Abstract:
:Cyclooxygenase 2 inhibitors (COX 2) such as parecoxib (par) and valdecoxib (val) are used in the treatment of neuropathic pain. Using the radioligand binding assay it was demonstrated that both the prodrug par as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue. Agonist activity was detected by GTPγS assays, cAMP formation experiments and ex vivo modulation of glutamate and GABA release of the rat brain tissue. In comparison to the specific cannabinoid agonist, WIN 55,212-2, the two COX 2 inhibitors are about 2 orders of magnitude less potent. The data suggest that the analgesic effects of par and its metabolite val in Wistar rats may be at least partially mediated by a direct interaction with the CB1 receptors. The COX 2 inhibitors appear to be a hypothetically useful tool for add-on therapy of neuropathic pain.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Schröder H,Höllt V,Becker Adoi
10.1016/j.neuint.2010.10.018subject
Has Abstractpub_date
2011-01-01 00:00:00pages
9-13issue
1eissn
0197-0186issn
1872-9754pii
S0197-0186(10)00331-1journal_volume
58pub_type
杂志文章abstract::Ubiquitin (Ub) carboxy terminal hydrolase (UCH)-L1 and UCH-L3 are two of the deubiquitinating enzymes expressed in the brain. Both gad mice, which lack UCH-L1 expression and Uchl3 knockout mice exhibit neurodegeneration, although at distinct areas. These phenotypes indicate the importance of UCH-L1 and UCH-L3 in the r...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2008.12.013
更新日期:2009-05-01 00:00:00
abstract::MicroRNAs represent an abundant class of endogenously expressed 18-25 nucleotide non-coding RNA molecules that function to silence gene expression through a process of post-transcriptional modification. They exhibit varied and widespread functions during normal development and tissue homeostasis, and accordingly their...
journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2014.06.002
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abstract::Chronic pain states and epilepsies are common therapeutic targets of voltage-gated sodium channel blockers. Inhibition of sodium channels results in central muscle relaxant activity as well. Selective serotonin reuptake inhibitors are also applied in the treatment of pain syndromes. Here, we investigate the pharmacody...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2006.12.008
更新日期:2007-03-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 评论,信件
doi:10.1016/j.neuint.2009.07.013
更新日期:2010-01-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2017.01.015
更新日期:2017-12-01 00:00:00
abstract::Tau isoforms constitute a family of microtubule-associated proteins that are mainly expressed in neurons of the central nervous system. They promote the assembly of tubulin monomers into microtubules and modulate their stability, thus playing a key structural role in the distal portion of axons. In Alzheimer's disease...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2011.02.010
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2009.05.007
更新日期:2009-12-01 00:00:00
abstract::Glutamine has multiple physiological and pathophysiological roles in the brain. Because of their position at the interface between blood and brain, the cerebral capillaries and the choroid plexuses that form the blood-brain barriers (BBB) and blood-cerebrospinal fluid (CSF) barriers, have the potential to influence br...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/s0197-0186(03)00013-5
更新日期:2003-09-01 00:00:00
abstract::Several glycoproteins in mammalian brains contain α2,8-linked disialic acid residues. We previously showed a constant expression of disialic acid (DiSia) in the hippocampus, olfactory bulb and cortex, and a gradual decrease of expression in the cerebellum from neonatal to senile mice. Previous publications indicate th...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2013.07.013
更新日期:2013-11-01 00:00:00
abstract::The cardiovascular and pulmonary responses to vasoactive intestinal contractor (VIC) were compared with those of endothelin (ET)-1, ET-2, ET-3 and sarafotoxin 6b (S6b) and the mechanism by which ET-1 alters vascular resistance was investigated in the hindquarters vascular bed of the cat. In a manner similar to ET-1 an...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/0197-0186(91)90154-6
更新日期:1991-01-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/s0197-0186(99)00107-2
更新日期:2000-02-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2008.12.018
更新日期:2009-07-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2011.01.019
更新日期:2011-05-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/s0197-0186(99)00125-4
更新日期:2000-03-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/0197-0186(85)90131-7
更新日期:1985-01-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/s0197-0186(02)00045-1
更新日期:2002-11-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2011.12.011
更新日期:2012-02-01 00:00:00
abstract::The effects of N-methyl-norsalsolinol on basal and inhibited activity of monoamine oxidase (MAO) in membrane preparations from the caudate nucleus of the rat have been studied. For the first time, the physiological step of dopamine oxidation to 3, 4 dihydroxyphenylacetic aldehyde (DPAA) was examined. N-methyl-norsalso...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/0197-0186(95)00048-d
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/s0197-0186(01)00109-7
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2004.03.005
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journal_title:Neurochemistry international
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更新日期:1987-01-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2016.05.014
更新日期:2016-10-01 00:00:00
abstract::The impact of dietary factors on brain health and vulnerability to disease is increasingly appreciated. The results of epidemiological studies, and intervention trials in animal models suggest that diets rich in phytochemicals can enhance neuroplasticity and resistance to neurodegeneration. Here we describe how intera...
journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2015.03.009
更新日期:2015-10-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/s0197-0186(96)00147-7
更新日期:1997-08-01 00:00:00
abstract::Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is an effective treatment option for those affected by obsessive compulsive disorder, who do not respond to pharmacological treatment strategies. Yet, little is known about the mechanism by which DBS achieve its therapeutic effects. Previous studies have show...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2015.10.002
更新日期:2015-11-01 00:00:00
abstract::In chicks submitted to light stimulation, the synthesis of gangliosides of the retina ganglion cell increases with respect to chicks maintained in the dark. In an attempt to elucidate if the activation of glycosyltransferases participates in the establishment of these light-dark differences detected in vivo, we examin...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/s0197-0186(96)00128-3
更新日期:1997-07-01 00:00:00
abstract::In recent years there has been a great deal of research within the stem cell field which has led to the definition and classification of a range of stem cells from a plethora of tissues and organs. Stem cells, by classification, are considered to be pluri- or multipotent and have both self-renewal and multi-differenti...
journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2016.08.001
更新日期:2017-06-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2011.03.006
更新日期:2011-06-01 00:00:00
abstract::An intraocular injection of [(3)H]proline was used to label rabbit retinal ganglion cells including components subjected to axonal transport. Degradation of rapidly axonally transported labelled proteins was estimated in an in vitro system using homogenates of the nerve terminal regions. The energy requirements of thi...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/0197-0186(85)90061-0
更新日期:1985-01-01 00:00:00
abstract::Precise anatomical distribution of 5HT1 binding sites has been investigated in the nuclei raphe dorsalis, raphe centralis and locus caeruleus of the rat brain. An original pattern of distribution was observed in the raphe nuclei, closely correlated to the already known distribution of 5HT containing elements. This pat...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/0197-0186(85)90156-1
更新日期:1985-01-01 00:00:00