Identification of two proteolipid antigens with different localization at torpedo neuromuscular synapses.

abstract：:The roles of membrane depolarization and calcium influx in the regulation of retinal serotonin N-acetyltransferase (NAT) activity were investigated in low-density monolayer cultures of chick retinal cells, in which photoreceptors represented approximately 70% of the total cell population. NAT activity expressed by the...

journal_title：Neurochemistry international

authors： Avendano G,Butler BJ,Michael Iuvone P

更新日期：1990-01-01 00:00:00

abstract：:In this study we determined the changes in the intracellular free Ca2+ concentration, associated with the inhibitory modulation of the exocytotic release of GABA by GABAB receptor activation in rat cerebrocortical synaptosomes. We observed that SK&F 97541 and (-)baclofen both act as agonists of the presynaptic GABAB r...

journal_title：Neurochemistry international

authors： Santos AE,Carvalho CM,Macedo TA,Carvalho AP

更新日期：1995-10-01 00:00:00

abstract：:Malfunctioning of high-affinity glutamate transporters is believed to contribute to the accumulation of toxic concentrations of glutamate and, thus, trigger the cellular mechanisms of neurodegeneration. Emerging data point to the presence of excitotoxic component in Alzheimer's disease (AD) and aberrant expression of ...

journal_title：Neurochemistry international

authors： Rodriguez-Kern A,Gegelashvili M,Schousboe A,Zhang J,Sung L,Gegelashvili G

更新日期：2003-09-01 00:00:00

abstract：:Rapid administration of large doses of ammonia leads to death of animals, which is largely prevented by pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists. The present study focuses on a subunit(s) of NMDA receptor involved in ammonia-induced death by use of NMDA receptor GluRepsilon subunit-deficient ...

journal_title：Neurochemistry international

authors： Kitano T,Matsumura S,Seki T,Hikida T,Sakimura K,Nagano T,Mishina M,Nakanishi S,Ito S

更新日期：2004-01-01 00:00:00

abstract：:The brain uses long-chain fatty acids (LCFAs) to a negligible extent as fuel for the mitochondrial energy generation, in contrast to other tissues that also demand high energy. Besides this generally accepted view, some studies using cultured neural cells or whole brain indicate a moderately active mitochondrial β-oxi...

journal_title：Neurochemistry international

authors： Schönfeld P,Reiser G

更新日期：2017-10-01 00:00:00

abstract：:The extracellular levels of the neurotransmitter glycine in the brain are tightly regulated by the glycine transporter 1 (GlyT1) and the clearance rate for glycine depends on its rate of transport and the levels of cell surface GlyT1. Over the years, it has been shown that PKC tightly regulates the activity of several...

journal_title：Neurochemistry international

authors： Vargas-Medrano J,Castrejon-Tellez V,Plenge F,Ramirez I,Miranda M

更新日期：2011-12-01 00:00:00

abstract：:To elucidate the role of Ca(2+)-activated K(+) (K(Ca)) channels in the presynaptic acetylcholine (ACh) release from splanchnic nerve endings and the postsynaptic catecholamine release from chromaffin cells, we applied microdialysis technique to the left adrenal medulla of anesthetized rats and investigated the effects...

journal_title：Neurochemistry international

authors： Akiyama T,Yamazaki T,Kawada T,Shimizu S,Sugimachi M,Shirai M

更新日期：2010-01-01 00:00:00

abstract：:The distribution of substance P in the colon of piebald lethal (s(1)/s(1)) mice was studied by radioimmunoassay and immunohistochemistry. These animals inherit as a Mendelian recessive trait an aganglionic distal colon. In the region proximal to the aganglionic segment, there is an extensive transitional or hypogangli...

journal_title：Neurochemistry international

authors： Bu'lock AJ,Vaillant C,Dockray GJ

更新日期：1984-01-01 00:00:00

abstract：:Both brain-derived neurotrophic factor (BDNF) and the serotonin receptor 2A (5-HT(2A)) have been related to depression pathology. Specific 5-HT(2A) receptor changes seen in BDNF conditional mutant mice suggest that BDNF regulates the 5-HT(2A) receptor level. Here we show a direct effect of BDNF on 5-HT(2A) receptor pr...

journal_title：Neurochemistry international

authors： Trajkovska V,Santini MA,Marcussen AB,Thomsen MS,Hansen HH,Mikkelsen JD,Arneberg L,Kokaia M,Knudsen GM,Aznar S

更新日期：2009-12-01 00:00:00

abstract：:Long-term potentiation (LTP), a model of activity-dependent synaptic plasticity and of certain forms of memory, comprises the persistent enhancement of excitatory neurotransmission that results from high-frequency activation. A presynaptic component of LTP is thought to be modulated by a retrograde messenger generated...

