Oleuropein and derivatives from olives as Tau aggregation inhibitors.

abstract：:Activation of astrocytes occurs during many forms of CNS injury, but its importance for neuronal survival is poorly understood. When hippocampal cultures of neurons and astrocytes were treated from day 2-4 in vitro (DIV 2-4) with 1 microM cytosine arabinofuranoside (AraC), we observed a stellation of astrocytes, an in...

journal_title：Neurochemistry international

authors： Ahlemeyer B,Kölker S,Zhu Y,Hoffmann GF,Krieglstein J

更新日期：2003-06-01 00:00:00

abstract：:The changes in intracellar Ca(2+)-concentration, which occur during stimulation of vascular smooth muscle cells with excitatory agonists, are discussed. The effects of these agonists on the membrane potential of these cells are indirect, and mainly due to an activation of K(+)- and Cl(?)-channels by the release of cal...

journal_title：Neurochemistry international

authors： Casteels R,Droogmans G,Missiaen L

更新日期：1990-01-01 00:00:00

abstract：:A sandwich enzyme immunoassay (EIA) was established by using purified human serum dopamine-?-hydroxylase (DBH) as a standard protein and a monospecific polyclonal antibody raised against human DBH purified from human pheochromocytoma. The EIA was applied to measuring DBH levels in human CSF from Parkinsonian patients ...

journal_title：Neurochemistry international

authors： Mogi M,Harada M,Kojima K,Inagaki H,Kondo T,Narabayashi H,Arai T,Teradaira R,Fujita K,Kiuchi K,Nagatsu T

更新日期：1988-01-01 00:00:00

abstract：:DJ-1 (also known as PARK7) is a redox-active protein that protects against oxidative stress. This study evaluated the hypothesis that DJ-1 sustains brainstem cardiovascular regulation via maintaining mitochondrial function in the rostral ventrolateral medulla (RVLM), a brainstem site known to maintain blood pressure a...

journal_title：Neurochemistry international

authors： Tsai CY,Wu CJ,Wu JCC,Fang C,Huang YH,Dai KY

更新日期：2020-10-01 00:00:00

abstract：:The ubiquitin proteasome system (UPS) is a major cellular protein degradation pathway that involves the modulation of key proteins controlling inflammation, cell cycle regulation and gene expression. Modulation of the UPS with proteasome inhibitors has indicated efficacy in the treatment of several disease states incl...

journal_title：Neurochemistry international

authors： Williams AJ,Dave JR,Tortella FC

更新日期：2006-07-01 00:00:00

abstract：:(RS)-2-Amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid (APPA), which is an analogue of (RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA), shows the characteristics of a partial AMPA receptor agonist. Since (S)-APPA is a full AMPA agonist and (R)-APPA a competitive antagonist, the partial ag...

journal_title：Neurochemistry international

authors： Ebert B,Madsen U,Søby KK,Krogsgaard-Larsen P

更新日期：1996-09-01 00:00:00

abstract：:The influence of alpha2-autoreceptors on the facilitation of [3H]-noradrenaline release mediated by angiotensin II was studied in prostatic portions of rat vas deferens preincubated with [3H]-noradrenaline. Angiotensin II enhanced tritium overflow evoked by trains of 100 pulses at 8 Hz, an effect that was attenuated b...

journal_title：Neurochemistry international

authors： Talaia C,Queiroz G,Pinheiro H,Moura D,Gonçalves J

更新日期：2006-12-01 00:00:00

abstract：:Maple syrup urine disease (MSUD) is an inherited neurometabolic disorder biochemically characterized by the accumulation of the branched-chain alpha-keto acids (BCKA) alpha-ketoisocaproic (KIC), alpha-keto-beta-methylvaleric (KMV) and alpha-ketoisovaleric (KIV) and their respective branched-chain alpha-amino acids in ...

journal_title：Neurochemistry international

authors： Funchal C,Latini A,Jacques-Silva MC,Dos Santos AQ,Buzin L,Gottfried C,Wajner M,Pessoa-Pureur R

更新日期：2006-12-01 00:00:00

abstract：:The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during n...

journal_title：Neurochemistry international

authors： Chia WJ,Tan FC,Ong WY,Dawe GS

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The major hallmark of Alzheimer's disease (AD) is the formation of amyloid aggregates, which are formed due to improper folding of proteins leading to the aggregation of amyloid beta (Aβ) 42 peptide. Inhibition of Aβ 42 aggregation using a drug such as carbenoxolone (Cbx), which has already been stated as ne...

