MicroRNAs in cancer: glioblastoma and glioblastoma cancer stem cells.

abstract：:Alcohol addiction is a worldwide concern as its detrimental effects go far beyond the addicted individual and can affect the entire family as well as the community. Considerable effort is being expended in understanding the neurobiological basis of such addiction in hope of developing effective prevention and/or inter...

journal_title：Neurochemistry international

authors： Reglodi D,Toth D,Vicena V,Manavalan S,Brown D,Getachew B,Tizabi Y

更新日期：2019-03-01 00:00:00

abstract：:The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during n...

journal_title：Neurochemistry international

authors： Chia WJ,Tan FC,Ong WY,Dawe GS

更新日期：2015-08-01 00:00:00

abstract：:The presence of acetylcholinesterase (AChE) mRNA and activity in the tissues and cells involved in immune responses prompted us to investigate the level and pattern of AChE components in spleen. AChE activity was higher in mouse spleen (0.46 +/- 0.13 micromol of acetylthiocholine split per hour and per mg protein) tha...

journal_title：Neurochemistry international

authors： Nieto-Cerón S,Moral-Naranjo MT,Muñoz-Delgado E,Vidal CJ,Campoy FJ

更新日期：2004-07-01 00:00:00

abstract：:The evolving role of mitochondria as a target for different death-inducing noxae prompted us to investigate trimethyltin (TMT)-dependent effects on mitochondrial functionality. For this purpose, we used a homogeneous cell culture model represented by undifferentiated PC12 cells. Mitochondria isolated from PC12 cells t...

journal_title：Neurochemistry international

authors： Misiti F,Orsini F,Clementi ME,Lattanzi W,Giardina B,Michetti F

更新日期：2008-05-01 00:00:00

abstract：:The effects of a cerebral anti-ischemic drug ifenprodil on the receptor ionophore complex of an N-methyl-D-aspartate (NMDA)-sensitive subclass of central excitatory amino acid receptors were examined using [3H](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10- imine (MK-801) binding in rat brain synaptic memb...

journal_title：Neurochemistry international

authors： Ogita K,Ohkawara A,Suzuki T,Ohgaki T,Uchida S,Meguri H,Yoneda Y

更新日期：1992-07-01 00:00:00

abstract：:Chronic ingestion of caffeine causes dependence and sleep disturbance in children and adolescents. In rodents, the administration of caffeine may produce behavioral cross-sensitization to some psychostimulants, such as dopaminergic psychoactive drugs. Methylphenidate (MPH; Ritalin) is a psychostimulant used in pediatr...

journal_title：Neurochemistry international

authors： Boeck CR,Marques VB,Valvassori SS,Constantino LC,Rosa DV,Lima FF,Romano-Silva MA,Quevedo J

更新日期：2009-09-01 00:00:00

abstract：:Concanavalin A-binding glycoprotein with 250 K M(r) found in the postsynaptic density (PSD)-enriched preparation (or synaptic cytoskeleton) from rat cerebellum was identified with P400 protein from the physicochemical properties and enrichment in the cerebellum. Proteins homologous to the cerebellar 250 K M(r) protein...

journal_title：Neurochemistry international

authors： Suzuki T,Abe-Dohmae S,Tanaka R

更新日期：1992-01-01 00:00:00

abstract：:The amyloid precursor protein (APP) and presenilin-1 (PS-1) are not only of importance for the normal functioning of the various neurons, but also play central roles in the pathogenesis of Alzheimer's disease (AD). Through the use of immunohistochemical and Western blot techniques, the bidirectional axonal transport o...

journal_title：Neurochemistry international

authors： Papp H,Pakaski M,Kasa P

更新日期：2002-12-01 00:00:00

abstract：:Allosteric modulation of [3H]strychnine binding to glycine receptors (GlyRs) was examined in synaptosomal membranes of rat spinal cord. An allosteric model enabled us to determine the cooperativity factors of the allosteric agents with [3H]strychnine and glycine bindings (alpha and beta, respectively). We modified the...

journal_title：Neurochemistry international

authors： Bíró T,Maksay G

更新日期：2004-06-01 00:00:00

abstract：:Posttranslational processing of peptide-precursors is nowadays believed to play an important role in the functioning of neurons and endocrine cells. Both proenkephalins and chromogranins/secretogranins are considered as precursor molecules in these tissues, resulting in posttranslationally formed degradation products ...

journal_title：Neurochemistry international

authors： Dillen L,Miserez B,Claeys M,Aunis D,De Potter W

更新日期：1993-04-01 00:00:00

abstract：:Repeated exposure to addictive drugs enhances dopamine receptor (DR) signaling and the ultimate phosphorylation of the cyclic adenosine 5'-monophosphate (cAMP)-response element-binding protein (CREB)-regulated cocaine- and amphetamine-regulated transcript (CART) expression in the nucleus accumbens (NAcc). These effect...

