BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures.

abstract：:Depression is highly comorbid with anxiety disorders and associated with profound cognitive impairment. Moreover, cognitive deficits associated with hippocampal dysfunction are central in depression and anxiety disorders. Furthermore, depression is accompanied by glutamatergic dysfunction which can further impair the ...

journal_title：Neurochemistry international

authors： Chakraborty S,Tripathi SJ,Srikumar BN,Raju TR,Shankaranarayana Rao BS

更新日期：2020-01-01 00:00:00

abstract：:The cardiovascular and pulmonary responses to vasoactive intestinal contractor (VIC) were compared with those of endothelin (ET)-1, ET-2, ET-3 and sarafotoxin 6b (S6b) and the mechanism by which ET-1 alters vascular resistance was investigated in the hindquarters vascular bed of the cat. In a manner similar to ET-1 an...

journal_title：Neurochemistry international

authors： Minkes RK,Kadowitz PJ

更新日期：1991-01-01 00:00:00

abstract：:The neuromodulator adenosine, has been shown to have the highest density of central uptake sites in the nucleus tractus solitarius in the dorsal brain stem. The nucleus tractus solitarius is involved in the central regulation of reflex cardiovascular activity suggesting that adenosine may also be involved in central c...

journal_title：Neurochemistry international

authors： Lawrence AJ,Castillo-Meléndez M,Jarrott B

更新日期：1994-09-01 00:00:00

abstract：:An intraocular injection of [(3)H]proline was used to label rabbit retinal ganglion cells including components subjected to axonal transport. Degradation of rapidly axonally transported labelled proteins was estimated in an in vitro system using homogenates of the nerve terminal regions. The energy requirements of thi...

journal_title：Neurochemistry international

authors： Gustavsson S,Karlsson JO

更新日期：1985-01-01 00:00:00

abstract：:Alzheimer disease (AD) is the most common form of adult dementia. Its pathological hallmarks are synaptic degeneration, deposition of amyloid plaques and neurofibrillary tangles, leading to neuronal loss. A few hypotheses have been proposed to explain AD pathogenesis. The beta-amyloid (Abeta) and hyperphosphorylated t...

journal_title：Neurochemistry international

authors： Bojarski L,Herms J,Kuznicki J

更新日期：2008-03-01 00:00:00

abstract：:Increased concentrations of kynurenine pathway metabolites have been reported by several groups for disorders involving psychosis, including schizophrenia and bipolar disorder. To identify components of the pathway that may be relevant as biomarkers or may underlie the etiology of psychosis, it is essential to charact...

journal_title：Neurochemistry international

authors： Miller CL,Llenos IC,Cwik M,Walkup J,Weis S

更新日期：2008-05-01 00:00:00

abstract：:A single molecular species of GTP-binding protein (G protein) has been purified from the bovine cerebral cortex. The immunoblot analysis indicated that the isolated G protein might be Gi1 or Gi2 but not Go, since it was reacted by specific antibodies, anti-Gi alpha 1-2 and anti-Gi alpha 1-1, but not anti-Go alpha. Whe...

journal_title：Neurochemistry international

authors： Nishikawa M,Hirouchi M,Kuriyama K

更新日期：1997-07-01 00:00:00

abstract：:Apart from acetyl-choline (Ach), adenosine-5'-trisphosphate (ATP) is thought to play a role in neuromuscular function, however little information is available on its cellular physiology. As such, effects of ATP and adenosine on contractility of mice diaphragmatic and skeletal muscles (m. extensor digitorum longa-MEDL)...

journal_title：Neurochemistry international

authors： Grishin SN,Teplov AY,Galkin AV,Devyataev AM,Zefirov AL,Mukhamedyarov MA,Ziganshin AU,Burnstock G,Palotás A

更新日期：2006-12-01 00:00:00

abstract：:The morphological differentiation of normal rat glioblasts induced by glia maturation factor (GMF) was investigated with regard to the reorganization of the cytoskeletal structures by the use of indirect immunofluorescence staining methods. The microfilaments were reorganized from a stress fiber form to a plasmalemmal...

journal_title：Neurochemistry international

authors： Ito J,Kato T,Tanaka R

更新日期：1990-01-01 00:00:00

abstract：:The influx of extracellular Zn(2+) into dentate granule cells is nonessential for dentate gyrus long-term potentiation (LTP) and the physiological significance of extracellular Zn(2+) dynamics is unknown in the dentate gyrus. Excess increase in extracellular Zn(2+) in the hippocampal CA1, which is induced with excitat...

