Chronic treatment with a dopamine uptake blocker changes dopamine and acetylcholine but not glutamate and GABA concentrations in prefrontal cortex, striatum and nucleus accumbens of the awake rat.

abstract：:E1 mice are an animal model of human epilepsy (idiopathic complex partial seizures). We have previously demonstrated abrupt poly(A)(+) RNA expression in liver from 1-day-old E1 mouse [Mita et al., 1991. Devl. Brain Res. 64, 27-35]. In the present study, we constructed a cDNA library of the poly(A)(+) RNA. By analyzing...

journal_title：Neurochemistry international

authors： Mita T,Kawazu I,Hirano H,Ohmori O,Janjua N,Shibata K

更新日期：2001-04-01 00:00:00

abstract：:Amyloid β (Aβ) oligomers are presumed to be one of the causes of Alzheimer's disease (AD). Previously, we identified the E693Δ mutation in amyloid precursor protein (APP) in patients with AD who displayed almost no signals of amyloid plaques in amyloid imaging. We generated APP-transgenic mice expressing the E693Δ mut...

journal_title：Neurochemistry international

authors： Takano M,Maekura K,Otani M,Sano K,Nakamura-Hirota T,Tokuyama S,Min KS,Tomiyama T,Mori H,Matsuyama S

更新日期：2012-08-01 00:00:00

abstract：:Lipid peroxidation has many deleterious effects on cells, and in the nervous system is considered to be involved in the pathogenesis of neurodegenerative diseases. To suppress lipid peroxidation, cells have various defense systems such as glutathione and thioredoxin, and defects in these defense systems will result in...

journal_title：Neurochemistry international

authors： Nagamine S,Kabuta T,Furuta A,Yamamoto K,Takahashi A,Wada K

更新日期：2010-09-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is the main chemical inhibitory neurotransmitter in the brain. In the central nervous system (CNS) it acts on two distinct types of receptor: an ion channel, i.e., an "ionotropic" receptor permeable to Cl- and HCO3- (GABAA receptors) and a G-protein coupled "metabotropic" receptor that i...

journal_title：Neurochemistry international

authors： Mody I

更新日期：2008-01-01 00:00:00

abstract：:Immunoglobulin G (IgG) antibodies against myelin oligodendrocyte glycoprotein (MOG) are detected in the serum of some patients with demyelinating diseases. These patients are known to show repeated clinical episodes of inflammatory demyelinating attacks in the central nervous system. Although the associated pathogenic...

journal_title：Neurochemistry international

authors： Akaishi T,Sato DK,Takahashi T,Nakashima I

更新日期：2019-11-01 00:00:00

abstract：:Quantitative autoradiography analysis of neurotensin (NT) and somatostatin (SS) binding sites was performed on coronal sections of the medulla oblongata from 2 fetuses, 6 controls and 7 victims of Sudden Infant Death Syndrome (SIDS). Throughout the first postnatal year, mean SS binding site density was similar in cont...

journal_title：Neurochemistry international

authors： Chigr F,Jordan D,Najimi M,Denoroy L,Sarrieau A,de Broca A,Rostene W,Epelbaum J,Kopp N

更新日期：1992-01-01 00:00:00

abstract：:Primary cortical neurons exposed to the mitochondrial toxin NaN3 (0.1-3 mM) were submitted to oxidative stress with H2O2 (30-150 μM), to mimic conditions observed in neurodegenerative disorders. The effects of such treatment on a series of parameters useful in characterizing neuronal damage were investigated: (i) the ...

journal_title：Neurochemistry international

authors： Selvatici R,Marani L,Marino S,Siniscalchi A

更新日期：2013-08-01 00:00:00

abstract：:A decrease in the osmolarity of incubation medium is accompanied by calcium influx in neuronal presynaptic endings. We studied the influence of Ca2+ on exocytosis induced by hypotonic shock using the hydrophilic fluorescent dye acridine orange and the hydrophobic fluorescent dye FM2-10. It was shown using acridine ora...

journal_title：Neurochemistry international

authors： Waseem TV,Rakovich AA,Lavrukevich TV,Konev SV,Fedorovich SV

更新日期：2005-02-01 00:00:00

abstract：:To clarify molecular mechanism for sustained activation of gamma protein kinase C (gammaPKC), a neuron-specific subtype, we investigated the involvement of phospholipase A2 (PLA2) products in the membrane association of gammaPKC upon activation of G protein coupled purinoceptors in CHO-K1 and NG 108-15 cells. In addit...

journal_title：Neurochemistry international

authors： Yagi K,Shirai Y,Hirai M,Sakai N,Saito N

更新日期：2004-07-01 00:00:00

abstract：:The aim of this study was to investigate the involvement of calmodulin in phospholipase D activation in SH-SY5Y cells. Cells prelabelled with [3H]-palmitic acid were incubated with calmodulin antagonists and/or other compounds. Phosphatidylethanol, a specific marker for phospholipase D activity, and phosphatidic acid ...