journal_title：Neurochemistry international

authors： Peng Q,Sun X,Liu Z,Yang J,Oh KW,Hu Z

更新日期：2014-09-01 00:00:00

abstract：:Even though the inducing effect of electromagnetic fields (EMF) on the neural differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) is a distinctive, the underlying mechanism of differentiation remains unclear. To find out the signaling pathways involved in the neural differentiation of BM-MSCs by EMF...

journal_title：Neurochemistry international

authors： Park JE,Seo YK,Yoon HH,Kim CW,Park JK,Jeon S

更新日期：2013-03-01 00:00:00

abstract：:Aging is a biological process characterized by impairment of cellular bioenergetic function, increased oxidative stress, attenuated ability to respond to stresses, increased risk of contracting age-associated disorders that affects many tissues, with a more marked effect on brain and heart function. Oxidative stress i...

journal_title：Neurochemistry international

authors： Paradies G,Petrosillo G,Paradies V,Ruggiero FM

更新日期：2011-03-01 00:00:00

abstract：:Rapid administration of large doses of ammonia leads to death of animals, which is largely prevented by pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists. The present study focuses on a subunit(s) of NMDA receptor involved in ammonia-induced death by use of NMDA receptor GluRepsilon subunit-deficient ...

journal_title：Neurochemistry international

authors： Kitano T,Matsumura S,Seki T,Hikida T,Sakimura K,Nagano T,Mishina M,Nakanishi S,Ito S

更新日期：2004-01-01 00:00:00

abstract：:Two polypeptides (designated DTX-A and DTX-B) were purified from crude snake venom of Dendroaspis angusticeps using gel filtration, cation exchange column chromatography and cation exchange high performance liquid chromatography, and their blocking actions of K+ channels were investigated in rat brain synaptosomes. Bo...

journal_title：Neurochemistry international

authors： Chaki S,Muramatsu M,Ushiyama Y,Otomo S

更新日期：1992-06-01 00:00:00

abstract：:To investigate the contribution of the dopamine (DA) synthesis to both the calcium-dependent and the carrier-mediated, mechanisms of DA release in the striatum, anaesthetized rats were locally superfused in the striatum with a push pull cannula supplied with an artificial CSF containing tritiated tyrosine. DA, dihydro...

journal_title：Neurochemistry international

authors： Olivier V,Gobert A,Guibert B,Leviel V

更新日期：1999-12-01 00:00:00

abstract：:In this review, we summarize the role of hyperglycemia during cerebral ischemia. Hyperglycemia occurring during experimental and clinical stroke has been associated with increased cerebral damage. Increased oxidative stress resulting from hyperglycemia is believed to contribute to the exacerbated damage. More specific...

journal_title：Neurochemistry international

authors： Bémeur C,Ste-Marie L,Montgomery J

更新日期：2007-06-01 00:00:00

abstract：:Vinpocetine (ethyl apovincaminate), a synthetic derivative of the Vinca minor alkaloid vincamine, is widely used for the treatment of cerebrovascular-related diseases. One of the proposed mechanisms underlying its action is to protect against the cytotoxic effects of glutamate overexposure. Glutamate excitotoxicity le...

journal_title：Neurochemistry international

authors： Tárnok K,Kiss E,Luiten PG,Nyakas C,Tihanyi K,Schlett K,Eisel UL

更新日期：2008-12-01 00:00:00

abstract：:The interaction of (±)-bupropion [(±)-BP] with the human (h) α4β2 nicotinic acetylcholine receptor (AChR) was compared to that for its photoreactive analog (±)-2-(N-tert-butylamino)-3'-iodo-4'-azidopropiophenone [(±)-SADU-3-72]. Ca2+ influx results indicated that (±)-SADU-3-72 and (±)-BP inhibit hα4β2 AChRs with pract...

journal_title：Neurochemistry international

authors： Arias HR,Feuerbach D,Ortells MO

更新日期：2016-11-01 00:00:00

abstract：:Catalpol has been shown to rescue neurons from kinds of damage in vitro and in vivo in previous reports. However, the effect of catalpol on the nitric oxide (NO) system via MAPKs signaling pathway of mesencephalic neurons largely remains to be verified. The current study examined that whether catalpol modulated NO and...

journal_title：Neurochemistry international

authors： Bi J,Jiang B,Hao S,Zhang A,Dong Y,Jiang T,An L

更新日期：2009-03-01 00:00:00

abstract：:Acetylcholine enhanced in a concentration-dependent way the K(+) (15 mM)-evoked release of [(3)H]dopamine from synaptosomes isolated from rat corpus striatum and prelabeled with the radioactive catecholamine. The concentration-effect curve of ACh obtained in presence of 1.2 mM Ca(2+) was progressively shifted to the l...

