging.

Abstract：

:In the present study we have investigated the relationship between serotonergic receptor(s) (5-HTR) and muscarinic cholinergic receptor (mAChR) activation, leading to the arachidonic acid (AA) release and inositol phosphates (IPs) formation in adult and aged brain cortex synaptoneurosomes. It was observed that serotonin (5-HT) almost completely inhibits carbachol-stimulated AA release in adult brain. This negative coupling between 5-HTR and mAChR probably depends on the direct stimulation of the acylation reaction coupled with 5-HT1AR. In the aged brain this type of interaction does not occur because aging eliminates carbachol and 5-HT effect. On the other hand, in aged brain, both 5-HT and carbachol more actively stimulate IPs accumulation than in adult brain. Serotonin inhibits carbachol-stimulated IPs release to the level observed during 5-HT2R activation. Our study indicates for the first time, the negative coupling between 5-HTR and mAChR for AA liberation in adult brain and a lack of this kind of receptors interaction in senescent brain. In adult brain, 5-HT1AR-stimulated AA incorporation is responsible for this coupling. Moreover, serotonin through the stimulation of 5-HT2R, suppresses mAChR-dependent IPs liberation in adult and aged brain similarly. The interactions between these two neurotransmitter receptors lead to the modification of lipid mediators formation and may have important implications in alteration of signal transduction in adult and in aged brain.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Samochocki M,Strosznajder J

doi

10.1016/0197-0186(95)00001-o

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

571-8

issue

6

eissn

0197-0186

issn

1872-9754

pii

019701869500001O

journal_volume

26

pub_type

杂志文章

相关文献

NEUROCHEMISTRY INTERNATIONAL文献大全
  • Caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid up-regulate NQO1 expression and prevent H₂O₂-induced apoptosis in primary cortical neurons.

    abstract：:Neurodegenerative disorders are strongly associated with oxidative stress, which is induced by reactive oxygen species including hydrogen peroxide (H₂O₂). Epidemiological studies have suggested that coffee may be neuroprotective, but the molecular mechanisms underlying this effect have not been clarified. In this stud...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2012.02.004

    authors： Kim J,Lee S,Shim J,Kim HW,Kim J,Jang YJ,Yang H,Park J,Choi SH,Yoon JH,Lee KW,Lee HJ

    更新日期：2012-04-01 00:00:00

  • Metabolism of [1-(13)C)glucose and [2-(13)C]acetate in the hypoxic rat brain..

    abstract：:The effects of hypoxia on the metabolism of the central nervous system were investigated in rats submitted to a low oxygen atmosphere (8% O(2); 92% N(2)). [1-(13)C]glucose and [2-(13)C]acetate were used as substrates, this latter being preferentially metabolized by glial cells. After 1-h substrate infusion, the incorp...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(00)00106-6

    authors： Chateil J,Biran M,Thiaudière E,Canioni P,Merle M

    更新日期：2001-04-01 00:00:00

  • The regulation of corticosteroid receptors in response to chronic social defeat.

    abstract：:Our previous studies demonstrated that chronic social defeat (CSD) up-regulated expression of the serotonin transporter (SERT) and norepinephrine transporter (NET) in the brain, which was mediated by corticosteroid receptors. In the present study we first analyzed the alterations of corticosteroid receptors in differe...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2017.05.021

    authors： Zhang J,Fan Y,Raza MU,Zhan Y,Du XD,Patel PD,Zhu MY

    更新日期：2017-09-01 00:00:00

  • Effect of bimoclomol (N-[2-hydroxy-3-(1-piperidinyl) propoxy]-3 pyridine-carboximidoyl-chloride) on iminodipropionitrile-induced central effects.

    abstract：:Dyskinesia is frequently seen in neurological disorders affecting the basal ganglia. Iminodipropionitrile (IDPN) produces a somewhat similar motor syndrome in rodents, one that is a possible model for dyskinesia. Because in previous studies the compound (N-[2-hydroxy-3-(1-piperidinyl) propoxy]-3 pyridine-carboximidoyl...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(98)00058-8

    authors： Tóth E,Gerevich Z,Dóda M,Lajtha A

    更新日期：1998-12-01 00:00:00

  • Effect of artemisinin on neuropathic pain mediated by P2X4 receptor in dorsal root ganglia.