journal_title：Neurochemistry international

authors： Bazan NG,Packard MG,Teather L,Allan G

更新日期：1997-02-01 00:00:00

abstract：:Prenatal exposure to diazepam (DZ), a positive allosteric modulator of the gamma-aminobutyric acid(A) (GABA(A)) receptor complex, exerts profound effects that become more evident during puberty and in many cases are sex-specific, suggesting that such exposure interferes with the activity of steroid hormones. Apart fro...

journal_title：Neurochemistry international

authors： Cannizzaro C,D'Amico M,Altobelli D,Preziosi P,Martire M

更新日期：2003-07-01 00:00:00

abstract：:Short-term supplementation of low protein diet (LPD) or high protein diet (HPD) to the aged (18 months old) rats did not change the hypothalamic GABAergic activity and immune response. Long-term supplementation of LPD on the other hand, enhanced hypothalamic GABAergic activity with an immunopotentiation by increasing ...

journal_title：Neurochemistry international

authors： Bandyopadhyay BC,Poddar MK

更新日期：1998-02-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease in which pathogenic T cells play an important role, and an experimental autoimmune encephalomyelitis (EAE) is used as an animal model of MS. Galectins are β-galactoside-binding lectins and involved in various physiological and pathological events. Among fifteen members ...

journal_title：Neurochemistry international

authors： Itabashi T,Arima Y,Kamimura D,Higuchi K,Bando Y,Takahashi-Iwanaga H,Murakami M,Watanabe M,Iwanaga T,Nio-Kobayashi J

更新日期：2018-09-01 00:00:00

abstract：:Five glutamate transporter genes have been identified; two of these (EAAT3 and EAAT4) are expressed in neurons and are predominantly confined to the membranes of cell bodies and dendrites. At an ultrastructural level, glutamate transporters have been shown to surround excitatory synapses in hippocampus and cerebellum ...

journal_title：Neurochemistry international

authors： Otis TS,Brasnjo G,Dzubay JA,Pratap M

更新日期：2004-09-01 00:00:00

abstract：:The effect of subcutaneous injections of saline (0.9% NaCl, 10-40 ?l/g b. wt) to 5- and 20-day old rats on the concentrations of tyrosine (Tyr) and tryptophan (Trp) in the serum and the brain and on the levels of biogenic amines and their metabolites in the developing brain at 6 h p.i. is described. At day 5 the conce...

journal_title：Neurochemistry international

authors： Huether G,Thoemke F,Sprotte U,Steinhaus U,Neuhoff V

更新日期：1985-01-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) levels and the activity of glutamate decarboxylase were measured in homogenates of rat brain cortical tissue, at different times after chronic intracortical infusion of GABA in vivo during 2, 6 or 24 h. Cortical electrical activity was also recorded. As previously described, about 1 h af...

journal_title：Neurochemistry international

authors： Salazar P,Montiel T,Brailowsky S,Tapia R

更新日期：1994-04-01 00:00:00

abstract：:The coenzyme functions of the B vitamins in intermediatry metabolism are well established; nevertheless, for none of them is it possible to determine precisely the connection between the biochemical lesions associated with deficiency and the neurological consequences. Although there is convincing evidence of a neurosp...

journal_title：Neurochemistry international

authors： Bender DA

更新日期：1984-01-01 00:00:00

abstract：:In the present study, we investigated the neuroprotective role of p38 inhibition on experimental stroke in rats. p38 inhibition treatment alleviated the brain infarction volume and neurological deficits following ischemia, promoted the activation of Extracellular signal-regulated kinases (ERK1/2), suppressed the activ...

journal_title：Neurochemistry international

authors： Zhang XM,Zhang L,Wang G,Niu W,He Z,Ding L,Jia J

更新日期：2015-11-01 00:00:00

abstract：:Lipid peroxidation has many deleterious effects on cells, and in the nervous system is considered to be involved in the pathogenesis of neurodegenerative diseases. To suppress lipid peroxidation, cells have various defense systems such as glutathione and thioredoxin, and defects in these defense systems will result in...

journal_title：Neurochemistry international

authors： Nagamine S,Kabuta T,Furuta A,Yamamoto K,Takahashi A,Wada K

更新日期：2010-09-01 00:00:00

abstract：:Serotonin (5-HT) is a prime candidate for studies of the interaction between the nervous and immune systems, since it is both an important neurotransmitter and released at high concentrations at sites of inflammation. Serotonergic neurotransmission is regulated by the 5-HT transporter (5-HTT), which determines the mag...

