Oleuropein and derivatives from olives as Tau aggregation inhibitors.


:Tau isoforms constitute a family of microtubule-associated proteins that are mainly expressed in neurons of the central nervous system. They promote the assembly of tubulin monomers into microtubules and modulate their stability, thus playing a key structural role in the distal portion of axons. In Alzheimer's disease and related tauopathies, Tau aggregation into fibrillary tangles contributes to intraneuronal and glial lesions. We report herein the ability of three natural phenolic derivatives obtained from olives and derived food products to prevent such Tau fibrillization in vitro, namely hydroxytyrosol, oleuropein, and oleuropein aglycone. The latter was found to be more active than the reference Tau aggregation inhibitor methylene blue on both wild-type and P301L Tau proteins, inhibiting fibrillization at low micromolar concentrations. These findings might provide further experimental support for the beneficial nutritional properties of olives and olive oil as well as a chemical scaffold for the development of new drugs aiming at neurodegenerative tauopathies.


Neurochem Int


Daccache A,Lion C,Sibille N,Gerard M,Slomianny C,Lippens G,Cotelle P




Has Abstract


2011-05-01 00:00:00














  • Cytosine arabinofuranoside-induced activation of astrocytes increases the susceptibility of neurons to glutamate due to the release of soluble factors.

    abstract::Activation of astrocytes occurs during many forms of CNS injury, but its importance for neuronal survival is poorly understood. When hippocampal cultures of neurons and astrocytes were treated from day 2-4 in vitro (DIV 2-4) with 1 microM cytosine arabinofuranoside (AraC), we observed a stellation of astrocytes, an in...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Ahlemeyer B,Kölker S,Zhu Y,Hoffmann GF,Krieglstein J

    更新日期:2003-06-01 00:00:00

  • Agonist-induced entry of Ca(2+) in smooth muscle cells.

    abstract::The changes in intracellar Ca(2+)-concentration, which occur during stimulation of vascular smooth muscle cells with excitatory agonists, are discussed. The effects of these agonists on the membrane potential of these cells are indirect, and mainly due to an activation of K(+)- and Cl(?)-channels by the release of cal...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Casteels R,Droogmans G,Missiaen L

    更新日期:1990-01-01 00:00:00

  • Sandwich enzyme immunoassay of dopamine-?-hydroxylase in cerebrospinal fluid from control and parkinsonian patients.

    abstract::A sandwich enzyme immunoassay (EIA) was established by using purified human serum dopamine-?-hydroxylase (DBH) as a standard protein and a monospecific polyclonal antibody raised against human DBH purified from human pheochromocytoma. The EIA was applied to measuring DBH levels in human CSF from Parkinsonian patients ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Mogi M,Harada M,Kojima K,Inagaki H,Kondo T,Narabayashi H,Arai T,Teradaira R,Fujita K,Kiuchi K,Nagatsu T

    更新日期:1988-01-01 00:00:00

  • Redox-active DJ-1 sustains brainstem cardiovascular regulation via maintenance of mitochondrial function during mevinphos intoxication.

    abstract::DJ-1 (also known as PARK7) is a redox-active protein that protects against oxidative stress. This study evaluated the hypothesis that DJ-1 sustains brainstem cardiovascular regulation via maintaining mitochondrial function in the rostral ventrolateral medulla (RVLM), a brainstem site known to maintain blood pressure a...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Tsai CY,Wu CJ,Wu JCC,Fang C,Huang YH,Dai KY

    更新日期:2020-10-01 00:00:00

  • Neuroprotection with the proteasome inhibitor MLN519 in focal ischemic brain injury: relation to nuclear factor kappaB (NF-kappaB), inflammatory gene expression, and leukocyte infiltration.

    abstract::The ubiquitin proteasome system (UPS) is a major cellular protein degradation pathway that involves the modulation of key proteins controlling inflammation, cell cycle regulation and gene expression. Modulation of the UPS with proteasome inhibitors has indicated efficacy in the treatment of several disease states incl...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审


    authors: Williams AJ,Dave JR,Tortella FC

    更新日期:2006-07-01 00:00:00

  • Functional partial agonism at ionotropic excitatory amino acid receptors.