journal_title：Neurochemistry international

authors： Sharma S,Nehru B,Saini A

更新日期：2017-09-01 00:00:00

abstract：:The Alzheimer's disease amyloid protein precursor (APP) gene is part of a multi-gene super-family from which sixteen homologous amyloid precursor-like proteins (APLP) and APP species homologues have been isolated and characterised. Comparison of exon structure (including the uncharacterised APL-1 gene), construction o...

journal_title：Neurochemistry international

authors： Coulson EJ,Paliga K,Beyreuther K,Masters CL

更新日期：2000-03-01 00:00:00

abstract：:The immunostains of GD3, c-pathway polysialogangliosides and gangliotetraosylgangliosides belonging to the a- and b-pathways were analyzed in embryo optic lobe cells. Cells were cultured in serum free media with, and without, bovine brain ganglioside mixture (largely gangliotetraosylgangliosides). Control cells differ...

journal_title：Neurochemistry international

authors： Cossy-Isasi S,Panzetta P

更新日期：1994-04-01 00:00:00

abstract：:An intraocular injection of [(3)H]proline was used to label rabbit retinal ganglion cells including components subjected to axonal transport. Degradation of rapidly axonally transported labelled proteins was estimated in an in vitro system using homogenates of the nerve terminal regions. The energy requirements of thi...

journal_title：Neurochemistry international

authors： Gustavsson S,Karlsson JO

更新日期：1985-01-01 00:00:00

abstract：:Oxidative stress (OS) has been related to cocaine's actions and also to numerous nervous system pathologies, including seizures. The purpose of this work was to determine the alterations in glutathione (GSH) content, nitrite/nitrate and MDA levels after cocaine-induced toxicity. Male Swiss mice were injected (i.p.) wi...

journal_title：Neurochemistry international

authors： Macêdo DS,Vasconcelos SM,Andrade-Neto M,Belchior LD,Honório Júnior JE,Gonçalves DO,Fonteles MM,Silva MI,Aguiar LM,Viana GS,de Sousa FC

更新日期：2010-01-01 00:00:00

abstract：:Sprague-Dawley rats were made chronically vitamin D deficient (VDD) and hypocalcemic, or VDD and normocalcemic. Rickets, severely reduced body weight, hair shedding, lethargy, muscular paralysis and a high mortality rate are characteristic features of the male VDD/hypocalcemic animals. An assessment was made of the ne...

journal_title：Neurochemistry international

authors： Tenenhouse A,Warner M,Commissiong JW

更新日期：1991-01-01 00:00:00

abstract：:Increased brain ammonia concentrations are a hallmark feature of several neurological disorders including congenital urea cycle disorders, Reye's syndrome and hepatic encephalopathy (HE) associated with liver failure. Over the last decade, increasing evidence suggests that hyperammonemia leads to alterations in the gl...

journal_title：Neurochemistry international

authors： Chan H,Butterworth RF

更新日期：2003-09-01 00:00:00

abstract：:Intrastriatal kainic acid (2 ?g/?l) administration gave rise to significant increase in activities of glutamine synthetase and arginase along with a significant decrease in the activity of glutaminase in the lesioned striatal tissue 7 days after the administration of kainic acid. The increase in the activity of glutam...

journal_title：Neurochemistry international

authors： Nadiger HA,Rani Marcus S,Chandrakala MV,Sadasivudu B

更新日期：1985-01-01 00:00:00

abstract：:The influence of citalopram on regional 5-hydroxytryptamine (serotonin, 5-HT) synthesis, one of the most important presynaptic parameters of serotonergic neurotransmission, was studied. Sprague-Dawley (SPD) rats were used as the controls, and Flinders Resistant Line (FRL) rats were used as auxiliary controls, to hopef...

journal_title：Neurochemistry international

authors： Kanemaru K,Nishi K,Hasegawa S,Diksic M

更新日期：2009-05-01 00:00:00

abstract：:Although the cerebral cortical dopamine D(1) receptor is considered to play a role in normal and abnormal brain function, little information is available on its characteristics in human brain. We compared dopamine-stimulated adenylyl cyclase (AC) activity in homogenates of cerebral cortex (frontal, temporal, parietal,...

journal_title：Neurochemistry international

authors： Tong J,Ross BM,Sherwin AL,Kish SJ

更新日期：2001-08-01 00:00:00

abstract：:Aminoethylcysteine ketimine is a sulfur-containing cyclic compound produced by the enzymatic alpha-deamination of the parent aminoethylcysteine that has been detected in bovine brain and cerebellum. Aminoethylcysteine ketimine is known to dimerize spontaneously and easily lose one carboxyl group. This decarboxylated c...