journal_title：Neurochemistry international

authors： Versace P,Bocchieri P,Marchi M,Raiteri M

更新日期：1987-01-01 00:00:00

abstract：:Both brain-derived neurotrophic factor (BDNF) and the serotonin receptor 2A (5-HT(2A)) have been related to depression pathology. Specific 5-HT(2A) receptor changes seen in BDNF conditional mutant mice suggest that BDNF regulates the 5-HT(2A) receptor level. Here we show a direct effect of BDNF on 5-HT(2A) receptor pr...

journal_title：Neurochemistry international

authors： Trajkovska V,Santini MA,Marcussen AB,Thomsen MS,Hansen HH,Mikkelsen JD,Arneberg L,Kokaia M,Knudsen GM,Aznar S

更新日期：2009-12-01 00:00:00

abstract：:Gap junctions are transcellular pathways that enable a dynamic metabolic coupling and a selective exchange of biological signaling mediators. Throughout the course of the brain development these intercellular channels are assembled into regionally and temporally defined patterns. The present review summarizes the poss...

journal_title：Neurochemistry international

authors： Fróes MM,Menezes JR

更新日期：2002-11-01 00:00:00

abstract：:SN1, a system N amino acid transporter specific for astrocytes, is mainly responsible for export of newly synthesized L-glutamine from the cells. Astrocytic retention of L-glutamine which plays a critical role in ammonia-induced astrocytic swelling resulting in brain edema, could be tentatively attributed to the impai...

journal_title：Neurochemistry international

authors： Dąbrowska K,Albrecht J,Zielińska M

更新日期：2018-09-01 00:00:00

abstract：:Traumatic brain injury (TBI) is one of the major cause of morbidity and mortality and it affects more than 1.7 million Americans each year. Depending on its location and severity, TBI leads to structural and functional damage in several parts of the brain such as cranial nerves, optic nerve tract or other circuitry in...

journal_title：Neurochemistry international

authors： Sen N

更新日期：2017-12-01 00:00:00

abstract：:Homozygous deletion or mutation in the survival motor neuron (SMN)1 gene causes proximal spinal muscular atrophy (SMA), whereas SMN2 acts as a modifying gene that can influence the severity of SMA. It has been suggested that restoration of the SMN protein level in neuronal cells may prevent cell loss and may be helpfu...

journal_title：Neurochemistry international

authors： Chang HC,Hung WC,Chuang YJ,Jong YJ

更新日期：2004-12-01 00:00:00

abstract：:The carotid bodies (CBs) are chemosensory organs that respond to hypoxemia with transmitter neurosecretion, leading to a respiratory reflex response. It has been proposed that acetylcholine is a key regulator of transmitter release through activation of presynaptic nicotinic acetylcholine receptors (nAChRs). In the pr...

journal_title：Neurochemistry international

authors： Meza RC,Ortiz FC,Bravo E,Iturriaga-Vásquez P,Eugenín JL,Varas R

更新日期：2012-01-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder mostly affecting the aging population over sixty. Cardinal symptoms including, tremors, muscle rigidity, drooping posture, drooling, walking difficulty, and autonomic symptoms appear when a significant number of nigrostriatal dopaminergic ne...

journal_title：Neurochemistry international

authors： Sharma S,Moon CS,Khogali A,Haidous A,Chabenne A,Ojo C,Jelebinkov M,Kurdi Y,Ebadi M

更新日期：2013-09-01 00:00:00

abstract：:Neuropathic pain is a type of chronic pain caused by nervous system damage and dysfunction. The pathogenesis of chronic pain is complicated, and there are no effective therapies for neuropathic pain. Studies show that the P2X4 receptor expressed in the satellite glial cells (SGCs) of dorsal root ganglia (DRG) is relat...

journal_title：Neurochemistry international

authors： Ying M,Liu H,Zhang T,Jiang C,Gong Y,Wu B,Zou L,Yi Z,Rao S,Li G,Zhang C,Jia T,Zhao S,Yuan H,Shi L,Li L,Liang S,Liu S

更新日期：2017-09-01 00:00:00

abstract：:The release of [(3)H]GABA which is newly synthesized from [(3)H]l-glutamic acid (GLU) has been examined using striatal slices obtained from the rat brain. It was found that 8-10% of [(3)H]GLU transported was converted to [(3)H]GABA during the incubation of striatal slices in the presence of nipecotic acid (5 x 10(?5) ...

journal_title：Neurochemistry international

authors： Yoneda Y,Kanmori K,Takahashi M,Zuo PP,Paik IH,Kuriyama K

更新日期：1984-01-01 00:00:00