    abstract::(RS)-2-Amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid (APPA), which is an analogue of (RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA), shows the characteristics of a partial AMPA receptor agonist. Since (S)-APPA is a full AMPA agonist and (R)-APPA a competitive antagonist, the partial ag...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Ebert B,Madsen U,Søby KK,Krogsgaard-Larsen P

    更新日期:1996-09-01 00:00:00

  • Involvement of G-protein βγ subunits on the influence of inhibitory α2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens.

    abstract::The influence of alpha2-autoreceptors on the facilitation of [3H]-noradrenaline release mediated by angiotensin II was studied in prostatic portions of rat vas deferens preincubated with [3H]-noradrenaline. Angiotensin II enhanced tritium overflow evoked by trains of 100 pulses at 8 Hz, an effect that was attenuated b...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Talaia C,Queiroz G,Pinheiro H,Moura D,Gonçalves J

    更新日期:2006-12-01 00:00:00

  • Morphological alterations and induction of oxidative stress in glial cells caused by the branched-chain alpha-keto acids accumulating in maple syrup urine disease.

    abstract::Maple syrup urine disease (MSUD) is an inherited neurometabolic disorder biochemically characterized by the accumulation of the branched-chain alpha-keto acids (BCKA) alpha-ketoisocaproic (KIC), alpha-keto-beta-methylvaleric (KMV) and alpha-ketoisovaleric (KIV) and their respective branched-chain alpha-amino acids in ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Funchal C,Latini A,Jacques-Silva MC,Dos Santos AQ,Buzin L,Gottfried C,Wajner M,Pessoa-Pureur R

    更新日期:2006-12-01 00:00:00

  • Expression and localisation of brain-type organic cation transporter (BOCT/24p3R/LCN2R) in the normal rat hippocampus and after kainate-induced excitotoxicity.

    abstract::The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during n...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Chia WJ,Tan FC,Ong WY,Dawe GS

    更新日期:2015-08-01 00:00:00

  • Inhibition of Alzheimer's amyloid-beta aggregation in-vitro by carbenoxolone: Insight into mechanism of action.

    abstract:BACKGROUND:The major hallmark of Alzheimer's disease (AD) is the formation of amyloid aggregates, which are formed due to improper folding of proteins leading to the aggregation of amyloid beta (Aβ) 42 peptide. Inhibition of Aβ 42 aggregation using a drug such as carbenoxolone (Cbx), which has already been stated as ne...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Sharma S,Nehru B,Saini A

    更新日期:2017-09-01 00:00:00

  • What the evolution of the amyloid protein precursor supergene family tells us about its function.

    abstract::The Alzheimer's disease amyloid protein precursor (APP) gene is part of a multi-gene super-family from which sixteen homologous amyloid precursor-like proteins (APLP) and APP species homologues have been isolated and characterised. Comparison of exon structure (including the uncharacterised APL-1 gene), construction o...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审


    authors: Coulson EJ,Paliga K,Beyreuther K,Masters CL

    更新日期:2000-03-01 00:00:00

  • In vitro changes of ganglioside immunostain localization in developing neural cells.

    abstract::The immunostains of GD3, c-pathway polysialogangliosides and gangliotetraosylgangliosides belonging to the a- and b-pathways were analyzed in embryo optic lobe cells. Cells were cultured in serum free media with, and without, bovine brain ganglioside mixture (largely gangliotetraosylgangliosides). Control cells differ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Cossy-Isasi S,Panzetta P

    更新日期:1994-04-01 00:00:00

  • Release of acid-soluble radioactivity from rapidly transported proteins in homogenates of rabbit superior colliculus.

    abstract::An intraocular injection of [(3)H]proline was used to label rabbit retinal ganglion cells including components subjected to axonal transport. Degradation of rapidly axonally transported labelled proteins was estimated in an in vitro system using homogenates of the nerve terminal regions. The energy requirements of thi...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Gustavsson S,Karlsson JO

    更新日期:1985-01-01 00:00:00

  • Cocaine-induced status epilepticus and death generate oxidative stress in prefrontal cortex and striatum of mice.

