Abstract：
:We have previously demonstrated that acute hyperhomocysteinemia induces oxidative stress in rat brain. In the present study, we initially investigated the effect of chronic hyperhomocysteinemia on some parameters of oxidative damage, namely total radical-trapping antioxidant potential and activities of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase), as well as on DNA damage in parietal cortex and blood of rats. We also evaluated the effect of folic acid on biochemical alterations elicited by hyperhomocysteinemia. Wistar rats received daily subcutaneous injection of Hcy (0.3-0.6 micromol/g body weight), and/or folic acid (0.011 micromol/g body weight) from their 6th to their 28th day of life. Twelve hours after the last injection the rats were sacrificed, parietal cortex and total blood was collected. Results showed that chronic homocysteine administration increased DNA damage, evaluated by comet assay, and disrupted antioxidant defenses (enzymatic and non-enzymatic) in parietal cortex and blood/plasma. Folic acid concurrent administration prevented homocysteine effects, possibly by its antioxidant and DNA stability maintenance properties. If confirmed in human beings, our results could propose that the supplementation of folic acid can be used as an adjuvant therapy in disorders that accumulate homocysteine.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Matté C,Mackedanz V,Stefanello FM,Scherer EB,Andreazza AC,Zanotto C,Moro AM,Garcia SC,Gonçalves CA,Erdtmann B,Salvador M,Wyse ATdoi
10.1016/j.neuint.2008.08.011subject
Has Abstractpub_date
2009-01-01 00:00:00pages
7-13issue
1eissn
0197-0186issn
1872-9754pii
S0197-0186(08)00160-5journal_volume
54pub_type
杂志文章abstract：:The extracellular levels of the neurotransmitter glycine in the brain are tightly regulated by the glycine transporter 1 (GlyT1) and the clearance rate for glycine depends on its rate of transport and the levels of cell surface GlyT1. Over the years, it has been shown that PKC tightly regulates the activity of several...
journal_title：Neurochemistry international
pub_type： 杂志文章
doi：10.1016/j.neuint.2011.08.006
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journal_title：Neurochemistry international
pub_type： 杂志文章,评审
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journal_title：Neurochemistry international
pub_type： 杂志文章
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journal_title：Neurochemistry international
pub_type： 杂志文章,评审
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journal_title：Neurochemistry international
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journal_title：Neurochemistry international
pub_type： 杂志文章
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journal_title：Neurochemistry international
pub_type： 杂志文章
doi：10.1016/s0197-0186(97)00130-7
更新日期：1998-05-01 00:00:00
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journal_title：Neurochemistry international
pub_type： 杂志文章,评审
doi：10.1016/j.neuint.2017.08.010
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journal_title：Neurochemistry international
pub_type： 杂志文章
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更新日期：2003-03-01 00:00:00
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journal_title：Neurochemistry international
pub_type： 杂志文章
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更新日期：2003-09-01 00:00:00
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journal_title：Neurochemistry international
pub_type： 杂志文章
doi：10.1016/j.neuint.2015.01.006
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journal_title：Neurochemistry international
pub_type： 杂志文章
doi：10.1016/j.neuint.2010.06.008
更新日期：2010-10-01 00:00:00
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journal_title：Neurochemistry international
pub_type： 杂志文章
doi：10.1016/j.neuint.2004.09.002
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journal_title：Neurochemistry international
pub_type： 杂志文章
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journal_title：Neurochemistry international
pub_type： 杂志文章,评审
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journal_title：Neurochemistry international
pub_type： 杂志文章
doi：10.1016/j.neuint.2016.12.005
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journal_title：Neurochemistry international
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journal_title：Neurochemistry international
pub_type： 杂志文章
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journal_title：Neurochemistry international
pub_type： 杂志文章
doi：10.1016/j.neuint.2006.12.008
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journal_title：Neurochemistry international
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journal_title：Neurochemistry international
pub_type： 杂志文章
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journal_title：Neurochemistry international
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journal_title：Neurochemistry international
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journal_title：Neurochemistry international
pub_type： 杂志文章
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journal_title：Neurochemistry international
pub_type： 杂志文章,评审
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journal_title：Neurochemistry international
pub_type： 杂志文章
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更新日期：2009-05-01 00:00:00
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journal_title：Neurochemistry international
pub_type： 杂志文章,评审
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更新日期：2001-02-01 00:00:00
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journal_title：Neurochemistry international
pub_type： 杂志文章
doi：10.1016/j.neuint.2017.03.004
更新日期：2017-09-01 00:00:00
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journal_title：Neurochemistry international
pub_type： 杂志文章
doi：10.1016/s0197-0186(97)00063-6
更新日期：1998-01-01 00:00:00
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journal_title：Neurochemistry international
pub_type： 杂志文章
doi：10.1016/j.neuint.2017.03.008
更新日期：2017-10-01 00:00:00