journal_title：Neurochemistry international

authors： Suzuki M,Fujise Y,Tsuchiya Y,Tamano H,Takeda A

更新日期：2015-08-01 00:00:00

abstract：:The disposition of labelled [3H]GM1lactone, the inner ester of ganglioside GM1, was studied in the rat. After i.v. administration [3H]GM1lactone was quickly converted to its corresponding open form most likely by plasma esterases, and then displayed a pharmacokinetic profile identical to [3H]GM1. Following intramuscul...

journal_title：Neurochemistry international

authors： Bellato P,Milan F,Facchinetti E,Toffano G

更新日期：1992-04-01 00:00:00

abstract：:A competitive RT-PCR assay was used to quantify the expression of the GABA(A) receptor beta(1), beta(2) and beta(3) isoform mRNA transcripts in the superior frontal cortex and motor cortex of 21 control and 22 alcoholic cases. A single set of primers was designed that permitted amplification of all three transcripts a...

journal_title：Neurochemistry international

authors： Buckley ST,Dodd PR

更新日期：2004-12-01 00:00:00

abstract：:Rasagiline is a propargylamine and irreversible monoamine oxidase (MAO) B inhibitor used for the treatment of Parkinson's disease (PD). It has demonstrated neuroprotective properties in laboratory studies. Current concepts of PD aetiopathogenesis include the role of alpha-synuclein, protein aggregation, free radical m...

journal_title：Neurochemistry international

authors： Chau KY,Cooper JM,Schapira AH

更新日期：2010-11-01 00:00:00

abstract：:Neuroinflammation is an important factor contributing to cognitive impairment and neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), ischemic injury, and multiple sclerosis (MS). These diseases are characterized by inexorable progressive injur...

journal_title：Neurochemistry international

authors： de Araújo Boleti AP,de Oliveira Flores TM,Moreno SE,Anjos LD,Mortari MR,Migliolo L

更新日期：2020-06-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Rupture of lysosome is a major cellular stress condition leading to cell death in PD. We have previously shown that environmenta...

journal_title：Neurochemistry international

authors： Dong H,Qin Y,Huang Y,Ji D,Wu F

更新日期：2019-06-01 00:00:00

abstract：:Neurons with colocalized cholecystokinin and dopamine are present predominantly in the ventral tegmental area and project mainly to the caudal part of the medial nucleus accumbens. The activity of this dopamine system can be evaluated by means of the intracranial self-stimulation behavior on male Wistar rats having ch...

journal_title：Neurochemistry international

authors： De Witte P,Heidbreder C,Roques B,Vanderhaeghen JJ

更新日期：1987-01-01 00:00:00

abstract：:It was shown previously that pure oligodendrocytes release proteins when maintained in a chemically defined medium. Among these proteins, a 53 kDa glycoprotein was characterized as a component accessible from the external surface of these glial cells. Specific antibodies directed against this glycoprotein were obtaine...

journal_title：Neurochemistry international

authors： Pari FM,Roussel G,Nussbaum F,Nussbaum JL

更新日期：1988-01-01 00:00:00

abstract：:Striatal quinolinic acid lesions have been used as a model for the pathology seen in Huntington's disease. Seven days following a unilateral injection of 100 nmol of quinolinic acid into the rat caudate-putamen (striatum), a large increase in the binding of [3H]WIN 35,428 to the lesioned caudate-putamen was seen when ...

journal_title：Neurochemistry international

authors： Gehlert DR,Schoepp DD

更新日期：1992-12-01 00:00:00

abstract：:Gap junctions are transcellular pathways that enable a dynamic metabolic coupling and a selective exchange of biological signaling mediators. Throughout the course of the brain development these intercellular channels are assembled into regionally and temporally defined patterns. The present review summarizes the poss...

journal_title：Neurochemistry international

authors： Fróes MM,Menezes JR

更新日期：2002-11-01 00:00:00

abstract：:RBFox proteins are well-known alternative splicing regulators. We have shown previously that during neuronal differentiation of P19 cells induced by all-trans retinoic acid and cell aggregation, RBFox1 shows markedly increased temporal expression. To find its key splicing regulation, we examined the effect of RBFox1 o...

journal_title：Neurochemistry international

authors： Alam S,Suzuki H,Tsukahara T

更新日期：2014-12-01 00:00:00

abstract：:Metabotropic glutamate receptors (mGluRs) are expressed in neural progenitor cells (NPCs) and may play important roles in the neurogenesis during embryonic development and adult brain repair following injuries. In the present study, we investigated the expression of metabotropic glutamate receptor 7 (mGluR7) and the p...