journal_title：Neurochemistry international

authors： del Carmen Boyano-Adánez M,Gustavsson L

更新日期：2002-03-01 00:00:00

abstract：:We showed that dextromethorphan (DM) provides neuroprotective/anticonvulsant effects and that DM and its major metabolite, dextrorphan, have a high-affinity for sigma(1) receptors, but a low affinity for sigma(2) receptors. In addition, we found that DM has a higher affinity than DX for sigma(1) sites, whereas DX has ...

journal_title：Neurochemistry international

authors： Shin EJ,Nah SY,Chae JS,Bing G,Shin SW,Yen TP,Baek IH,Kim WK,Maurice T,Nabeshima T,Kim HC

更新日期：2007-05-01 00:00:00

abstract：:Phosphodiesterase 7B (PDE7B) inhibition has been considered as a therapeutic target for the treatment of several neurological disorders. Currently, there are no radio-labeled tracers available to determine receptor occupancy (RO) of this target. Developing such a tracer could greatly facilitate the identification of v...

journal_title：Neurochemistry international

authors： Chen J,Gu G,Chen M,Scott T,Heger L,Zook D,Chung D,Keenan T,Renick J,Santora VJ,Vivian J,Stauber K,Breitenbucher JG,Tabatabaei A

更新日期：2020-07-01 00:00:00

abstract：:Iron accumulation is considered to be involved in the pathogenesis of Parkinson's disease. To demonstrate the relationship between peripheral iron overload and dopaminergic neuron loss in rat substantia nigra (SN), in the present study we used fast cyclic voltammetry, tyrosine hydroxylase (TH) immunohistochemistry, Pe...

journal_title：Neurochemistry international

authors： Jiang H,Song N,Wang J,Ren LY,Xie JX

更新日期：2007-07-01 00:00:00

abstract：:Brain cortex synaptoneurosomes actively incorporated [14C]arachidonic acid (AA) into lipids. Serotonin (5-HT), at a concentration range of 10 microM-1 mM, significantly stimulates the incorporation of AA mainly into phosphatidylinositol (PI) of brain cortex synaptoneurosomes. The stimulation rate of AA incorporation b...

journal_title：Neurochemistry international

authors： Strosznajder J,Samochocki M,Duran M

更新日期：1994-08-01 00:00:00

abstract：:Radial glial cells play a significant role in the repair of spinal cord injuries as they exert critical role in the neurogenesis and act as a scaffold for neuronal migration. Our previous study showed that mature astrocytes of spinal cord can undergo a de-differentiation process and further transform into pluripotenti...

journal_title：Neurochemistry international

authors： Yang H,Ling W,Vitale A,Olivera C,Min Y,You S

更新日期：2011-12-01 00:00:00

abstract：:Reserch progresses in understanding the pathogenicity of multiple sclerosis (MS) in the last couple of decade has enabled us to develop new drug entities available in the clinic. However, we still have not succeeded in preventing conversion from relapsing-remitting MS (RR-MS) to secondary progressive MS (SP-MS) and cu...

journal_title：Neurochemistry international

authors： Oki S

更新日期：2019-11-01 00:00:00

abstract：:Although microvascular cell death is a well established hallmark of diabetic retinopathy, which is a major cause of vision loss, much remains to be learned about the functional changes that precede the onset of morphological damage to retinal blood vessels. Early alterations of function are of interest since they may ...

journal_title：Neurochemistry international

authors： Nakaizumi A,Zhang T,Puro DG

更新日期：2012-11-01 00:00:00

abstract：:A procedure for studying 5-hydroxytryptamine synthesis by determining the rate of accumulation of 5-hydroxytryptophan after administering m-hydroxybenzylhydrazine, an inhibitor of aromatic-l-amino acid decarboxylase, and large doses of l-tryptophan was characterized. The utility of this method as an index of 5-hydroxy...

journal_title：Neurochemistry international

authors： Nielsen JA

更新日期：1986-01-01 00:00:00

abstract：:Cerebral edema is a potentially life-threatening complication shared by diseases of different etiology, such as diabetic ketoacidosis, acute liver failure, high altitude exposure, dialysis disequilibrium syndrome, and salicylate intoxication. Pulmonary edema is also habitually present in these disorders, indicating th...

journal_title：Neurochemistry international

authors： Adeva MM,Souto G,Donapetry C,Portals M,Rodriguez A,Lamas D

更新日期：2012-07-01 00:00:00

abstract：:Sprague-Dawley rats exposed to uncontrollable shock can be separated by a subsequent shock escape test into two groups: a "helpless" (LH) group which demonstrates a deficit in escape behavior, and a "nonlearned helpless" (NLH) group which shows no escape deficit and acquires the escape response as readily as naive con...