journal_title：Neurochemistry international

authors： Matarese RM,Macone A,Crescentini G,Duprè S,Cavallini D

更新日期：1998-04-01 00:00:00

abstract：:Thromboxane A2(TxA2) is a potent vasoconstrictor associated with cerebrovascular disease and is thought to be synthesized within tissues of the brain. In order to determine the cellular sources of TxA2 in the central nervous system (CNS), we measured the release of the stable metabolite TxB2 in cultures of mixed or hi...

journal_title：Neurochemistry international

authors： Giulian D,Corpuz M,Richmond B,Wendt E,Hall ER

更新日期：1996-07-01 00:00:00

abstract：:The results of the present study showed the presence of a high-affinity and saturable binding of [3H]-ketanserin to frontal and parietal brain membranes obtained postmortem from bipolar, depressed, schizophrenic patients and normal controls. The human brain samples (60 frontal cortex and 51 parietal cortex), were dona...

journal_title：Neurochemistry international

authors： Marazziti D,Giannaccini G,Giromella A,Betti L,Pesce D,Nardi I,Rossi A,Lucacchini A,Cassano GB

更新日期：2003-05-01 00:00:00

abstract：:The evolving role of mitochondria as a target for different death-inducing noxae prompted us to investigate trimethyltin (TMT)-dependent effects on mitochondrial functionality. For this purpose, we used a homogeneous cell culture model represented by undifferentiated PC12 cells. Mitochondria isolated from PC12 cells t...

journal_title：Neurochemistry international

authors： Misiti F,Orsini F,Clementi ME,Lattanzi W,Giardina B,Michetti F

更新日期：2008-05-01 00:00:00

abstract：:Depression is highly comorbid with anxiety disorders and associated with profound cognitive impairment. Moreover, cognitive deficits associated with hippocampal dysfunction are central in depression and anxiety disorders. Furthermore, depression is accompanied by glutamatergic dysfunction which can further impair the ...

journal_title：Neurochemistry international

authors： Chakraborty S,Tripathi SJ,Srikumar BN,Raju TR,Shankaranarayana Rao BS

更新日期：2020-01-01 00:00:00

abstract：:The coenzyme functions of the B vitamins in intermediatry metabolism are well established; nevertheless, for none of them is it possible to determine precisely the connection between the biochemical lesions associated with deficiency and the neurological consequences. Although there is convincing evidence of a neurosp...

journal_title：Neurochemistry international

authors： Bender DA

更新日期：1984-01-01 00:00:00

abstract：:The less active form of human tyrosine hydroxylase has been previously reported but its physiological role is unknown. We partially purified the less active form of tyrosine hydroxylase from human adrenals, and examined differences in the properties of the active and less active forms. We succeeded in activation of th...

journal_title：Neurochemistry international

authors： Ishii A,Kiuchi K,Matsuyama M,Satake T,Nagatsu T

更新日期：1990-01-01 00:00:00

abstract：:Glycine can be substrate for two transporters: GlyT1, largely expressed by astrocytes but also by some non-glycinergic neurons, and GlyT2, most frequently present in glycine-storing nerve endings. In morphological studies, GlyT2 expression had been found to be restricted to caudal regions, being almost undetectable in...

journal_title：Neurochemistry international

authors： Romei C,Raiteri L

更新日期：2016-10-01 00:00:00

abstract：:Although microvascular cell death is a well established hallmark of diabetic retinopathy, which is a major cause of vision loss, much remains to be learned about the functional changes that precede the onset of morphological damage to retinal blood vessels. Early alterations of function are of interest since they may ...

journal_title：Neurochemistry international

authors： Nakaizumi A,Zhang T,Puro DG

更新日期：2012-11-01 00:00:00

abstract：:Deficiency of 5-methyltetrahydrofolate (5-MTHF) in cerebrospinal fluid (CSF) is associated with a number of neurometabolic conditions including mitochondrial electron transport chain defects. Whilst failure of the active transport of 5-methyltetrahydrofolate (5-MTHF) into the CSF compartment has been proposed as a pot...

journal_title：Neurochemistry international

authors： Aylett SB,Neergheen V,Hargreaves IP,Eaton S,Land JM,Rahman S,Heales SJ

更新日期：2013-12-01 00:00:00

abstract：:Esters of dimethylcarbamic acid are known to be poor substrates of acetylcholinesterase. They carbamylate the active catalytic site of the enzyme and the subsequent decarbamylation is a slow but measurable process. Similarly, acetylcholinesterase can be phosphonylated, and the dephosphonylation is extremely slow. Rapi...

journal_title：Neurochemistry international

authors： Dawson RM,Poretski M,Upsher CM

更新日期：1981-01-01 00:00:00