journal_title：Neurochemistry international

authors： Tian Y,Liu Y,Chen X,Kang Q,Zhang J,Shi Q,Zhang H

更新日期：2010-08-01 00:00:00

abstract：:Air pollution is an important contributor to the global burden of disease, particularly to respiratory and cardiovascular diseases. In recent years, evidence is accumulating that air pollution may adversely affect the nervous system as shown by human epidemiological studies and by animal models. Age appears to play a ...

journal_title：Neurochemistry international

authors： Costa LG,Cole TB,Dao K,Chang YC,Garrick JM

更新日期：2019-12-01 00:00:00

abstract：:Parkinson's disease (PD), a progressive neurodegenerative disorder, has long been associated with mitochondrial dysfunction in both sporadic and familial forms of the disease. Mitochondria are crucial for maintaining cellular homeostasis, and their dysfunction is detrimental to dopaminergic neurons. These neurons are ...

journal_title：Neurochemistry international

authors： Müller-Nedebock AC,Brennan RR,Venter M,Pienaar IS,van der Westhuizen FH,Elson JL,Ross OA,Bardien S

更新日期：2019-10-01 00:00:00

abstract：:ATPase activities in CNS membranes were studied after administration of desipramine (DMI), a noradrenaline (NA) uptake inhibitor. In a previous paper we reported that Na+,K(+)-ATPase activity significantly increased 3 h after DMI administration (10 mg/kg) in hypothalamus and mesencephalus but not in cerebral cortex an...

journal_title：Neurochemistry international

authors： Viola MS,Rodríguez de Lores Arnaiz G,Enero MA

更新日期：1994-01-01 00:00:00

abstract：:Oxidative stress has for long been linked to the neuronal cell death in many neurodegenerative conditions. Conventional antioxidant therapies have been less effective in preventing neuronal damage caused by oxidative stress due to their inability to cross the blood brain barrier. Nanoparticle antioxidants constitute a...

journal_title：Neurochemistry international

authors： Sandhir R,Yadav A,Sunkaria A,Singhal N

更新日期：2015-10-01 00:00:00

abstract：:Sodium-dependent transporters regulate extracellular glutamate in the CNS. Recent studies suggest that the activity of several different neurotransmitter transporters can be rapidly regulated by a variety of mechanisms. In the present study, we report that pre-incubation of primary 'astrocyte-poor' neuronal cultures w...

journal_title：Neurochemistry international

authors： Munir M,Correale DM,Robinson MB

更新日期：2000-08-01 00:00:00

abstract：:Platelet-activating factor (PAF), a biologically active lipid (1-O-alkyl-2-acetyl-sn-glycero-3-phosphoholine), is identified in different regions of brain, including hippocampus. Specific PAF-activated receptors (PAFRs) are expressed in corresponding brain areas. PAF has been proposed to be a retrograde messenger of l...

journal_title：Neurochemistry international

authors： Kondratskaya EL,Pankratov YV,Lalo UV,Chatterjee SS,Krishtal OA

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:The major hallmark of Alzheimer's disease (AD) is the formation of amyloid aggregates, which are formed due to improper folding of proteins leading to the aggregation of amyloid beta (Aβ) 42 peptide. Inhibition of Aβ 42 aggregation using a drug such as carbenoxolone (Cbx), which has already been stated as ne...

journal_title：Neurochemistry international

authors： Sharma S,Nehru B,Saini A

更新日期：2017-09-01 00:00:00

abstract：:Major depressive disorder is the leading cause of disability and suicidality worldwide. Here, we evaluated neural metabolic activity in prefrontal cortex (PFC) in C57BL6 mice undergoing a chronic unpredictable mild stress (CUMS) for three weeks to induce depression. Further, the efficacy of Lanicemine, a low trapping ...

journal_title：Neurochemistry international

authors： Mishra PK,Adusumilli M,Deolal P,Mason GF,Kumar A,Patel AB

更新日期：2020-07-01 00:00:00

abstract：:Recent data indicate that BMY 7378 demonstrates high affinity, selectivity and low intrinsic activity at hippocampal 5-HT(1A) receptors, suggesting that BMY 7378 may represent the first selective 5-HT(1A) functional antagonist. The present study examined the agonist and antagonist properties of BMY 7378 at spinal cord...

journal_title：Neurochemistry international

authors： Zemlan FP,Zieleniewski-Murphy A,Maureen Murphy R,Behbehani MM

更新日期：1990-01-01 00:00:00