Evidence for a role for transglutaminase in Huntington's disease and the potential therapeutic implications.

abstract：:The mechanism of action of lithium (Li) alone or with pilocarpine (Pilo), focusing on muscarinic and dopaminergic systems and also on phosphoinositide metabolism was studied. Li (3 mEq/kg) administered to rats once (1 d) or daily for 7 days (7 d), 24 h before Pilo (15 mg/kg), exacerbated cholinergic signs, leading to ...

journal_title：Neurochemistry international

authors： Marinho MM,de Sousa FC,de Bruin VM,Vale MR,Viana GS

更新日期：1998-10-01 00:00:00

abstract：:We have previously demonstrated that acute hyperhomocysteinemia induces oxidative stress in rat brain. In the present study, we initially investigated the effect of chronic hyperhomocysteinemia on some parameters of oxidative damage, namely total radical-trapping antioxidant potential and activities of antioxidant enz...

journal_title：Neurochemistry international

authors： Matté C,Mackedanz V,Stefanello FM,Scherer EB,Andreazza AC,Zanotto C,Moro AM,Garcia SC,Gonçalves CA,Erdtmann B,Salvador M,Wyse AT

更新日期：2009-01-01 00:00:00

abstract：:Taurine-like immunoreactivity (TLI) is found in the pigeon retina at high levels within cones, in select cells of the inner nuclear layer and in sublaminae of the inner plexiform layer. At the ultrastructural level a high density of immuno-gold particles in visualized in the ellipsoid, but not in the paraboloid area o...

journal_title：Neurochemistry international

authors： Ueck M,Hach A,Verdone-Smith C,Lake N

更新日期：1995-12-01 00:00:00

abstract：:Some biochemical and histological studies of Parkinson's disease patients' brains and 6-OHDA-lesioned rats suggest that dopaminergic dennervation of the striatum leads to the nitrergic system hypofunction in this structure. Hence, recently the modulation of nitric oxide (NO)- soluble guanylyl cyclase-cyclic GMP signal...

journal_title：Neurochemistry international

authors： Lorenc-Koci E,Czarnecka A,Lenda T,Kamińska K,Konieczny J

更新日期：2013-12-01 00:00:00

abstract：:Glycine can be substrate for two transporters: GlyT1, largely expressed by astrocytes but also by some non-glycinergic neurons, and GlyT2, most frequently present in glycine-storing nerve endings. In morphological studies, GlyT2 expression had been found to be restricted to caudal regions, being almost undetectable in...

journal_title：Neurochemistry international

authors： Romei C,Raiteri L

更新日期：2016-10-01 00:00:00

abstract：:AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) excitotoxicity was examined in cultured neocortical neurons using the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to measure cell viability. Neurons were exposed to AMPA at different culture periods during development o...

journal_title：Neurochemistry international

authors： Jensen JB,Schousboe A,Pickering DS

更新日期：1998-05-01 00:00:00

abstract：:Viral infections are implicated in the onset and promotion of autoimmunity in genetically predisposed individuals. In this study, immune response patterns to herpes viruses were compared in aquaporin 4 (AQP4) antibody positive central nervous system (CNS) autoimmunity and multiple sclerosis (MS). Serum samples of pati...

journal_title：Neurochemistry international

authors： Sellner J,Cepok S,Kalluri SR,Nestler A,Kleiter I,Kümpfel T,Linker R,Melms A,Menge T,Tumani H,Paul F,Hemmer B,Berthele A

更新日期：2010-11-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) affecting more than 2.5 million individuals worldwide. In the present study, myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) mice were treated with adenosine recept...

journal_title：Neurochemistry international

authors： Chen Y,Zhang ZX,Zheng LP,Wang L,Liu YF,Yin WY,Chen YY,Wang XS,Hou ST,Chen JF,Zheng RY

更新日期：2019-10-01 00:00:00

abstract：:Immunoglobulin G (IgG) antibodies against myelin oligodendrocyte glycoprotein (MOG) are detected in the serum of some patients with demyelinating diseases. These patients are known to show repeated clinical episodes of inflammatory demyelinating attacks in the central nervous system. Although the associated pathogenic...

journal_title：Neurochemistry international

authors： Akaishi T,Sato DK,Takahashi T,Nakashima I

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:The major hallmark of Alzheimer's disease (AD) is the formation of amyloid aggregates, which are formed due to improper folding of proteins leading to the aggregation of amyloid beta (Aβ) 42 peptide. Inhibition of Aβ 42 aggregation using a drug such as carbenoxolone (Cbx), which has already been stated as ne...