    abstract::Oxidative stress (OS) has been related to cocaine's actions and also to numerous nervous system pathologies, including seizures. The purpose of this work was to determine the alterations in glutathione (GSH) content, nitrite/nitrate and MDA levels after cocaine-induced toxicity. Male Swiss mice were injected (i.p.) wi...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Macêdo DS,Vasconcelos SM,Andrade-Neto M,Belchior LD,Honório Júnior JE,Gonçalves DO,Fonteles MM,Silva MI,Aguiar LM,Viana GS,de Sousa FC

    更新日期:2010-01-01 00:00:00

  • Neurotransmitters in the CNS of the vitamin D deficient, hypocalcemic rat.

    abstract::Sprague-Dawley rats were made chronically vitamin D deficient (VDD) and hypocalcemic, or VDD and normocalcemic. Rickets, severely reduced body weight, hair shedding, lethargy, muscular paralysis and a high mortality rate are characteristic features of the male VDD/hypocalcemic animals. An assessment was made of the ne...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Tenenhouse A,Warner M,Commissiong JW

    更新日期:1991-01-01 00:00:00

  • Cell-selective effects of ammonia on glutamate transporter and receptor function in the mammalian brain.

    abstract::Increased brain ammonia concentrations are a hallmark feature of several neurological disorders including congenital urea cycle disorders, Reye's syndrome and hepatic encephalopathy (HE) associated with liver failure. Over the last decade, increasing evidence suggests that hyperammonemia leads to alterations in the gl...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审


    authors: Chan H,Butterworth RF

    更新日期:2003-09-01 00:00:00

  • Activities of glutamine synthetase, glutaminase and arginase in kainic acid lesioned rat brain corpus striatum.

    abstract::Intrastriatal kainic acid (2 ?g/?l) administration gave rise to significant increase in activities of glutamine synthetase and arginase along with a significant decrease in the activity of glutaminase in the lesioned striatal tissue 7 days after the administration of kainic acid. The increase in the activity of glutam...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Nadiger HA,Rani Marcus S,Chandrakala MV,Sadasivudu B

    更新日期:1985-01-01 00:00:00

  • Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague-Dawley rats.

    abstract::The influence of citalopram on regional 5-hydroxytryptamine (serotonin, 5-HT) synthesis, one of the most important presynaptic parameters of serotonergic neurotransmission, was studied. Sprague-Dawley (SPD) rats were used as the controls, and Flinders Resistant Line (FRL) rats were used as auxiliary controls, to hopef...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Kanemaru K,Nishi K,Hasegawa S,Diksic M

    更新日期:2009-05-01 00:00:00

  • Dopamine D1-stimulated adenylyl cyclase activity in cerebral cortex of autopsied human brain.

    abstract::Although the cerebral cortical dopamine D(1) receptor is considered to play a role in normal and abnormal brain function, little information is available on its characteristics in human brain. We compared dopamine-stimulated adenylyl cyclase (AC) activity in homogenates of cerebral cortex (frontal, temporal, parietal,...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Tong J,Ross BM,Sherwin AL,Kish SJ

    更新日期:2001-08-01 00:00:00

  • Detection of a decarboxylated dimer of aminoethylcysteine ketimine in bovine cerebellum.

    abstract::Aminoethylcysteine ketimine is a sulfur-containing cyclic compound produced by the enzymatic alpha-deamination of the parent aminoethylcysteine that has been detected in bovine brain and cerebellum. Aminoethylcysteine ketimine is known to dimerize spontaneously and easily lose one carboxyl group. This decarboxylated c...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Matarese RM,Macone A,Crescentini G,Duprè S,Cavallini D

    更新日期:1998-04-01 00:00:00

  • Activated microglia are the principal glial source of thromboxane in the central nervous system.

    abstract::Thromboxane A2(TxA2) is a potent vasoconstrictor associated with cerebrovascular disease and is thought to be synthesized within tissues of the brain. In order to determine the cellular sources of TxA2 in the central nervous system (CNS), we measured the release of the stable metabolite TxB2 in cultures of mixed or hi...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Giulian D,Corpuz M,Richmond B,Wendt E,Hall ER

    更新日期:1996-07-01 00:00:00

  • [3H]-ketanserin binding sites in different psychiatric disorders.