    abstract：:Neuropathic pain is a type of chronic pain caused by nervous system damage and dysfunction. The pathogenesis of chronic pain is complicated, and there are no effective therapies for neuropathic pain. Studies show that the P2X4 receptor expressed in the satellite glial cells (SGCs) of dorsal root ganglia (DRG) is relat...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2017.02.004

    authors： Ying M,Liu H,Zhang T,Jiang C,Gong Y,Wu B,Zou L,Yi Z,Rao S,Li G,Zhang C,Jia T,Zhao S,Yuan H,Shi L,Li L,Liang S,Liu S

    更新日期：2017-09-01 00:00:00

  • Neurons and astrocytes in an infantile neuroaxonal dystrophy (INAD) mouse model show characteristic alterations in glutamate-induced Ca2+ signaling.

    abstract：:INAD (infantile neuroaxonal dystrophy, OMIM#256600), an autosomal recessive inherited degenerative disease, is associated with PLA2G6 mutations. PLA2G6 encodes Ca2+-independent phospholipase A2 (VIA iPLA2). However, it is unclear how the PLA2G6-mutations lead to disease. Non-canonical functions, which were suggested f...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2017.03.004

    authors： Strokin M,Reiser G

    更新日期：2017-09-01 00:00:00

  • NR2A and NR2B subunits differentially mediate MAP kinase signaling and mitochondrial morphology following excitotoxic insult.

    abstract：:NMDA receptors are essential for neurotransmission and key mediators of synaptic signaling, but they can also trigger deleterious degenerative processes that lead to cell death. Growing evidence suggests that selective blockade of the heterogeneous subunits that comprise the NMDA receptor may enable better control of ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2012.02.007

    authors： Choo AM,Geddes-Klein DM,Hockenberry A,Scarsella D,Mesfin MN,Singh P,Patel TP,Meaney DF

    更新日期：2012-04-01 00:00:00

  • Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus.

    abstract：:To identify whether the process of apoptosis bears a topographic relationship to selected aspects of Alzheimer's disease (AD) pathology, we used an in situ nick translation method (TUNEL) to map DNA fragmentation in hippocampal sections immunostained for abnormally phosphorylated tau, which exists in the neurofibrilla...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(96)00158-1

    authors： Sugaya K,Reeves M,McKinney M

    更新日期：1997-08-01 00:00:00

  • Decrease of glutamate decarboxylase activity after in vivo cortical infusion of gamma-aminobutyric acid.

    abstract：:gamma-Aminobutyric acid (GABA) levels and the activity of glutamate decarboxylase were measured in homogenates of rat brain cortical tissue, at different times after chronic intracortical infusion of GABA in vivo during 2, 6 or 24 h. Cortical electrical activity was also recorded. As previously described, about 1 h af...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(94)90114-7

    authors： Salazar P,Montiel T,Brailowsky S,Tapia R

    更新日期：1994-04-01 00:00:00

  • Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue.

    abstract：:Cyclooxygenase 2 inhibitors (COX 2) such as parecoxib (par) and valdecoxib (val) are used in the treatment of neuropathic pain. Using the radioligand binding assay it was demonstrated that both the prodrug par as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2010.10.018

    authors： Schröder H,Höllt V,Becker A

    更新日期：2011-01-01 00:00:00

  • Regulation of gene expression by natural antisense RNA transcripts.

    abstract：:The use of synthetic antisense oligonucleotides as specific inhibitors of gene expression exploits the susceptibility of mRNA to functional blockade at several levels, including mRNA processing, transport, translation and degradation. It is becoming increasingly apparent that the actions of these synthetic oligomers a...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/s0197-0186(96)00108-8

    authors： Knee R,Murphy PR

    更新日期：1997-09-01 00:00:00

  • Gallamine and tubocurarine as possible allosteric modifiers of soluble acetylcholinesterase activity at physiological ionic strength.

    abstract：:Esters of dimethylcarbamic acid are known to be poor substrates of acetylcholinesterase. They carbamylate the active catalytic site of the enzyme and the subsequent decarbamylation is a slow but measurable process. Similarly, acetylcholinesterase can be phosphonylated, and the dephosphonylation is extremely slow. Rapi...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(81)90061-9

    authors： Dawson RM,Poretski M,Upsher CM

    更新日期：1981-01-01 00:00:00

  • Repeated exposure to methiopropamine increases dendritic spine density in the rat nucleus accumbens core.

    abstract：:Repeated exposure to classical psychomotor stimulants, like amphetamine (AMPH), produces locomotor sensitization and accompanied structural plasticity of dendritic spines in the nucleus accumbens (NAcc). Following our previous report that repeated administration of methiopropamine (MPA), a structural analog to meth-AM...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2019.104487

    authors： Cai WT,Yoon HS,Lee S,Kim JH

    更新日期：2019-10-01 00:00:00

  • Pharmacologic modeling of primary mitochondrial respiratory chain dysfunction in zebrafish.