journal_title：Neurochemistry international

authors： Sharma S,Nehru B,Saini A

更新日期：2017-09-01 00:00:00

abstract：:Alzheimer disease (AD) is the most common form of adult dementia. Its pathological hallmarks are synaptic degeneration, deposition of amyloid plaques and neurofibrillary tangles, leading to neuronal loss. A few hypotheses have been proposed to explain AD pathogenesis. The beta-amyloid (Abeta) and hyperphosphorylated t...

journal_title：Neurochemistry international

authors： Bojarski L,Herms J,Kuznicki J

更新日期：2008-03-01 00:00:00

abstract：:The consequences of irreversibly-inhibiting D2 dopaminergic receptors on the expression of D1 and D2 dopamine receptor mRNAs and proenkephalin mRNA and on the levels of mu- and delta-opioid receptors in rat striatum were studied following single or repeated administration of the irreversibly-acting D2 dopamine recepto...

journal_title：Neurochemistry international

authors： Chen JF,Aloyo VJ,Qin ZH,Weiss B

更新日期：1994-10-01 00:00:00

abstract：:Pediatric brain tumors are the leading cancer-related cause of death in children and adolescents in the United States, affecting on average 1 in 2000 children per year. Recent advances in cancer genomics have led to profound discoveries about the underlying molecular biology and ontogeny of these tumors. In particular...

journal_title：Neurochemistry international

authors： Alencastro Veiga Cruzeiro G,Rota C,Hack OA,Segal R,Filbin MG

更新日期：2020-12-15 00:00:00

abstract：:To investigate the contribution of the dopamine (DA) synthesis to both the calcium-dependent and the carrier-mediated, mechanisms of DA release in the striatum, anaesthetized rats were locally superfused in the striatum with a push pull cannula supplied with an artificial CSF containing tritiated tyrosine. DA, dihydro...

journal_title：Neurochemistry international

authors： Olivier V,Gobert A,Guibert B,Leviel V

更新日期：1999-12-01 00:00:00

abstract：:The distribution of substance P in the colon of piebald lethal (s(1)/s(1)) mice was studied by radioimmunoassay and immunohistochemistry. These animals inherit as a Mendelian recessive trait an aganglionic distal colon. In the region proximal to the aganglionic segment, there is an extensive transitional or hypogangli...

journal_title：Neurochemistry international

authors： Bu'lock AJ,Vaillant C,Dockray GJ

更新日期：1984-01-01 00:00:00

abstract：:One hour of ischemia significantly increased protein S100B release from rat brain slices without altering lactate dehydrogenase leakage. Reoxygenation of the ischemic slices, however, increased the levels of these biochemical markers in the medium. Although removal of extracellular Ca(+2) ions from the medium did not ...

journal_title：Neurochemistry international

authors： Büyükuysal RL

更新日期：2005-12-01 00:00:00

abstract：:The present study was carried out to clarify whether the imidazolines clonidine, moxonidine and cirazoline as well as the guanidine aganodine inhibit noradrenaline release in the rat and rabbit brain via imidazoline receptors, alpha 2-adrenoceptors and/or histamine H3 receptors. Slices or synaptosomes from the rat or ...

journal_title：Neurochemistry international

authors： Schlicker E,Fink K,Kathmann M,Molderings GJ,Göthert M

更新日期：1997-01-01 00:00:00

abstract：:Deficiency of 5-methyltetrahydrofolate (5-MTHF) in cerebrospinal fluid (CSF) is associated with a number of neurometabolic conditions including mitochondrial electron transport chain defects. Whilst failure of the active transport of 5-methyltetrahydrofolate (5-MTHF) into the CSF compartment has been proposed as a pot...

journal_title：Neurochemistry international

authors： Aylett SB,Neergheen V,Hargreaves IP,Eaton S,Land JM,Rahman S,Heales SJ

更新日期：2013-12-01 00:00:00

abstract：:Marked age-related changes are noted in the neurotensin distribution of the human hippocampus. Different neuronal structures containing neurotensin are detected by immunohistochemistry during postnatal brain growth from birth to 4 years but no later. They are the neurotensin-immunoreactive pyramidal cells of the subic...

journal_title：Neurochemistry international

authors： Lotstra F,Mailleux P,Schiffmann SN,Vierendeels G,Vanderhaeghen JJ

更新日期：1989-01-01 00:00:00

abstract：:Evidences have indicated a high degree of comorbidity of alcoholism and depression. N-acetylcysteine (NAC) has shown its clinical efficiency in the treatment of several psychiatric disorders and is identified as a multi-target acting drug. The ability of NAC to prevent alcohol abstinence-induced depression-like effect...