journal_title：Neurochemistry international

authors： Edwards E,Kornrich W,van Houtten P,Henn FA

更新日期：1992-07-01 00:00:00

abstract：:A purification procedure to obtain peroxisomes (microperoxisomes) from the brain of suckling rats is reported. A P2 fraction, (crude light mitochondria) frozen and thawed seven times, was subfractionated yielding a P4 fraction, 4-fold enriched in catalase activity with respect to the cytoplasmic extract S1. The P4 fra...

journal_title：Neurochemistry international

authors： Cimini AM,Moreno S,Giorgi M,Serafini B,Cerú MP

更新日期：1993-09-01 00:00:00

abstract：:In the past few years, several studies have demonstrated in the rat subcommissural organ the presence of nerve endings and modified ependymocytes showing an uptake of [(3)H]GABA. The present work was performed to demonstrate in this cerebral zone the possibility of a GABA synthesis by the immunohistochemical localizat...

journal_title：Neurochemistry international

authors： Weissmann-Nanopoulos D,Belin MF,Didier M,Aguera M,Partisani M,Maitre M,Pujol JF

更新日期：1983-01-01 00:00:00

abstract：:Diabetic neuropathic pain (DNP) plays a major role in decreased life quality of diabetes patients, however, the neural mechanisms underlying DNP remain unclear. Endomorphins are the endogenous ligands for mu-opioid receptor. There is increasing evidence implicating the involvement of spinal endomorphin-2 (EM2) in neur...

journal_title：Neurochemistry international

authors： Niu L,Dai GH,He GL,Yang M,Hu HM,Liu ZK,Qian NS,Chen YL

更新日期：2017-09-01 00:00:00

abstract：:The precise function of activated microglia and their secretory products remains controversial. In order to assess the role of microglial secretion products, we established an in vitro model of an inflammatory reaction in the brain by co-culturing microglial and neuronal cell lines. Upon stimulation with interferon-ga...

journal_title：Neurochemistry international

authors： Hemmer K,Fransen L,Vanderstichele H,Vanmechelen E,Heuschling P

更新日期：2001-06-01 00:00:00

abstract：:We have previously reported that, unlike their rat counterparts, the survival of mouse cerebellar granule cells is independent of chronic stimulation whether owing to elevated K(+)-induced depolarization or NMDA (N-methyl-D-aspartate) receptor activation. One explanation could be that during the critical period mouse ...

journal_title：Neurochemistry international

authors： Mogensen HS,Jørgensen OS

更新日期：1996-11-01 00:00:00

abstract：:Positron-emitting beta-adrenoceptor ligands for the CNS could allow determination of changes in beta-adrenoceptor availability after treatment of patients with norepinephrine reuptake inhibitors or tricyclic antidepressants, and differential diagnosis between multiple sclerosis and other brain disorders in an early st...

journal_title：Neurochemistry international

authors： van Waarde A,Doorduin J,de Jong JR,Dierckx RA,Elsinga PH

更新日期：2008-03-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) levels and the activity of glutamate decarboxylase were measured in homogenates of rat brain cortical tissue, at different times after chronic intracortical infusion of GABA in vivo during 2, 6 or 24 h. Cortical electrical activity was also recorded. As previously described, about 1 h af...

journal_title：Neurochemistry international

authors： Salazar P,Montiel T,Brailowsky S,Tapia R

更新日期：1994-04-01 00:00:00

abstract：:Autism spectrum disorder is a neurodevelopmental disorder characterized by impaired social interaction, poor communication skills, and repetitive/restrictive behaviors. Elevated blood levels of pro-inflammatory cytokines have been reported in subjects with autism spectrum disorder. On the other hand, early childhood a...

journal_title：Neurochemistry international

authors： Makinodan M,Iwata K,Ikawa D,Yamashita Y,Yamamuro K,Toritsuka M,Kimoto S,Okumura K,Yamauchi T,Yoshino H,Tsujii M,Sugiyama T,Tsuchiya K,Mori N,Matsuzaki H,Kishimoto T

更新日期：2017-03-01 00:00:00

abstract：:G protein-coupled receptors are cell surface receptors that mediate the effects of extracellular signals in the endocrine/paracrine and sensory systems. Experimental evidence is accumulating, which suggest that these receptors form dimers or higher order oligomers. The functional relevance of G protein-coupled recepto...

journal_title：Neurochemistry international

authors： Karip E,Turu G,Süpeki K,Szidonya L,Hunyady L

更新日期：2007-10-01 00:00:00

abstract：:Schizophrenia is a neuropsychiatric condition that reaches around 1% of people worldwide. Because taurine exerts a neuroprotective role in the brain, this molecule is a promising candidate to reduce schizophrenia-like symptoms. Here, we investigated a possible neuroprotective role of taurine against MK-801-induced mem...

journal_title：Neurochemistry international

authors： Franscescon F,Müller TE,Bertoncello KT,Rosemberg DB

更新日期：2020-05-01 00:00:00