    abstract：:Mitochondrial respiratory chain (RC) disease is a heterogeneous and highly morbid group of energy deficiency disorders for which no proven effective therapies exist. Robust vertebrate animal models of primary RC dysfunction are needed to explore the effects of variation in RC disease subtypes, tissue-specific manifest...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2017.07.008

    authors： Byrnes J,Ganetzky R,Lightfoot R,Tzeng M,Nakamaru-Ogiso E,Seiler C,Falk MJ

    更新日期：2018-07-01 00:00:00

  • Ageing and monoamine turnover in the lateral geniculate nucleus and visual cortex of the rat.

    abstract：:The effects of ageing on the turnover of dopamine, noradrenaline and serotonin in the lateral geniculate nucleus and the visual cortex were evaluated, using high performance liquid chromatography (HPLC) with electrochemical detection. Compared to adult animals, aged rats showed more changes in the visual cortex than i...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(93)90027-3

    authors： Herrera AJ,Machado A,Cano J

    更新日期：1993-06-01 00:00:00

  • Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipin.

    abstract：:Aging is a biological process characterized by impairment of cellular bioenergetic function, increased oxidative stress, attenuated ability to respond to stresses, increased risk of contracting age-associated disorders that affects many tissues, with a more marked effect on brain and heart function. Oxidative stress i...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuint.2010.12.016

    authors： Paradies G,Petrosillo G,Paradies V,Ruggiero FM

    更新日期：2011-03-01 00:00:00

  • The significance of dendritic release of transmitter and protein in the substantia nigra.

    abstract：:The transmitter dopamine and the protein acetylcholinesterase are released within the substantia nigra from the dendrites of nigrostriatal neurons. These phenomena do not correspond to the familiar events involved in information transfer at the classic axons synapse. It is possible that both dopamine and acetylcholine...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(85)90136-6

    authors： Greenfield SA

    更新日期：1985-01-01 00:00:00

  • Revisiting the neuropathogenesis of Zellweger syndrome.

    abstract：:Zellweger syndrome (ZS) is a neonatal-lethal genetic disease that affects all tissues, and features neuropathology that involves primary developmental defects as well as neurodegeneration. Neuropathological changes include abnormal neuronal migration affecting the cerebral hemispheres, cerebellum and inferior olivary ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuint.2014.02.007

    authors： Crane DI

    更新日期：2014-04-01 00:00:00

  • Brain edema in diseases of different etiology.

    abstract：:Cerebral edema is a potentially life-threatening complication shared by diseases of different etiology, such as diabetic ketoacidosis, acute liver failure, high altitude exposure, dialysis disequilibrium syndrome, and salicylate intoxication. Pulmonary edema is also habitually present in these disorders, indicating th...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuint.2012.05.007

    authors： Adeva MM,Souto G,Donapetry C,Portals M,Rodriguez A,Lamas D

    更新日期：2012-07-01 00:00:00

  • Differential effect of acute reserpine administration on D-1 and D-2 dopaminergic receptor density and function in rat striatum.

    abstract：:In the present study we investigated the effects of a single injection of reserpine on dopamine receptor function in rat striatum. The measurement of adenylate cyclase activity indicated that cAMP formation induced by the selective D-1 agonist SKF 82526 was greatly increased 2 and 20 h after reserpine; in contrast, th...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(89)90010-7

    authors： Liberini P,Nisoli E,Missale C,Memo M,Buonamici M,Rossi A,Spano PF

    更新日期：1989-01-01 00:00:00

  • Matching kinetics of synaptic vesicle recycling and enhanced neurotransmitter influx by Ca2+ in brain plasma membrane vesicles.

    abstract：:Using native plasma membrane vesicle suspensions from the rat cerebral cortex under conditions designed to alter intravesicular [Ca2+], we found that Ca2+ induced 47 +/- 5% more influx of [3H]GABA, [3H]D-aspartate and [3H]glycine at 37 degrees C with half-times 1.7 +/- 0.5, 1.3 +/- 0.4 and 1.3 +/- 0.4 min, respectivel...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(98)00039-4

    authors： Kovács I,Szárics E,Nyitrai G,Blandl T,Kardos J

    更新日期：1998-11-01 00:00:00

  • Neurotransmitters in the CNS of the vitamin D deficient, hypocalcemic rat.