journal_title：Neurochemistry international

authors： Yawalkar R,Changotra H,Gupta GL

更新日期：2018-09-01 00:00:00

abstract：:The immunostains of GD3, c-pathway polysialogangliosides and gangliotetraosylgangliosides belonging to the a- and b-pathways were analyzed in embryo optic lobe cells. Cells were cultured in serum free media with, and without, bovine brain ganglioside mixture (largely gangliotetraosylgangliosides). Control cells differ...

journal_title：Neurochemistry international

authors： Cossy-Isasi S,Panzetta P

更新日期：1994-04-01 00:00:00

abstract：:P2Y purinergic receptors expressed in neurons and satellite glial cells (SGCs) of the trigeminal ganglion (TG) contribute to inflammatory and neuropathic pain. P2Y14 receptor expression is reported in the spinal cord, dorsal root ganglion (DRG), and TG. In present study, the role of P2Y14 receptor in the TG in inflamm...

journal_title：Neurochemistry international

authors： Lin J,Zhang YY,Liu F,Fang XY,Liu MK,Huang CL,Wang H,Liao DQ,Zhou C,Shen JF

更新日期：2019-12-01 00:00:00

abstract：:The system of GABA transporters in neural cells constitutes an efficient mechanism for terminating inhibitory GABAergic neurotransmission. As such these transporter are important therapeutical targets in epilepsy and potentially other neurological diseases related to the GABA system. In this study a number of analogs ...

journal_title：Neurochemistry international

authors： Sarup A,Larsson OM,Bolvig T,Frølund B,Krogsgaard-Larsen P,Schousboe A

更新日期：2003-09-01 00:00:00

abstract：:Immunohistochemical study on growth inhibitory factor (GIF) in rat brain has revealed that a glial cell layer on the surface of cerebral cortex and the cells surrounding Purkinje cells has been reported. In addition, neurons in gray matter were weakly immunostained for GIF. In situ hybridization using digoxigenin-labe...

journal_title：Neurochemistry international

authors： Anezaki T,Ishiguro H,Hozumi I,Inuzuka T,Hiraiwa M,Kobayashi H,Yuguchi T,Wanaka A,Uda Y,Miyatake T

更新日期：1995-07-01 00:00:00

abstract：:The aim of this study was to investigate the involvement of calmodulin in phospholipase D activation in SH-SY5Y cells. Cells prelabelled with [3H]-palmitic acid were incubated with calmodulin antagonists and/or other compounds. Phosphatidylethanol, a specific marker for phospholipase D activity, and phosphatidic acid ...

journal_title：Neurochemistry international

authors： del Carmen Boyano-Adánez M,Gustavsson L

更新日期：2002-03-01 00:00:00

abstract：:Oxidative stress-induced neuronal death plays a pivotal role in pathogenesis of neurodegenerative disorders. Recently, 7,8-dihydroxyflavone (7,8-DHF) has been shown to exert neuroprotective effects by acting as a selective tyrosine kinase receptor B (TrkB) agonist. In addition, the antioxidant action of 7,8-DHF may pr...

journal_title：Neurochemistry international

authors： Han X,Zhu S,Wang B,Chen L,Li R,Yao W,Qu Z

更新日期：2014-01-01 00:00:00

abstract：:L-serine-O-sulphate is a member of a group of amino acids collectively called gliotoxins and is a substrate for the high affinity sodium-dependent glutamate transporters. Previous studies have shown that it is toxic to primary cultures of astrocytes but the mode of toxicity is unknown. The current study demonstrates t...

journal_title：Neurochemistry international

authors： Brennan L,Alves PM,Hewage C,Malthouse JP,McBean GJ

更新日期：2006-06-01 00:00:00

abstract：:Much attention has been paid to the connection between periodontitis and Alzheimer's disease (AD). We previously showed that infection of P. gingivalis, one of major periodontal pathogen causing periodontitis, induced migration and inflammatory responses in murine microglia through gingipain-induced activation of prot...

journal_title：Neurochemistry international

authors： Nonaka S,Nakanishi H

更新日期：2020-11-01 00:00:00

abstract：:(RS)-2-Amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid (APPA), which is an analogue of (RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA), shows the characteristics of a partial AMPA receptor agonist. Since (S)-APPA is a full AMPA agonist and (R)-APPA a competitive antagonist, the partial ag...

journal_title：Neurochemistry international

authors： Ebert B,Madsen U,Søby KK,Krogsgaard-Larsen P

更新日期：1996-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder and is characterized by pathological aggregates of amyloid β-protein (Aβ) and tau protein. On the basis of genetic evidence, biochemical data, and animal models, Aβ has been suggested to be responsible for the pathogenesis of AD (the am...

journal_title：Neurochemistry international

authors： Ono K

更新日期：2018-10-01 00:00:00