journal_title：Neurochemistry international

authors： Mössner R,Heils A,Stöber G,Okladnova O,Daniel S,Lesch KP

更新日期：1998-09-01 00:00:00

abstract：:A sandwich enzyme immunoassay (EIA) was established by using purified human serum dopamine-?-hydroxylase (DBH) as a standard protein and a monospecific polyclonal antibody raised against human DBH purified from human pheochromocytoma. The EIA was applied to measuring DBH levels in human CSF from Parkinsonian patients ...

journal_title：Neurochemistry international

authors： Mogi M,Harada M,Kojima K,Inagaki H,Kondo T,Narabayashi H,Arai T,Teradaira R,Fujita K,Kiuchi K,Nagatsu T

更新日期：1988-01-01 00:00:00

abstract：:The system of GABA transporters in neural cells constitutes an efficient mechanism for terminating inhibitory GABAergic neurotransmission. As such these transporter are important therapeutical targets in epilepsy and potentially other neurological diseases related to the GABA system. In this study a number of analogs ...

journal_title：Neurochemistry international

authors： Sarup A,Larsson OM,Bolvig T,Frølund B,Krogsgaard-Larsen P,Schousboe A

更新日期：2003-09-01 00:00:00

abstract：:The present experiments investigated the effect of a neurotoxin purified from the venom of the spider Phoneutria nigriventer. This toxic component, P. nigriventer toxin 3-6 (PnTx3-6), abolished Ca(2+)-dependent glutamate release with an IC(50) of 74.4nM but did not alter Ca(2+)-independent secretion of glutamate when ...

journal_title：Neurochemistry international

authors： Vieira LB,Kushmerick C,Reis HJ,Diniz CR,Cordeiro MN,Prado MA,Kalapothakis E,Romano-Silva MA,Gomez MV

更新日期：2003-03-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), an inducer of parkinsonism, causes degeneration of nigro-striatal dopaminergic neurons by producing its neurotoxic metabolite, 1-methyl-4-phenylpiridium ion (MPP+), by monoamine oxidase B in glial cells. We used PC12 (rat pheochromocytoma cell line) as a model cell ...

journal_title：Neurochemistry international

authors： Itano Y,Kitamura Y,Nomura Y

更新日期：1994-11-01 00:00:00

abstract：:Agomelatine is a novel antidepressant with agonistic actions at melatonergic (MT1 and MT2 receptors) and antagonistic actions at 5HT-2C receptors. Venlafaxine, a serotonin norepinephrine reuptake inhibitor, is a widely prescribed drug in depression. The present study evaluated the low dose combinations of venlafaxine ...

journal_title：Neurochemistry international

authors： Thomas J,Khanam R,Vohora D

更新日期：2016-10-01 00:00:00

abstract：:Increased noradrenaline, induced by rapid eye movement (REM) sleep deprivation, stimulates Na-K ATPase activity in the rat brain. The brain contains neurons as well as glia and both possess Na-K ATPase, however, it was not known if REM sleep deprivation affects the enzyme in both types of cells identically. Rats were ...

journal_title：Neurochemistry international

authors： Baskey G,Singh A,Sharma R,Mallick BN

更新日期：2009-01-01 00:00:00

abstract：:Posttranslational processing of peptide-precursors is nowadays believed to play an important role in the functioning of neurons and endocrine cells. Both proenkephalins and chromogranins/secretogranins are considered as precursor molecules in these tissues, resulting in posttranslationally formed degradation products ...

journal_title：Neurochemistry international

authors： Dillen L,Miserez B,Claeys M,Aunis D,De Potter W

更新日期：1993-04-01 00:00:00

abstract：:In the present investigation we address the question of whether one of the responses to increased neuronal activity is a modification of the expression of the different subunits of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-selective glutamate receptors (GluR-1, GluR-2, GluR-3). Thus, we used two dif...

journal_title：Neurochemistry international

authors： Condorelli DF,Belluardo N,Mudò G,Dell'Albani P,Jiang X,Giuffrida-Stella AM

更新日期：1994-10-01 00:00:00

abstract：:Alzheimer disease (AD) is the most common form of adult dementia. Its pathological hallmarks are synaptic degeneration, deposition of amyloid plaques and neurofibrillary tangles, leading to neuronal loss. A few hypotheses have been proposed to explain AD pathogenesis. The beta-amyloid (Abeta) and hyperphosphorylated t...

journal_title：Neurochemistry international

authors： Bojarski L,Herms J,Kuznicki J

更新日期：2008-03-01 00:00:00

abstract：:Striatal quinolinic acid lesions have been used as a model for the pathology seen in Huntington's disease. Seven days following a unilateral injection of 100 nmol of quinolinic acid into the rat caudate-putamen (striatum), a large increase in the binding of [3H]WIN 35,428 to the lesioned caudate-putamen was seen when ...

journal_title：Neurochemistry international

authors： Gehlert DR,Schoepp DD

更新日期：1992-12-01 00:00:00