    abstract::The results of the present study showed the presence of a high-affinity and saturable binding of [3H]-ketanserin to frontal and parietal brain membranes obtained postmortem from bipolar, depressed, schizophrenic patients and normal controls. The human brain samples (60 frontal cortex and 51 parietal cortex), were dona...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Marazziti D,Giannaccini G,Giromella A,Betti L,Pesce D,Nardi I,Rossi A,Lucacchini A,Cassano GB

    更新日期:2003-05-01 00:00:00

  • Mitochondrial oxygen consumption inhibition importance for TMT-dependent cell death in undifferentiated PC12 cells.

    abstract::The evolving role of mitochondria as a target for different death-inducing noxae prompted us to investigate trimethyltin (TMT)-dependent effects on mitochondrial functionality. For this purpose, we used a homogeneous cell culture model represented by undifferentiated PC12 cells. Mitochondria isolated from PC12 cells t...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Misiti F,Orsini F,Clementi ME,Lattanzi W,Giardina B,Michetti F

    更新日期:2008-05-01 00:00:00

  • N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes.

    abstract::Depression is highly comorbid with anxiety disorders and associated with profound cognitive impairment. Moreover, cognitive deficits associated with hippocampal dysfunction are central in depression and anxiety disorders. Furthermore, depression is accompanied by glutamatergic dysfunction which can further impair the ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Chakraborty S,Tripathi SJ,Srikumar BN,Raju TR,Shankaranarayana Rao BS

    更新日期:2020-01-01 00:00:00

  • B vitamins in the nervous system.

    abstract::The coenzyme functions of the B vitamins in intermediatry metabolism are well established; nevertheless, for none of them is it possible to determine precisely the connection between the biochemical lesions associated with deficiency and the neurological consequences. Although there is convincing evidence of a neurosp...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Bender DA

    更新日期:1984-01-01 00:00:00

  • Ferrous ion activates the less active form of human adrenal tyrosine hydroxylase.

    abstract::The less active form of human tyrosine hydroxylase has been previously reported but its physiological role is unknown. We partially purified the less active form of tyrosine hydroxylase from human adrenals, and examined differences in the properties of the active and less active forms. We succeeded in activation of th...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Ishii A,Kiuchi K,Matsuyama M,Satake T,Nagatsu T

    更新日期:1990-01-01 00:00:00

  • Advances in understanding the functions of native GlyT1 and GlyT2 neuronal glycine transporters.

    abstract::Glycine can be substrate for two transporters: GlyT1, largely expressed by astrocytes but also by some non-glycinergic neurons, and GlyT2, most frequently present in glycine-storing nerve endings. In morphological studies, GlyT2 expression had been found to be restricted to caudal regions, being almost undetectable in...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Romei C,Raiteri L

    更新日期:2016-10-01 00:00:00

  • The electrotonic architecture of the retinal microvasculature: diabetes-induced alteration.

    abstract::Although microvascular cell death is a well established hallmark of diabetic retinopathy, which is a major cause of vision loss, much remains to be learned about the functional changes that precede the onset of morphological damage to retinal blood vessels. Early alterations of function are of interest since they may ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Nakaizumi A,Zhang T,Puro DG

    更新日期:2012-11-01 00:00:00

  • Levels of 5-methyltetrahydrofolate and ascorbic acid in cerebrospinal fluid are correlated: implications for the accelerated degradation of folate by reactive oxygen species.

    abstract::Deficiency of 5-methyltetrahydrofolate (5-MTHF) in cerebrospinal fluid (CSF) is associated with a number of neurometabolic conditions including mitochondrial electron transport chain defects. Whilst failure of the active transport of 5-methyltetrahydrofolate (5-MTHF) into the CSF compartment has been proposed as a pot...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Aylett SB,Neergheen V,Hargreaves IP,Eaton S,Land JM,Rahman S,Heales SJ

    更新日期:2013-12-01 00:00:00

  • Gallamine and tubocurarine as possible allosteric modifiers of soluble acetylcholinesterase activity at physiological ionic strength.

    abstract::Esters of dimethylcarbamic acid are known to be poor substrates of acetylcholinesterase. They carbamylate the active catalytic site of the enzyme and the subsequent decarbamylation is a slow but measurable process. Similarly, acetylcholinesterase can be phosphonylated, and the dephosphonylation is extremely slow. Rapi...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Dawson RM,Poretski M,Upsher CM

    更新日期:1981-01-01 00:00:00