    abstract：:Sprague-Dawley rats were made chronically vitamin D deficient (VDD) and hypocalcemic, or VDD and normocalcemic. Rickets, severely reduced body weight, hair shedding, lethargy, muscular paralysis and a high mortality rate are characteristic features of the male VDD/hypocalcemic animals. An assessment was made of the ne...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(91)90192-g

    authors： Tenenhouse A,Warner M,Commissiong JW

    更新日期：1991-01-01 00:00:00

  • MicroRNAs in cancer: glioblastoma and glioblastoma cancer stem cells.

    abstract：:MicroRNAs represent an abundant class of endogenously expressed 18-25 nucleotide non-coding RNA molecules that function to silence gene expression through a process of post-transcriptional modification. They exhibit varied and widespread functions during normal development and tissue homeostasis, and accordingly their...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuint.2014.06.002

    authors： Brower JV,Clark PA,Lyon W,Kuo JS

    更新日期：2014-11-01 00:00:00

  • Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder.

    abstract：:Increased concentrations of kynurenine pathway metabolites have been reported by several groups for disorders involving psychosis, including schizophrenia and bipolar disorder. To identify components of the pathway that may be relevant as biomarkers or may underlie the etiology of psychosis, it is essential to charact...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2008.01.013

    authors： Miller CL,Llenos IC,Cwik M,Walkup J,Weis S

    更新日期：2008-05-01 00:00:00

  • Functional partial agonism at ionotropic excitatory amino acid receptors.

    abstract：:(RS)-2-Amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid (APPA), which is an analogue of (RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA), shows the characteristics of a partial AMPA receptor agonist. Since (S)-APPA is a full AMPA agonist and (R)-APPA a competitive antagonist, the partial ag...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(95)00151-4

    authors： Ebert B,Madsen U,Søby KK,Krogsgaard-Larsen P

    更新日期：1996-09-01 00:00:00

  • R659S mutation of gammaPKC is susceptible to cell death: implication of this mutation/polymorphism in the pathogenesis of retinitis pigmentosa.

    abstract：:It has been reported that mutations of gammaPKC cause hereditary spinocerebellar atrophy type 14 (SCA14). Our recent study has revealed that the SCA14 mutant gammaPKC is susceptible to aggregation and causes cell death. Among mutations/polymorphisms of gammaPKC, the R659S mutation was firstly segregated from families ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2006.05.005

    authors： Mochizuki H,Seki T,Adachi N,Saito N,Mishima HK,Sakai N

    更新日期：2006-12-01 00:00:00

  • Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells.

    abstract：:Gliomas are the most common and malignant primary brain tumours and are associated with a poor prognosis despite the availability of multiple therapeutic options. Quercetin, a traditional Chinese medicinal herb, is an important flavonoid and has anti-cancer activity. Here, we evaluated whether quercetin could inhibit ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2014.12.001

    authors： Pan HC,Jiang Q,Yu Y,Mei JP,Cui YK,Zhao WJ

    更新日期：2015-01-01 00:00:00

  • Modifiable risk factors promoting neurodegeneration is associated with two novel brain degradation markers measured in serum.

    abstract：:There has been limited success with blood-based biomarkers of neurodegeneration. One perceived reason is that blood has no direct contact to the brain. Recently developed blood-based biomarkers of tau-degradation have shown promise as potential tools for peripheral assessment of neurodegeneration; however, factors con...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2017.05.002

    authors： Neergaard JS,Dragsbæk K,Christiansen C,Nielsen HB,Workman CT,Brix S,Henriksen K,Karsdal MA

    更新日期：2017-09-01 00:00:00

  • Copper disrupts S-nitrosothiol signaling in activated BV2 microglia.

    abstract：:Microglia, the primary resident immune cells of the central nervous system (CNS), responds rapidly to pathogens and injury by secreting immune mediators including nitric oxide (NO). The reaction of NO with the anti-oxidant glutathione forms S-nitrosoglutathione (GSNO), the major pool of biologic NO in the body. GSNO i...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2016.05.011

    authors： Rossi-George A,Guo CJ

    更新日期：2016-10-01 00:00:00

  • Electrical high frequency stimulation modulates GABAergic activity in the nucleus accumbens of freely moving rats.

    abstract：:Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is an effective treatment option for those affected by obsessive compulsive disorder, who do not respond to pharmacological treatment strategies. Yet, little is known about the mechanism by which DBS achieve its therapeutic effects. Previous studies have show...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2015.10.002

    authors： Varatharajan R,Joseph K,Neto SC,Hofmann UG,Moser A,Tronnier V

    更新日期：2015-11-01 00:00:00