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15,16-dihydrotanshinone I suppresses the activation of BV-2 cell, a murine microglia cell line, by lipopolysaccharide.

Abstract：

:Microglial activation has been implicated in neurodegenerative diseases. Therefore, inhibition of inflammation mediated by microglia is a strategy in neurodegenerative disease therapy. In this study, we isolated cryptotanshinone and 15,16-dihydrotanshinone I from Salvia miltiorrhiza, a traditional Korean herb medicine, by bioactivity-guided fractionation based on inhibitory effect on nitric oxide in a lipopolysaccharide-stimulated BV-2 cells, a murine microglial cell line. 15,16-Dihydotanshinoe I suppressed the expression of not only inducible nitric oxide synthase but also of interleukin-1beta, tumor necrosis factor-alpha, and of TNF-alpha converting enzyme.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Lee P,Hur J,Lee J,Kim J,Jeong J,Kang I,Kim SY,Kim H

doi

10.1016/j.neuint.2005.07.004

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

60-6

issue

1

eissn

0197-0186

issn

1872-9754

pii

S0197-0186(05)00189-0

journal_volume

48

pub_type

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